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41. 发明专利

JP2007054288A Composition for iontophoresis and electrode structure 审中-公开
标题翻译：用于静电和电极结构的组合物
公开(公告)号：JP2007054288A
公开(公告)日：2007-03-08
申请号：JP2005242996
申请日：2005-08-24
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： MATSUMURA TAKEHIKO , NAKAYAMA HATOO , AKIYAMA HIDEO , MATSUMURA AKIHIKO
IPC分类号： A61N1/30
摘要： PROBLEM TO BE SOLVED: To provide a composition for iontophoresis and an electrode structure to stably keep a medical agent and percutaneously administer the medical agent at a high transport number.
SOLUTION: The composition for iontophoresis contains an ionic medical agent A and a non-ionic medicative additive B, and the electrode structure keeps this composition. The medicative additive B, for its non-ionicity, does not block electrophoretic movement of the ionic medical agent A but keeps the high transport number of the ionic medical agent A when electric power is distributed, and stabilizes physicochemical state of the ionic medical agent A when the electric power is not distributed. The non-ionic medicative additive B is at least one selected from a group comprising methylparaben, chlorobutanol, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate, propyl parahydroxybenzoate, methyl parahydroxybenzoate, and D-sorbitol.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于离子电渗疗法的组合物和电极结构，以稳定地保持药剂并以高输送数经皮给药。解决方案：用于离子电渗疗法的组合物含有离子药剂A和非离子药物添加剂B，电极结构保持该组成。由于其非离子性，药物添加剂B不会阻止离子药剂A的电泳运动，而是在分配电力时保持离子药剂A的高输送量，并稳定离子药剂A的物理化学状态当电力不分配时。非离子型药物添加剂B是选自对羟基苯甲酸甲酯，氯丁醇，对羟基苯甲酸异丙酯，对羟基苯甲酸异丙酯，对羟基苯甲酸乙酯，对羟基苯甲酸丁酯，对羟基苯甲酸丙酯，对羟基苯甲酸甲酯和D-山梨糖醇的至少一种。版权所有（C）2007，JPO＆INPIT

42. 发明专利

JP2006334292A Medicine bipolar driving type iontophoresis apparatus 审中-公开
标题翻译：医用双极型驱动型IOPOPHORESIS装置
公开(公告)号：JP2006334292A
公开(公告)日：2006-12-14
申请号：JP2005165634
申请日：2005-06-06
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： MATSUMURA AKIHIKO , MATSUMURA TAKEHIKO , NAKAYAMA HATOO , AKIYAMA HIDEO
IPC分类号： A61N1/30 , A61N1/04
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis apparatus capable of administering medicine into a living body at a high rate of penetration and simultaneously administering a plurality of medicines. SOLUTION: This iontophoresis apparatus is provided with a power supply device, a first electrode structure connected to the power supply device and retaining a first ionic medicine, and a second electrode structure retaining a second ionic medicine ionized to a polarity opposite to that of the first ionic medicine. This iontophoresis apparatus is characterized in percutaneously administering the first ionic medicine from the fist electrode structure to the living body and percutaneously administering the second ionic medicine from the second electrode structure to the living body. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：解决问题：提供能够以高的渗透率向生物体施用药物并同时施用多种药物的离子电渗疗法装置。解决方案：该离子电渗装置设置有电源装置，连接到电源装置并保持第一离子药物的第一电极结构，以及保持电离至极性相反极性的第二离子药物的第二电极结构的第一种离子药。该离子电渗疗法的特征在于，将第一离子药从第一电极结构经皮给药至生物体，并将第二离子药从第二电极结构经皮给药至生物体。版权所有（C）2007，JPO＆INPIT

43. 发明专利

JP2006334164A Iontophoresis apparatus and method for controlling the same 审中-公开
标题翻译： IOPOPHORESIS设备及其控制方法
公开(公告)号：JP2006334164A
公开(公告)日：2006-12-14
申请号：JP2005163002
申请日：2005-06-02
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： MATSUMURA AKIHIKO , MATSUMURA TAKEHIKO , NAKAYAMA HATOO , AKIYAMA HIDEO
IPC分类号： A61N1/30 , A61F7/08 , A61N5/06
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/0444
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis apparatus which can prescribe a medicament of a higher molecular weight to a living body by accelerating moving of the medicament to the living body, and to provide a method of control the same.
SOLUTION: The iontophoresis apparatus which is provided with an acting-side structure having a first electrode, a medicament holding part conducted from the first electrode and a first ion exchange membrane arranged on the front face side of the medicament holding part to transmit a first conductive ion selectively, and which prescribes the first conductive medicament ion generated by dissociation of the medicament held by the medicament holding part to the living body through the first ion exchange membrane made to abut on the skin of the living body is provided with a warming means for warming the skin of the living body on which the first ion exchange membrane abuts.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种离子电渗疗法装置，其可以通过加速药物向生物体的移动而向生物体开出较高分子量的药物，并提供其控制方法。解决方案：设置有具有第一电极的作用侧结构的离子电渗疗法装置，从第一电极传导的药剂保持部和布置在药剂保持部的正面侧的第一离子交换膜，选择性地形成第一导电离子，并且规定通过由药物保持部保持的药物通过使生物抵接在生物体的皮肤上的第一离子交换膜而解离产生的第一导电药剂离子，设置有用于加温第一离子交换膜抵接的生物体的皮肤的加温装置。版权所有（C）2007，JPO＆INPIT

44. 发明专利

JP2006149891A Iontophoresis apparatus 有权
标题翻译： IOPOPHORESIS设备
公开(公告)号：JP2006149891A
公开(公告)日：2006-06-15
申请号：JP2004347814
申请日：2004-11-30
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： MATSUMURA AKIHIKO , MATSUMURA TAKEHIKO , NAKAYAMA HATOO , AKIYAMA HIDEO
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0436 , A61N1/0448
摘要： PROBLEM TO BE SOLVED: To provide an iontophresis apparatus for allowing an action pole structure body to exist in a stable state for a long term by restricting the compositional change of a chemical liquid of the action pole structure body and/or an electrolyte solution.
SOLUTION: A first ion exchange membrane for selectively passing second conductive ions and a porous separation membrane for blocking the passage of not less than a prescribed value amount of molecules and ions are arranged between an electrolyte solution holding part for holding the chemical solution, where a chemical to be dissociated into a first conductive first electrolyte ion and the second conductive second electrolyte ion in the solution, is dissolved, and a chemical liquid holding part for holding the chemical liquid, which is dissociated into a first conductive chemical ion and a second conductive chemical counterion, is dissolved.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：解决问题的方案：提供一种离子透射装置，其用于通过限制作用极结构体和/或电解质的化学液体的组成变化来使作用极结构体长期稳定地存在解。解决方案：用于选择性地通过第二导电离子的第一离子交换膜和用于阻止不少于规定数量的分子和离子的通过的多孔分离膜布置在用于保持化学溶液的电解液保持部分其中溶解有待分解为第一导电性第一电解质离子的化学物质和溶液中的第二导电性第二电解质离子溶解，将用于保持化学液体的化学液体保持部分分离成第一导电化学离子，第二导电化学抗衡离子溶解。版权所有（C）2006，JPO＆NCIPI

45. 发明专利

JP2008000543A Iontophoresis device 审中-公开
标题翻译： IONTOPHORESIS设备
公开(公告)号：JP2008000543A
公开(公告)日：2008-01-10
申请号：JP2006175662
申请日：2006-06-26
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： ITO MASAO , KOSHIBA NOBUHARU
IPC分类号： A61N1/30
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis device, the function of which is not impaired by mixing of cutting debris as foreign matter into the operation side electrode structure of the iontophoresis device.
SOLUTION: This iontophoresis device for dosing ionized pharmaceutical includes: an operation side electrode structure 20 holding medical solution containing medicament; and a support 40 supporting the operation side electrode structure 20 and having a pressure-sensitive adhesive layer on one side thereof, wherein the support 40 is cut by laser.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种离子电渗疗装置，其功能不会因为异物将切屑残留在离子电渗疗装置的操作侧电极结构中而受损。解决方案：用于给药离子化药物的离子电渗装置包括：操作侧电极结构20，其保持含有药物的药液; 以及支撑操作侧电极结构20的支撑体40，并且在其一侧具有压敏粘合剂层，其中支撑体40被激光切割。版权所有（C）2008，JPO＆INPIT

46. 发明专利

JP2008000463A Iontophoresis apparatus 审中-公开
标题翻译： IOPOPHORESIS设备
公开(公告)号：JP2008000463A
公开(公告)日：2008-01-10
申请号：JP2006174324
申请日：2006-06-23
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： MATSUMURA TAKEHIKO , NAKAYAMA HATOO , AKIYAMA HIDEO , TANIOKA AKIHIKO , KANEMURA KIYOSHI
IPC分类号： A61N1/30
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis apparatus in which an active agent mounted on the outermost ion selective membrane of a working electrode is substantially held by the selective membrane in a no electromotive force applied state and is transferred to outside from the selective membrane in an electromotive force applied state. SOLUTION: The iontophoresis apparatus 10a includes a working-side electrode structure 12a having an electrode element 20 and the outermost ion selective membrane 22 for temporarily holding the active agent 24. The outermost ion selective membrane 22 is formed of not less than one ion exchange membranes. The working-side electrode structure 12a includes an electrolytic solution 26 and/or not less than one internal ion selective membrane. The internal ion selective membrane is separated from the outermost ion selective membrane by not less than one nonionic selective porous membranes, a buffering substance and/or a buffering tub. The iontophoresis apparatus 10a also includes an opposite side electrode structure 14 and a voltage source 16. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种离子电渗仪装置，其中安装在工作电极的最外层离子选择膜上的活性剂在无电动势施加状态下基本上被选择性膜保持并从选择性膜在电动势施加状态。解决方案：离子电渗仪器10a包括具有电极元件20的工作侧电极结构12a和用于临时保持活性剂24的最外层离子选择膜22.最外层离子选择膜22由不小于1个离子交换膜。工作侧电极结构12a包括电解液26和/或不少于一个内部离子选择性膜。内部离子选择性膜通过不少于一种非离子选择性多孔膜，缓冲物质和/或缓冲桶与最外层离子选择性膜分离。离子渗透装置10a还包括相对侧电极结构14和电压源16.版权所有（C）2008，JPO＆INPIT

47. 发明专利

JP2007289482A Transdermal administration apparatus 审中-公开
标题翻译：超导管理装置
公开(公告)号：JP2007289482A
公开(公告)日：2007-11-08
申请号：JP2006121895
申请日：2006-04-26
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： MINE KAORI , SHIBATA TSUTOMU , NAKAYAMA HATOO , MATSUMURA TAKEHIKO
IPC分类号： A61N1/30 , A61M37/00
摘要： PROBLEM TO BE SOLVED: To provide a transdermal administration apparatus for tightly attaching the front end face of an iontophoresis device or a microneedle device to the skin turned to a flat shape by being pulled when transdermally administering drugs by iontophoresis or a microneedle. SOLUTION: The transdermal administration apparatus 10 has the iontophoresis device 11 and a pulling device 60 attached to it. The pulling device 60 pulls the skin to be flat by rollers 64A and 6B driven by motors 66A and 66B from both sides of the front end faces 20A and 40A of an operating side electrode structure 20 and a non-operating side electrode structure 40, and the front end faces 20A and 40A of the iontophoresis device 11 are tightly attached. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种透皮给药装置，用于通过离子电渗疗法或微针进行透皮给药时，将离子电渗疗法装置或微针装置的前端面紧密地附接到被变形为平坦形状的皮肤上。解决方案：透皮给药装置10具有附着于其上的离子电渗疗装置11和牵引装置60。拉动装置60通过由电动机66A和66B从操作侧电极结构20和非操作侧电极结构40的前端面20A和40A的两侧驱动的辊64A和6B将皮肤拉平以平坦，以及离子电渗透装置11的前端面20A，40A紧贴。版权所有（C）2008，JPO＆INPIT

48. 发明专利

JP2007282900A Iontophoresis apparatus 审中-公开
标题翻译： IOPOPHORESIS设备
公开(公告)号：JP2007282900A
公开(公告)日：2007-11-01
申请号：JP2006114554
申请日：2006-04-18
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： YAMAUCHI MITSUGU , HAYAKAWA YOSHITSUNE
IPC分类号： A61N1/30
摘要： PROBLEM TO BE SOLVED: To increase the transmission amount of medicine ions to skin by raising adhesiveness between the skin and an ion selection film. SOLUTION: An iontophoresis apparatus 10 comprises: a DC power source 12; an action side electrode structural body 20 connected to the anode or cathode of the DC current power source; and a non-action side electrode structural body 40 connected to the other, for administering the medicine ions held by the action side electrode structural body to a living body with a voltage from the current power source. The action side electrode structural body includes at least: an action side electrode 24 connected to the anode or cathode with polarity being the same as that of the medicine ion; a chemical liquid holding part 30 electrically connected to the action side electrode so as to hold the medicine to be the medicine ion; and an action side ion selection film 32 electrically connected to the chemical liquid holding part so as to selectively pass the ion being the same in kind as the medicine ion. When the iontophoresis apparatus is mounted on the skin of the living body, a viscous liquid 70 is held between the action side ion selection film 32 and the skin. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：通过提高皮肤和离子选择膜之间的粘附性来增加药物离子对皮肤的透过量。解决方案：离子电渗疗法装置10包括：直流电源12; 连接到直流电源的阳极或阴极的动作侧电极结构体20; 以及与动作侧电极结构体保持的药物离子相互连接的非作用侧电极结构体40，其具有来自电流源的电压。动作侧电极结构体至少至少包括：与阳极或阴极连接的作用侧电极24，其极性与药物离子的极性相同; 与动作侧电极电连接以将药物保持为药物离子的药液保持部30; 以及与药液保持部电连接以便选择性地通过与药物离子类似的离子的动作侧离子选择膜32。当离子电渗疗法装置安装在生物体的皮肤上时，粘性液体70被保持在动作侧离子选择膜32和皮肤之间。版权所有（C）2008，JPO＆INPIT

49. 发明专利

JP2007268194A Iontophoresis device 审中-公开
标题翻译： IONTOPHORESIS设备
公开(公告)号：JP2007268194A
公开(公告)日：2007-10-18
申请号：JP2006100875
申请日：2006-03-31
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： KOSHIBA NOBUHARU , AWANO JUNJIRO , MAEKAWA YUKINORI
IPC分类号： A61N1/30
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis device, provided with an electrode structure having a polarization electrode, which actuates securely. SOLUTION: In the iontophoresis device, an action side electrode 24 is composed of an action side collector 24A connected to a DC power source 12, an action side bonding agent layer 24C disposed on the front surface of the action side collector 24A, and an action side polarization electrode 24B, disposed on a front surface of the action side bonding agent layer 24C, and electrically connected and bonded to the action side collector 24A by the action side bonding agent layer 24C. For the action side bonding agent layer 24C, conductive bonding agent should preferably be used. For the action side polarization electrode 24B, viscous fluid including chemical should preferably be impregnated. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种具有电极结构的离子电渗疗法装置，该电极结构具有可靠地启动的极化电极。解决方案：在离子电渗疗法装置中，动作侧电极24由与直流电源12连接的动作侧集电体24A，配置在动作侧集电体24A的前表面上的动作侧接合剂层24C构成，和动作侧极化电极24B，配置在动作侧接合剂层24C的前表面，并通过动作侧接合剂层24C与动作侧集电体24A电连接接合。对于动作侧接合剂层24C，优选使用导电性接合剂。对于作用侧极化电极24B，应优选浸渍包含化学品的粘性流体。版权所有（C）2008，JPO＆INPIT

50. 发明专利

JP2007268184A Iontophoresis apparatus 审中-公开
标题翻译： IOPOPHORESIS设备
公开(公告)号：JP2007268184A
公开(公告)日：2007-10-18
申请号：JP2006100753
申请日：2006-03-31
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： MATSUMURA TAKEHIKO , NAKAYAMA HATOO , SHIBATA TSUTOMU , SERIZAWA KOJI
IPC分类号： A61N1/30
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis apparatus by which iontophoresis can be more safely applied. SOLUTION: The iontophoresis apparatus 10 has an apparatus body 50 percutaneously administering an ionized medical drug by iontophoresis, a power source 60 supplying electricity to the apparatus body 50, and the flexible connector 70 extending from the apparatus body 50 and electrically connected to the apparatus body 50 and the power source 60, the power source 60 is arranged on the face opposite to the face contact with the skin in the apparatus body 50 with the connector 70 curved, and the connector 70 has an insulation film on a curved outside face. COPYRIGHT: (C)2008,JPO&INPIT

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