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41. 发明公开

KR1020080067333A 규소를 포함하는 영상 제제 无效
标题翻译：包含硅的成像剂
公开(公告)号：KR1020080067333A
公开(公告)日：2008-07-18
申请号：KR1020087009661
申请日：2006-09-22
申请人： 아이온 다이아그노스틱스 리미티드
发明人： 캔햄리트레버 , 크룩제스카안나앙니에즈카 , 발리제롬폴 , 바라자오라파엘라포르티스드룸몬드치카리노
IPC分类号： A61K49/04 , A61K49/06 , A61K49/18 , A61K49/22
CPC分类号： A61K49/04 , A61B6/506 , A61K49/0043 , A61K49/0045 , A61K49/0047 , A61K49/0091 , A61K49/0419 , A61K49/06 , A61K49/1818 , A61K49/1887 , A61K49/22 , A61K49/225 , A61K51/1244
摘要： The use of silicon as an imaging agent is described.
摘要翻译：描述了使用硅作为成像剂。

42. 发明公开

KR1020000052830A 진단/치료제 또는 그와 관련된 개선 无效
标题翻译：诊断/治疗药物的改善或相关
公开(公告)号：KR1020000052830A
公开(公告)日：2000-08-25
申请号：KR1019997003659
申请日：1997-10-28
申请人： 지이 헬스케어 에이에스
发明人： 클라베네스,요 , 롱베트,폴 , 회그세트,안데르스 , 톨레샤우그,헬게 , 쿠트베르트슨,알란 , 고달,아슬락 , 호프,라르스 , 고그스타트,가이르 , 브린,클라우스 , 네베스타트,안네 , 뢰프하우그,다그핀 , 헬레부스트,할디스 , 솔바켄,마그네
IPC分类号： A61K51/08
CPC分类号： A61K49/0056 , A61K47/542 , A61K47/549 , A61K47/55 , A61K47/554 , A61K47/62 , A61K47/6925 , A61K49/0043 , A61K49/0054 , A61K49/0091 , A61K51/0497 , A61K51/088
摘要： PURPOSE: Diagnostic and/or therapeutically active agents, more particularly to diagnostic and/or therapeutically active agents incorporating moieties having affinity for sites and/or structures within the body so that diagnostic imaging and/or therapy of particular locations within the body may be enhanced. CONSTITUTION: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprises a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, the agent being capable of forming at least two types of binding pairs with a target.
摘要翻译：目的：诊断和/或治疗活性剂，更具体地涉及结合具有对体内的位点和/或结构具有亲和性的部分的诊断和/或治疗活性剂，使得可以增强体内特定位置的诊断成像和/或治疗。构成：靶向诊断和/或治疗活性剂，例如超声造影剂包含在包含含气体或气体发生材料的报告物的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种类型的结合对。

43. 发明授权

KR101434879B1 암 조직 타겟팅 박테리아 기반의 마이크로로봇 및 그의 용도 有权
标题翻译：癌组织靶向细菌基底微杆菌
公开(公告)号：KR101434879B1
公开(公告)日：2014-09-11
申请号：KR1020120082536
申请日：2012-07-27
申请人： 전남대학교산학협력단
发明人： 박석호 , 박종오 , 박성준 , 고성영 , 민정준 , 박승환
IPC分类号： A61K9/16 , A61K47/30 , A61P35/00
CPC分类号： A61K35/74 , A61K47/6901 , A61K47/6925 , A61K49/0032 , A61K49/0091 , A61K49/0097 , Y02A50/473 , Y02A50/481
摘要： 본 발명은 생체 내에서 암 조직에 대하여 특이적으로 타겟팅 될 수 있는 박테리아 기반의 마이크로비드를 제공하기 위하여, 바이오틴(biotin)이 표면에 결합된 갖는 박테리아와 스트렙타비딘(streptavidin)이 표면에 코팅되고, 약물이 물리적으로 봉입된 마이크로비드를 포함하는 암 조직에 대한 약물운반체을 제공한다.

44. 发明公开

KR1020100016167A 눈 투명 조직 가시화용 현탁제 无效
标题翻译：暂停透视眼透视组织
公开(公告)号：KR1020100016167A
公开(公告)日：2010-02-12
申请号：KR1020097022956
申请日：2008-04-01
申请人： 센주 세이야꾸 가부시키가이샤
发明人： 마츠히사게이이치
IPC分类号： A61K9/10 , A61P27/02 , A61K31/765 , A61K47/02
CPC分类号： A61K31/765 , A61K9/0048 , A61K9/1647 , A61K49/0091
摘要： Disclosed is a suspension for visualizing a transparent tissue in an eye, which can be used as a means which is easy to use for improving the visibility of a transparent tissue in an eye during the surgery and which is highly safe. The suspension comprises a microparticle comprising a biodegradable polymeric compound, at least one salt selected from the group consisting of a trivalent metal salt and a bivalent metal salt, and an aqueous medium having the microparticle and the salt contained therein.
摘要翻译：公开了用于使眼睛中的透明组织可视化的悬浮液，其可以用作在手术期间易于使用以改善眼睛中的透明组织的可视性并且是高度安全的手段。悬浮液包含包含可生物降解的聚合化合物的微粒，选自三价金属盐和二价金属盐的至少一种盐，以及含有微粒和其盐的水性介质。

45. 发明授权

US11666664B2 Self assembling molecules for targeted drug delivery 有权
公开(公告)号：US11666664B2
公开(公告)日：2023-06-06
申请号：US16694437
申请日：2019-11-25
申请人： The General Hospital Corporation
发明人： David R. Elmaleh , Kazue Takahashi
IPC分类号： A61K39/00 , C07K16/00 , A61K47/69 , A61K9/51 , A61K47/62 , A61K47/68 , A61P35/00 , A61K9/50 , A61K31/337 , A61K31/473 , A61K31/7068 , A61K39/39 , A61K49/00 , A61K49/18 , A61K51/12
CPC分类号： A61K47/6949 , A61K9/5052 , A61K9/5169 , A61K31/337 , A61K31/473 , A61K31/7068 , A61K39/39 , A61K47/62 , A61K47/6849 , A61K47/6925 , A61K49/0069 , A61K49/0091 , A61K49/189 , A61K49/1821 , A61K51/1251 , A61K51/1268 , A61P35/00
摘要： Described herein are self-assembling protein molecules for delivering a payload, for example, a toxic anti-cancer agent, a cancer immunotherapy, a toxic anti-cancer agent and a cancer immunotherapy, or an imaging agent, to specific tissues. Examples of self-assembled proteins include clathrin and derivatives of clathrin.

46. 发明申请

US20170189881A1 Reversible Microcapsule Filter Cake 审中-公开
公开(公告)号：US20170189881A1
公开(公告)日：2017-07-06
申请号：US15436932
申请日：2017-02-20
申请人： Encapsys, LLC
发明人： Biao Duan
IPC分类号： B01J13/20 , C08J3/00 , C08J3/05 , C02F1/66 , F28D20/02 , C02F1/52 , C02F1/54 , C02F11/14 , B01D37/03 , B01J13/02 , C02F11/12
CPC分类号： B01J13/206 , A61K9/50 , A61K9/5089 , A61K49/0091 , A61K49/18 , A61K51/12 , B01D37/03 , B01J13/02 , B01J13/025 , B01J13/04 , B01J13/046 , B01J13/20 , B01J13/22 , C02F1/5236 , C02F1/542 , C02F1/66 , C02F1/68 , C02F11/121 , C02F11/122 , C02F11/127 , C02F11/14 , C02F2209/06 , C08J3/00 , C08J3/05 , C08J2333/00 , C10N2250/16 , C11D3/505 , F28D20/023 , Y02E60/145
摘要： The invention teaches a method of efficiently dewatering a microcapsule slurry to form a water re-suspendable filter cake of microcapsules. The process comprises providing an aqueous slurry of microcapsules dispersed in an aqueous solution; adding an agglomeration agent and dispersing the agglomeration agent into the aqueous slurry; adjusting the pH to a pH level sufficient to agglomerate the dispersed microcapsules; and filtering the aqueous slurry of microcapsules by gravity, vacuum or pressure filtration to thereby form a filter cake of dewatered microcapsules. The agglomeration agent is sodium polyphosphate, sodium tetrapolyphosphate, sodium hexametaphosphate, and/or sodium tripolyphosphate; or with anionic microcapsules or coatings even alkaline earth metal salts such as magnesium chloride, calcium chloride or barium chloride, or even aluminum salt such as aluminum chloride.

47. 发明授权

US09656233B2 Reversible microcapsule filter cake 有权
公开(公告)号：US09656233B2
公开(公告)日：2017-05-23
申请号：US14599014
申请日：2015-01-16
申请人： Biao Duan
发明人： Biao Duan
IPC分类号： B01J13/02 , A61K9/50 , B01J13/04 , B01D21/01 , C02F1/52 , B01J13/20 , C02F1/54 , C02F11/12 , C02F1/66 , C02F11/14 , B01D37/03 , B32B5/16 , B32B27/00 , B32B27/34 , B32B27/30 , B01J13/00 , B01D21/00 , C02F1/00 , B03D3/00 , B01D37/00 , A61K49/18 , A61K51/12 , A61K49/00 , C02F1/68 , C08J3/00 , C08J3/05
CPC分类号： B01J13/206 , A61K9/50 , A61K9/5089 , A61K49/0091 , A61K49/18 , A61K51/12 , B01D37/03 , B01J13/02 , B01J13/025 , B01J13/04 , B01J13/046 , B01J13/20 , B01J13/22 , C02F1/5236 , C02F1/542 , C02F1/66 , C02F1/68 , C02F11/121 , C02F11/122 , C02F11/127 , C02F11/14 , C02F2209/06 , C08J3/00 , C08J3/05 , C08J2333/00 , C10N2250/16 , C11D3/505 , F28D20/023 , Y02E60/145
摘要： The invention teaches a method of efficiently dewatering a microcapsule slurry to form a water re-suspendable filter cake of microcapsules. The process comprises providing an aqueous slurry of microcapsules dispersed in an aqueous solution; adding an agglomeration agent and dispersing the agglomeration agent into the aqueous slurry; adjusting the pH to a pH level sufficient to agglomerate the dispersed microcapsules; and filtering the aqueous slurry of microcapsules by gravity, vacuum or pressure filtration to thereby form a filter cake of dewatered microcapsules. The agglomeration agent is sodium polyphosphate, sodium tetrapolyphosphate, sodium hexametaphosphate, and/or sodium tripolyphosphate; or with anionic microcapsules or coatings even alkaline earth metal salts such as magnesium chloride, calcium chloride or barium chloride, or even aluminum salt such as aluminum chloride.

48. 发明授权

US09259474B2 Lipidated glycosaminoglycan particles and their use in drug and gene delivery for diagnosis and therapy 有权
公开(公告)号：US09259474B2
公开(公告)日：2016-02-16
申请号：US13629089
申请日：2012-09-27
申请人： TEL-AVIV UNIVERSITY FUTURE TECHNOLOGY DEVELOPMENT L.P.
发明人： Rimona Margalit , Dan Peer
IPC分类号： A61K9/14 , A61K47/36 , A61K9/00 , A61K9/16 , A61K9/50 , A61K9/51 , A61K47/48 , C07K14/47 , A61K38/00
CPC分类号： A61K9/5036 , A61K9/0043 , A61K9/1652 , A61K9/5123 , A61K9/5161 , A61K9/5192 , A61K31/165 , A61K31/407 , A61K31/704 , A61K38/00 , A61K38/212 , A61K38/28 , A61K38/385 , A61K47/36 , A61K47/544 , A61K47/61 , A61K47/6927 , A61K47/6939 , A61K48/0008 , A61K49/0043 , A61K49/0091 , A61K51/1251 , C07K14/4725
摘要： Lipidated glycosaminoglycan particles, prepared by reacting a glycosaminoglycan with at least one lipid to cross-link the carboxylic acid groups in the glycosaminoglycan with a primary amine in the lipid, are used to encapsulate drugs for use in the treatment of pathological conditions in an animal.

49. 发明授权

US09233084B2 Calcium carbonate microstructures useful in encapsulation applications and a process for the preparation thereof 有权
标题翻译：用于封装应用的碳酸钙微结构及其制备方法
公开(公告)号：US09233084B2
公开(公告)日：2016-01-12
申请号：US13045757
申请日：2011-03-11
申请人： Rohit Kumar Rana , Gousia Begum
发明人： Rohit Kumar Rana , Gousia Begum
IPC分类号： A61K31/155 , A61K31/65 , A61K31/704 , A61K49/00
CPC分类号： A61K31/155 , A61K31/65 , A61K31/704 , A61K49/0043 , A61K49/0054 , A61K49/0091
摘要： A facile method to synthesize stable calcium carbonate microstructures is demonstrated which allows in situ encapsulation of sensitive molecules like drugs. The methodology involves a macromolecular assembly of anionic polypeptide with cationic peptide oligomer to concurrently template and hold to stabilize the mineralized structure. The heterogeneously distributed mixture of anionic and cationic residues in the macromolecular assembly, similar to that is found in natural systems assists in recognizing and coassembling Ca2+ and CO32− ionic clusters, especially for formation of a disordered precursor phase such as amorphous calcium carbonate (ACC) and further crystallization to form a metastable vaterite phase. The assembly also facilitates encapsulation of a guest molecule such as tetracycline at ambient conditions without affecting the mineralization process. The tetracycline-loaded microstructures show excellent antibacterial activities against many Gram-positive and Gram-negative bacterial strains and hence together with the fluorescence property of tetracycline and appropriate drug release profile, they can be used as multifunctional materials for therapeutic and imaging applications.
摘要翻译：证明了合成稳定的碳酸钙微结构的简便方法，其允许诸如药物的敏感分子的原位包裹。该方法涉及阴离子多肽与阳离子肽低聚物的大分子组装，同时模板并保持以稳定矿化结构。在大分子组装中的非均匀分布的阴离子和阳离子残基的混合物类似于天然系统中发现的，有助于识别和组装Ca 2+和CO 32离子簇，特别是用于形成无序碳酸钙（ACC）的无序前体相，并进一步结晶以形成亚稳球霰石相。组合物还有助于在环境条件下包封客体分子例如四环素而不影响矿化过程。四环素负载的微结构对许多革兰氏阳性和革兰氏阴性细菌菌株显示出优异的抗菌活性，因此与四环素的荧光性质和合适的药物释放曲线一起，它们可以用作治疗和成像应用的多功能材料。

50. 发明授权

US09011819B2 Optical imaging contrast agents and uses thereof 有权
标题翻译：光学成像造影剂及其用途
公开(公告)号：US09011819B2
公开(公告)日：2015-04-21
申请号：US12888345
申请日：2010-09-22
申请人： Joshua J. Rychak
发明人： Joshua J. Rychak
IPC分类号： A61B8/00 , A61K49/22 , A61K49/00
CPC分类号： A61K49/0032 , A61K49/0002 , A61K49/0091 , A61K49/223
摘要： The present invention generally relates to microbubble contrast agent compositions which are detectable by optical imaging methods, such as fluorescence, near-infrared or bioluminescence. Uses of the described compositions for imaging and therapeutic applications are contemplated.
摘要翻译：本发明一般涉及通过诸如荧光，近红外或生物发光的光学成像方法可检测的微泡造影剂组合物。考虑了用于成像和治疗应用的所述组合物的用途。

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