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41. 发明专利

JP2000034227A SOLID COMPOSITION CONTAINING 4-AMINO-3-SUBSTITUTED- BUTANOIC ACID DERIVATIVE AND ITS PRODUCTION 失效
公开(公告)号：JP2000034227A
公开(公告)日：2000-02-02
申请号：JP13376999
申请日：1999-05-14
申请人： WARNER LAMBERT CO
发明人： AOMATSU AKIRA
IPC分类号： A61K9/14 , A01C11/02 , A61K20060101 , A61K9/16 , A61K9/20 , A61K9/28 , A61K9/48 , A61K31/00 , A61K31/195 , A61K31/197 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/439 , A61K31/4427 , A61K31/443 , A61K31/454 , A61K31/496 , A61K31/55 , A61K31/565 , A61K47/10 , A61K47/14 , A61K47/18 , A61P5/00 , A61P5/30 , A61P9/00 , A61P15/00 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , B60K17/06 , B62D25/22 , C07C229/28 , C07D209/08 , C07D209/10 , C07D209/12 , C07D401/12 , C07D405/04
摘要： PROBLEM TO BE SOLVED: To obtain a solid composition preparation effective for preventing a deterioration caused by lactam formation and having excellent storage stability by making the preparation include an amino-substituted butanoic acid derivative and a water-retaining agent. SOLUTION: The objective preparation is prepared by including (A) a 4- amino-3-substituted-butanoic acid derivative of formula I (R1 is H, methyl or the like; R2 is a 3-8C alkyl, a halogen, trifluoromethyl or the like) [e.g. 1-(aminomethyl)cyclohexane-acetic acid (gabapentin) of formula II], (B) a water- retaining agent (ethylene glycol, butylene glycol, monacetyl glyceride, etc.), and, as necessary, (C) an assistant for drug preparation. The amount of the component B is preferably 0.01-25 wt.% based on the component A. Preferably, the above component C is replaced with a neutral amino acid including L- leucine, L-valine, etc.

42. 发明专利

JPH11290561A RAZOR DEVICE 失效
公开(公告)号：JPH11290561A
公开(公告)日：1999-10-26
申请号：JP34839598
申请日：1998-12-08
申请人： WARNER LAMBERT CO
发明人： ORLOFF GLENNIS J
IPC分类号： B26B21/40
摘要： PROBLEM TO BE SOLVED: To provide a razor device having an electricity detecting device which responds to the force applied on the blade while shaving to provide automatic signals when the blade doesn't cut well and needs to be changed. SOLUTION: When a razor blade 18 of this device doesn't cut well, a user applies a strong force to the blade to achieve sufficient shaving. And, when such a strong force is applied, a piston 12, responding to the increased force during the shaving, moves in the direction to be apart from the blade. When the piston 12 moves sufficiently apart, it is pressed into an electronic device such as a potentiometer, which connects a signal processing circuit 15. And, the signal processing circuit 15 starts an indicator 16 such as a light emitting diode. Signals outputted when the indicator 16 is started are those informing the user that the blade 18 needs to be changed.

43. 发明专利

JPH10277277A RAZOR HEAD 失效
公开(公告)号：JPH10277277A
公开(公告)日：1998-10-20
申请号：JP34774297
申请日：1997-12-17
申请人： WARNER LAMBERT CO
发明人： ORTIZ ERNEST ALBERT , FERRARO FRANK ANTHONY
IPC分类号： B26B21/22 , B26B21/40
摘要： PROBLEM TO BE SOLVED: To closely arrange a razor' edge to contact the rugged outline or the skin face during shaving, by providing a material such as rubber which is compressible in response to a shaving force acting on the edge, as an elastic edge-support body and flexible in response to the shaving force to form protrusions or recessions. SOLUTION: A flexible upper support member 30 is provided with a rubber- like cap 32 fitted to a cap edge 22, rubber-like members 34 of both sides in which the ends of edges extend, and a plurality of rubber spacers supporting razor's edges 22, 24, 26 at every certain distance. In this way, the edges are surrounded and elastically and flexibly supported at every vertical distance in the upper part of the razor head 10 and at every horizontal distance across the breadthwise direction of the supporting body. In addition to such an elastic support of the edges, a rubber-like material is preferably used for the cap 32 and the side wall. Then, a contact face with one's skin having a relatively large friction can be obtained.

44. 发明专利

JPH10195071A PRODUCTION OF 6-(2-(SUBSTITUTED PYROL-1-IL)ALKYL)PYRAN-2-ON, AND ITS INTERMEDIATE 失效
公开(公告)号：JPH10195071A
公开(公告)日：1998-07-28
申请号：JP2255998
申请日：1998-01-21
申请人： WARNER LAMBERT CO
发明人： BUTLER DONALD EUGENE , DEERING CARL F , MILLAR ALAN , NANNINGA THOMAS N , ROTH BRUCE D
IPC分类号： A61K31/40 , A61K31/4025 , A61P3/06 , C07C235/80 , C07D207/34 , C07D319/06 , C07D319/08 , C07D405/06 , C07D405/14
摘要： PROBLEM TO BE SOLVED: To produce a 6-[2-substituted pyrol-1-il)alkyl]pyran-2-on useful as an inhibitor of cholesterol synthesis with fewer processes by using a new intermediate obtained by making 4-methyl-3-oxo-N-phenylpentaneamide react with benzaldehyde. SOLUTION: This 6-[2-substituted pyrol-1-il)alkyl]pyran-2-on is produced by making 4-methyl-3-oxo-N-phenylpentaneamide react with benzaldehyde by using β-alanine and glacial acetic acid as catalysts preferably in hexane to form a compound of formula I, making the resultant react with 4- fluorobenzaldehyde preferably in ethanol in the presence of 3-ethyl-5-(2- hydroxyethyl)-4-methylthiazolium and triethylamine, making the obtained compound react with a compound of formula II [R10 and R11 are each a 1-8C alkyl, or R10 and R11 form, in their combination, -CH2 CH(-CH3 ), etc.] in the presence of pivalic acid and a mixture of toluene and heptane to produce a compound of formula III, and converting the compound into the objective compound by a conventional method.

45. 发明专利

JPH09255593A INFORMATION MANAGEMENT SYSTEM FOR AUTOMATED MULTIPLE SIMULTANEOUS SYNTHESIS 失效
公开(公告)号：JPH09255593A
公开(公告)日：1997-09-30
申请号：JP8559697
申请日：1997-03-21
申请人： WARNER LAMBERT CO
发明人： SHIIRA HEREN HOTSUBUSU DEIUITS , MAAKU JIEI DAFUIIRUDO , ERIONOORA EMU HOOGAN , DEIBITSUDO GUREN NITSUKERU
IPC分类号： C07B61/00 , B01J19/00 , C40B60/14

46. 发明专利

JP2650644B2 失效
公开(公告)号：JP2650644B2
公开(公告)日：1997-09-03
申请号：JP14260696
申请日：1996-06-05
申请人： WARNER LAMBERT CO
发明人： KOSTLAN CATHERINE R , SIRCAR JAGADISH C
IPC分类号： A61K31/505 , A61P17/00 , A61P19/06 , A61P37/00 , A61P43/00 , C07D239/36 , C07D239/46 , C07D239/47 , C07D239/52 , C07D239/88 , C07D405/06 , C07D409/06 , C07D487/04

47. 发明专利

JPH09205994A MASTICATORY SWEET COMPOSITION AND ITS PREPARATION 失效
公开(公告)号：JPH09205994A
公开(公告)日：1997-08-12
申请号：JP1551597
申请日：1997-01-29
申请人： WARNER LAMBERT CO
发明人： ARAN EICHI GURAFU , JIEEMUZU II BAGAN
IPC分类号： A23G4/00 , A23G3/00 , A23G3/20 , A23G3/40 , A23G3/44 , A23G3/54 , A23G4/04 , A23G4/08 , A23G4/20 , A23G3/30
摘要： PROBLEM TO BE SOLVED: To obtain a new sweet product the core and the external shell of which are provided with texture different from each other and which gives the taste of the change of masicating feeling during masticating by including a chewing gum composition in its core and soft sweet composition in its external shell. SOLUTION: The product consists of the core and the external shell. The core includes a chewing gum composition including a chewing gum base (A), a sweetener (B), a softening agent (C) (desirably, a absolute glycerine) and a flavor (D), and the external shell includes the soft sweet composition including a sweetener (E), a whipping agent (F) (casein, e.g.) and the fat of 0 to 7% in weight based on the composition (G). It is desirable that the chewing gum composition includes the component (A) of 35 to 55% by weight based on the weight of the gum. The soft sweet composition is desirably a rough-feeling and nougat- like sweet including sucrose and cone syirup in the weight ratio of 3/2 to 4/1.

48. 发明专利

JP2506094B2 失效
公开(公告)号：JP2506094B2
公开(公告)日：1996-06-12
申请号：JP29064286
申请日：1986-12-08
申请人： WARNER LAMBERT CO
发明人： FURANSHISU AARU KAANII
IPC分类号： C07C59/125 , C07C51/00 , C07C51/09 , C07C51/347 , C07C51/367 , C07C59/68 , C07C67/00

49. 发明专利

JPH0826003B2 失效
公开(公告)号：JPH0826003B2
公开(公告)日：1996-03-13
申请号：JP17242094
申请日：1994-07-25
申请人： WARNER LAMBERT CO
发明人： TOMASU EFU MITSUKU , JOZEFU PII SANSHEZU , JON EMU DOOMAGARA
IPC分类号： C07D215/56 , A61K31/435 , A61K31/47 , A61P31/04 , C07D401/04 , C07D471/04 , C07D471/10 , C07D487/10 , C07D498/06 , C07D513/00 , C07D519/00

50. 发明专利

JPH07110829B2 失效
公开(公告)号：JPH07110829B2
公开(公告)日：1995-11-29
申请号：JP16678094
申请日：1994-07-19
申请人： WARNER LAMBERT CO
发明人： HAWAADO DANIERU HORISU SHOOORUTAA , JUUDEISU ERU JONSON , REZURII EMU WAABERU , EDOWAADO EFU ERUSURAAGAA
IPC分类号： A01N43/52 , A01N43/56 , A61K31/415 , A61K31/495 , A61K31/535 , A61P31/00 , A61P31/04 , A61P35/00 , A61P35/02 , C07C45/00 , C07C50/16 , C07C50/24 , C07C67/00 , C07C241/00 , C07C243/14 , C07D231/00 , C07D231/54 , C07D295/205 , C07D317/00 , C07D405/06 , C09B5/16

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