专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

US20080286262A1 Photosensitizers for Photodynamic Therapy at Infrared Excitation 有权
标题翻译：用于红外激发光动力疗法的光敏剂
公开(公告)号：US20080286262A1
公开(公告)日：2008-11-20
申请号：US11750896
申请日：2007-05-18
申请人： Peng Zhang
发明人： Peng Zhang
IPC分类号： A61K39/395 , A61K47/02
CPC分类号： A61K9/0019 , A61K9/5115 , A61K41/008 , B82Y5/00
摘要： A photosensitizer that is excitable via infrared radiation and is adapted to be used to treat a selected biological target. The photosensitizer comprises a core nanoparticle adapted to convert infrared radiation into a visible light emission, and a coating disposed about the core nanoparticle. The coating contains a light excitable agent that is adapted to be excited by the visible light emission from the core nanoparticle. The photosensitizer can be surface modified with an antibody to make the photosensitizer specific to the biological target that is to be treated. Such surface modified photosensitizer is introduced to the target site and irradiated with infrared radiation.
摘要翻译：一种可通过红外辐射激发的光敏剂，适于用于治疗选定的生物靶。光敏剂包括适于将红外辐射转化成可见光发射的核心纳米颗粒，以及围绕芯纳米颗粒设置的涂层。该涂层含有适于被核心纳米颗粒的可见光发射激发的光可兴奋剂。光敏剂可用抗体进行表面改性，使光敏剂对待处理的生物靶标具有特异性。将这种表面改性的光敏剂引入目标部位并用红外辐射照射。

42. 发明申请

US20070010575A1 Intracorporeal medicaments for photodynamic treatment of disease 审中-公开
标题翻译：用于光动力治疗疾病的体内药物
公开(公告)号：US20070010575A1
公开(公告)日：2007-01-11
申请号：US11522145
申请日：2006-09-15
申请人： H. Dees , Timothy Scott , Eric Wachter , Walter Fisher , John Smolik
发明人： H. Dees , Timothy Scott , Eric Wachter , Walter Fisher , John Smolik
IPC分类号： A61K31/353
CPC分类号： A61K31/352 , A61B2017/00057 , A61B2017/22062 , A61B2017/22087 , A61F7/00 , A61K9/0019 , A61K41/0038 , A61K41/0057 , A61K41/0071 , A61K41/008 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/6803 , A61K49/0041 , A61K49/0433 , A61N5/0601 , A61N5/062 , C07D311/82 , Y02A50/473 , Y10T436/153333 , Y10T436/19 , Y10T436/193333
摘要： New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.
摘要翻译：描述了新的体内光动力学药物和用于治疗人或动物组织中的这种光动力药物的某些医学用途和方法，其中这种药物的主要活性成分是卤代呫吨或卤代呫吨衍生物。在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官，循环系统内脏和淋巴系统及相关器官，各种其他组织，如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。在另一个优选的实施方案中，这些药物以包括液体，半固体，固体或气溶胶递送载体的各种制剂生产。

43. 发明申请

US20030191458A1 Light-activated drug delivery method and device 审中-公开
标题翻译：光激活药物递送方法和装置
公开(公告)号：US20030191458A1
公开(公告)日：2003-10-09
申请号：US10116699
申请日：2002-04-03
发明人： Cornelius Diamond , Scott Arouh
IPC分类号： A61B018/18
CPC分类号： A61K41/008
摘要： A capsule, or a matrix, of a substance, most typically a polymer, that is degraded by a photo-acid or, less preferably, by a photo-base, physically contains or incorporates (i) a photo-acid, or a photo-base, or precursors to same, and (ii) one or more molecular agents, normally drugs. Placed in vivo, the photo-acid or photo-base or its precursors is (are) changed into an acid or base, as the case may be, by impinging radiation, most preferably by one or more light beams of green or longer wavelengths to which tissues are transparent, or else x-rays. The preferred light beams are two in number, spatially and temporally intersecting to produce the acid or base in vivo at precise regions and times by process of two-photon absorption. The photogenerated acid or base ruptures or dissolves the containment capsules or matrix, loosing the contained molecular agents (i) at precise subcutaneous tissue locations (ii) at precise rates (iii) over precise time intervals.
摘要翻译：被光酸降解的物质（最典型地是聚合物）的胶囊或基质，或者较不优选由光碱降解，物理地含有或包含（i）光酸或照片碱基或前体相同，和（ii）一种或多种分子试剂，通常为药物。根据情况，通过照射辐射，最优选地通过一个或多个绿色或更长波长的光束将光酸或光碱或其前体置换成酸或碱，视情况而定哪些组织是透明的，或者是x射线。优选的光束是数量上的两个，在空间和时间上相交，以通过双光子吸收的过程在精确的区域和时间在体内产生酸或碱。光生酸或碱破裂或溶解容纳胶囊或基质，以精确的时间间隔以精确的速率（iii）以精确的皮下组织位置（iii）使所含的分子试剂（i）松动。

44. 发明申请

US20030093092A1 Optically-absorbing nanoparticles for enhanced tissue repair 有权
标题翻译：光学吸收纳米粒子用于增强组织修复
公开(公告)号：US20030093092A1
公开(公告)日：2003-05-15
申请号：US10254233
申请日：2002-09-25
发明人： Jennifer L. West , Rebekah Drezek , Scott Sershen , Nancy J. Halas
IPC分类号： A61B017/58
CPC分类号： A61L24/02 , A61B18/20 , A61B18/203 , A61B18/28 , A61B2017/00508 , A61B2018/00452 , A61B2018/0047 , A61K41/0052 , A61K41/008 , A61K47/6923 , A61K47/6929 , A61L24/001 , A61L24/0089 , A61L26/0004 , A61L26/0095 , A61L2400/12 , B82Y5/00
摘要： This invention is generally in the field of improved methods for the localized delivery of heat and the use thereof for the repair of tissue. The method involves localized induction of hyperthermia in tissue or materials by delivering nanoparticles to the tissue or materials and exposing the nanoparticles to an excitation source under conditions wherein they emit heat. The generation of heat effects the joining of the tissue or materials.
摘要翻译：本发明通常在用于局部传递热量的改进方法及其用于组织修复的用途领域中。该方法包括通过将纳米颗粒递送到组织或材料并将纳米颗粒暴露于其发射热的条件下的激发源来在组织或材料中局部诱导热疗。热的产生影响组织或材料的接合。

45. 发明授权

US06402037B1 Two-photon upconverting dyes and applications 失效
标题翻译：双光子上变色染料及其应用
公开(公告)号：US06402037B1
公开(公告)日：2002-06-11
申请号：US09441720
申请日：1999-11-16
申请人： Paras N. Prasad , Jayant D. Bhawalker , Ping Chin Cheng , Shan Jen Pan
发明人： Paras N. Prasad , Jayant D. Bhawalker , Ping Chin Cheng , Shan Jen Pan
IPC分类号： G06K1900
CPC分类号： A61K49/0021 , A61K41/008 , A61K49/0084 , G11C13/04
摘要： The present invention is directed to styryl dyes having the formula: wherein D is an electron donating group; Q is an electron acceptor selected from the group consisting of electron acceptors having the formulae: W is an electron accepting group, R3 is selected from the group consisting of substituted or unsubstituted alkyl or substituted or unsubstituted aryl moieties, n is an integer from 0 to 4, A, B, and C are substituents of their rings and are each independently selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, sulfoalkyl, carboxyalkyl, and hydrogen, and Y is a counterion The present invention discloses media and methods for recording data. A three-dimensional matrix including a plurality of dye molecules, such a styryl dye molecule of the present invention, is provided. A first volume element in the matrix is exposed to actinic radiation for a duration and at an intensity effective to alter detectably a fraction between 0.3 and 0.7 of the dye molecules contained therein. The detectably altered dye molecules are substantially uniformly dispersed in the first volume element. The data storage methods and media of the present invention have approximately 1012 volume elements per square centimeter, and each of the volume elements can store a single bit, digital information of approximately 8 bits, or analog information. The data storage methods and media of the present invention are particularly useful for storing or archiving a series of two-dimensional black and white or color images, such as frames of a movie. Methods for reading data stored in the data storage media of the present invention using confocal microscopy are also disclosed.
摘要翻译：本发明涉及具有下式的苯乙烯基染料：其中D是给电子基团; Q是选自下组的电子受体：具有下式的电子受体：W是电子接受基团，R 3选自的取代或未取代的烷基或取代或未取代的芳基部分，n为0至4的整数，A，B和C为它们的环的取代基，并且各自独立地选自烷基，烷氧基，羟基烷基，磺基烷基，羧基烷基和氢，Y是抗衡离子。本发明公开了用于记录数据的介质和方法。提供了包含多个染料分子，如本发明的苯乙烯基染料分子的三维基质。基质中的第一体积元素暴露于光化辐射持续时间，强度有效地改变其中所含的染料分子的0.3至0.7之间的分数。可检测地改变的染料分子基本均匀地分散在第一容积元件中。本发明的数据存储方法和介质具有每平方厘米大约1012体积的元素，并且每个体积元素可以存储大约8位的单位数字信息或模拟信息。本发明的数据存储方法和媒体对于存储或归档一系列二维黑白图像或彩色图像（例如电影帧）特别有用。还公开了使用共焦显微镜读取存储在本发明的数据存储介质中的数据的方法。

46. 发明授权

US5998597A Method for improved selectivity in photo-activation of molecular agents 失效
标题翻译：提高分子试剂光激活选择性的方法
公开(公告)号：US5998597A
公开(公告)日：1999-12-07
申请号：US989231
申请日：1997-12-11
申请人： Walter G. Fisher , Eric A. Wachter , H. Craig Dees
发明人： Walter G. Fisher , Eric A. Wachter , H. Craig Dees
IPC分类号： C07D487/22 , A61B17/00 , A61B19/00 , A61K41/00 , A61N5/06 , A61P35/00 , C07H21/64 , C07K5/00 , C07K14/00
CPC分类号： A61K41/0057 , A61K41/008 , A61B2017/00057 , A61N5/062 , B82Y15/00
摘要： A method for the treatment of a particular volume of plant or animal tissue comprising the steps of treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue. There is also disclosed a method for the treatment of cancer in plant or animal tissue and a method for producing at least one photo-activated molecular agent in a particular volume of a material.
摘要翻译：一种用于治疗特定体积的植物或动物组织的方法，包括以下步骤：用至少一种光活性分子试剂处理所述植物或动物组织，其中所述植物或动物组织的特定体积保留至少一部分所述至少一种光活性分子试剂，然后用足以促进保留在所述至少一种光活性分子试剂中的所述至少一种光活性分子试剂中的至少一种的同时双光子激发的光来处理所述植物或动物组织的特定体积植物或动物组织的特定体积，其中至少一种光活性分子试剂在植物或动物组织的特定体积中变得活跃。还公开了一种用于在植物或动物组织中治疗癌症的方法以及在特定体积的材料中产生至少一种光活化分子试剂的方法。

47. 发明授权

US5957960A Internal two photon excitation device for delivery of PDT to diffuse abnormal cells 失效
标题翻译：内部双光子激发装置用于传递PDT以扩散异常细胞
公开(公告)号：US5957960A
公开(公告)日：1999-09-28
申请号：US850909
申请日：1997-05-05
申请人： James C. Chen , Brent Wiscombe
发明人： James C. Chen , Brent Wiscombe
IPC分类号： A61K41/00 , A61K45/00 , A61N5/06 , A61P43/00
CPC分类号： A61N5/062 , A61K41/008 , A61N5/0601 , A61N2005/0645 , A61N2005/0652
摘要： A plurality of light sources that emit light having a long wavelength are energized for an extended period of time to increase the likelihood of two photon absorption by cells that have preferentially absorbed a photoreactive agent such as psoralen. The cells are preferably microscopic metastatic cancer cells that are diffusely distributed throughout a treatment site, for example, within an organ. The plurality of light sources are arranged in a spaced-apart array, mounted on a support plate that includes a plurality of conductive traces. A plurality of such arrays are preferably mounted to a flexible sheet that can conform to an outer surface of an organ being treated. Because the light emitted by the light sources is in the infrared or near infrared waveband, it penetrates deeply into the tissue at the treatment site. The duration of the treatment and the number of light sources employed for administering the therapy increases the likelihood of two photon absorption by the metastatic cancer cells, which has been shown to activate the photoreactive agent to destroy cancer cells in a tumor, even though the characteristic light absorption waveband of the photoreactive agent is in the ultraviolet waveband.
摘要翻译：发射长波长的光的多个光源被激励一段较长的时间，以增加优先吸收光活性剂如补骨脂素的细胞的双光子吸收的可能性。细胞优选是扩散分布在整个治疗部位，例如器官内的微观转移癌细胞。多个光源被布置成间隔开的阵列，安装在包括多个导电迹线的支撑板上。多个这样的阵列优选地安装到柔性片材上，该柔性片材可以符合被处理器官的外表面。由于光源发出的光线处于红外线或近红外线波段，所以在治疗部位深入到组织中。用于治疗的持续时间和用于治疗该治疗的光源的数量增加了转移癌细胞的两个光子吸收的可能性，已经显示活化光反应剂以破坏肿瘤中的癌细胞，即使特征光反应剂的光吸收波段处于紫外波段。

48. 发明授权

EP2243783B1 Bisporphyrin conjugates as two photon absorption materials 有权
标题翻译： Bisporphyrinkonjugate作为双光子吸收材料
公开(公告)号：EP2243783B1
公开(公告)日：2014-01-01
申请号：EP10170353.6
申请日：2009-04-15
申请人： Ricoh Company, Ltd.
发明人： Tomura, Tatsuya , Sato, Tsutomu , Miki, Takeshi , Takada, Mikiko , Kamezaki, Hisamitsu
IPC分类号： C07D519/00 , G11B7/0045 , A61K41/00
CPC分类号： C07D487/22 , A61K41/008 , B82Y10/00 , C07D519/00 , G11B7/00455 , G11B7/248 , G11B7/2492 , G11B2007/0009 , G11B2007/24624

49. 发明公开

EP2635341A1 UPCONVERSION OF LIGHT FOR USE IN OPTOGENETIC METHODS 审中-公开
标题翻译： UP变换光中的用途OPTO遗传程序
公开(公告)号：EP2635341A1
公开(公告)日：2013-09-11
申请号：EP11838859.4
申请日：2011-11-04
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： DEISSEROTH, Karl , ANIKEEVA, Polina
IPC分类号： A61M37/00
CPC分类号： A61N5/0613 , A61D7/00 , A61K9/0019 , A61K9/1611 , A61K38/177 , A61K41/00 , A61K41/0038 , A61K41/008 , A61K48/0083 , A61N5/062 , A61N5/0622 , A61N2005/0659 , A61N2005/0662 , A61N2005/0663 , B82Y5/00 , C12N7/00 , C12N2750/14143
摘要： Provided herein are compositions comprising lanthanide-doped nanoparticles which upconvert electromagnetic radiation from infrared or near infrared wavelengths into the visible light spectrum. Also provided herein are methods activating light-responsive opsin proteins expressed on plasma membranes of neurons and selectively altering the membrane polarization state of the neurons using the light delivered by the lanthanide-doped nanoparticles.

50. 发明公开

EP2453922A1 ANTIBACTERIAL ORAL COMPOSITION 无效转让
标题翻译：抗菌口服组合
公开(公告)号：EP2453922A1
公开(公告)日：2012-05-23
申请号：EP10799337.0
申请日：2010-07-19
申请人： Klox Technologies Inc.
发明人： PIERGALLINI, Remigio , LOUPIS, Nikolaos
IPC分类号： A61K41/00 , A61K31/4166 , A61K31/7008 , A61K31/728 , A61P1/00 , A61P1/02
CPC分类号： A61K41/0057 , A61K8/38 , A61K8/494 , A61K8/498 , A61K8/602 , A61K8/735 , A61K8/97 , A61K9/006 , A61K31/327 , A61K31/4166 , A61K31/7008 , A61K31/728 , A61K33/40 , A61K41/0038 , A61K41/0042 , A61K41/008 , A61K45/06 , A61N5/0603 , A61N5/062 , A61N5/0624 , A61N2005/0606 , A61N2005/0652 , A61N2005/0663 , A61Q11/00 , A61Q17/005 , A61K2300/00
摘要： The present document describes methods of use of photoactivated compositions for oral disinfection and/or treatments which comprise at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmacologically acceptable carrier.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式