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41. 发明授权

US5585381A Pyrimidine derivatives and pharmaceutical composition 失效
标题翻译：嘧啶衍生物和药物组合物
公开(公告)号：US5585381A
公开(公告)日：1996-12-17
申请号：US454629
申请日：1995-05-31
申请人： Mikiro Yanaka , Fuyuhiko Nishijima , Hiroyuki Enari , Michihito Ise
发明人： Mikiro Yanaka , Fuyuhiko Nishijima , Hiroyuki Enari , Michihito Ise
IPC分类号： A61P13/12 , C07D239/48 , C07D239/50 , A61K31/505
CPC分类号： C07D239/48 , C07D239/49 , C07D239/50
摘要： A pyrimidine derivative of the formula (I): ##STR1## wherein R.sup.1 is a hydrogen atom, alkyl of 1 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, or --NHR.sup.11 group; R.sup.2 is a hydrogen or halogen atom, alkyl of 1 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, --(CH.sub.2).sub.m C.sub.6 H.sub.5, --NH.sub.2, --NHR.sup.12, --NH(CH.sub.2).sub.n C.sub.6 H.sub.5, --NH(CH.sub.2).sub.p C.sub.6 H.sub.4 --OR.sup.13, --N(R.sup.14)(CH.sub.2).sub.q C.sub.6 H.sub.5, --NHC(.dbd.O)R.sup.15, --NHC(.dbd.O)(CH.sub.2).sub.r C.sub.6 H.sub.5, --NHC(.dbd.O)CH(C.sub.6 H.sub.5).sub.2, --OR.sup.16, or --O(CH.sub.2).sub.s C.sub.6 H.sub.5 group; R.sup.3 is --COOH, --COOR.sup.17, hydroxyl, --OR.sup.18, --NH.sub.2, --N(R.sup.19).sub.2, --NHR.sup.20, azole, or sulfonic acid group; R.sup.11 is alkyl of 1 to 6 carbon atoms or haloalkyl of 1 to 6 carbon atoms; R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16, R.sup.17, R.sup.18, R.sup.19, and R.sup.20 are independently alkyl of 1 to 6 carbon atoms; m is 0 or an integer of 1 to 6; n is 0 or an integer of 1 to 6; p is 0 or an integer of 1 to 6; q is 0 or an integer of 1 to 6; r is 0 or an integer of 1 to 6; and s is 0 or an integer of 1 to 6, or a salt thereof, and a pharmaceutical composition comprising said pyrimidine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier are disclosed.
摘要翻译：式（I）的嘧啶衍生物：其中R 1为氢原子，1至6个碳原子的烷基，1至6个碳原子的卤代烷基或-NHR 11基团; R2是氢或卤素原子，1-6个碳原子的烷基，1-6个碳原子的卤代烷基， - （CH2）mC6H5，-NH2，-NHR12，-NH（CH2）nC6H5，-NH（CH2）pC6H4- OR 13，-N（R 14）（CH 2）q C 6 H 5，-NHC（= O）R 15，-NHC（= O）（CH 2）rC 6 H 5，-NHC（= O）CH（C 6 H 5）2，-OR 16或-O CH2）sC6H5组; R3是-COOH，-COOR17，羟基，-OR18，-NH2，-N（R19）2，-NHR20，唑或磺酸基团; R11为1〜6个碳原子的烷基或1〜6个碳原子的卤代烷基; R 12，R 13，R 14，R 15，R 16，R 17，R 18，R 19和R 20独立地为1至6个碳原子的烷基; m为0或1〜6的整数; n为0或1〜6的整数， p为0或1〜6的整数; q为0或1〜6的整数; r为0或1〜6的整数，和s为0或1〜6的整数，或其盐，以及包含所述嘧啶衍生物或其药学上可接受的盐和药学上可接受的载体的药物组合物。

42. 发明授权

US5569524A Laminated sheet and a bonded laminated sheet 失效
标题翻译：层压片材和粘合层压片材
公开(公告)号：US5569524A
公开(公告)日：1996-10-29
申请号：US163754
申请日：1993-12-07
申请人： Masamichi Akatsu , Takeo Higashi , Hiromitsu Makita , Tomoo Susa , Toshiya Mizuno
发明人： Masamichi Akatsu , Takeo Higashi , Hiromitsu Makita , Tomoo Susa , Toshiya Mizuno
IPC分类号： B29C65/04 , B32B7/12 , B32B27/12 , B32B27/30 , B32B37/00 , B32B7/10 , B32B27/08
CPC分类号： B32B27/30 , B29C65/04 , B29K2027/06 , B29K2027/16 , B29K2033/04 , B29K2105/0085 , B29K2105/0088 , B29L2007/005 , B32B2309/105 , B32B2459/00 , B32B37/00 , B32B37/1284 , Y10T428/24967 , Y10T428/266 , Y10T428/2809 , Y10T428/3154 , Y10T428/3192 , Y10T428/31928 , Y10T428/31935 , Y10T442/387
摘要： A laminated sheet suitable for high-frequency welding comprises a vinylidene fluoride resin layer (A), a bonding layer (B) consisting of a blend of vinylidene fluoride resin and a copolymer resin consisting of methyl methacrylate and alkyl ester of acrylate, whose alkyl group has 3-5 carbon atoms, a base-material layer (C) of vinyl chloride resin bonded to the bonding layer (B), and a base-cloth layer (D) bonded to the base-material layer (C). A bonded laminated sheet obtained by bonding two laminated sheets with high-frequency welding and the application of the bonded laminated sheet to tents are also disclosed.
摘要翻译：适用于高频焊接的层压片包括偏二氟乙烯树脂层（A），由偏氟乙烯树脂和由甲基丙烯酸甲酯和丙烯酸烷基酯组成的共聚物树脂的共混物组成的粘合层（B），其烷基具有3-5个碳原子，与粘合层（B）接合的氯乙烯树脂的基材层（C）和与基材层（C）结合的基布层（D）。还公开了通过将两个高频焊接的层叠片接合并将接合的层叠片施加到帐篷而获得的粘合层叠片。

43. 发明授权

US5455268A Esculetin derivatives and pharmaceutical composition 失效
标题翻译：新颖的七叶亭衍生物和药物组成
公开(公告)号：US5455268A
公开(公告)日：1995-10-03
申请号：US204445
申请日：1994-03-02
申请人： Koju Watanabe , Koichi Niimura , Kiyonori Umekawa
发明人： Koju Watanabe , Koichi Niimura , Kiyonori Umekawa
IPC分类号： A61K31/37 , A61P43/00 , C07D311/16 , A61K31/35
CPC分类号： A61K31/37 , C07D311/16 , Y10S514/825
摘要： A pharmaceutical composition comprising a compound of the general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are, independently, a hydrogen atom, a saturated or unsaturated aliphatic acyl having 2 to 25 carbon atoms or benzoyl group and R.sup.3 is a hydrogen atom or alkyl group, and a pharmaceutically acceptable carrier is disclosed. Further, a novel compound of the general formula (I) wherein R.sup.1 and R.sup.2 are, independently, a hydrogen atom, pivaloyl, capryloyl, lauroyl, palmitoyl, stearoyl, linoleoyl, docosahexaenoyl, or benzoyl group, and R.sup.3 is a hydrogen atom or methyl group, is also disclosed.
摘要翻译：一种药物组合物，其包含通式（I）的化合物：其中R 1和R 2独立地为氢原子，具有2至25个碳原子的饱和或不饱和脂族酰基或苯甲酰基，R 3为公开了氢原子或烷基，以及药学上可接受的载体。此外，通式（I）的新化合物，其中R 1和R 2独立地为氢原子，新戊酰基，辛酰基，月桂酰基，棕榈酰基，硬脂酰基，亚油酰基，二十二碳六烯酰基或苯甲酰基，R 3为氢原子或甲基，也被披露。

44. 发明授权

US5426240A Process for the co-production of dichloroacetaldehyde hydrate and chloral 失效
标题翻译：共同生产二氯乙醛水合物和氯醛的方法
公开(公告)号：US5426240A
公开(公告)日：1995-06-20
申请号：US271779
申请日：1994-07-07
申请人： Takashi Wakasugi , Tadashi Miyakawa , Fukuichi Suzuki
发明人： Takashi Wakasugi , Tadashi Miyakawa , Fukuichi Suzuki
IPC分类号： C07C29/09 , C07C31/42 , C07C45/63 , C07C45/81 , C07C45/82 , C07C47/14 , C07C47/16 , C07C45/00
CPC分类号： C07C31/42 , C07C45/63
摘要： A process for producing dichloroacetaldehyde hydrate together with chloral from acetaldehyde or para-aldehyde. The process comprises a step of chlorinating acetaldehyde or para-aldehyde to obtain a chlorinated solution containing dichloroacetaldehyde as a major component, a step of distilling this chlorinated solution to obtain a distillate having a boiling point of 90.degree.-100.degree. C. and containing 50% or more of dichloroacetaldehyde, a step of adding water to this distillate, crystallizing dichloroacetaldehyde hydrate, and separating the crystals, and a step of chlorinating the remaining aldehyde components into chloral. The process enables dichloroacetaldehyde hydrate to be separated at a high purity and the raw materials to be utilized efficiently.
摘要翻译：一种从乙醛或对醛生产二氯乙醛水合物和氯醛的方法。该方法包括将乙醛或对醛进行氯化以获得含有二氯乙醛为主要成分的氯化溶液的步骤，蒸馏该氯化溶液以获得沸点为90-100℃的馏出物并含有50 ％以上的二氯乙醛，向该馏出物中加入水，结晶二氯乙醛水合物和分离晶体的步骤，以及将剩余的醛组分氯化为氯醛的步骤。该方法能够使二氯乙醛水合物以高纯度分离，并且有效地利用原料。

45. 发明授权

US5414139A Process for the manufacture of monochloroacetaldehyde trimer and chloral 失效
标题翻译：一氯乙醛三聚体和氯醛的制备方法
公开(公告)号：US5414139A
公开(公告)日：1995-05-09
申请号：US214123
申请日：1994-03-15
申请人： Takashi Wakasugi , Tadashi Miyakawa , Fukuichi Suzuki
发明人： Takashi Wakasugi , Tadashi Miyakawa , Fukuichi Suzuki
IPC分类号： B01J23/06 , B01J23/14 , C07B61/00 , C07C45/55 , C07C45/63 , C07D323/06 , C07C45/53 , C07C45/61
CPC分类号： C07D323/06 , C07C45/55 , C07C45/63
摘要： A process for manufacturing monochloroacetaldehyde trimer and chloral together by effectively utilizing a raw material acetaldehyde or para-aldehyde. The process comprises a step of chlorinating acetaldehyde or para-aldehyde to produce a chlorinated liquid of which the major component is monochloroacetaldehyde, a step comprising adding chloral to said chlorinated liquid and distilling the mixture to obtain a fraction of which the major components are monochloroacetaldehyde and chloral, a step of trimerizing monochloroacetaldehyde by reacting said fraction in the presence of a trimerization catalyst and separating the MCA trimer by filtration, and a step of chlorinating other fractions from said distillation step and the filtrate from said trimerization step to produce chloral. According to this process all raw material aldehydes and components derived from aldehydes which have not been consumed for the production of MCA trimer can be easily converted into chloral which is useful as an industrial chemical. The process is also free from the problem of the waste water treatment.
摘要翻译：通过有效利用原料乙醛或对醛制备单氯乙醛三聚物和氯醛的方法。该方法包括氯化乙醛或对醛以产生其主要成分为一氯乙醛的氯化液体的步骤，该步骤包括向所述氯化液体中加入氯醛并蒸馏该混合物，得到主要成分为一氯乙醛的馏分，氯醛，通过在三聚催化剂存在下使所述级分反应并通过过滤分离MCA三聚体，以及从所述蒸馏步骤氯化其它级分的步骤和来自所述三聚步骤的滤液以产生氯醛的步骤，使一氯乙醛三聚。根据该方法，所有原料醛和源自未用于生产MCA三聚体的醛的组分可以容易地转化成可用作工业化学品的氯醛。该过程也没有废水处理的问题。

46. 发明授权

US5344904A Vinylidene fluoride polymer and method of making same 失效
标题翻译：偏二氟乙烯聚合物及其制备方法
公开(公告)号：US5344904A
公开(公告)日：1994-09-06
申请号：US111541
申请日：1993-08-25
申请人： Hideki Wakamori , Fujio Suzuki , Katsuo Horie
发明人： Hideki Wakamori , Fujio Suzuki , Katsuo Horie
IPC分类号： C08F214/22 , C08F14/22
CPC分类号： C08F214/22
摘要： This invention provides PVDF having such crystallization properties as to produce small spherulite sizes without sacrifices to properties, processability, purity, etc., and a suspension polymerization method to obtain the same.The PVDF obtained by this invention comprises the monomer unit content of 99.5-96 wt. % of vinylidene fluoride, and the monomer unit content of 0.5-4 wt. % of comonomers selected from hexafluoropropylene and/or tetrafluoroethylene, and has a logarithmic viscosity of 0.9-1.3 dl/g, and a molecular-weight distribution, as expressed in the ratio (Mw/Mn) of weight-average molecular weight and number-average molecular weight, of 2.2-2.8.In order to manufacture the PVDF of this invention, a mixture of vinylidene fluoride monomers containing 1-5 wt. % of monomers selected from hexafluoropropylene and/or tetrafluoroethylene is suspension-polymerized in an aqueous medium, using an oil-soluble initiator so that the logarithmic viscosity [.eta..sub.1 ] is kept at 1.3-1.9 dl/g until the polymerization conversion rate of vinylidene fluoride monomers becomes 10-50%, and the polymerization is continued by adding a chain transfer agent at that polymerization conversion rate so that the logarithmic viscosity [.eta..sub.2 ] of the eventually obtained polymers becomes 0.3-0.7 dl/g lower than [.eta..sub.1 ], and yet remains in the range of 0.9-1.3 dl/g.
摘要翻译：本发明提供了具有这样的结晶性能的PVDF，即在不牺牲性能，加工性，纯度等的情况下产生小球晶尺寸，以及获得其的悬浮聚合方法。通过本发明获得的PVDF包含单体单元含量为99.5-96wt。％偏二氟乙烯，单体单元含量为0.5-4wt。％的选自六氟丙烯和/或四氟乙烯的共聚单体，其对数粘度为0.9-1.3dl / g，分子量分布以重均分子量（Mw / Mn）与数均分子量平均分子量为2.2-2.8。为了制造本发明的PVDF，将含有1-5重量％选择六氟丙烯和/或四氟乙烯的单体的％，使用油溶性引发剂在水性介质中悬浮聚合，使得对数粘度η保持在1.3-1.9dl / g，直到亚乙烯基的聚合转化率氟化物单体变为10-50％，并且通过以该聚合转化率加入链转移剂继续聚合，使得最终得到的聚合物的对数粘度[η]为比0.3 ]，但仍保持在0.9-1.3dl / g的范围内。

47. 发明授权

US5324740A Azole derivatives, pharmaceutical compositions containing the same, and method for treating mycosis and estrogen-dependent diseases 失效
标题翻译：唑衍生物，含有它们的药物组合物，以及治疗真菌病和雌激素依赖性疾病的方法
公开(公告)号：US5324740A
公开(公告)日：1994-06-28
申请号：US67052
申请日：1993-05-26
申请人： Koichi Niimura , Yuko Ikeda , Akira Kato , Takao Ando
发明人： Koichi Niimura , Yuko Ikeda , Akira Kato , Takao Ando
IPC分类号： A61K31/41 , A61K31/415 , A61P31/04 , A61P31/10 , A61P35/00 , A61P43/00 , C07D249/08 , C07D307/33 , C07D333/38 , C07D403/06 , C07D405/06 , C07D409/06 , C07D493/10 , C07D495/10 , C07D521/00
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56
摘要： Azole derivatives (including stereoisomers and pharmaceutically acceptable salts) of the formula: ##STR1## wherein R.sub.1 and R.sub.2 each are H or C.sub.1 -C.sub.4 alkyl; R.sub.3 is H, OH, CN, halogen, haloalkyl, C.sub.1 -C.sub.4 alkyl or phenyl, and if there are two or more R.sub.3 groups, such R.sub.3 groups may be the same or different; n is an integer from 0 to 5; Y is N or CH; and X is O, S or NH have antimycotic and aromatase inhibitory activities. Compositions containing the azole derivatives and a method of treating mycosis and estrogen-dependent diseases by administering effective quantities of the azole derivatives are also disclosed.
摘要翻译： C4烷基的唑衍生物（包括立体异构体和药学上可接受的盐） R3是H，OH，CN，卤素，卤代烷基，C1-C4烷基或苯基，如果有两个或更多个R 3基团，则这样的R 3基团可以相同或不同; n为0〜5的整数， Y为N或CH; X是O，S或NH具有抗真菌和芳香酶抑制活性。还公开了含有唑衍生物的组合物和通过施用有效量的唑衍生物治疗真菌病和雌激素依赖性疾病的方法。

48. 发明授权

US5279719A Method for chlorination of methylated aromatic compounds 失效
标题翻译：甲基化芳香族化合物氯化方法
公开(公告)号：US5279719A
公开(公告)日：1994-01-18
申请号：US970305
申请日：1992-11-02
申请人： Kazuhiko Sunagawa , Hajime Hoshi , Tsumoru Watanabe
发明人： Kazuhiko Sunagawa , Hajime Hoshi , Tsumoru Watanabe
IPC分类号： C07C17/12 , C07C17/14 , C07C25/02 , C07C25/125 , C07C25/22 , C07C17/00
CPC分类号： C07C17/12 , C07C17/14 , C07C25/125
摘要： A process for chlorination of methylated aromatic compounds in a titanium tetrachloride is disclosed. The ring chlorination is first carried out by reacting said methylated aromatic compounds with chlorine gas under reduced light conditions, and then the side chain chlorination is carried out by reacting the resulting mixture with chlorine gas under light irradiation conditions. The process ensures continuous chlorination of aromatic rings and side chains of methylated aromatic compounds at a high yield without using any catalysts or perilous solvents such as carbon tetrachloride.
摘要翻译：公开了一种在四氯化钛中氯化甲基化芳族化合物的方法。环氯化首先通过使所述甲基化芳香族化合物与降低光照条件下的氯气反应进行，然后通过在光照射条件下使所得混合物与氯气反应来进行侧链氯化。该方法确保甲基化芳族化合物的芳香环和侧链在不使用任何催化剂或危险溶剂如四氯化碳的情况下以高产率连续氯化。

49. 发明授权

US4664161A Automatic filling apparatus, and bag mouth opening device thereof 失效
标题翻译：自动灌装装置及其开口装置
公开(公告)号：US4664161A
公开(公告)日：1987-05-12
申请号：US707967
申请日：1985-03-04
申请人： Yuhji Sawa , Toshio Itoh
发明人： Yuhji Sawa , Toshio Itoh
IPC分类号： B65B43/30 , B65B43/36 , B65B43/04
CPC分类号： B65B43/36 , B65B43/30
摘要： An apparatus for automatically filling bags with a material after separating each bag from a continuous chain of bags along perforations where each bag is joined to its neighbor has a guide section for guiding the chain of bags, a separating section for separating the chain of bags into individual bags at the perforations, a mouth opening device for opening a mouth located at one side edge of each bag, and a filling section for blowing air into the bag through its opened mouth and for filling the bag through the opened mouth. The mouth opening device has a pressing assembly supported above the mouth of the bag, and a chuck assembly situated at one side of the mouth. The pressing assembly has pressing pads brought into pressured contact with an outer surface of one side sheet of the bag near its mouth, and the chuck assembly has means for moving the pressing pads toward the bottom of the bag while the pressing pads are in pressured contact with the one side sheet, and means for grasping the other side sheet of the bag at the mouth thereof as the pressing pads are moved. The mouth opening device thus grasps one side sheet of the bag and partially opens the mouth, in which state the bag is delivered to the filling section to be fully opened by the expelled air and filled while held firmly in place.
摘要翻译：一种用于在每个袋与连续的袋子沿着穿孔分离每个袋子之后自动填充袋子的装置，其中每个袋子连接到其邻居处具有用于引导袋子链的引导部分，用于将袋子链分离成的分离部分穿孔处的单个袋，用于打开位于每个袋的一个侧边缘处的口的开口装置，以及用于通过其打开的口将空气吹入袋中并用于通过打开的口填充袋的填充部分。开口装置具有支撑在袋口的上方的按压组件和位于口的一侧的卡盘组件。按压组件具有与靠近其口的袋的一个侧片的外表面压力接触的压垫，并且卡盘组件具有用于在按压垫处于加压接触的状态下将压垫朝向底部移动的装置以及用于在按压垫移动时在其口部抓住袋的另一侧片的装置。因此，开口装置抓住袋的一个侧片并部分地打开口，在该状态下，袋被输送到填充部分以被排出的空气完全打开，并在牢固地保持在适当位置的同时填充。

50. 发明授权

US4645566A Process for producing electroconductive films 失效
标题翻译：制造导电膜的方法
公开(公告)号：US4645566A
公开(公告)日：1987-02-24
申请号：US694638
申请日：1985-01-24
申请人： Ippei Kato , Masao Takasu , Nobuo Maruyama
发明人： Ippei Kato , Masao Takasu , Nobuo Maruyama
IPC分类号： C08J5/18 , C08K7/02 , H01B1/22 , H01B1/24 , H05K9/00 , D21H5/18
CPC分类号： H05K9/009 , D21H13/10 , D21H5/12 , H01B1/22 , H01B1/24
摘要： A process for producing an electroconductive film having a volume resistivity of fiber oriented direction of not more than 1.times.10.sup.8 ohm cm comprising mixing from 94.5% to 40% volume of a thermoplastic synthetic pulp with from 5% to 30% by volume of thermoplastic composite fibers comprising of a first component having a lower melting point than that of said thermoplastic synthetic pulp and a second component having a higher melting point than that of said thermoplastic synthetic pulp, and from 0.5% to 30% by volume of electroconductive fibers to prepare a paper stock; forming a wet web from the paper stock; heating and drying said wet web at a specific first temperature to melt the first component of the composite fibers, thereby forming a base paper; and thereafter heating said base paper under pressure at a specific second temperature to melt the thermoplastic synthetic pulp, thereby forming a film having dispersed said second component and said electroconductive fibers therein.
摘要翻译：制造具有纤维取向方向的体积电阻率不大于1×10 8欧姆厘米的导电膜的方法，包括将94.5％至40％体积的热塑性合成纸浆与5％至30％体积的热塑性复合纤维混合，所述热塑性复合纤维包含具有比所述热塑性合成纸浆低的熔点的第一组分和具有比所述热塑性合成纸浆更高的熔点的第二组分和0.5至30体积％的导电纤维以制备纸料 ; 从纸料形成湿纸幅; 在特定的第一温度下加热和干燥所述湿纸幅以熔化复合纤维的第一成分，从而形成原纸; 然后在特定的第二温度下加压所述原纸以熔化热塑性合成纸浆，从而形成分散有所述第二成分和所述导电纤维的膜。

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