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41. 发明公开

US20240000473A1 SYSTEMS AND METHODS FOR SUBMUCOSAL TISSUE SEPARATION 审中-公开
公开(公告)号：US20240000473A1
公开(公告)日：2024-01-04
申请号：US18468853
申请日：2023-09-18
申请人： Boston Scientific Scimed, Inc.
发明人： Shawn Ryan , Samuel Raybin , Matthew B. Hollyer
IPC分类号： A61B17/32 , A61L31/14 , A61L31/04 , A61B17/00 , A61M5/19 , A61M5/28 , A61B17/34 , G01R33/00 , H01F27/34
CPC分类号： A61B17/320016 , A61L31/148 , A61L31/042 , A61B17/00234 , A61M5/19 , A61M5/285 , A61B17/3478 , G01R33/0011 , G01R33/0017 , H01F27/346 , A61B18/14
摘要： The present disclosure relates to the field of medical devices generally and specifically, to endoscopic systems and methods for resection of malignant and pre-malignant lesions within the gastrointestinal (GI) tract. In particular, the present disclosure relates to systems and methods for delivering injectable compositions between tissue layers (e.g., between the muscularis and submucosa layers) to elevate and stabilize the lesion for fast and efficient resection.

42. 发明授权

US11826481B2 Systems and approaches for sterilizing a drug delivery device 有权
公开(公告)号：US11826481B2
公开(公告)日：2023-11-28
申请号：US18069682
申请日：2022-12-21
申请人： AMGEN INC.
发明人： Loic Barbedette , Shaun Devitt , Wael Mismar
IPC分类号： H01J27/00 , A61N5/00 , A61L2/08 , A61M5/28 , A61M5/00 , B65B3/00 , B65B55/08 , A61L2/26 , G21F1/02 , G21F1/06 , G21F1/08
CPC分类号： A61L2/08 , A61L2/081 , A61L2/087 , A61L2/26 , A61M5/008 , A61M5/285 , B65B3/003 , B65B55/08 , G21F1/02 , G21F1/06 , G21F1/08 , A61L2202/23 , A61M5/001 , A61M5/002
摘要： An on-body injector system includes a drug container assembly including a container, a seal member, and a sealing interface between the seal member and the container. The container includes an opening and the seal member at least partially covers the opening in the container. A fluid pathway assembly is coupled to the drug container assembly and includes a needle that is movable between a storage position, in which a point of the needle is spaced from the seal member, and a delivery position, in which the point of the needle is disposed at least partially through the seal member. A radiation generator is configured to emit rays of radiation to sterilize and/or disinfect the sealing interface. A barrier is disposed adjacent to the sealing interface and has an opening. At least a portion of the drug container assembly is positioned adjacent to the opening in the barrier.

43. 发明授权

US11771830B2 Medicament delivery device and methods for delivering drugs to infants and children 有权
公开(公告)号：US11771830B2
公开(公告)日：2023-10-03
申请号：US17085761
申请日：2020-10-30
申请人： kaleo, Inc.
发明人： Eric S. Edwards , Evan T. Edwards , Glen L. Kelley , Paul F. Meyers
IPC分类号： A61M5/20 , A61M5/32 , A61K31/137 , A61M5/24 , A61M5/142 , A61M5/315 , A61M5/28
CPC分类号： A61M5/2033 , A61K31/137 , A61M5/2066 , A61M5/24 , A61M5/3202 , A61M5/2046 , A61M5/285 , A61M5/31533 , A61M2005/14288 , A61M2005/206 , A61M2005/2013 , A61M2005/2026 , A61M2005/2474 , A61M2005/31588 , A61M2205/3306 , A61M2205/3317 , A61M2205/3561 , A61M2205/581 , A61M2205/584
摘要： A method of delivering epinephrine includes placing a distal end surface of a medical injector into contact with a target location of a patient. The medical injector includes a housing, an energy storage member, and a medicament container containing a dose of epinephrine effective for administration to the patient experiencing anaphylaxis and having a weight of less than 15 kg. The medicament container is coupled to a needle. The medical injector is actuated such that the energy storage member produces a force to move the needle from a first needle position to a second needle position. A distal tip of the needle extends from the distal end surface by a distance of between 7 millimeters and 8 millimeters when the needle is in the second needle position. A portion of the force is exerted to expel the dose of epinephrine when the needle is in the second position.

44. 发明申请

US20180200444A1 CARTRIDGE HOLD-UP VOLUME REDUCTION 审中-公开
公开(公告)号：US20180200444A1
公开(公告)日：2018-07-19
申请号：US15875115
申请日：2018-01-19
申请人： Insulet Corporation
发明人： Maureen MCCAFFREY , David NAZZARO , Ian MCLAUGHLIN , Simon KOZIN
IPC分类号： A61M5/28 , A61M5/24 , A61M5/32 , A61M5/34
CPC分类号： A61M5/285 , A61J1/2089 , A61M5/142 , A61M5/2455 , A61M5/2466 , A61M5/31573 , A61M5/3293 , A61M5/34 , A61M2005/31516
摘要： Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.

45. 发明申请

US20180133375A1 Pre-Filled Syringe Formulation With Needle, Which Is Equipped With Syringe Cap 审中-公开
公开(公告)号：US20180133375A1
公开(公告)日：2018-05-17
申请号：US15522571
申请日：2015-10-30
申请人： Chugai Seiyaku Kabushiki Kaisha
发明人： Rieko SHIOZAKI , Yuji YAMANAKA , Mika TAKAHASHI , Tadao YAMAZAKI , Masakazu FUKUDA , Shogo YAMASHITA
IPC分类号： A61L31/04 , A61M5/32 , A61M5/28 , A61L31/16
CPC分类号： A61L31/049 , A61L31/048 , A61L31/16 , A61M5/28 , A61M5/285 , A61M5/32 , A61M5/3202 , A61M5/329 , A61M2207/00
摘要： The purpose of the present invention is to provide a pre-filled syringe formulation with staked needle, which contains an antibody at a high concentration and can be produced on an industrial scale in a simple manner without causing clogging. A pre-filled syringe formulation with staked needle, in which a protein solution is packed. The pre-filled syringe formulation is characterized in that a cap formed with a material having low water vapor permeability is provided at the needle.

46. 发明申请

US20170197040A1 SYRINGE ASSEMBLY, CAP, AND PUNCTURE NEEDLE 审中-公开
公开(公告)号：US20170197040A1
公开(公告)日：2017-07-13
申请号：US15470835
申请日：2017-03-27
申请人： TERUMO KABUSHIKI KAISHA
发明人： Kaori FUNATSU , Yoshihiko ABE , Ruriko IIBUCHI
IPC分类号： A61M5/32 , A61M5/28
CPC分类号： A61M5/3202 , A61M5/28 , A61M5/285 , A61M5/32 , A61M5/343 , A61M2005/3107 , A61M2005/311
摘要： A syringe assembly includes a barrel having a barrel tip portion, a puncture needle projecting from the barrel tip portion, and a cap that is detachably mountable to the barrel so as to seal a distal end of a needle hole. The cap has a receiving hole that receives the puncture needle, a bottom wall portion into which the puncture needle is inserted, and a stopper portion that defines an insertion length of the puncture needle relative to the bottom wall portion. In a state in which the cap is mounted to the barrel, the length from the most proximal position of a contact region between the cap and the puncture needle to the most proximal position of an edge surface is 1 to 3 mm.

47. 发明申请

US20170049969A1 INDICATOR 审中-公开
标题翻译：指示符
公开(公告)号：US20170049969A1
公开(公告)日：2017-02-23
申请号：US15307886
申请日：2015-05-01
申请人： New Injection Systems Ltd
发明人： Stephen Dunne , Tom Oakley , Douglas Arthur Emmott
IPC分类号： A61M5/315 , A61M5/20 , A61M5/24
CPC分类号： A61M5/31591 , A61M5/1454 , A61M5/2033 , A61M5/24 , A61M5/2466 , A61M5/282 , A61M5/285 , A61M5/315 , A61M2005/3126 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/6027
摘要： An auto-injector for delivering a liquid medicament comprises: a collapsible container for containing the liquid medicament (26); an openable closure; and an elongate indication member (21) located at least partially within the rigid outer container (22) and arranged to move longitudinally towards the distal end of the collapsible container when the openable closure is opened, in which longitudinal movement of the elongate indication member (21) produces visual, and/or audio and/or tactile feedback relating to injection progress to a user of the auto-injector.
摘要翻译：用于输送液体药物的自动注射器包括：用于容纳液体药物（26）的可收缩容器; 可开封以及细长的指示构件（21），其至少部分地位于所述刚性外部容器（22）内并且被布置成当所述可打开的封闭件打开时朝向所述可折叠容器的远端纵向移动，产生与自动注射器的使用者注射进度相关的视觉和/或音频和/或触觉反馈。

48. 发明授权

US08919390B2 Reagent preparation and dispensing device 有权
标题翻译：试剂准备和分配装置
公开(公告)号：US08919390B2
公开(公告)日：2014-12-30
申请号：US13988279
申请日：2010-11-18
申请人： Timothy Pearcy , James G. Skakoon
发明人： Timothy Pearcy , James G. Skakoon
IPC分类号： B01L3/02 , G01N1/10
CPC分类号： B01L3/0206 , A61M5/284 , A61M5/285 , A61M5/31511 , A61M2005/1787 , A61M2005/3104 , A61M2005/312 , A61M2005/3123 , B01L3/52
摘要： A reagent preparation and dispensing device includes a body having a reaction chamber for a reagent and a solution reservoir for a solution. The solution reservoir is isolated from the reaction chamber. A plunger is movably coupled with the body. Movement of the plunger from a starting position to a seated position pushes the solution into the reaction chamber. A dispensing path extends from the reaction chamber out of the body. The dispensing path is configured to dispense a reagent mixture formed from the solution and the reagent. A vent path extends from the reaction chamber, the vent path vents reaction chamber gas displaced by the addition of the solution to the reaction chamber throughout movement of the plunger from the starting position to the seated position.
摘要翻译：试剂制备和分配装置包括具有用于试剂的反应室和用于溶液的溶液储存器的主体。溶液储存器与反应室隔离。柱塞与主体可移动地联接。柱塞从起始位置移动到就座位置将溶液推入反应室。分配路径从反应室延伸出体外。分配路径被配置为分配由溶液和试剂形成的试剂混合物。通气路径从反应室延伸出来，排气路径通过将溶液加入反应室而使反应室气体发生位移，从而将柱塞从起始位置移动到就座位置。

49. 发明申请

US20140170594A1 DUAL MEDICAMENT CARPULE FOR DENTAL SYRINGES 审中-公开
标题翻译：用于牙科注射剂的双药卡片
公开(公告)号：US20140170594A1
公开(公告)日：2014-06-19
申请号：US14106555
申请日：2013-12-13
申请人： Bryan Larson
发明人： Bryan Larson
IPC分类号： A61C19/08
CPC分类号： A61C19/08 , A61M5/19 , A61M5/24 , A61M5/2448 , A61M5/282 , A61M5/283 , A61M5/284 , A61M5/285 , A61M5/286 , A61M2005/1787 , A61M2005/2474
摘要： A carpule for a dental syringe provides an internal piston disposed between a front septum and a rear plunger. The internal piston is hollow and includes a thin membrane front. The internal piston is designed to offer minimum resistance to movement in the carpule body to allow for aspiration and for easy dispensing. The internal piston divides the carpule into two anesthetic chambers, allowing an anesthetic without a vasoconstrictor and an anesthetic with a vasoconstrictor to be dispensed sequentially in a single injection and without causing undue trauma to the patient.
摘要翻译：用于牙科注射器的毛孔提供设置在前隔膜和后柱塞之间的内部活塞。内部活塞是中空的，并且包括薄膜前部。内部活塞被设计成能够提供最小的卡片体内的移动阻力，以允许抽吸和容易分配。内部活塞将黄铜分成两个麻醉室，允许没有血管收缩剂的麻醉剂和具有血管收缩剂的麻醉剂在单次注射中依次分配，并且不会对患者造成不适当的创伤。

50. 发明申请

US20100239355A1 Apparatus for Discharging a Pourable Substance 有权
标题翻译：排出易挥发物质的装置
公开(公告)号：US20100239355A1
公开(公告)日：2010-09-23
申请号：US12664849
申请日：2008-06-19
申请人： Alberto C. Sogaro
发明人： Alberto C. Sogaro
IPC分类号： B43K5/02
CPC分类号： A61M5/285 , A45D33/00 , A61M5/282 , A61M35/003 , A61M2039/229 , B65D47/205
摘要： Proposed is a device for applying a flowable substance comprising an outer shell (14) forming a receptacle for the flowable substance, as well as at least one portionally cylindrical insert (12) assigned to an application tip (22) and open at one end and closed at the other end and its shell featuring at least one orifice (34) connected to the open end. The outer shell (14) is shiftable in relation to the insert (12) between a blocked position in which a fluid flow between the outer shell (14) and the insert (12) is blocked by means of a sealing device and an activated position in which the fluid flow between the outer shell (14) and the insert (12) is released. The insert (12) has a male screw thread (20) mating the outer shell (14), the flowable substance flowing after twisting of the insert (12) in relation to the outer shell (14) and release of the orifice (34) into the insert (12). The outer shell is made, at least portionally, of an elastomeric plastics material. The insert (12) comprises a collar ring acting as a stop for the insert (12) at the outer shell (14) and as an actuator for shifting the outer shell (14) in relation to the insert (12)
摘要翻译：提出了一种用于施加可流动物质的装置，该可流动物质包括形成用于可流动物质的容器的外壳（14），以及分配给施用尖端（22）并在一端敞开的至少一个圆形圆柱形插入件（12）在另一端封闭，其壳体具有至少一个连接到开口端的孔口（34）。外壳（14）可相对于插入件（12）移动，在阻塞位置之间，其中外壳（14）和插入件（12）之间的流体流动通过密封装置和启动位置被阻挡其中外壳（14）和插入件（12）之间的流体流动被释放。插入件（12）具有与外壳（14）相配合的外螺纹（20），在插入件（12）相对于外壳（14）扭转之后流动的可流动物质和孔口（34）的释放，插入到插入件（12）中。至少在外壳上形成弹性体塑料材料。插入件（12）包括用作在外壳（14）处的用于插入件（12）的止动件的套环，并且作为用于相对于插入件（12）移动外壳（14）的致动器，

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