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41. 发明授权

US09803252B2 Virus causing respiratory tract illness in susceptible mammals 有权
公开(公告)号：US09803252B2
公开(公告)日：2017-10-31
申请号：US15453764
申请日：2017-03-08
申请人： Erasmus University Medical Center Rotterdam
发明人： Jan Cornelius De Jong , Ronaldus Adrianus Maria Fouchier , Jan Groen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Bernadetta Gerarda Van Den Hoogen
IPC分类号： C12Q1/70 , C07K14/005 , C12N7/00 , C12N15/86 , A61K39/12 , A61K39/155 , C07K16/10 , G01N33/50 , G01N33/569 , A61K39/00
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single-stranded RNA virus (MPV) within the subfamily Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.

42. 发明授权

US09567653B2 Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences 有权
标题翻译：肺炎病毒菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体
公开(公告)号：US09567653B2
公开(公告)日：2017-02-14
申请号：US14460285
申请日：2014-08-14
申请人： Erasmus University Medical Center Rotterdam
发明人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Jan Cornelius De Jong , Jan Groen
IPC分类号： C12Q1/70 , A61K39/155 , C07K14/005 , C07K16/10 , C12N7/00 , C12N15/86 , G01N33/50 , G01N33/569 , A61K39/12 , A61K39/00
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/552 , A61K2039/58 , A61K2039/70 , A61K2123/00 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2710/22034 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18522 , C12N2760/18534 , C12N2760/18621 , C12N2760/18622 , C12N2760/18634 , C12N2760/18643 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5088 , G01N33/56983 , G01N2333/08 , Y02A90/26
摘要： Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. Also provided are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular, provided is a mammalian MPV, subgroups and variants thereof. Also provided are genomic nucleotide sequences of different isolates of mammalian MPV, in particular, human MPV. Disclosed is the use of the sequence information of different isolates of mammalian MPV for diagnostic and therapeutic methods. Provided are nucleotide sequences encoding the genome of an MPV or a portion thereof, including both mammalian and avian MPV. Further described are chimeric or recombinant viruses encoded by the nucleotide sequences and chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. Also provided are vaccine formulations comprising mammalian or avian MPV, including recombinant and chimeric forms thereof. The vaccine preparations encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.
摘要翻译：提供了副粘病毒科家族肺炎链球菌中分离的哺乳动物负链RNA病毒，偏肺病毒（MPV）。还提供了分离的哺乳动物负链RNA病毒，其可鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。特别地，提供哺乳动物MPV，亚组及其变体。还提供了哺乳动物MPV，特别是人MPV的不同分离物的基因组核苷酸序列。公开了哺乳动物MPV的不同分离株的序列信息用于诊断和治疗方法。提供编码MPV或其部分的基因组的核苷酸序列，包括哺乳动物和禽类MPV。进一步描述的是由核苷酸序列和包含一个或多个非天然或异源序列的嵌合和重组哺乳动物MPV编码的嵌合或重组病毒。还提供了包含哺乳动物或禽类MPV的疫苗制剂，包括其重组和嵌合形式。疫苗制剂包括多价疫苗，包括二价和三价疫苗制剂。

43. 发明授权

US08927206B2 Virus causing respiratory tract illness in susceptible mammals 有权
标题翻译：易感染哺乳动物引起呼吸道疾病的病毒
公开(公告)号：US08927206B2
公开(公告)日：2015-01-06
申请号：US10466811
申请日：2002-01-18
申请人： Jan Cornelius De Jong , Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Jan Groen
发明人： Jan Cornelius De Jong , Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Jan Groen
IPC分类号： C12Q1/70 , C12N15/86 , C07K14/005 , C12N7/00 , A61K39/00
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single stranded RNA virus (MPV) within the sub-family Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.
摘要翻译：本发明涉及病毒学领域。本发明提供了一种分离的基本上哺乳动物的负义义单链RNA病毒（MPV），其在副粘病毒亚科家族肺炎链球菌中，并且可以鉴定为与亚属肺炎病毒属及其组分的系统发育相关。

44. 发明申请

US20090246855A1 Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences 有权
标题翻译：肺炎病毒菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体
公开(公告)号：US20090246855A1
公开(公告)日：2009-10-01
申请号：US12284347
申请日：2008-09-18
申请人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Jan Cornelius De Jong , Jan Groen
发明人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Jan Cornelius De Jong , Jan Groen
IPC分类号： C12N7/04 , C07H21/04 , C12N7/00
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/552 , A61K2039/58 , A61K2039/70 , A61K2123/00 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2710/22034 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18522 , C12N2760/18534 , C12N2760/18621 , C12N2760/18622 , C12N2760/18634 , C12N2760/18643 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5088 , G01N33/56983 , G01N2333/08 , Y02A90/26
摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.
摘要翻译：本发明提供分离的哺乳动物负链RNA病毒，亚型家族肺炎链球菌中的亚型副粘病毒亚科病毒（MPV）。本发明还提供可分离的哺乳动物负链RNA病毒，其可鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。特别地，本发明提供哺乳动物MPV，亚组及其变体。本发明涉及哺乳动物偏肺炎病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。本发明涉及用于诊断和治疗方法的哺乳动物偏肺病毒的不同分离株的序列信息的使用。本发明涉及编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。本发明还包括由所述核苷酸序列编码的嵌合或重组病毒。本发明还涉及包含一种或多种非天然或异源序列的嵌合和重组哺乳动物MPV。本发明还涉及包含哺乳动物或禽类偏肺病毒的疫苗制剂，包括所述病毒的重组和嵌合形式。本发明的疫苗制剂包括多价疫苗，包括二价和三价疫苗制剂。

45. 发明授权

US07510863B2 Avian pneumovirus genes, recombinant avian pneumoviruses and methods of making 失效
标题翻译：禽流感病毒基因，重组禽流感病毒及其制备方法
公开(公告)号：US07510863B2
公开(公告)日：2009-03-31
申请号：US10868381
申请日：2004-06-16
申请人： Siba K. Samal , Govindarajan Dhanasekaran
发明人： Siba K. Samal , Govindarajan Dhanasekaran
IPC分类号： C12N7/00 , C12N7/04 , A61K39/155
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N2760/18321 , C12N2760/18322
摘要： The present invention is directed to novel avian pneumovirus strain Colorado (APV/CO) genes and intergenic sequences. Also disclosed are methods of making recombinant avian pneumovirus and live-attenuated APV/CO. Further disclosed are methods of diagnosing avian pneumovirus.
摘要翻译：本发明涉及新型禽流感病毒科罗拉多（APV / CO）基因和基因间序列。还公开了制备重组禽肺病毒和活减毒APV / CO的方法。进一步披露的是诊断禽肺病毒的方法。

46. 发明授权

US07449324B2 Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences 有权
标题翻译：肺炎病毒菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体
公开(公告)号：US07449324B2
公开(公告)日：2008-11-11
申请号：US10371099
申请日：2003-02-21
申请人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Jan Cornelius De Jong , Jan Groen
发明人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Jan Cornelius De Jong , Jan Groen
IPC分类号： C12N7/02
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/552 , A61K2039/58 , A61K2039/70 , A61K2123/00 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2710/22034 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18522 , C12N2760/18534 , C12N2760/18621 , C12N2760/18622 , C12N2760/18634 , C12N2760/18643 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5088 , G01N33/56983 , G01N2333/08 , Y02A90/26
摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.
摘要翻译：本发明提供分离的哺乳动物负链RNA病毒，亚型家族肺炎链球菌中的亚型副粘病毒亚科病毒（MPV）。本发明还提供可分离的哺乳动物负链RNA病毒，其可鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。特别地，本发明提供哺乳动物MPV，亚组及其变体。本发明涉及哺乳动物偏肺炎病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。本发明涉及用于诊断和治疗方法的哺乳动物偏肺病毒的不同分离株的序列信息的使用。本发明涉及编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。本发明还包括由所述核苷酸序列编码的嵌合或重组病毒。本发明还涉及包含一种或多种非天然或异源序列的嵌合和重组哺乳动物MPV。本发明还涉及包含哺乳动物或禽类偏肺病毒的疫苗制剂，包括所述病毒的重组和嵌合形式。本发明的疫苗制剂包括多价疫苗，包括二价和三价疫苗制剂。

47. 发明申请

US20160039884A1 Metapneumovirus Immunogens and Related Materials and Methods 审中-公开
标题翻译：偏肺病毒免疫原及相关材料与方法
公开(公告)号：US20160039884A1
公开(公告)日：2016-02-11
申请号：US14777095
申请日：2014-03-14
申请人： OHIO STATE INNOVATION FOUNDATION , RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
发明人： Jianrong Li , Yongwei Wei , Yu Zhang , Mark E. Peeples
IPC分类号： C07K14/005 , C12N7/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/543 , C07K16/2842 , C07K2317/76 , C12N7/00 , C12N2760/18321 , C12N2760/18333 , C12N2760/18334
摘要： The present invention provides compositions useful to induce immune response to human metapneumovirus. Also provided are related materials and methods, including methods to induce an immune response in a mammal, comprising administering the compositions herein.
摘要翻译：本发明提供了可用于诱导对人类偏肺病毒的免疫应答的组合物。还提供了相关材料和方法，包括在哺乳动物中诱导免疫应答的方法，包括施用本文的组合物。

48. 发明申请

US20150093746A1 Virus Causing Respiratory Tract Illness in Susceptible Mammals 有权
标题翻译：病毒导致呼吸道疾病易感哺乳动物
公开(公告)号：US20150093746A1
公开(公告)日：2015-04-02
申请号：US14553957
申请日：2014-11-25
申请人： ViroNovative BV
发明人： Jan Cornelius De Jong , Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus D M E Osterhaus , Jan Groen
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single-stranded RNA virus (MPV) within the subfamily Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.
摘要翻译：本发明涉及病毒学领域。本发明提供了分离的基本上哺乳动物的负义义单链RNA病毒（MPV），在亚科副粘病毒亚科的肺炎链球菌中，并且可鉴定为与亚属肺炎病毒属及其组分的系统发育。

49. 发明授权

US08715922B2 Virus causing respiratory tract illness in susceptible mammals 有权
标题翻译：易感染哺乳动物引起呼吸道疾病的病毒
公开(公告)号：US08715922B2
公开(公告)日：2014-05-06
申请号：US10722045
申请日：2003-11-25
申请人： Jan Cornelius De Jong , Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Jan Groen
发明人： Jan Cornelius De Jong , Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Jan Groen
IPC分类号： G01N33/53 , C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single stranded RNA virus (MPV) within the subfamily Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.
摘要翻译：本发明涉及病毒学领域。本发明提供分离的基本上哺乳动物的负义义单链RNA病毒（MPV），其在副粘病毒科的肺炎链球菌亚科内，并且可被鉴定为与亚属肺炎病毒属及其组分的系统发育相关。

50. 发明授权

US07704720B2 Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus 有权
标题翻译：肺炎病毒菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体和用于繁殖病毒的方法
公开(公告)号：US07704720B2
公开(公告)日：2010-04-27
申请号：US10831780
申请日：2004-04-23
申请人： Roderick Tang , Jeanne H. Schickli
发明人： Roderick Tang , Jeanne H. Schickli
IPC分类号： C12N7/00 , C12N7/02 , C12N7/04
CPC分类号： C07K16/1027 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/505 , A61K2039/543 , A61K2039/544 , A61K2039/70 , C07K14/005 , C07K2317/21 , C07K2317/23 , C12N7/00 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18351 , C12N2760/18361 , C12N2760/18534 , G01N2333/115
摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations. The invention also provide methods for propagating virus.
摘要翻译：本发明提供分离的哺乳动物负链RNA病毒，亚型家族肺炎链球菌中的亚型副粘病毒亚科病毒（MPV）。本发明还提供可分离的哺乳动物负链RNA病毒，其可鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。特别地，本发明提供哺乳动物MPV，亚组及其变体。本发明涉及哺乳动物偏肺炎病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。本发明涉及用于诊断和治疗方法的哺乳动物偏肺病毒的不同分离株的序列信息的使用。本发明涉及编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。本发明还包括由所述核苷酸序列编码的嵌合或重组病毒。本发明还涉及包含一种或多种非天然或异源序列的嵌合和重组哺乳动物MPV。本发明还涉及包含哺乳动物或禽类偏肺病毒的疫苗制剂，包括所述病毒的重组和嵌合形式。本发明的疫苗制剂包括多价疫苗，包括二价和三价疫苗制剂。本发明还提供了传播病毒的方法。

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