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41. 发明申请

US20100291537A1 METHODS AND COMPOSITIONS RELATED TO PHAGE-NANOPARTICLE ASSEMBLIES 审中-公开
标题翻译：相关的纳米材料组合物的方法和组合物
公开(公告)号：US20100291537A1
公开(公告)日：2010-11-18
申请号：US11719508
申请日：2005-11-16
申请人： Glauco Souza , Wadih Arap , Renata Pasqualini , J. Houston Miller
发明人： Glauco Souza , Wadih Arap , Renata Pasqualini , J. Houston Miller
IPC分类号： C12Q1/70 , C12M1/34
CPC分类号： G01N33/587 , A61K35/76 , A61K47/6901 , A61K49/0065 , A61K49/0097 , C07K7/06 , C07K14/005 , C07K2319/01 , C07K2319/20 , C12N7/00 , C12N2795/14122 , C12N2795/14142 , C12N2810/50 , G01N33/569
摘要： Embodiments of the invention include additional compositions and related methods and devices for the use of phage-nanoparticle assemblies. Embodiments of the invention include compositions, methods and devices related to phage-nanoparticle assemblies and their use in a variety of methods including detection methods, in vitro and in vivo diagnostic methods, direct and/or indirect therapeutic methods, or combinations thereof. Phage-nanoparticle assemblies of the invention comprise a plurality of nanoparticles complexed with one or more phage particles to form a phage-nanoparticle assembly. In certain aspects, the phage-nanoparticle assembly may also include other agents, including but not limited to organizing agents and/or therapeutic agents.
摘要翻译：本发明的实施方案包括另外的组合物和用于使用噬菌体 - 纳米颗粒组件的相关方法和装置。本发明的实施方案包括与噬菌体 - 纳米颗粒组件相关的组合物，方法和装置及其在各种方法中的应用，包括检测方法，体外和体内诊断方法，直接和/或间接治疗方法或其组合。本发明的噬菌体纳米颗粒组件包含与一个或多个噬菌体颗粒复合以形成噬菌体 - 纳米颗粒组件的多个纳米颗粒。在某些方面，噬菌体 - 纳米颗粒组件还可以包括其它试剂，包括但不限于组织试剂和/或治疗剂。

42. 发明申请

US20090137424A1 Selective Posttranslational Modification of Phage-Displayed Polypeptides 有权
标题翻译：噬菌体展示多肽的选择性翻译后修饰
公开(公告)号：US20090137424A1
公开(公告)日：2009-05-28
申请号：US11992341
申请日：2006-10-11
申请人： Meng-Lin Tsao , Feng Tian , Peter Schultz
发明人： Meng-Lin Tsao , Feng Tian , Peter Schultz
IPC分类号： C40B40/02 , C12N7/00
CPC分类号： C12P21/02 , C07K14/005 , C07K2319/00 , C07K2319/50 , C12N7/00 , C12N9/93 , C12N15/1037 , C12N15/67 , C12N2795/14122
摘要： The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e.g., an aryl-azide amino acid such asp-azido-L-phenylalanine, or an alkynyl-amino acid such as para-propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2]cycloaddition reactions and Staudinger modifications.
摘要翻译：本发明涉及噬菌体展示多肽的翻译后修饰。这些显示的多肽包含至少一个非天然氨基酸，例如芳基叠氮化物氨基酸，例如叠氮基-L-苯丙氨酸，或炔基 - 氨基酸如对 - 炔丙氧基苯丙氨酸，其被并入噬菌体展示的融合多肽通过使用包含合适的正交氨酰-tRNA合成酶和合适的正交tRNA物质的体内正交翻译系统在选定的位置。这些非天然氨基酸有利地提供翻译后修饰的靶标，例如叠氮炔 - 炔[3 + 2]环加成反应和施陶丁格修饰。

43. 发明授权

US07332321B2 Viral fibers 有权
标题翻译：病毒纤维
公开(公告)号：US07332321B2
公开(公告)日：2008-02-19
申请号：US10965665
申请日：2004-10-15
申请人： Angela M. Belcher , Seung-Wuk Lee
发明人： Angela M. Belcher , Seung-Wuk Lee
IPC分类号： C12N7/01 , D01F8/18 , D02G3/04
CPC分类号： C12Q1/70 , A61K35/76 , A61K47/58 , A61K47/62 , B82Y5/00 , C12N7/00 , C12N2795/14111 , C12N2795/14122 , D01D5/0007 , D01D5/0053 , D01F1/10 , D01F9/00 , Y10T428/2927 , Y10T442/2525
摘要： Long rod shaped M13 viruses were used to fabricate one dimensional (1D) micro- and nanosized diameter fibers by mimic the spinning process of the silk spider. Liquid crystalline virus suspensions were extruded through the micrometer diameter capillary tubes in cross-linking solution (glutaraldehyde). Resulting fibers were tens of micrometers in diameter depending on the inner diameter of the capillary tip. AFM image verified that molecular long axis of the virus fibers were parallel to the fiber long axis. Although aqueous M13 virus suspension could not be spun by electrospinning, M13 viruses suspended in 1,1,1,3,3,3-hexafluoro-2-propanol were spun into fibers. After blending with highly water soluble polymer, polyvinyl 2-pyrolidone (PVP), M13 viruses was spun into continuous uniform virus blended PVP (virus-PVP) fibers. Resulting virus-PVP electrospun fibers showed intact infecting ability to bacterial hosts after suspending in the buffer solution.
摘要翻译：长棒状M13病毒用于通过模拟丝蜘蛛的纺丝过程制造一维（1D）微米和纳米尺寸的纤维。将液晶病毒悬浮液通过交联溶液（戊二醛）中的微米直径毛细管挤出。所得纤维的直径为几十微米，取决于毛细管尖端的内径。 AFM图像验证了病毒纤维的分子长轴平行于纤维长轴。虽然M13病毒悬浮液不能通过静电纺丝而旋转，但悬浮在1,1,1,3,3,3-六氟-2-丙醇中的M13病毒被纺成纤维。在与高度水溶性聚合物共混后，将聚乙烯吡咯烷酮（PVP），M13病毒纺丝成连续均匀的病毒混合PVP（病毒 - PVP）纤维。得到的病毒PVP静电纺纤维悬浮于缓冲溶液中后显示细菌宿主的完整感染能力。

44. 发明申请

US20040023205A1 Method of recovering a nucleic acid encoding a proteinaceous binding domain which binds a target material 有权
标题翻译：回收编码结合目标材料的蛋白质结合结构域的核酸的方法
公开(公告)号：US20040023205A1
公开(公告)日：2004-02-05
申请号：US10126544
申请日：2002-04-22
发明人： Robert Charles Ladner , Sonia Kosow Guterman , Bruce Lindsay Roberts , William Markland , Arthur Charles Ley , Rachel Baribault Kent
IPC分类号： C12Q001/70 , C12Q001/68 , C07H021/04
CPC分类号： C40B40/02 , A61K38/00 , C07K1/047 , C07K1/107 , C07K14/43522 , C07K14/805 , C07K14/8114 , C07K14/8117 , C12N7/00 , C12N15/1037 , C12N2795/14111 , C12N2795/14122 , C12N2795/14143
摘要： In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained. In one embodiment, the first family of potential binding domains is related to bovine pancreatic trypsin inhibitor, the genetic package is M13 phage, and the protein includes the outer surface transport signal of the M13 gene III protein.
摘要翻译：为了获得针对所选靶标的新型结合蛋白，每个编码包含相似潜在结合结构域的家族之一的蛋白质的DNA分子和要求在选择的细菌细胞的外表面上显示蛋白质的结构信号，细菌孢子或噬菌体（遗传包装）被引入到遗传包装中。蛋白质被表达，并且潜在的结合结构域显示在包装的外表面上。分离和扩增具有识别靶分子的结合域的细胞或病毒。然后表征成功的结合结构域。将这些成功结合结构域中的一个或多个用作设计新的潜在结合结构域家族的模型，并重复该过程，直到获得对靶分子具有所需亲和力的新结合结构域。在一个实施方案中，第一潜在结合域家族与牛胰蛋白酶抑制剂有关，遗传包是M13噬菌体，蛋白质包括M13基因III蛋白的外表面转运信号。

45. 发明申请

US20030219722A1 Fusion proteins, modified filamentous bacteriophage, and populations or libraries of same 审中-公开
标题翻译：融合蛋白，修饰的丝状噬菌体，以及相同的群体或文库
公开(公告)号：US20030219722A1
公开(公告)日：2003-11-27
申请号：US10126685
申请日：2002-04-22
发明人： Robert Charles Ladner , Sonia Kosow Guterman , Bruce Lindsay Roberts , William Markland , Arthur Charles Ley , Rachel Baribault Kent
IPC分类号： C07K014/01 , C12Q001/70 , C07H021/04 , C12P021/04 , C12N001/21 , C12N015/74
CPC分类号： C40B40/02 , A61K38/00 , C07K1/047 , C07K1/107 , C07K14/43522 , C07K14/805 , C07K14/8114 , C07K14/8117 , C12N7/00 , C12N15/1037 , C12N2795/14111 , C12N2795/14122 , C12N2795/14143
摘要： In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained. In one embodiment, the first family of potential binding domains is related to bovine pancreatic trypsin inhibitor, the genetic package is M13 phage, and the protein includes the outer surface transport signal of the M13 gene III protein.
摘要翻译：为了获得针对所选靶标的新型结合蛋白，每个编码包含相似潜在结合结构域的家族之一的蛋白质的DNA分子和要求在选择的细菌细胞的外表面上显示蛋白质的结构信号，细菌孢子或噬菌体（遗传包装）被引入到遗传包装中。蛋白质被表达，并且潜在的结合结构域显示在包装的外表面上。分离和扩增具有识别靶分子的结合域的细胞或病毒。然后表征成功的结合结构域。将这些成功结合结构域中的一个或多个用作设计新的潜在结合结构域家族的模型，并重复该过程，直到获得对靶分子具有所需亲和力的新结合结构域。在一个实施方案中，第一潜在结合域家族与牛胰蛋白酶抑制剂有关，遗传包是M13噬菌体，蛋白质包括M13基因III蛋白的外表面转运信号。

46. 发明授权

US5834598A Human growth hormone variants 失效
标题翻译：人生长激素变体
公开(公告)号：US5834598A
公开(公告)日：1998-11-10
申请号：US463667
申请日：1995-06-05
申请人： Henry B. Lowman , James A. Wells
发明人： Henry B. Lowman , James A. Wells
IPC分类号： A61K47/48 , C07K14/01 , C07K14/47 , C07K14/575 , C07K14/61 , C07K19/00 , C12N5/10 , C12N15/10 , C12N15/11 , C12N15/62 , C12N15/85 , C12Q1/68 , C40B40/02 , G01N33/554 , G01N33/566 , G01N33/74 , A61K38/27
CPC分类号： C40B40/02 , C07K14/005 , C07K14/575 , C07K14/61 , C12N15/1037 , C12N15/62 , G01N33/6845 , G01N33/74 , C07K2319/00 , C07K2319/02 , C07K2319/735 , C07K2319/75 , C12N2750/00011 , C12N2795/14022 , C12N2795/14122 , G01N2333/61 , Y10S436/802 , Y10S930/12
摘要： A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants.
摘要翻译：提供了选择新型蛋白质如生长激素和具有改变其各自受体分子的结合特性的抗体片段变体的方法。该方法包括将编码目的蛋白质的基因融合到丝状噬菌体M13的基因III外壳蛋白的羧基末端结构域上。基因融合突变以形成在噬菌粒粒子表面上以低量表达的结构相关融合蛋白的文库。使用生物选择和筛选来鉴定可用作候选药物的新型配体。公开了优选的噬菌粒表达载体和选择的人生长激素变体。

47. 发明授权

US5534617A Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 失效
标题翻译：在位点1对人生长激素受体具有更高亲和力的人生长激素变体
公开(公告)号：US5534617A
公开(公告)日：1996-07-09
申请号：US67160
申请日：1993-05-25
申请人： Brian C. Cunningham , Henry Lowman , James A. Wells
发明人： Brian C. Cunningham , Henry Lowman , James A. Wells
IPC分类号： A61K38/27 , C07K14/01 , C07K14/475 , C07K14/575 , C07K14/61 , C12N1/21 , C12N15/10 , C12N15/18 , C12N15/62 , C12N15/63 , C40B40/02 , G01N33/68 , G01N33/74 , A61K38/25 , C12P21/06
CPC分类号： C40B40/02 , A61K38/27 , C07K14/005 , C07K14/575 , C07K14/61 , C12N15/1037 , C12N15/62 , G01N33/6878 , G01N33/74 , C07K2319/00 , C07K2319/02 , C07K2319/735 , C07K2319/75 , C12N2795/14122 , G01N2333/61 , Y10S930/12
摘要： Human growth hormone variants are disclosed wherein the lysine at position 41 and/or the leucine at position 45 of native human growth hormone, numbered from the mature N-terminus of native human growth hormone, has been replaced with another amino acid. Also claimed are combination variants that have a higher binding affinity to the growth hormone receptor than wild-type human growth hormone.
摘要翻译：公开了人生长激素变体，其中天然人生长激素的编号自天然人生长激素的成熟N末端的位置41的赖氨酸和/或第45位的亮氨酸已被另一个氨基酸替代。还要求的是与野生型人生长激素相比具有比生长激素受体更高的结合亲和力的组合变体。

48. 发明授权

EP2190982B1 SYSTEM, UMFASSEND WIRKSTOFFE UMFASSENDE PARTIKEL UND BAKTERIOPHAGEN 有权
标题翻译：系统包括积极全面粒子噬菌体
公开(公告)号：EP2190982B1
公开(公告)日：2013-04-17
申请号：EP08785277.8
申请日：2008-08-01
申请人： Bayer Intellectual Property GmbH
发明人： EIDEN, Stefanie , EBLE, Axel , WEISS, Martin , DUFF, Daniel, Gordon , BORK, Olaf , EGGER, Holger , BUDDE, Bastian , PLUG, Sascha
IPC分类号： C12N7/00
CPC分类号： A61K35/76 , A61K47/6901 , C07K7/06 , C07K7/08 , C07K14/005 , C07K17/02 , C07K17/14 , C07K2319/01 , C12N7/00 , C12N15/1037 , C12N2795/14122 , Y10T442/2508 , Y10T442/2525

49. 发明公开

EP1934343A4 SELECTIVE POSTTRANSLATIONAL MODIFICATION OF PHAGE-DISPLAYED POLYPEPTIDES 审中-公开
标题翻译：噬菌体PRESENTED多肽的选择性翻译后修饰
公开(公告)号：EP1934343A4
公开(公告)日：2009-09-16
申请号：EP06825758
申请日：2006-10-11
申请人： SCRIPPS RESEARCH INST
发明人： TSAO MENG-LIN , TIAN FENG , SCHULTZ PETER
IPC分类号： C12N15/10 , C12N7/00 , C12N9/00
CPC分类号： C12P21/02 , C07K14/005 , C07K2319/00 , C07K2319/50 , C12N7/00 , C12N9/93 , C12N15/1037 , C12N15/67 , C12N2795/14122

50. 发明公开

EP2054515A2 USE OF A PHAGE DISPLAYING A PEPTIDE FROM AN ADHESION PROTEIN FOR TREATING A DISEASE ASSOCIATED WITH INTRACELLULAR FORMATION OF PROTEIN FIBRILLAR INCLUSIONS OR AGGREGATES 有权
标题翻译：使用噬菌体带显示的肽的用于疾病相关的与INTRA CELLULAR地层蛋白纤维状的治疗中粘附蛋白聚集内含物或
公开(公告)号：EP2054515A2
公开(公告)日：2009-05-06
申请号：EP07799710.4
申请日：2007-07-19
申请人： Ramot at Tel-Aviv University Ltd.
发明人： SOLOMON, Beka , SHARON, Noa , GRINSTEIN, Oded
IPC分类号： C12N15/10 , A61K48/00 , C12N7/04 , A61K35/76 , A61P25/28
CPC分类号： C12N7/00 , A61K35/00 , A61K38/00 , C07K14/005 , C07K2319/01 , C12N2795/14122 , C12N2795/14161 , C12N2810/405
摘要： A therapeutic agent which carries a peptide sequence containing a mammalian cell adhesion sequence can be used to inhibit or treat diseases associated with intracellular formation of protein fibrillar inclusions or aggregates, to inhibit the intracellular formation of protein fibrillar inclusions or aggregates, and to disaggregate pre-formed intracellular protein fibrillar inclusions or aggregates. Filamentous bacteriophage which displays a non-filamentous bacteriophage RGD cell adhesion sequence on its surface, but not an antibody or non-filamentous bacteriophage antigen other than said RGD cell adhesion sequence, is a preferred embodiment of such a therapeutic agent.

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