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41. 发明申请

WO9965942A8 CYCLIC SOMATOSTATIN ANALOGS 审中-公开
公开(公告)号：WO9965942A8
公开(公告)日：2000-02-17
申请号：PCT/US9913304
申请日：1999-06-11
申请人： SOD CONSEILS RECH APPLIC , GORDON THOMAS D
发明人： GORDON THOMAS D
IPC分类号： C07D233/64 , A61K31/4164 , A61K38/00 , A61K38/22 , A61K38/31 , A61P1/00 , A61P1/04 , A61P3/06 , A61P3/10 , A61P13/12 , A61P19/02 , A61P27/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/06 , A61P43/00 , C07K7/64 , C07K14/655 , A61K31/415
CPC分类号： C07K14/6555 , A61K38/00
摘要： The present invention is directed to cyclic derivatives containing an imidazole cis amide bond mimetic which bind selectively to somatostatin receptor subtypes and the use thereof in treating conditions which can be treated by eliciting an agonist or antagonist effect from the somatostatin subtype receptors. This invention is also directed to methods for making the compounds of the instant invention.
摘要翻译：本发明涉及含有与生长抑素受体亚型选择性结合的咪唑顺式酰胺键模拟物的环状衍生物及其在治疗可通过从生长抑素亚型受体引发激动剂或拮抗剂作用治疗的病症中的用途。本发明还涉及制备本发明化合物的方法。

42. 发明申请

WO9956769A2 INHIBITION OF HELICOBACTER PYLORI PROLIFERATION 审中-公开
标题翻译：抑制HELICOBACTER PYLORI增殖
公开(公告)号：WO9956769A2
公开(公告)日：1999-11-11
申请号：PCT/US9910058
申请日：1999-05-06
申请人： SOD CONSEILS RECH APPLIC , KANEKO HIROSHI , MITSUMA TERUNORI , YAMASHITA KOICHI , MORGAN BARRY
发明人： KANEKO HIROSHI , MITSUMA TERUNORI , YAMASHITA KOICHI , MORGAN BARRY
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K38/31 , A61K45/00 , A61P1/04 , A61P31/04 , A61P35/00 , A61P43/00 , C07K14/655
CPC分类号： A61K38/31
摘要： The present invention is directed to a method of using somatostatin or a somatostatin agonist to inhibit the proliferation of Helicobacter pylori (H.pylori), which comprises administering to a patient in need thereof an effective amount of said somatostatin or somatostatin agonist. Preferably, a somatostatin sub-type receptor 2 (SSTR-2) selective somatostatin agonist is administered in a method of this invention. The inhibition of H.pylori proliferation is useful in treating various gastroduodenal diseases such as peptic ulcers, gastric cancer and gastric lymphoma.
摘要翻译：本发明涉及使用生长抑素或生长抑素激动剂来抑制幽门螺杆菌（幽门螺杆菌）增殖的方法，其包括向有需要的患者施用有效量的所述生长抑素或生长抑素激动剂。优选地，在本发明的方法中施用生长抑素亚型受体2（SSTR-2）选择性生长抑素激动剂。幽门螺杆菌增殖的抑制可用于治疗各种胃十二指肠疾病如消化性溃疡，胃癌和胃淋巴瘤。

43. 发明申请

WO2008090287A3 USE OF AT LEAST ONE BOTULISM NEUROTOXIN FOR TREATING THE PAIN INDUCED BY THERAPEUTIC TREATMENTS FOR THE AIDS VIRUS 审中-公开
标题翻译：使用至少一种神经毒素神经毒素治疗由艾滋病病毒治疗引起的疼痛
公开(公告)号：WO2008090287A3
公开(公告)日：2008-10-02
申请号：PCT/FR2007002091
申请日：2007-12-17
申请人： SOD CONSEILS RECH APPLIC , FAVRE CHRISTINE , AUGUET MICHEL , CHABRIER DE LASSAUNIERE PIERRE ETIENNE
发明人： FAVRE CHRISTINE , AUGUET MICHEL , CHABRIER DE LASSAUNIERE PIERRE ETIENNE
IPC分类号： A61K38/48 , A61P31/18
CPC分类号： A61K38/4893
摘要： The invention relates to the use of at least one botulism neurotoxin for the production of a medicament for treating or preventing the pain induced by a medicament used to treat the AIDS virus.
摘要翻译：本发明涉及至少一种肉毒杆菌毒素神经毒素用于制备用于治疗或预防由用于治疗AIDS病毒的药物诱导的疼痛的药物的用途。

44. 发明申请

WO2008063279A9 METHOD OF DRUG DELIVERY FOR BONE ANABOLIC PROTEIN 审中-公开
标题翻译：骨质疏松蛋白药物递送方法
公开(公告)号：WO2008063279A9
公开(公告)日：2008-07-10
申请号：PCT/US2007021216
申请日：2007-10-03
申请人： RADIUS HEALTH INC , SOD CONSEILS RECH APPLIC , DEY MICHAEL J , MONDOLY NATHALIE , RIGAUD BENEDICTE , HENDERSON BART , LYTTLE C RICHARD
发明人： DEY MICHAEL J , MONDOLY NATHALIE , RIGAUD BENEDICTE , HENDERSON BART , LYTTLE C RICHARD
CPC分类号： A61K9/08 , A61K9/0019 , A61K38/29
摘要： The present invention provides a storage-stable composition containing a parathyroid hormone-related protein (PTHrP) analogue and methods of using a PTHrP analogue and the PTHrP compositions described herein to treat osteoporosis, to increase bone mass or to increase bone quality. The composition is storage stable, in sterile form, and in general may be stored at room temperature for at least several weeks to allow convenient parenteral administration to human patients.
摘要翻译：本发明提供含有甲状旁腺激素相关蛋白（PTHrP）类似物的储存稳定组合物和使用本文所述的PTHrP类似物和PTHrP组合物治疗骨质疏松症，增加骨量或增加骨质量的方法。该组合物是储存稳定的，为无菌形式，并且通常可以在室温下储存至少数周，以方便肠胃外给予人类患者。

45. 发明申请

WO2008012439A3 USE OF A GINKGO BILOBA EXTRACT FOR THE TREATMENT OF MITOCHONDRIAL DISEASES OF GENETIC ORIGIN 审中-公开
标题翻译：银杏叶提取物治疗遗传性原发性线粒体病的研究
公开(公告)号：WO2008012439A3
公开(公告)日：2008-04-17
申请号：PCT/FR2007001286
申请日：2007-07-26
申请人： SOD CONSEILS RECH APPLIC , MUNNICH ARNOLD , CLOSTRE FRANCOIS , OUZID MEHEMED
发明人： MUNNICH ARNOLD , CLOSTRE FRANCOIS , OUZID MEHEMED
IPC分类号： A61K36/16 , A61P25/00
CPC分类号： A61K36/16
摘要： The invention relates to the use of Ginkgo biloba for the treatment of mitochondrial diseases of genetic origin and more particularly mitochondrial encephalomyophathies.
摘要翻译：本发明涉及银杏用于治疗遗传来源的线粒体疾病，更特别是线粒体脑脊髓萎缩症的用途。

46. 发明申请

WO02070701A9 NOVEL HUMAN GNRH RECEPTOR 审中-公开
标题翻译：新人类GNRH受体
公开(公告)号：WO02070701A9
公开(公告)日：2007-06-28
申请号：PCT/FR0200741
申请日：2002-03-01
申请人： SOD CONSEILS RECH APPLIC , FERRANDIS ERIC , THURIEAU CHRISTOPHE
发明人： FERRANDIS ERIC , THURIEAU CHRISTOPHE
IPC分类号： A61K38/00 , C07K14/72 , C12N1/21 , C12N15/12 , G01N33/68 , G01N33/74 , G01N33/76
CPC分类号： C07K14/723 , A61K38/00 , G01N33/6893 , G01N33/74 , G01N33/76 , G01N2500/00
摘要： The invention concerns a gene coding for a novel human GnRH receptor (gonadotropin-releasing hormone receptor), hereafter referred to as GnR-R2. The DNA sequences of the invention can be placed in expression systems so as to produce GnRH-R2 and/or cell lines expressing GnRH and preferably responding to GnRH-induced transduction signals. Such cell lines can advantageously be used for screening and identifying novel GnRH agonists and antagonists. In other aspects of the invention, the DNA encoding GnRH-R2, antisense oligonucleotide sequences, GnRH-R2 expression products, antibodies against such products can be used in diagnostic methods or for treatment of disorders related to an abnormal expression of GnRH-R2, for example an overexpression, a subexpression or an expression of a mutant receptor. Transgenic animals containing the GnRH-R2 transgene can be used as models for evaluating analogues of GnRH in vivo.
摘要翻译：本发明涉及编码新型人GnRH受体（促性腺激素释放激素受体）的基因（以下称为GnR-R2）。可以将本发明的DNA序列置于表达系统中，以产生表达GnRH的GnRH-R2和/或细胞系，并优选响应于GnRH诱导的转导信号。这种细胞系可以有利地用于筛选和鉴定新的GnRH激动剂和拮抗剂。在本发明的其它方面，编码GnRH-R2，反义寡核苷酸序列，GnRH-R2表达产物，抗这些产物的抗体的DNA可用于诊断方法或用于治疗与GnRH-R2异常表达有关的疾病，用于例如突变型受体的过表达，亚表达或表达。含有GnRH-R2转基因的转基因动物可用作评价体内GnRH类似物的模型。

47. 发明申请

WO2005034989A3 USE OF SOMATOSTATIN OR ONE OF THE ANALOGS THEREOF FOR PRODUCING A MEDICAMENT SERVING TO REGULATE THE OVARIAN FOLLICULAR RESERVE IN NON-MENOPAUSAL WOMEN 审中-公开
标题翻译：使用SOMATOSTATIN或其类似物之一用于生产服用于调节非男性女性中的OVARIAN FOLLICULAR RESERVE的药物
公开(公告)号：WO2005034989A3
公开(公告)日：2005-06-16
申请号：PCT/FR2004002536
申请日：2004-10-08
申请人： SOD CONSEILS RECH APPLIC , GOUGEON ALAIN , LOUMAYE ERNEST
发明人： GOUGEON ALAIN , LOUMAYE ERNEST
IPC分类号： A61K38/16 , A61K38/31
CPC分类号： A61K38/31
摘要： The invention primarily relates to the use of somatostatin or one of the agonistic analogs thereof for producing a medicament serving to regulate the ovarian follicular reserve and, in particular, to reduce the depletion of the ovarian follicular reserve over time in non-menopausal women or to the use of an antagonistic analog of somatostatin for producing a medicament serving to accelerate the start of growing of quiescent follicles in non-menopausal women. The invention also relates to in vitro applications of somatostatin and of agonistic and antagonistic analogs thereof.
摘要翻译：本发明主要涉及生长抑素或其激动类似物之一用于产生用于调节卵巢滤泡储备的药物，特别是在非绝经妇女中随时间减少卵巢滤泡储备的消耗，或者使用生长抑素的拮抗类似物来生产用于加速非绝经妇女中静止卵泡生长开始的药物。本发明还涉及生长抑素及其激动和拮抗类似物的体外应用。

48. 发明申请

WO2004075823A8 NOVEL BENZIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AND USE THEREOF AS A MEDICAMENT 审中-公开
标题翻译：新型苯并咪唑和咪唑并吡啶衍生物及其用作药物的用途
公开(公告)号：WO2004075823A8
公开(公告)日：2004-10-28
申请号：PCT/FR2004000418
申请日：2004-02-25
申请人： SOD CONSEILS RECH APPLIC , POITOUT LYDIE , BRAULT VALERIE , SACKUR CAROLE , ROUBERT PIERRE , PLAS PASCALE
发明人： POITOUT LYDIE , BRAULT VALERIE , SACKUR CAROLE , ROUBERT PIERRE , PLAS PASCALE
IPC分类号： A61P3/04 , A61P15/10 , A61P25/22 , A61P25/24 , C07D235/30 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/12 , C07D491/10 , A61K31/4184
CPC分类号： C07D401/04 , C07D235/30 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10
摘要： The invention relates to novel benzimidazole and imidazopyridine derivatives which have a good affinity with certain sub-types of melanocortin receptors, particularly MC4 receptors. Said derivatives are particularly interesting for the treatment of pathological states and diseases involving one or several melanocortin receptors. The invention also relates to pharmaceutical compositions containing said products.
摘要翻译：本发明涉及与某些亚型黑皮质素受体，特别是MC4受体具有良好亲和力的新型苯并咪唑和咪唑并吡啶衍生物。所述衍生物对于涉及一种或几种黑皮质素受体的病理状态和疾病的治疗特别有用。本发明还涉及含有所述产品的药物组合物。

49. 发明申请

WO2004028541A3 COMPOSITION FOR THE TREATMENT OF NASOPHARYNGEAL CARCINOMA AND USE THEREOF 审中-公开
标题翻译：用于治疗鼻咽癌的组合物及其用途
公开(公告)号：WO2004028541A3
公开(公告)日：2004-07-01
申请号：PCT/IB0304922
申请日：2003-09-29
申请人： SOD CONSEILS RECH APPLIC , CENTRE NAT RECH SCIENT , PREVOST GREGOIRE , BUSSON PIERRE , VICAT JEAN-MICHEL
发明人： PREVOST GREGOIRE , BUSSON PIERRE , VICAT JEAN-MICHEL
IPC分类号： A61K31/4985 , A61K31/5517 , A61P35/00
CPC分类号： A61K31/4985 , A61K31/5517 , A61K2300/00
摘要： Disclosed is a novel drug combination which is useful for the treatment of nasopharyngeal carcinoma, said novel drug combination comprising one or more of a farnesyl transferase inhibitor and one or more of an anthracyline.
摘要翻译：公开了一种可用于治疗鼻咽癌的新型药物组合，所述新型药物组合包含法呢基转移酶抑制剂和一种或多种蒽环类药物中的一种或多种。

50. 发明申请

WO2004011402A3 NOVEL ARYLIMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译：新型芳基咪唑衍生物，其制备和治疗用途
公开(公告)号：WO2004011402A3
公开(公告)日：2004-04-29
申请号：PCT/FR0302336
申请日：2003-07-24
申请人： SOD CONSEILS RECH APPLIC , BIGG DENNIS , LIBERATORE ANNE-MARIE , CHABRIER DE LASSAUNIERE PIERRE
发明人： BIGG DENNIS , LIBERATORE ANNE-MARIE , CHABRIER DE LASSAUNIERE PIERRE
IPC分类号： C07D233/64 , A61K31/4164 , A61K31/4178 , A61P1/04 , A61P1/14 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P15/00 , A61P15/10 , A61P15/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P25/36 , A61P27/02 , A61P27/16 , A61P29/00 , A61P29/02 , A61P31/12 , A61P31/18 , A61P31/22 , A61P33/00 , A61P35/00 , A61P37/06 , A61P37/08 , A61P39/02 , A61P43/00 , C07D409/12 , C07D409/14 , A61K31/417
CPC分类号： C07D409/12 , C07D409/14
摘要： The invention concerns compounds of general formula (I), wherein R1 represents H, alkyl, cycloalkyl or cycloalkylalkyl and R2 represents H or alkyl; R3 represents H, alkyl or aralkyl; X represents a bond or a linear or branched alkylene radical (II); Y represents H, cycloalkyl, OR14, SR15, NR4R5 or A represents a bond or phenyl; B and B' are independently selected among alkyl, NR6R7, SR8 and carbocyclic aryl or heterocyclic aryl radicals with five or six members optionally substituted; R4 represents H, alkyl, aryl, cycloalkyl, cycloalkylalkyl, aralkyl, -C(O)R9, -C(O)OR9, -C(O)NHR9 or -SO2R9, or further aryl or aralkyl whereof the aromatic ring is optionally substituted and R5 represents in particular H or alkyl, or further R4 and R5 form with the nitrogen atom bearing them a non-aromatic heterocycle of five to seven members optionally substituted; R6 represents (in particular) H or alkyl and R7 represents (in particular) H or alkyl; R8 represents an alkyl radical optionally substituted; R9 represents alkyl, haloakyl, cycloalkyl or cycloalkylalkyl, or further one of the aralkyl or aryl or heteroaryl radicals optionally substituted; R14 and R15 independently represent (in particular) alkyl, phenyl or aralkyl. The compounds of general formula (I) can be used as NO synthase inhibitors and as modulators of sodium channels (for treating pains, multiple sclerosis, the central nervous system or the peripheral nervous system and the like).
摘要翻译：本发明涉及通式（I）的化合物，其中R 1表示H，烷基，环烷基或环烷基烷基，R 2表示H或烷基; R3表示H，烷基或芳烷基; X表示键或直链或支链亚烷基（II）; Y表示H，环烷基，OR14，SR15，NR4R5或A表示键或苯基; B和B'独立地选自烷基，NR 6 R 7，SR 8和具有5或6个任选取代的碳环的芳基或杂环芳基; R 4表示H，烷基，芳基，环烷基，环烷基烷基，芳烷基，-C（O）R 9，-C（O）OR 9，-C（O）NHR 9或-SO 2 R 9，或芳基或芳烷基，并且R 5特别表示H或烷基，或者另外R 4和R 5与氮原子一起形成，它们带有5-7个任选取代的非芳族杂环; R 6表示（特别是）H或烷基，R 7表示（特别是）H或烷基; R8表示任选取代的烷基; R 9代表烷基，卤代烷基，环烷基或环烷基烷基，或任选取代的芳烷基或芳基或杂芳基之一; R 14和R 15独立地表示（特别是）烷基，苯基或芳烷基。通式（I）的化合物可用作NO合成酶抑制剂和钠通道的调节剂（用于治疗疼痛，多发性硬化，中枢神经系统或周围神经系统等）。

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