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41. 发明专利

CA2568751A1 METHODS AND APPARATUS FOR LABEL-INDEPENDENT MONITORING OF BIOLOGICAL INTERACTIONS ON SENSITIZED SUBSTRATES 未知
公开(公告)号：CA2568751A1
公开(公告)日：2005-12-15
申请号：CA2568751
申请日：2005-06-03
申请人： ZYOMYX INC
发明人： INDERMUEHLE PIERRE , HEIDECKER MANFRED , WAGNER PETER , FOLLONIER STEPHANE
IPC分类号： G01N21/29 , B01L3/00 , B01L3/12 , G01N21/21
摘要： Sensor interrogation systems based on optical phase changes are configured to quantify analytes. Sensor chips and wells can include light scattering regions, light absorbing regions, or tilted regions to reduce or eliminate unwanted portions of an interrogation optical beam. In some examples, a spatial phase modulation is used to compensate static birefringence or to provide a selected sensor bias point. Phase changes can be detected based on state of polarization using interferometry. Optical resonator structures can be used to enhance phase changes to simplify detection of optical phase changes.

42. 发明专利

AU2004201126A1 Arrays of protein-capture agents and methods of use thereof 未知
公开(公告)号：AU2004201126A1
公开(公告)日：2004-04-22
申请号：AU2004201126
申请日：2004-03-17
申请人： ZYOMYX INC
发明人： ITIN CHRISTIAN , AULT-RICHE DANA , NOCK STEFFEN , WAGNER PETER
IPC分类号： G01N33/543

43. 发明专利

AU2003262452A1 Arrays of proteins and methods of use thereof I 未知
公开(公告)号：AU2003262452A1
公开(公告)日：2004-01-15
申请号：AU2003262452
申请日：2003-11-21
申请人： ZYOMYX INC
发明人： ITIN CHRISTIAN , NOCK STEFFENS , AULT-RICHE DANA , WAGNER PETER
IPC分类号： G01N33/543 , G01N33/551

44. 发明专利

AU765508B2 Arrays of proteins and methods of use thereof 未知
公开(公告)号：AU765508B2
公开(公告)日：2003-09-18
申请号：AU5102599
申请日：1999-07-14
申请人： ZYOMYX INC
发明人： WAGNER PETER , AULT-RICHE DANA , NOCK STEFFEN , ITIN CHRISTIAN
IPC分类号： C40B40/10 , G01N33/543 , G01N33/551 , G01N33/68 , G01N37/00

45. 发明专利

AU6822501A Screening of phage displayed peptides without clearing of the cell culture 未知
公开(公告)号：AU6822501A
公开(公告)日：2001-12-17
申请号：AU6822501
申请日：2001-06-05
申请人： ZYOMYX INC
发明人： NOCK STEFFEN , KASSNER PAUL D
IPC分类号： C12N15/10 , C40B40/02 , G01N33/569
摘要： This invention provides methods for screening populations of phage-displayed polypeptides that are particularly well-suited for high-throughput screening. The methods do not require the clearing of cells from a culture used to obtain the population of phage or other replicable genetic packages. Accordingly, the invention provides methods for forming complexes between a replicable genetic package displaying a polypeptide fusion and a target molecule in an uncleared cell culture containing replicable genetic package. Compositions made up of an uncleared cell culture containing replicable genetic packages displaying a polypeptide fusion and a target molecule are provided in the invention as well.

46. 发明专利

AU5102399A Arrays of protein-capture agents and methods of use thereof 未知
公开(公告)号：AU5102399A
公开(公告)日：2000-02-07
申请号：AU5102399
申请日：1999-07-14
申请人： ZYOMYX INC
发明人： WAGNER PETER , NOCK STEFFEN , AULT-RICHE DANA , ITIN CHRISTIAN
IPC分类号： C40B40/10 , G01N33/543 , G01N33/551 , G01N33/68 , G01N37/00

47. 发明专利

CA2337075A1 ARRAYS OF PROTEIN-CAPTURE AGENTS AND METHODS OF USE THEREOF 未知
公开(公告)号：CA2337075A1
公开(公告)日：2000-01-27
申请号：CA2337075
申请日：1999-07-14
申请人： ZYOMYX INC
发明人： ITIN CHRISTIAN , NOCK STEFFEN , AULT-RICHE DANA , WAGNER PETER
IPC分类号： C40B40/10 , G01N33/543 , G01N33/551 , G01N33/68 , G01N37/00
摘要： Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereo f, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.

48. 发明专利

ES2389437T3 Estuche y método de ensayo de células 未知
公开(公告)号：ES2389437T3
公开(公告)日：2012-10-26
申请号：ES08860287
申请日：2008-12-05
申请人： ZYOMYX INC
发明人： ZAUGG FRANK , TOBIAS RENEE , MCMANUS-MUNOZ SILVIA , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
IPC分类号： G01N33/543 , G01N33/49 , G01N33/569
摘要： Un método para ensayar una muestra de células por la presencia de al menos una concentración umbral decélulas de un tipo determinado, que comprende:(a) hacer reaccionar una muestra de células que contiene células del tipo de células determinado con partículascapaces de unión específica a las células y que son eficaces, cuando se unen a las células, para aumentar ladensidad o susceptibilidad magnética de las células, permitiendo que se separen células ligadas a partículas ypartículas libres de células no ligadas a partículas en la muestra basado en su mayor velocidad de migración por unmedio seleccionado bajo la influencia de una fuerza gravitatoria o centrífuga aplicada o de campo magnético,(b) hacer que las células unidas a partículas y las partículas en la muestra de células migren por una cámara derecogida alargada con dimensiones de ancho y profundidad entre 10 - 500 micrómetros y que contiene el medioseleccionado y que tiene a lo largo de su longitud, una pluralidad de regiones de recogida de células, sometiendo lamuestra a una fuerza gravitatoria o centrífuga seleccionada o de campo magnético durante un periodo de tiemposuficiente para causar sustancialmente que todas las células unidas a partículas y las partículas llenencompletamente regiones de recogida de células sucesivas en la cámara de recogida e(c) inspeccionar la cámara para determinar si al menos una región de recogida seleccionada se llena parcialmente ocompletamente, como demuestra que la muestra de células contenga al menos una concentración umbral de célulasdel tipo de células determinado

49. 发明专利

CA2708256A1 CELL ASSAY KIT AND METHOD 未知
公开(公告)号：CA2708256A1
公开(公告)日：2009-06-18
申请号：CA2708256
申请日：2008-12-05
申请人： ZYOMYX INC
发明人： ZAUGG FRANK , TOBIAS RENEE , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
IPC分类号： C12Q1/06 , C12M1/00 , G01N33/49 , G01N33/53 , G01N33/543 , G01N33/569
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell- collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

50. 发明专利

AU2003262452B2 Arrays of proteins and methods of use thereof I 未知
公开(公告)号：AU2003262452B2
公开(公告)日：2007-02-08
申请号：AU2003262452
申请日：2003-11-21
申请人： ZYOMYX INC
发明人： AULT-RICHE DANA , NOCK STEFFENS , WAGNER PETER , ITIN CHRISTIAN
IPC分类号： G01N33/543 , G01N33/551

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