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41. 发明申请

WO2020245759A1 ANTIBACTERIAL COMPOUNDS 审中-公开
公开(公告)号：WO2020245759A1
公开(公告)日：2020-12-10
申请号：PCT/IB2020/055270
申请日：2020-06-04
申请人： UNIVERSITA' DEGLI STUDI DI SIENA
发明人： CORELLI, Federico , BRIZZI, Antonella , MUGNAINI, Claudia , DOCQUIER, Jean-Denis , SANNIO, Filomena
IPC分类号： C07D487/04 , A61K31/437 , A61P31/04
摘要： The present invention relates to compounds of formula (I) their salts and derivatives. Further object of the present invention are compositions, which comprise at least one compound of formula (I) or its pharmaceutically acceptable salts and derivatives and excipients and, optionally, a further active compound. Further object of the present invention are compounds of formula (I) or compositions which comprise them for use as antibacterial agents.

42. 发明申请

WO2020079574A1 CRISPR SYSTEM FOR GENOME EDITING 审中-公开
公开(公告)号：WO2020079574A1
公开(公告)日：2020-04-23
申请号：PCT/IB2019/058760
申请日：2019-10-15
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , ISTITUTO PER LO STUDIO, LA PREVENZIONE E LA RETE ONCOLOGICA (ISPRO) , UNIVERSITA' DEGLI STUDI DI FIRENZE
发明人： RENIERI, Alessandra , CONTICELLO, Silvestro , DONATI, Francesco , NICCHERI, Francesca , MARI, Francesca , PAPA, Filomena Tiziana , LORENZETTI, Flaminia Clelia
IPC分类号： C12N9/22 , C12N15/10 , C12N15/63 , C12N15/102 , C12N9/1211
摘要： A genome editing system, in particular a CRISPR system, is described, which targets a genomic target sequence in a eukaryotic cell and is capable of promoting the death of said cell. A viral particle and an isolated eukaryotic cell including the CRISPR system, a method that uses the system, and the use of the system as a medicament, in particular in the treatment of neoplastic diseases, are also described.

43. 发明申请

WO2019224732A1 SYSTEM FOR MONITORING ELECTRO-MEDICAL APPARATUSES INSTALLED IN THE HOME 审中-公开
公开(公告)号：WO2019224732A1
公开(公告)日：2019-11-28
申请号：PCT/IB2019/054216
申请日：2019-05-22
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , AZIENDA USL TOSCANA SUD EST
发明人： PAPEI, Claudio , CALIANI, Mauro , ABRARDO, Andrea
IPC分类号： G16H40/40 , G16H80/00 , H02J7/00
摘要： A system for monitoring electro-medical apparatuses installed in a patient's home is described, comprising a control device that includes: a control node that may be associated with at least one electro-medical apparatus; a plurality of functional modules coupled to the electro-medical apparatus, arranged to perform at least one of the following functions: - detecting operating parameters of the apparatus; - communicating information to the patient; - receiving commands from the patient, wherein the control node is adapted to establish a first communication link with each of the functional modules through a first communication protocol and a second communication link with a remote management unit through a second communication protocol, and wherein a module (20) is arranged for detecting over time a supply energy provided to the apparatus (A), to record variations in the consumption of electrical power by the apparatus (A) and to identify the operating status of the apparatus (A).

44. 发明申请

WO2018029588A1 FUNCTIONALIZED HYALURONIC ACID 审中-公开
标题翻译：功能化的透明质酸
公开(公告)号：WO2018029588A1
公开(公告)日：2018-02-15
申请号：PCT/IB2017/054811
申请日：2017-08-07
申请人： CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI , UNIVERSITA' DEGLI STUDI DI FIRENZE , UNIVERSITA' DEGLI STUDI DI SIENA
发明人： MAGNANI, Agnese , NATIVI, Cristina , LEONE, Gemma , LAMPONI, Stefania , CONSUMI, Marco , FRAGAI, Marco , BALDONESCHI, Veronica , RICHICHI, Barbara , FRANCESCONI, Oscar
IPC分类号： A61K47/61 , A61P27/04 , A61P19/02
摘要： The present invention describes the functionalization of sodium hyaluronate in a homogeneous phase with small molecules with proven inhibitory activity against membrane metalloproteins involved in the dry eye disease (MMP-2, MMP-9), in inflammatory processes at an osteoarticular level (MMP-12 and MMP-13) and in the formation of wrinkles (MMP-1 ). The hyaluronic acid derivative thus obtained (MMP- HA inhibitor) is useful for the medical treatment of dry eye and of inflammatory processes at the osteoarticular level, but also for the cosmetic treatment of skin blemishes due to aging processes.
摘要翻译：本发明描述了透明质酸钠与小分子在均相中的官能化，所述小分子对炎性过程中涉及干眼症（MMP-2，MMP-9）的膜金属蛋白具有证实的抑制活性在骨关节水平（MMP-12和MMP-13）和皱纹形成（MMP-1）。由此获得的透明质酸衍生物（MMP-HA抑制剂）可用于治疗干眼症和骨关节炎症过程，也可用于治疗因老化过程引起的皮肤瑕疵。

45. 发明申请

WO2017199171A1 A HAPTIC SYSTEM FOR PROVIDING A GAIT CADENCE TO A SUBJECT 审中-公开
标题翻译：一种为某个主题提供一个习题的时间系统
公开(公告)号：WO2017199171A1
公开(公告)日：2017-11-23
申请号：PCT/IB2017/052887
申请日：2017-05-16
申请人： UNIVERSITA' DEGLI STUDI DI SIENA
发明人： PRATTICHIZZO, Domenico , ROSSI, Simone , CIONCOLONI, David , LISINI BALDI, Tommaso , MOHAMMADI, Mostafa , AGGRAVI, Marco
IPC分类号： A61H3/00 , A61H23/02 , A61H39/00 , A61B5/11
CPC分类号： A61H3/00 , A61B5/1038 , A61B5/112 , A61B5/4836 , A61B5/6828 , A61B2505/09 , A61B2562/0219 , A61B2562/04 , A61H23/02 , A61H39/007 , A61H2003/007 , A61H2201/165 , A61H2201/5012 , A61H2201/5015 , A61H2201/5035 , A61H2201/5084 , A61H2201/5097
摘要： A haptic system (10,20,30,50,60,70) for providing a gait cadence to a subject (1,2) comprising a portable telecommunication device (16,26) with a control unit (17,27) and a wireless transmission means (18,28); a vibrotactile device (11, 11d,11s, 21, 21 d, 21s) configured to be tightly worn on a portion (6,6d,6s) of the subject's (1, 2) body, including at least one motor (12, 22) configured to generate vibrations (13, 23) that can be perceived by the subject (1, 2) and an actuation unit (14, 24) configured to actuate the motor (12, 22). The actuation unit (14, 24) is configured to receive wireless signals (15, 25) from the wireless transmission means (18,28) of the portable telecommunication device (16,26) and to cause the motor to produce vibrations (12, 22) responsive to the wireless signals (15,25). In the control unit (17, 27) a generation program is resident configured to generate cadence signals (17') and to transmit the wireless signals (15) responsive to the cadence signals (17') by the wireless transmission means (18,28) to the actuation unit (14, 24). The generation program is configured to provide corresponding cadence pulses (19,29) to the motor (12, 22), in order to cause the motor to generate the vibrations (13,23) in such a way that the subject (1, 2) can cadence the gait responsive to the cadence pulses (19, 29), the generation program configured to generate, through the cadence signals: a cadence pulse rate (19,29) set between 0,5 and 3 pulses per second; a single pulse duration (D) set between 0,1 and 1,0 second; a repeating the pulses (19,29) for at least 30 seconds.
摘要翻译：用于向包括便携式电信设备（16,26）的对象（1,2）提供步态节奏的触觉系统（10,20,30,50,60,70），所述便携式电信设备（16,26）具有控制器单元（17,27）和无线传输装置（18,28）; （1,2）本体部分（6,6d，6s）上紧密地佩戴的振动触觉装置（11,11d，11s，21,21d，21s），所述振动触觉装置包括至少一个电动机（12，（12,22）和被配置为致动所述马达（12,22）的致动单元（14,24），所述致动单元被配置为产生可由所述对象（1,2）感知的振动（13,23）。致动单元（14,24）被配置为从便携式电信设备（16,26）的无线传输装置（18,28）接收无线信号（15,25）并且使电动机产生振动（12,12）响应于无线信号（15,25）。在控制单元（17,27）中，驻留生成程序被配置为生成节奏信号（17'）并且响应于节奏信号（17'）通过无线传输装置（18,28）传输无线信号（15））到所述致动单元（14,24）。生成程序被配置为向马达（12,22）提供相应的节奏脉冲（19,29），以便使马达以这样的方式产生振动（13,23），使得受检者（1,2 ）可以响应于节奏脉冲（19,29）而步调，所述生成程序被配置为通过节奏信号生成：设定在0.5与3个脉冲每秒之间的节奏脉冲频率（19,29）; 单脉冲持续时间（D）设定在0.1和1.0秒之间; 重复脉冲（19,29）至少30秒。

46. 发明申请

WO2015028983A1 METHOD FOR THE EVALUATION OF THE SYNERGY BETWEEN ANTIBIOTICS, AND RELATED KIT OF PRODUCTS FOR CARRYING OUT THIS METHOD 审中-公开
标题翻译：用于评估抗生素合成之间的协同作用的方法以及用于实施该方法的相关产品的方法
公开(公告)号：WO2015028983A1
公开(公告)日：2015-03-05
申请号：PCT/IB2014/064148
申请日：2014-08-29
申请人： UNIVERSITA' DEGLI STUDI DI SIENA
发明人： ARENA, Fabio , ROSSOLINI, Gian Maria , GIANI, Tommaso
IPC分类号： C12Q1/18
CPC分类号： C12Q1/18 , C12Q1/20
摘要： The invention refers to a method for the simultaneous evaluation, in a single assay, of the synergy of antibiotic products in multiple associations of two and three antibiotics, against bacterial strains of carbapenem-resistant Enterobacteriaceae , which is reliable and reproducible, and at the same time is fast; the invention also refers to a kit of products for carrying out the aforementioned method.
摘要翻译：本发明涉及一种在单次测定中同时评价抗生素产品在两种和三种抗生素的多重结合中的协同作用，其对于耐药性良好且可重复的碳青霉烯类细菌菌株，同时进行评估时间快本发明还涉及用于实施上述方法的一组产品。

47. 发明申请

WO2003095493A3 TOXIN-RELATED ANTIBODIES WITH ANTIMICROBIAL AND ANTIVIRAL ACTIVITY 审中-公开
公开(公告)号：WO2003095493A3
公开(公告)日：2003-11-20
申请号：PCT/IB2003/002348
申请日：2003-05-09
申请人： UNIVERSITA DEGLI STUDI DI SIENA , POLONELLI, Luciano , CASSONE, Antonio
发明人： POLONELLI, Luciano , CASSONE, Antonio
IPC分类号： C07K16/42
摘要： Anti-idiotypic antibodies which recognise the idiotope of an antibody specific for a yeast killer toxin possess microbicidal activity. Fragments (e.g. decapeptides) of these anti-idiotypic antibodies, particularly those comprising CDR residues, also show microbicidal activity, as do peptides having 5 the same sequence but composed of D-amino acids, or including amino acid substitutions. Peptidomimetics of these microbicidal polypeptides are also provided. Antiviral activity is also seen.

48. 发明申请

WO2020127272A1 CRISPR-CAS SYSTEM FOR GENE THERAPY 审中-公开
公开(公告)号：WO2020127272A1
公开(公告)日：2020-06-25
申请号：PCT/EP2019/085659
申请日：2019-12-17
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , ISTITUTO PER LO STUDIO, LA PREVENZIONE E LA RETE ONCOLOGICA (ISPRO) , AZIENDA OSPEDALIERA UNIVERSITARIA SENESE (AOUS)
发明人： RENIERI, Alessandra , CONTICELLO, Silvestro , PINTO, Anna Maria , MELONI, Ilaria , DAGA, Sergio , DONATI, Francesco , CROCI, Susanna , LOPERGOLO, Diego
IPC分类号： C12N15/10 , C12N15/63 , C12N15/90
摘要： There is described a genome editing system, more particularly a dual vector CRISPR- Cas system suitable for gene editing - mediated correction of a mutant genomic target sequence in a target cell. There are further described a set of two viral particles and a host eukaryotic cell comprising the CRISPR-Cas system of the invention as well as the therapeutic use of this system, particularly for the treatment of genetic diseases.

49. 发明申请

WO2019219708A1 RECONFIGURABLE ANTENNA ASSEMBLY HAVING A METASURFACE OF METASURFACES 审中-公开
公开(公告)号：WO2019219708A1
公开(公告)日：2019-11-21
申请号：PCT/EP2019/062383
申请日：2019-05-14
申请人： PARIS SCIENCES ET LETTRES - QUARTIER LATIN , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITA DEGLI STUDI DI SIENA , TORINO POLITECNICO , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , SORBONNE UNIVERSITE
发明人： TRIPON-CANSELIET, Charlotte , MACI, Stefano , DELLA GIOVAMPAOLA, Cristian , VECCHI, Giuseppe
IPC分类号： H01Q15/00
摘要： The invention concerns an antenna assembly, comprising: - a single substrate (1) having a lower surface (11) and a upper surface (12); - an isotropic source of spherical electromagnetic waves configured for emitting surfaces waves on the upper surface (12) of the substrate; - a ground plane formed on the lower surface (11) of the substrate constituted by a metallic deposit on the entire lower surface (11); - an antenna element (2) formed on the upper surface (12) of the substrate (1) said antenna element (2) being constituted by a periodic patterns metasurface formed on the substrate by a texture of subwavelength patches, said antenna element being constituted of - a first-scale metasurface defined by a two-dimensional alternation (2) of metal or metamaterial patches (21, 22, 23) having closely spaced vertices in each contiguous element thus forming small gaps; - a plurality of switches (211, 212) disposed in the gap (200) between the vertexes of the patches, each switch (211, 212) permitting to connect several patches through the vertexes for defining a second-scale metasurface having a pattern thus forming the antenna element; wherein each patch has dimensions which do not depend to the frequency of the waves to be radiated, the antenna element being configured for transforming the emitting surface waves on leaky waves.

50. 发明申请

WO2017081709A1 BACTERIOPHAGE ABLE TO LYSE KLEBSIELLA PNEUMONIAE EXPRESSING A CPSKKBO-4 CAPSULAR POLYSACCHARIDE AND RELATED MEDICAL USES THEREOF 审中-公开
标题翻译：噬菌体能够表达CPSKKBO-4荚膜多糖的KLEBSIELLA PNEUMONIAE及其相关医学应用
公开(公告)号：WO2017081709A1
公开(公告)日：2017-05-18
申请号：PCT/IT2016/000261
申请日：2016-11-09
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , UNIVERSITA' DEGLI STUDI DI ROMA "TOR VERGATA"
发明人： THALLER, Maria, Cristina , D'ANDREA, Marco, Maria , ROSSOLINI, Gian, Maria
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12N2795/10221
摘要： The present invention concerns a bacteriophage able to lyse Klebsiella pneumoniae expressing a CPS KKBO-4 capsular polysaccharide, including but not limited to, strains of sequence type ST258-2, the major genotype of Klebsiella pneumoniae carbapenemase (KPC) producing strains, and related uses thereof in surface sanitization, colonization prevention, decolonization of carriers, diagnosis and therapy.
摘要翻译：本发明涉及能够裂解表达CPSKKBO-4荚膜多糖的肺炎克雷伯氏菌的噬菌体，所述荚膜多糖包括但不限于（KPC）产生菌株的主要基因型的序列类型ST258-2及其在表面消毒，定殖预防，载体的非结构化，诊断和治疗中的相关用途。

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