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41. 发明公开

EP1847600A1 Specific protease for inactivation of human tumour necrosis factor-alpha 审中-公开
标题翻译： Spezifische蛋白酶zur Inaktivierung von Tumornekrosefaktor alpha
公开(公告)号：EP1847600A1
公开(公告)日：2007-10-24
申请号：EP06112706.4
申请日：2006-04-18
申请人： Direvo Biotech AG
发明人： Kettling, Ulrich , Koltermann, André , Haupts, Ulrich , Rarbach, Markus , Tebbe, Jan , Votsmeier, Christian , Scheidig, Andreas , Coco, Wayne M. , Da Silva, Antonio , Hesse, Oliver , Scholz, Peter , Gritzan, Uwe , Zeidler, Georg , Kalmbach, Rolf
IPC分类号： C12N9/76 , A61K38/48 , C07K14/525
CPC分类号： C07K14/525 , A61K38/00 , C12N9/6424 , C12N9/6427 , Y02A50/411
摘要： The present invention is directed to specific proteases, fragments and derivatives thereof that specifically inactivate tumour necrosis factor-alpha, methods for their preparation, pharmaceutical and diagnostic compositions comprising such a protease. The proteases of the invention are useful for the treatment of clinical conditions resulting from the detrimental activity of tumour necrosis factor. The invention further relates to nucleotide sequences thereof encoding the protease, as well as vectors and hosts containing such sequences.
摘要翻译：本发明涉及特异性灭活肿瘤坏死因子-α的特异性蛋白酶，其片段和衍生物，其制备方法，包含这种蛋白酶的药物和诊断组合物。本发明的蛋白酶可用于治疗由肿瘤坏死因子的有害活性引起的临床病症。本发明还涉及其编码蛋白酶的核苷酸序列，以及含有这些序列的载体和宿主。

42. 发明公开

EP1827486A2 TARGETED USE OF ENGINEERED ENZYMES 审中-公开
标题翻译：技术操作酶的有针对性地使用
公开(公告)号：EP1827486A2
公开(公告)日：2007-09-05
申请号：EP05823713.2
申请日：2005-12-21
申请人： Direvo Biotech AG , Voetsmeier, Christian
发明人： HAUPTS, Ulrich, c/o Direvo Biotech Ag , KOLTERMANN, Andre, c/o Direvo Biotech Ag , SCHEIDIG, Andreas, c/o Direvo Biotech Ag , KETTLING, Ulrich, c/o Direvo Biotech Ag , COCO, Wayne Michael, c/o Direvo Biotech Ag
IPC分类号： A61K38/43 , C12N9/00
CPC分类号： C12N9/6424 , A61K38/00 , C12N9/6427
摘要： The present invention provides method for the treatment of a disease by applying a medicament comprising a protease with a defined specificity is capable to hydrolyze specific peptide bonds within a target substrate related to such disease. The proteases with such a defined specificity can further be used for related therapeutic or diagnostic purposes.

43. 发明公开

EP1726643A1 Method for the provision, identification and selection of proteases with altered sensitivity to activity-modulating substances 审中-公开
标题翻译：用于提供具有改变的敏感性键入改变物质的蛋白酶，识别和选择方法
公开(公告)号：EP1726643A1
公开(公告)日：2006-11-29
申请号：EP05104543.3
申请日：2005-05-27
申请人： Direvo Biotech AG
发明人： Koltermann, André , Kettling, Ulrich , Haupts, Ulrich , Coco, Wayne , Tebbe, Jan , Votsmeier, Christian , Scheidig, Andreas
IPC分类号： C12N9/00 , C12N15/00 , C12Q1/37
CPC分类号： C12Q1/37 , A61K38/00 , C12N9/64 , G01N2500/00
摘要： The present invention provides a method for the selection of proteases with altered sensitivity to one or more activity-modulating substances. The method combines the provision of a protease library encoding polynucleotide sequences, expression of the enzymes, screening of the library in the presence of one or several activity-modulating substances, selection of variants with altered sensitivity to one or several activity-modulating substances and isolation of those polynucleotide sequences that encode for the selected variants.
摘要翻译：本发明提供了用于蛋白酶的选择与一个或多个活动的调节物质改变的灵敏度的方法。该方法结合蛋白酶库编码多核苷酸序列的委托，酶的表达，在一个或几个活性调节物质，具有改变的灵敏度变体的选择存在的库的筛选，以一个或几个活性调节物质和隔离这些多核苷酸序列编码的那样选定的变体。

44. 发明授权

EP1230390B1 METHOD FOR THE PRODUCTION OF BIOPOLYMERS WITH MODIFIED PROPERTIES 有权
标题翻译：用于生产具有改变性质的生物聚合物
公开(公告)号：EP1230390B1
公开(公告)日：2004-09-22
申请号：EP00977514.9
申请日：2000-11-08
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , Direvo Biotech AG
发明人： KOLTERMANN, Andre , KETTLING, Ulrich , EIGEN, Manfred
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12N15/1027
摘要： A method for the production of biopolymers with modified properties as well as a kit containing instructions for carrying out said method are described.

45. 发明公开

EP1411345A1 Multi-parameter fluorimetric analysis in a parallel multi-focal arrangement 有权
标题翻译：荧光测量多参数分析在einer并行多Fokus-Anordnung
公开(公告)号：EP1411345A1
公开(公告)日：2004-04-21
申请号：EP02023100.7
申请日：2002-10-17
申请人： Direvo Biotech AG
发明人： Walla, Peter Jomo , Kettling, Ulrich , Koltermann, Andre , Scharte, Mathias
IPC分类号： G01N21/64
CPC分类号： G01N21/6458 , G01N21/645 , G01N21/6486 , G01N2201/0631
摘要： A method for analyzing properties of a sampIe by measuring fluorescence parameters in multiple foci, comprises the steps of splitting a collimated primary laser beam (101) with a splitting device (102) into at least two collimated secondary laser beams (103) and deflecting the secondary laser beams such that they propagate at different propagation angles with respect to an optical axis of a focussing optic (107), focussing the secondary laser beams with the focussing optic (107) into at least two volume elements (108) in the sample, detecting light emitted from the volume elements with a detecting device (110), and evaluating the detected light for obtaining the properties to be analyzed. Furthermore, a device for implementing this method is described. The invention is particularly suited for high-throughput screening applications.
摘要翻译：生物化学样品的荧光平行分析涉及激光诱导荧光的检测，随后提取时间分辨的关于样品的多参数信息：生物化学样品的荧光平行分析涉及用分束器（102）分裂准直的主激光束（101））到至少两个准直次级激光束（103）中，偏转光束使得它们相对于聚焦光学元件（109）的光轴以不同的角度传播，用检测器组（110）检测从体积元件（108）发射的光）并评估检测到的光。还包括用于分析样品性质的装置的独立权利要求。

46. 发明公开

EP1394251A1 Method for the selective randomization of polynucleotides 审中-公开
标题翻译： Verfahren zur selektiven Zufallsmutagenese von Polynukleotiden
公开(公告)号：EP1394251A1
公开(公告)日：2004-03-03
申请号：EP02018855.3
申请日：2002-08-23
申请人： Direvo Biotech AG
发明人： Koltermann, Andre, Direvo BioTech AG , Kettling, Ulrich, Direvo BioTech AG , Pilling, Jens, Direvo BioTech AG , Spangenberg, Oliver, Direvo BioTech AG
IPC分类号： C12N15/10
CPC分类号： C12N15/102
摘要： The present invention provides a method for the randomization of polynucleotides at specific sites which comprises providing a double stranded polynucleotide sequence having at least one differing site and selectively randomizing the polynucleotide at or in the proximity to the differing sites.
摘要翻译：本发明提供了在特定位点随机化多核苷酸的方法，该方法包括提供具有至少一个不同位点的双链多核苷酸序列，并在多个位点附近选择性随机化该多核苷酸。

47. 发明公开

EP1281757A1 Method for the production of nucleic acids consisting of stochastically combined parts of source nucleic acids 审中-公开
标题翻译：用于生产核酸与源核酸随机地组合的部件的方法
公开(公告)号：EP1281757A1
公开(公告)日：2003-02-05
申请号：EP01118416.5
申请日：2001-07-31
申请人： Direvo Biotech AG
发明人： Koltermann, Andre, Dr. c/o DIREVO BIOTECH AG , Kettling, Ulrich, Dr. c/o DIREVO BIOTECH AG , Greiner-Stöffele, Thomas, Dr. c/ DIREVO BIOTECH AG
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/1027
摘要： Methods and kit for producing recombinant chimeric polynucleotides comprising: forming heteroduplices with single-stranded, partially heterologous source nucleic acids which contain at least one marker nucleotide, introducing single-stranded nicks at sites of the marker nucleotides, and starting synthesis of single-stranded nucleic acids at the nick sites, the non-nicked strand serving as template.
摘要翻译：的方法和试剂盒用于产生重组嵌合多核苷酸，其包括：具有单链，部分异源源核酸，其包含至少一个标记的核苷酸，单链核酸中的所述标记的核苷酸的位点引入单链缺口，并开始合成形成的异源双链在切口部位酸，非缺口海滩作为模板。

48. 发明授权

EP1419247B1 METHOD FOR THE PRODUCTION OF NUCLEIC ACIDS CONSISTING OF STOCHASTICALLY COMBINED PARTS OF SOURCE NUCLEIC ACIDS 有权
标题翻译：用于生产NUCLEIC包含碱性NUCLEIC的随机联合股份
公开(公告)号：EP1419247B1
公开(公告)日：2006-09-20
申请号：EP02754920.3
申请日：2002-07-20
申请人： Direvo Biotech AG
发明人： KOLTERMANN, Andre, c/o Direvo Biotech AG , KETTLING, Ulrich, c/o Direvo Biotech AG , GREINER-STÖFFELE, Thomas , SPANGENBERG, Oliver, c/o DIREVO BIOTECH AG
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/1027
摘要： The present invention relates to a method for the production of nucleic acids consisting of stochastically combined parts of source nucleic acids as well as to a kit containing instructions for carrying out said method.

49. 发明授权

EP1419248B1 METHOD FOR THE SELECTIVE COMBINATORIAL RANDOMIZATION OF POLYNUCLEOTIDES 有权
标题翻译：用于随机选择性多核苷酸
公开(公告)号：EP1419248B1
公开(公告)日：2005-03-16
申请号：EP03747925.0
申请日：2003-08-22
申请人： Direvo Biotech AG
发明人： KOLTERMANN, André, cc/DIREVO BIOTECH AG , KETTLING, Ulrich, cc/DIREVO BIOTECH AG , PILLING, Jens, cc/DIREVO BIOTECH AG , SPANGENBERG, Oliver, cc/DIREVO BIOTECH AG
IPC分类号： C12N15/10
CPC分类号： C12N15/102
摘要： The present invention provides a method for the selective combinatorial randomization (SCR) of polynucleotides at specific sites which comprises providing a double stranded polynucleotide sequence having at least one differing site and selectively randomizing the polynucleotide at or in the proximity to the differing sites without the need for a determination of the sequence position of the differing site.

50. 发明公开

EP1504117A2 PROCESS FOR GENERATING SEQUENCE-SPECIFIC PROTEASES BY DIRECTED EVOLUTION AND USE THEREOF 有权
标题翻译：制造序列特异性蛋白酶通过定向演化方法
公开(公告)号：EP1504117A2
公开(公告)日：2005-02-09
申请号：EP03727460.2
申请日：2003-05-09
申请人： Direvo Biotech AG
发明人： KOLTERMANN, André , KETTLING, Ulrich,c/o DIREVO BIOTECH AG , HAUPTS, Ulrich , TEBBE, Jan , SCHOLZ, Peter , PILLING, Jens , WERNER, Susanne , RARBACH, Markus
IPC分类号： C12Q1/37 , C12N9/50 , C12N9/60
CPC分类号： C12N9/60 , C12N15/1058
摘要： A process for generating sequence-specific proteases by screening-based directed evolution is disclosed. The use of the process provides proteases recognizing and cleaving user-definable amino-acid sequences with high sequence-specificity. Proteases obtainable by the process can be used in a variety of medical, diagnostic and industrial applications.

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