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41. 发明申请

WO2004042025A2 CELL-SPECIFIC ADENOVIRUS VECTOR COMPRISING EBV-SPECIFIC PROMOTER 审中-公开
标题翻译：包含EBV特异性启动子的细胞特异性腺病毒载体
公开(公告)号：WO2004042025A2
公开(公告)日：2004-05-21
申请号：PCT/US0334858
申请日：2003-10-30
申请人： CELL GENESYS INC , YU DE CHAO , RAMESH NAGARAJAN
发明人： YU DE CHAO , RAMESH NAGARAJAN
IPC分类号： A61K38/00 , A61K48/00 , C07K14/05 , C12N7/01 , C12N15/861 , C12N
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/005 , C12N2710/10343 , C12N2710/10345 , C12N2710/16222 , C12N2830/00 , C12N2830/205 , C12N2830/30 , C12N2830/60 , C12N2840/203
摘要： Replication-competent adenoviral vectors comprising an EBV-specific transcriptional regulatory element (TRE) operably linked to a gene required for adenovirus replication are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication can be restricted to particular target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity for treating neoplasia.
摘要翻译：提供了包含与腺病毒复制所需基因可操作连接的EBV特异性转录调控元件（TRE）的有复制能力的腺病毒载体。通过提供依赖于仅在特定的有限的细胞类型中有活性的转录因子的转录起始调控，病毒复制可以限于特定的靶细胞。修饰的腺病毒可以用作介导新的遗传能力的载体，特别是与治疗瘤形成的细胞毒性有关。

42. 发明申请

WO2004009790A2 METASTATIC COLON CANCER SPECIFIC PROMOTER AND USES THEREOF 审中-公开
标题翻译：转移性结肠癌特异性启动子及其用途
公开(公告)号：WO2004009790A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/023032
申请日：2003-07-22
申请人： CELL GENESYS, INC. , LI, Yuanhao , YU, De Chao
发明人： LI, Yuanhao , YU, De Chao
IPC分类号： C12N
CPC分类号： C12N15/86 , A61K48/00 , A61K48/0058 , C12N2710/10343 , C12N2710/10345 , C12N2830/008 , C12N2830/85
摘要： Colon cancer specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to the target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity for treating neoplasia.
摘要翻译：提供了结肠癌特异性启动子序列和腺病毒载体。通过提供依赖于仅在特定的有限的细胞类型中有活性的转录因子的转录起始调节，病毒复制将限于靶细胞。修饰的腺病毒可以用作介导新的遗传能力的载体，特别是与治疗瘤形成的细胞毒性有关。

43. 发明申请

WO0052184A9 ANTI-NEOPLASTIC COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：抗神经组合物及其用途
公开(公告)号：WO0052184A9
公开(公告)日：2002-12-27
申请号：PCT/US0005350
申请日：2000-03-01
申请人： CELL GENESYS INC , GPC BIOTECH INC
发明人： PATEL SALIL , MCARTHUR JAMES , GYURIS JENO , MENDEZ MICHAEL J , FINER MITCHELL
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K38/45 , A61K48/00 , A61P35/00 , C07K14/075 , C07K14/47 , C07K19/00 , C12N15/62 , C12N15/861 , C12N15/867 , C12N15/86 , A61K31/70 , A61K38/17
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/4738 , C07K2319/00 , C07K2319/02 , C07K2319/10 , C07K2319/21 , C07K2319/23 , C07K2319/42 , C07K2319/43 , C07K2319/75 , C12N15/62 , C12N2710/10322 , C12N2710/10343 , C12N2740/16043 , C12N2830/002 , C12N2830/60
摘要： Disclosed is a nucleic acid composition consisting essentially of a first nucleic acid sequence encoding a chimeric CDKi protein and a second nucleic acid sequence encoding an adenovirus E4 protein, wherein the first and second nucleic acid sequences are operably linked to at least one regulatory sequence.
摘要翻译：公开了一种基本上由编码嵌合CDKi蛋白的第一核酸序列和编码腺病毒E4蛋白的第二核酸序列组成的核酸组合物，其中第一和第二核酸序列可操作地连接至至少一个调节序列。

44. 发明申请

WO9961595A3 ADENO-ASSOCIATED VIRAL VECTOR-MEDIATED EXPRESSION OF FACTOR VIII ACTIVITY 审中-公开
标题翻译： ADENO相关病毒载体介导的因子VIII活性表达
公开(公告)号：WO9961595A3
公开(公告)日：2000-01-27
申请号：PCT/US9910472
申请日：1999-05-27
申请人： CELL GENESYS INC
发明人： COHEN LAWRENCE K , SPRATT S KAYE , COUTO LINDA
IPC分类号： C12N15/09 , A61K35/76 , A61K38/43 , A61K48/00 , A61P7/04 , C07K14/755 , C12N15/864 , C12N15/86
CPC分类号： A61K48/00 , C07K14/755 , C12N15/86 , C12N2750/14143
摘要： The instant invention provides methods and materials for expressing polypeptides with factor VIII activity comprising administering at least two rAAV vectors encoding different domains of human factor VIII and at least the heavy and light chains.
摘要翻译：本发明提供用于表达具有因子VIII活性的多肽的方法和材料，包括施用至少两种编码人因子VIII不同结构域的rAAV载体和至少重链和轻链。

45. 发明申请

WO9931251A9 METHOD AND MEANS FOR PRODUCING HIGH TITER, SAFE, RECOMBINANT LENTIVIRUS VECTORS 审中-公开
标题翻译：用于生产高TITR，安全，重组生物活性载体的方法和手段
公开(公告)号：WO9931251A9
公开(公告)日：1999-10-07
申请号：PCT/US9825719
申请日：1998-12-11
申请人： CELL GENESYS INC
发明人： NALDINI LUIGI , DULL THOMAS , FARSON DEBORAH A , WITT ROCHELLE
IPC分类号： C12N15/09 , A61K48/00 , C07K14/16 , C12N5/10 , C12N7/01 , C12N15/49 , C12N15/867 , C12N15/64 , C12N15/86
CPC分类号： C12N7/00 , A61K48/00 , C07K14/005 , C12N15/86 , C12N2740/11044 , C12N2740/16022 , C12N2740/16043 , C12N2740/16052
摘要： Lentiviral vectors modified at the 5' LTR or both the 5' and 3' LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production.
摘要翻译：在5'LTR或5'和3'LTR两者修饰的慢病毒载体可用于重组慢病毒载体的生产。这种载体可以在不存在功能性tat基因的情况下产生。携带转基因载体的宿主细胞多次转化增强了病毒的产生。

46. 发明申请

WO9707225A3 HIGH EFFICIENCY RETROVIRAL PACKAGING SYSTEM 审中-公开
标题翻译：高效率退火包装系统
公开(公告)号：WO9707225A3
公开(公告)日：1997-06-26
申请号：PCT/US9613737
申请日：1996-08-21
申请人： CELL GENESYS INC
发明人： FINER MITCHELL H , DULL THOMAS J , ZSEBO KRISZTINA M , COOKE KEEGAN , FARSON DEBORAH A
IPC分类号： C12N15/09 , A61K48/00 , C07K14/15 , C07K14/72 , C07K14/725 , C07K14/73 , C07K16/10 , C12N5/00 , C12N5/10 , C12N7/00 , C12N7/04 , C12N15/867 , C12N15/87 , C12R1/91 , C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C07K14/7051 , C07K14/70514 , C07K14/721 , C07K16/10 , C07K2319/00 , C12N7/00 , C12N15/87 , C12N2740/13022 , C12N2740/13023 , C12N2740/13043 , C12N2740/13052 , C12N2740/13062
摘要： The invention provides a novel retroviral packaging system, in which retroviral packaging plasmids and packageable vector transcripts are produced from high expression plasmids after stable or transient transfection in mammalian cells. High titers of recombinant retrovirus are produced in these transfected mammalian cells and can then transduce a mammalian target cell by cocultivation or supernatant infection. The methods of the invention include the use of the novel retroviral packaging plasmids and vectors to transduce primary human cells, including T cells and human hematopoietic stem cells, with foreign genes by cocultivation or supernatant infection at high efficiencies. The invention is useful for the rapid production of high titer viral supernatants, and to transduce with high efficiency cells that are refractory to transduction by conventional means.

47. 发明申请

WO1996033735A1 HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENOMICE 审中-公开
标题翻译：从免疫的XENOMICE衍生的人类抗体
公开(公告)号：WO1996033735A1
公开(公告)日：1996-10-31
申请号：PCT/US1996005928
申请日：1996-04-29
申请人： CELL GENESYS, INC.
发明人： CELL GENESYS, INC. , KUCHERLAPATI, Raju , JAKOBOVITS, Aya , KLAPHOLZ, Sue , BRENNER, Daniel, G. , CAPON, Daniel, J.
IPC分类号： A61K39/00
CPC分类号： C07K16/2863 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K16/00 , C07K16/1282 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/248 , C07K16/2812 , C07K16/2854 , C07K16/2875 , C07K2317/21 , C07K2317/24
摘要： Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
摘要翻译：针对特定抗原的完全人抗体可以通过将抗原施用于转基因动物来制备，所述转基因动物已经被修饰以响应于抗原性攻击而产生这样的抗体，但是其内源性位点已被禁用。可以进行各种随后的操作以获得本身或其类似物的抗体。

48. 发明申请

WO1996031241A1 TRANSPLANTATION OF GENETICALLY MODIFIED CELLS HAVING LOW LEVELS OF CLASS I MHC PROTEINS ON THE CELL SURFACE 审中-公开
标题翻译：在细胞表面上转移具有低水平I类MHC蛋白的遗传修饰细胞
公开(公告)号：WO1996031241A1
公开(公告)日：1996-10-10
申请号：PCT/US1996004648
申请日：1996-04-03
申请人： CELL GENESYS, INC. , OTTEN, Gillis, R.
发明人： CELL GENESYS, INC.
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , A61K39/001 , A61K48/00 , A61K2035/122 , C07K14/005 , C12N5/0647 , C12N2710/10322 , C12N2710/16122 , C12N2710/16622 , C12N2740/13043 , C12N2840/203
摘要： Mammalian cells are genetically modified by the introduction of genes encoding virus-derived MHC down-regulatory proteins. Suitable cells for transplantation are taken from a donor, and transfected with an expression vector encoding one or more virus-derived MHC down-regulatory proteins. The genetically modified donor cells are expanded ex vivo, if appropriate, and transplanted into a recipient mammalian host. The decreased levels of class I MHC protein allow the transplanted cells to survive under conditions where the genetically unmodified cells would be otherwise subject to attack by the recipient immune system. The donor cells may be additionally modified to target cells or to enhance effector function of the donor cells in the mammalian host.
摘要翻译：通过引入编码病毒来源的MHC下调蛋白的基因对哺乳动物细胞进行遗传修饰。用于移植的合适细胞来自供体，并用编码一种或多种病毒衍生的MHC下调蛋白的表达载体转染。如果合适，将遗传修饰的供体细胞离体扩增，并移植到受体哺乳动物宿主中。 I类MHC蛋白水平的降低允许移植的细胞在基因未修饰的细胞将被受体免疫系统攻击的条件下存活。供体细胞可另外修饰为靶细胞或增强哺乳动物宿主中供体细胞的效应子功能。

49. 发明申请

WO1996023881A1 CHIMERIC RECEPTORS FOR REGULATING CELLULAR PROLIFERATION AND EFFECTOR FUNCTION 审中-公开
标题翻译：用于调节细胞增殖和影响功能的CHIMERIC受体
公开(公告)号：WO1996023881A1
公开(公告)日：1996-08-08
申请号：PCT/US1996001292
申请日：1996-02-02
申请人： CELL GENESYS, INC.
发明人： CELL GENESYS, INC. , CAPON, Daniel, J. , TIAN, Huan , SMITH, Douglas, H. , WINSLOW, Genine, A. , SIEKEVITZ, Miriam
IPC分类号： C12N15/12
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/705 , C07K14/70514 , C07K14/7155 , C07K2319/00
摘要： The invention is directed to chimeric proliferation receptors and DNA sequences encoding the proteins. The first group of chimeric proteins comprised of an extracellular clustering domain (ECD), transmembrane domain (TM), proliferation signaling domain (PSD) which can signal a host cell to divide. The second group of chimeric proteins comprised of an intracellular clustering domain (ICD) and a proliferation signaling domain (PSD) which can signal a host cell to divide. The third group of chimeric proteins comprised of an extracellular clustering domain (ECD) or an intracellular clustering domain (ICD), a transmembrane domain (TM), proliferation signaling domain (PSD), and an effector signaling domain which can signal an effector function and a host cell to divide. The invention further relates to expression vectors containing the nucleic acids encoding the chimeric receptors, cells expressing the chimeric receptors and therapeutic methods of using cells expressing the chimeric receptors for the treatment of cancer, infectious disease, and autoimmune diseases.
摘要翻译：本发明涉及编码蛋白质的嵌合增殖受体和DNA序列。第一组嵌合蛋白由细胞外聚簇结构域（ECD），跨膜结构域（TM），增殖信号转导域（PSD）组成，其可以信号传导宿主细胞分裂。由细胞内聚集域（ICD）和增殖信号转导域（PSD）组成的第二组嵌合蛋白，其可以信号传导宿主细胞分裂。由细胞外聚簇结构域（ECD）或细胞内聚簇结构域（ICD），跨膜结构域（TM），增殖信号转导域（PSD）和可以发挥效应子功能的效应信号结构域组成的第三组嵌合蛋白，宿主细胞分裂。本发明还涉及包含编码嵌合受体的核酸，表达嵌合受体的细胞和使用表达嵌合受体的细胞治疗癌症，感染性疾病和自身免疫疾病的治疗方法的表达载体。

50. 发明申请

WO1996023814A1 CHIMERIC RECEPTOR MOLECULES FOR DELIVERY OF CO-STIMULATORY SIGNALS 审中-公开
标题翻译：用于输送共刺激信号的CHIMERIC受体分子
公开(公告)号：WO1996023814A1
公开(公告)日：1996-08-08
申请号：PCT/US1996001293
申请日：1996-02-02
申请人： CELL GENESYS, INC.
发明人： CELL GENESYS, INC. , ROBERTS, Margo, R. , ANDERSON, Stephen, J.
IPC分类号： C07K14/705
CPC分类号： C07K14/70507 , A61K38/00 , C07K14/55 , C07K14/705 , C07K14/7051 , C07K14/70514 , C07K14/70521 , C07K14/70528 , C07K2319/00
摘要： The present invention is directed to novel chimeric co-stimulatory receptor proteins and DNA sequences encoding these proteins. The chimeric receptors comprise at least three domains in a single chain molecule: an extracellular ligand binding domain, a transmembrane domain and a cytoplasmic co-stimulatory effector function signaling domain that acts synergistically with an effector function signal in the host cell. Novel hybrid co-stimulatory receptor proteins include a second cytoplasmic effector function signaling domain. The invention further relates to expression cassettes containing the nucleic acids encoding the novel chimeric receptors, to host cells expressing the novel chimeric receptors and to methods of using the receptors to co-stimulate effector functions in the cells and for using cells expressing the receptors for treatment of cancer, disease and viral infections.
摘要翻译：本发明涉及新型嵌合共刺激受体蛋白和编码这些蛋白的DNA序列。嵌合受体在单链分子中包含至少三个结构域：细胞外配体结合结构域，跨膜结构域和与宿主细胞中的效应子功能信号协同作用的细胞质共刺激效应子功能信号结构域。新型杂合共刺激受体蛋白包括第二细胞质效应子功能信号结构域。本发明还涉及含有编码新型嵌合受体的核酸，表达新型嵌合受体的宿主细胞的表达盒以及使用受体共同刺激细胞中的效应子功能并使用表达受体的细胞进行治疗的方法的癌症，疾病和病毒感染。

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