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41. 发明授权

US08626276B2 Cardiac activation sequence monitoring for ischemia detection 失效
标题翻译：心脏激活序列监测缺血检测
公开(公告)号：US08626276B2
公开(公告)日：2014-01-07
申请号：US12847657
申请日：2010-07-30
申请人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald L. Hopper
发明人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald L. Hopper
IPC分类号： A61B5/04
CPC分类号： A61N1/3702 , A61B5/0452 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。可以使用后续分离来检测信号矢量的变化。该变化可以是心脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。与矢量相关联的信息可以被存储并用于跟踪矢量。

42. 发明申请

US20130308489A1 Minimizing Drive Tests Measurements Configuration for Signal Strength Reporting in Mobile Communications Environments 有权
标题翻译：最小化驱动器测试测量在移动通信环境中的信号强度报告配置
公开(公告)号：US20130308489A1
公开(公告)日：2013-11-21
申请号：US13981928
申请日：2011-02-21
申请人： Malgorzata Tomala , Yi Zhang
发明人： Malgorzata Tomala , Yi Zhang
IPC分类号： H04W24/10
CPC分类号： H04W24/10 , H04W24/08
摘要： At least one table for mapping measured quantity values of a signal strength, which are measured by a user equipment according to a minimizing drive tests policy in a mobile communications environment, to reported values is generated by including a number n of thresholds therein which are adjustable and indicate signal strength ranges defining the reported values, wherein n is greater or equal to two. The number n and values of the thresholds are adjusted to filter the measured quantity values in the user equipment, and the minimizing drive tests policy is controlled based on the at least one table.
摘要翻译：至少一个用于将用户设备根据移动通信环境中的最小化驱动测试策略测量的信号强度的测量量值映射到所报告的值的至少一个表通过在其中包括n个可调节的阈值来生成并且指示定义报告值的信号强度范围，其中n大于或等于2。调整数字n和阈值以过滤用户设备中的测量数量，并且基于至少一个表来控制最小化驱动器测试策略。

43. 发明申请

US20130203152A1 Method for Reducing DNA Impurities in Viral Compositions 有权
标题翻译：减少病毒组合物中DNA杂质的方法
公开(公告)号：US20130203152A1
公开(公告)日：2013-08-08
申请号：US13813897
申请日：2010-08-12
申请人： Yi Zhang , Jinming Dai , Yajin Ni
发明人： Yi Zhang , Jinming Dai , Yajin Ni
IPC分类号： C12N7/02 , C12N7/06
CPC分类号： C12N7/02 , A61K39/12 , A61K2039/525 , C12N7/00 , C12N7/06 , C12N2760/20134 , C12N2760/20151
摘要： A method for purification of viral compositions is provided. In particular, a method for reduction of unwanted residual DNA in a viral composition while retaining the immunogenicity of the virus itself is provided. The resulting immunogenic viral composition is substantially free of residual DNA, and is useful for the manufacture of medical products, such as vaccines designed for human or animal.
摘要翻译：提供了病毒组合物的纯化方法。具体地，提供了在保持病毒本身的免疫原性的同时还原病毒组合物中不需要的残留DNA的方法。所得的免疫原性病毒组合物基本上不含残留的DNA，并且可用于制造医疗产品，例如为人或动物设计的疫苗。

44. 发明申请

US20130194945A1 METHODS AND APPARATUSES FOR IMPLEMENTING A MULTI-RAB MINIMUM TFC DETERMINATION ALGORITHM BASED ON TRANSMIT POWER 有权
标题翻译：用于实现基于发射功率的多RAB最小TFC确定算法的方法和装置
公开(公告)号：US20130194945A1
公开(公告)日：2013-08-01
申请号：US13563961
申请日：2012-08-01
申请人： Sitaramanjaneyulu Kanamarlapudi , Liangchi Hsu , Rajasekar Arulprakasam , Yi Zhang
发明人： Sitaramanjaneyulu Kanamarlapudi , Liangchi Hsu , Rajasekar Arulprakasam , Yi Zhang
IPC分类号： H04W72/02
CPC分类号： H04W72/02 , H04W52/367 , H04W76/10
摘要： In an aspect of the present disclosure, presented is a method for wireless communication that includes obtaining at least one transport format combination (TFC), determining a minimum TFC (MinTFC) mode based on at least one TFC state of at least one TFC inside or outside a MinTFC set, and controlling at least one TFC based on the MRAB MinTFC mode. Through this method, pack-switched transmission power can be managed in a manner that will cause a circuit-switched call to function properly in challenging power conditions.
摘要翻译：在本公开的一方面，提出了一种用于无线通信的方法，包括获得至少一种传输格式组合（TFC），基于至少一个TFC内部的至少一个TFC状态确定最小TFC（MinTFC）模式，或在MinTFC集之外，并且基于MRAB MinTFC模式来控制至少一个TFC。通过这种方法，可以以使得电路交换呼叫在具有挑战性的电力条件下正常工作的方式来管理分组交换传输功率。

45. 发明授权

US08468342B2 Computer system and method for performing integrity detection on the same 有权
标题翻译：用于执行完整性检测的计算机系统和方法
公开(公告)号：US08468342B2
公开(公告)日：2013-06-18
申请号：US12083894
申请日：2006-03-15
申请人： Yi Zhang , Jian Zhou , Zhenxin Xi , Hongping Tian
发明人： Yi Zhang , Jian Zhou , Zhenxin Xi , Hongping Tian
IPC分类号： G06F7/20 , G06F11/30
CPC分类号： G06F21/577 , G06F11/2284
摘要： The present invention proposes a computer system and a method capable of performing integrity detection, comprising: a running mode unit which comprises an integrity detection boot variable to determine whether or not to initiate an integrity detection boot mode by judging said running mode unit; an EFI integrity detection unit (5), which is used for performing an integrity detection on EFI image codes in the integrity detection boot mode, and comprises an integrity metric value for being compared with an EFI integrity calculated value generated after the EFI integrity detection unit performs the integrity detection on the EFI image codes, to determine the integrity of the EFI image codes; an operating system integrity detection unit (6); and an integrity management unit. The present invention is based on the EFI BIOS to perform the integrity detection on the operating system during the pre-boot stage, having better reliability and security.
摘要翻译：本发明提出一种能够执行完整性检测的计算机系统和方法，包括：运行模式单元，其包括完整性检测引导变量，以通过判断所述运行模式单元来确定是否启动完整性检测引导模式; EFI完整性检测单元（5），其用于对完整性检测引导模式中的EFI图像代码执行完整性检测，并且包括与EFI完整性检测单元之后生成的EFI完整性计算值进行比较的完整性度量值对EFI图像代码执行完整性检测，以确定EFI图像代码的完整性; 操作系统完整性检测单元（6）; 和诚信管理单位。本发明基于EFI BIOS，以在预引导阶段对操作系统执行完整性检测，具有更好的可靠性和安全性。

46. 发明申请

US20130144035A1 COMPOSITIONS AND METHODS FOR LEUKOCYTE-TARGETING MULTI-VALENT IMAGING PROBES 审中-公开
标题翻译：用于低成本定位多成像成像探针的组合物和方法
公开(公告)号：US20130144035A1
公开(公告)日：2013-06-06
申请号：US13642670
申请日：2011-04-21
申请人： Dongfeng Pan , Stuart S. Berr , Yi Zhang
发明人： Dongfeng Pan , Stuart S. Berr , Yi Zhang
IPC分类号： A61K51/08
CPC分类号： A61K51/088 , A61K49/0002 , A61K49/0034 , A61K51/06
摘要： The present application discloses a new multivalent peptide ligand specifically targeting polymorphonuclear leukocytes (PMNs) with favorable pharmacological parameters to monitor sites of inflammation for imaging. The detailed synthesis, characterization, and pharmacological evaluation of the ligands are reported here. Two separate peptide binding ligands for formyl peptide and tuftsin receptors were chosen to link together based on the high expression levels of the two receptors on activated PMNs The heterobivalency and pegylated links were incorporated in the structural design to improve the sensitivity of the detection and to improve the bioavailability along with blood clearance profile, respectively. Two chemical constructs: cFLFLF-(PEG)n-TKPPR-99mTc (n=4, 12) were evaluated in vitro with human PMNs for binding affinity and bioavailability. As a result, FLFLF-(PEG)12-TKPPR99mTc was found to have more favorable pharmacological properties and was therefore used for further in vivo studies. Preliminary in vivo assessment of the agent was performed using Single Gamma Emission Computed Tomography (SPECT) imaging of a mouse model of ear inflammation. The results of these studies indicate cFLFLF-(PEG)12-TKPPR-99mTc may be a desirable imaging agent for binding to PMNs to identify sites of inflammation by SPECT.
摘要翻译：本申请公开了一种特异靶向多形核白细胞（PMN）的新型多价肽配体，具有良好的药理学参数，用于监测成像的炎症部位。这里报道了配体的详细合成，表征和药理学评估。基于激活的PMN上的两种受体的高表达水平，选择两种单独的用于甲酰肽和簇状蛋白受体的肽结合配体连接在一起。将异源和聚乙二醇化的链接并入结构设计中，以提高检测的灵敏度和改善分别具有生物利用度和血液清除曲线。两种化学构建体：cFLFLF-（PEG）n-TKPPR-99mTc（n = 4,12）在体外用人PMNs进行了评估，用于结合亲和力和生物利用度。结果发现FLFLF-（PEG）12-TKPPR99mTc具有更好的药理学特性，因此用于进一步的体内研究。使用单发伽马发射计算机断层扫描（SPECT）成像小鼠耳炎的模型进行药物的初步体内评估。这些研究的结果表明，cFLFLF-（PEG）12-TKPPR-99mTc可能是用于结合PMN的理想显像剂，以通过SPECT鉴定炎症部位。

47. 发明申请

US20130116578A1 RISK STRATIFICATION BASED HEART FAILURE DETECTION ALGORITHM 有权
标题翻译：基于风险分析的心脏失效检测算法
公开(公告)号：US20130116578A1
公开(公告)日：2013-05-09
申请号：US13726786
申请日：2012-12-26
申请人： Qi An , Pramodsingh Hirasingh Thakur , Viktoria A. Averina , Yi Zhang , Robert J. Sweeney
发明人： Qi An , Pramodsingh Hirasingh Thakur , Viktoria A. Averina , Yi Zhang , Robert J. Sweeney
IPC分类号： A61B5/0205
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/02007 , A61B5/024 , A61B5/0816 , A61B5/4842 , A61B5/7275 , A61N1/37282 , G06F19/00 , G06Q10/00 , G06Q50/22 , G16H50/20 , G16H50/30 , G16H50/50
摘要： A system comprises a risk analysis module and a worsening heart failure (WHF) detection module. The risk analysis module measures at least one first physiological parameter of a subject using a physiological sensor of an ambulatory medical device, and determines a heart failure (HF) risk score for the subject according to the at least one measured first physiological parameter. The HF risk score indicates susceptibility of the subject to experiencing a HF event. The WHF detection module measures at least one second physiological parameter of the subject using the same or different physiological sensor, and generates an indication of prediction that the subject will experience a WHF event when the at least one second physiological parameter satisfies a WHF detection algorithm. The risk analysis module adjusts generation of the indication by the WHF detection algorithm according to the determined HF risk score.
摘要翻译：系统包括风险分析模块和恶化心力衰竭（WHF）检测模块。风险分析模块使用移动医疗装置的生理传感器测量受试者的至少一个第一生理参数，并且根据至少一个测量的第一生理参数确定受试者的心力衰竭（HF）风险评分。 HF风险评分表示受试者经历HF事件的易感性。 WHF检测模块使用相同或不同的生理传感器测量受试者的至少一个第二生理参数，并且当至少一个第二生理参数满足WHF检测算法时，生成预测对象将经历WHF事件的指示。风险分析模块根据确定的HF风险评分调整WHF检测算法生成指示。

48. 发明申请

US20130096035A1 SELF-SUSTAINED FLUIDIC DROPLET CASSETTE AND SYSTEM FOR BIOCHEMICAL ASSAYS 审中-公开
标题翻译：自主持续流体液体和生物化学测定系统
公开(公告)号：US20130096035A1
公开(公告)日：2013-04-18
申请号：US13805625
申请日：2011-07-26
申请人： Tza-Huei Wang , Seungkyung Park , Samuel Yang , Yi Zhang
发明人： Tza-Huei Wang , Seungkyung Park , Samuel Yang , Yi Zhang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6844 , C12Q2565/629
摘要： A fluidic cartridge for biochemical assays includes a cartridge body defining a first droplet region and a second droplet region with a droplet restraining barrier therebetween. The droplet restraining barrier has a gap between the first and the second droplet regions. The fluidic cartridge also includes a first droplet dispensed in the first droplet region. The first droplet includes a plurality of magnetic particles dispersed therein. The fluidic cartridge also includes a second droplet disposed in the second droplet region. The plurality of magnetic particles are sufficiently small to be drawn through the gap between the first and second droplet regions when compelled by an applied magnetic field, and the first droplet is restrained by the restraining barrier while the plurality of magnetic particles are drawn through the gap. A biochemical assay system includes a stage adapted to receive a fluidic cartridge, and a magnetic control assembly that includes a magnet. The magnet of the magnetic control assembly is movable to direct motion of magnetic particles contained within the fluidic cartridge.
摘要翻译：用于生物化学测定的流体盒包括限定第一液滴区域的盒体和在其间具有液滴限制屏障的第二液滴区域。液滴限制屏障在第一和第二液滴区域之间具有间隙。流体盒还包括分配在第一液滴区域中的第一液滴。第一液滴包括分散在其中的多个磁性颗粒。流体盒还包括设置在第二液滴区域中的第二液滴。当被施加的磁场强迫时，多个磁性颗粒足够小以便被吸入第一和第二液滴区域之间的间隙，并且第一液滴被约束屏障约束，同时多个磁性颗粒被吸引通过间隙。生物化学测定系统包括适于接收流体盒的阶段和包括磁体的磁性控制组件。磁性控制组件的磁体可移动以引导包含在流体盒内的磁性颗粒的运动。

49. 发明授权

US08401636B2 Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device 有权
标题翻译：使用一个或多个可植入装置监测疾病和药物管理的计时生理节律
公开(公告)号：US08401636B2
公开(公告)日：2013-03-19
申请号：US13209938
申请日：2011-08-15
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61N1/18
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译：使用至少一个可植入装置自动评价或预测受试者的健康状况。在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。也可以使用昼夜节律以外的其他时间生理节律。可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

50. 发明申请

US20130046493A1 SYSTEMS AND METHODS FOR DATA ANOMALY DETECTION 有权
标题翻译：用于数据异常检测的系统和方法
公开(公告)号：US20130046493A1
公开(公告)日：2013-02-21
申请号：US13213899
申请日：2011-08-19
申请人： Bethany Hoogs , Jason Black , Yi Zhang , Weiwei Chen , Ming Li
发明人： Bethany Hoogs , Jason Black , Yi Zhang , Weiwei Chen , Ming Li
IPC分类号： G06F19/00
CPC分类号： G06Q10/0631 , G06Q10/04 , H02J3/00 , H02J2003/003 , H02J2003/007 , Y02E60/76 , Y02P90/82 , Y04S10/54 , Y04S40/22
摘要： Systems and methods for performing data anomaly detection and/or removal are usable to accurately assess baseline power consumption. According to one embodiment of the invention, a system can be provided. The system can be operable to receive energy consumption data of a location; select, based at least in part on a collection period of the energy consumption data, an algorithm for detecting anomalies in the energy consumption data; perform the algorithm on the energy consumption data to detect the anomalies in the energy consumption data; and determine an energy consumption baseline for the location based at least in part on a result of the algorithm.
摘要翻译：用于执行数据异常检测和/或移除的系统和方法可用于准确评估基线功耗。根据本发明的一个实施例，可以提供一种系统。该系统可操作以接收位置的能量消耗数据; 至少部分地基于能量消耗数据的收集周期来选择用于检测能量消耗数据中的异常的算法; 执行能耗数据算法，检测能耗数据中的异常情况; 并且至少部分地基于所述算法的结果来确定所述位置的能量消耗基准。

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