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41. 发明申请

WO00071038A1 MICROFLUIDIC DEVICES AND METHODS FOR PRODUCING PULSED MICROFLUIDIC JETS IN A LIQUID ENVIRONMENT 审中-公开
标题翻译：用于在液体环境中生产脉冲微流体喷射的微流体装置和方法
公开(公告)号：WO00071038A1
公开(公告)日：2000-11-30
申请号：PCT/US2000/013762
申请日：2000-05-19
IPC分类号： A61B17/22 , A61B17/32 , A61F9/007 , A61F9/011 , A61B17/39
CPC分类号： A61B17/3203 , A61B2017/22008 , A61B2017/32032 , A61B2018/263 , A61F9/00736 , A61F9/00825
摘要： Micro-fluid devices (10), and methods for their use in producing pulsed micro-fluid jets in a fluid environment are provided. The subject micro-fluid devices are characterized by the presence of a micro-fluid chamber (14) at their distal ends. The micro-fluid chamber (14) is bounded by an opening (16) at one end, a vapor producing means (18) opposite the opening (16), and sidewalls between the opening, and the vapor producing means (18). The micro-fluid chambers (14) are further characterized in that the only way fluid can exit the micro-fluid chambers is through the opening (16). In using the subject devices to produce a fluid jet in a fluid environment, the chamber is first contacted with the fluid environment. The vapor producing means (18) is then actuated in a manner sufficient to produce a vapor bubble (11) in the chamber (14) which, in turn, produces a micro-fluid jet in the fluid environment. The subject devices (10), and methods find use in a variety of different applications, e.g., cutting tissue, introducing fluid into a cell, and the like.
摘要翻译：提供微流体装置（10）及其在流体环境中生产脉冲微流体射流中的方法。目标微流体装置的特征在于在其远端处存在微流体室（14）。微流体室（14）由一端的开口（16），与开口（16）相对的蒸气产生装置（18）以及开口和蒸气产生装置（18）之间的侧壁限定。微流体室（14）的特征还在于流体可以离开微流体室的唯一方式是通过开口（16）。在使用主体装置在流体环境中产生流体射流时，腔室首先与流体环境接触。然后，蒸汽产生装置（18）以足以在室（14）中产生蒸汽气泡（11）的方式被致动，这又在流体环境中产生微流体射流。主题装置（10）和方法可用于各种不同的应用，例如切割组织，将流体引入细胞等。

42. 发明公开

EP3319538A1 LASER INDUCED COLLAGEN CROSSLINKING IN TISSUE 无效
标题翻译：激光诱导胶原蛋白在组织中的交联
公开(公告)号：EP3319538A1
公开(公告)日：2018-05-16
申请号：EP16858413.4
申请日：2016-10-23
申请人： The Trustees of Columbia University in the City of New York
发明人： VUKELIC, Sinisa , TROKEL, Stephen
IPC分类号： A61B18/20 , A61F2/16 , A61F9/008 , A61F9/01 , A61N1/44
CPC分类号： A61F9/008 , A61B18/042 , A61B18/203 , A61B18/26 , A61B90/361 , A61B2018/00702 , A61B2018/00785 , A61B2018/00791 , A61B2018/20359 , A61B2018/20553 , A61B2018/205545 , A61B2018/263 , A61F2009/00851 , A61F2009/00872 , A61F2009/00882 , A61F2009/00897 , A61N1/44 , A61N5/062 , A61N2005/067
摘要： The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage or cornea, without using a photosensitizer (e.g., riboflavin), by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of tissue. In an embodiment, the femtosecond laser operates in the infrared frequency range.

43. 发明公开

EP3240494A1 LASER-INDUCED PRESSURE WAVE EMITTING CATHETER SHEATH 有权
标题翻译：激光引起的压力波发射导管鞘
公开(公告)号：EP3240494A1
公开(公告)日：2017-11-08
申请号：EP15876302.9
申请日：2015-12-30
申请人： The Spectranetics Corporation
发明人： GRACE, Kenneth, P. , TRIFFO, Thomas , CEZO, James
IPC分类号： A61B18/24 , A61M25/00 , A61B18/26 , A61M25/09
CPC分类号： A61B17/3203 , A61B17/00234 , A61B17/22004 , A61B17/22022 , A61B17/320068 , A61B18/245 , A61B18/26 , A61B2017/00292 , A61B2017/00778 , A61B2017/22025 , A61B2017/22038 , A61B2017/22049 , A61B2017/32032 , A61B2018/263
摘要： The present disclosure relates generally to the use of medical devices for the treatment of vascular conditions. In particular, the present disclosure provides devices and methods for using electrically-induced pressure waves created within a sheath to disrupt vascular blockages via the sheath and/or a tip at the end of the sheath.

44. 发明公开

EP3003209A4 SYSTEM AND METHOD FOR TREATMENT OF ENDODONTIC/PERIODONTIC CONDITIONS 无效转让
标题翻译： SYSTEM UND VERFAHREN ZUR BEHANDLUNG VON ENDODONTISCHEN / PERIODONTISCHEN ERKRANKUNGEN
公开(公告)号：EP3003209A4
公开(公告)日：2017-06-28
申请号：EP14765398
申请日：2014-03-17
申请人： PIPSTEK LLC
发明人： DIVITO ENRICO E , TUBBS KEMMONS A , GLOVER DOUGLAS L , COLONNA MARK P , BARR ROBERT E
IPC分类号： A61C17/00 , A61C1/00 , A61N5/06
CPC分类号： A61N5/0603 , A61B2018/263 , A61C1/0046 , A61N5/0624 , A61N2005/0606 , A61N2005/067

45. 发明授权

EP2630918B1 OPTICAL FIBER AND UNDERWATER SHOCKWAVE GENERATING DEVICE EMPLOYING SAME 有权转让
标题翻译：纤维与器具，用于产生下WASER激波为了
公开(公告)号：EP2630918B1
公开(公告)日：2017-03-08
申请号：EP11834109.8
申请日：2011-07-27
申请人： Tohoku University
发明人： TAKAYAMA Kazuyoshi , YAMAMOTO Hiroaki , SHIMOKAWA Hiroaki
IPC分类号： A61B17/00 , A61B17/22 , A61B18/20
CPC分类号： A61B18/22 , A61B17/22012 , A61B18/26 , A61B2017/22024 , A61B2017/22025 , A61B2018/263 , G02B6/262

46. 发明公开

EP2969369A1 CONTROLLED PHOTOMECHANICAL AND PHOTOTHERMAL TISSUE TREATMENT IN THE PICOSECOND REGIME 有权转让
标题翻译： GESTEUERTE PHOTOMECHANISCHE UND PHOTOTHERMALE GEWEBEBEHANDLUNG IM PICOSEKUNDENBEREICH
公开(公告)号：EP2969369A1
公开(公告)日：2016-01-20
申请号：EP14723550.1
申请日：2014-03-13
申请人： Cynosure, Inc. , Welches, Richard, Shaun , Mirkov, Mirko Georgiev
发明人： WELCHES, Richard, Shaun , MIRKOV, Mirko Georgiev
IPC分类号： B23K26/06 , A61B18/26 , A61B18/20 , A61N5/067
CPC分类号： A61B18/20 , A61B18/203 , A61B18/26 , A61B2018/00398 , A61B2018/00458 , A61B2018/00577 , A61B2018/00702 , A61B2018/263 , B23K26/0624
摘要： Systems and methods for treating tissue by concentrating a laser emission to at least one depth at a fluence sufficient to create an ablation volume in at least a portion of the target tissue and controlling pulse width within the picosecond regime to provide a desired mechanical pressure in the form of shock waves and/or pressure waves.
摘要翻译：通过将激光发射集中到至少一个深度以足以在目标组织的至少一部分中产生消融体积并且控制皮秒范围内的脉冲宽度以在所述皮秒范围内提供期望的机械压力来处理组织的系统和方法形式的冲击波和/或压力波。

47. 发明公开

EP2763618A4 SURGICAL LASER CUTTING DEVICE 审中-公开
标题翻译： CHIRURGISCHE LASERSCHNEIDVORRICHTUNG
公开(公告)号：EP2763618A4
公开(公告)日：2015-06-24
申请号：EP12839133
申请日：2012-10-03
申请人： BIOLASE INC
发明人： BOUTOUSSOV DMITRI , NETCHITAILO VLADIMIR , CARINO AMADO
IPC分类号： A61B18/22 , A61B18/26
CPC分类号： A61B18/22 , A61B18/26 , A61B2018/20351 , A61B2018/20359 , A61B2018/208 , A61B2018/2211 , A61B2018/2222 , A61B2018/225 , A61B2018/2266 , A61B2018/2288 , A61B2018/263 , A61B2218/002 , A61B2218/005
摘要： Provided is a surgical handpiece for providing an electromagnetic cutting blade. The handpiece, comprises a body portion having an input end and an output end, a plurality of optical fibers for receiving laser energy having a wavelength within a predetermined wavelength range, wherein the optical fibers are received in the body portion at the input end and extend to the output end, and an optical fiber transition region within the body portion for arranging the plurality of optical fibers into a predetermine cutting shape at the output end, wherein laser energy transmitted from the arranged optical fibers at the output end interact with water molecules near the surgical target to generate micro-explosions that result in a cutting effect.
摘要翻译：提供了一种用于提供电磁切割刀片的外科手机。手机包括具有输入端和输出端的主体部分，用于接收波长在预定波长范围内的激光能量的多个光纤，其中光纤被接收在输入端的主体部分中并且延伸到输出端，以及主体部分内的光纤过渡区域，用于将多根光纤布置在输出端处的预定切割形状，其中在输出端从布置的光纤传输的激光能量与靠近的水分子相互作用手术目标产生导致切割效果的微爆炸。

48. 发明公开

EP2804659A1 SKIN TREATMENT SYSTEM AND METHOD 有权
标题翻译： HAUTBEHANDLUNGSSYSTEM
公开(公告)号：EP2804659A1
公开(公告)日：2014-11-26
申请号：EP13762558.8
申请日：2013-06-25
申请人： Koninklijke Philips N.V.
发明人： BRATCHENIA, Aliaksandr , VERHAGEN, Rieko
IPC分类号： A61M37/00 , A61B18/20 , A61N1/32 , A61M5/30 , A61N5/06
CPC分类号： A61N5/062 , A61B18/203 , A61B18/26 , A61B2018/00452 , A61B2018/0047 , A61B2018/00577 , A61B2018/202 , A61B2018/263 , A61B2018/266 , A61M5/14248 , A61M37/00 , A61M2005/3022 , A61M2037/0007 , A61M2205/058 , A61N5/0616
摘要： A system (101) for treatment of an epithelial tissue layer (3) is provided. The system comprises a reservoir (107), for containing an amount of a flowable medium, arranged to enable the medium, when contained in the reservoir, to be in contact with a surface (5) of the epithelial tissue layer, a light source (109) for generating a laser beam (11) during at least a predetermined pulse time, and an optical system for focusing the laser beam into a focal spot (15), and for positioning the focal spot in a target position. The target position of the focal spot is within the reservoir and within the medium, when contained in the reservoir, and the dimension of the focal spot and the power of the generated laser beam are such that, in the focal spot, the laser beam has a power density, which is above the characteristic threshold value for the medium, above which, for the predetermined pulse time, a laser induced optical breakdown event occurs in the medium. A method for treatment of an epithelial tissue layer is also provided.
摘要翻译：提供了一种用于治疗上皮组织层（3）的系统（101）。该系统包括用于容纳一定量的可流动介质的储存器（107），其布置成使得当容纳在储存器中时能够使介质与上皮组织层的表面（5）接触，光源（ 109），用于在至少预定的脉冲时间内产生激光束（11）;以及光学系统，用于将激光束聚焦到焦斑（15）中，并将焦点定位在目标位置。焦点的目标位置在储存器内并且在介质内，当容纳在储存器中时，焦点的尺寸和所产生的激光束的功率使得在焦点中激光束具有功率密度高于介质的特征阈值，其中在预定脉冲时间内，在介质中发生激光诱导光击穿事件。还提供了治疗上皮组织层的方法。

49. 发明公开

EP2265927A4 METHOD FOR CREATING, TRAPPING AND MANIPULATING A GAS BUBBLE IN LIQUID 审中-公开
标题翻译：制备方法技术，并捉对操纵气泡在液体
公开(公告)号：EP2265927A4
公开(公告)日：2014-02-26
申请号：EP09729002
申请日：2009-04-05
申请人： ZEISS CARL SMS LTD
发明人： OSHEMKOV SERGEY , DVORKIN LEV , DMITRIEV VLADIMIR
IPC分类号： G01N21/01 , A61B18/26 , G02B21/32
CPC分类号： G02B21/32 , A61B18/26 , A61B2018/263

50. 发明公开

EP2630918A1 OPTICAL FIBER AND UNDERWATER SHOCKWAVE GENERATING DEVICE EMPLOYING SAME 有权转让
标题翻译：纤维与器具，用于产生下WASER激波为了
公开(公告)号：EP2630918A1
公开(公告)日：2013-08-28
申请号：EP11834109.8
申请日：2011-07-27
申请人： Tohoku University
发明人： TAKAYAMA Kazuyoshi , YAMAMOTO Hiroaki , SHIMOKAWA Hiroaki
IPC分类号： A61B17/00 , A61B17/22 , A61B18/20
CPC分类号： A61B18/22 , A61B17/22012 , A61B18/26 , A61B2017/22024 , A61B2017/22025 , A61B2018/263 , G02B6/262
摘要： Provided are an optical fiber which has good laser beam condensation efficiency and is highly resilient, and a shockwave generating device employing same. An optical fiber (11) is employed in an underwater shockwave generating device (10) which projects a laser beam underwater and generates an underwater shockwave. The optical fiber (11) comprises: a main body part (16); and a laser convergence part (17) which is disposed upon a leading end thereof. The laser convergence part (17) is configured so as to exhibit an approximately frustum shape wherein the diameter of the leading end (18a) is narrower than the diameter of the base end (18b), and such that an interior angle θ with respect to a radial direction of a lateral face of an axial cross-section gradually decreases toward the front thereof.

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