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41. 发明申请

WO1997007222A1 PLANT GENE ENCODING ACETYL COENZYME A CARBOXYLASE BIOTIN CARBOXYLASE CARRIER PROTEIN 审中-公开
标题翻译：植物基因编码乙酰胆碱酯酶羧基酶生物素羧酰酶载体蛋白
公开(公告)号：WO1997007222A1
公开(公告)日：1997-02-27
申请号：PCT/GB1996001894
申请日：1996-08-06
申请人： ZENECA LIMITED , SLABAS, Antoni, Ryszard , ELBOROUGH, Kieran, Michael
发明人： ZENECA LIMITED
IPC分类号： C12N15/82
CPC分类号： C12N9/93 , C12N15/8247
摘要： The capacity of a plant to produce fatty acids is modulated by controlling the expression of a gene specifying the acetyl CoA carboxylase biotin carboxyl carrier protein. Modulation may comprise increasing the expression of the gene by insertion of additional copies into the genome or inhibiting expression by insertion of an antisense or cosuppression vector directed against the endogenous gene.
摘要翻译：植物产生脂肪酸的能力通过控制指定乙酰辅酶A羧化酶羧基羧酸载体蛋白的基因的表达来调节。调节可以包括通过将额外的拷贝插入基因组来增加基因的表达，或通过插入针对内源基因的反义或共抑制载体来抑制表达。

42. 发明申请

WO1997006138A1 4-MERCAPTOPYRROLIDINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS 审中-公开
标题翻译：作为呋喃葡萄糖转运酶抑制剂的4-巯基吡啶衍生物
公开(公告)号：WO1997006138A1
公开(公告)日：1997-02-20
申请号：PCT/GB1996001810
申请日：1996-07-30
申请人： ZENECA LIMITED , BOYLE, Francis, Thomas , DAVIES, David, Huw , KENNY, Peter, Wedderburn , MATUSIAK, Zbigniew, Stanley , SCHOLES, Peter, Beverley , WARDLEWORTH, James, Michael
发明人： ZENECA LIMITED
IPC分类号： C07D207/12
CPC分类号： C07D401/12 , C07D207/12 , C07D409/12
摘要： Pharmaceutical compositions comprising an inhibitor of ras farnesylation of formula (I) wherein, R is for example H and further values as defined in the specification; R is for example H and further values as defined in the specification; R is for example H or a substituent having values as defined in the specification; p is 0-3 in which R values can be the same or different; L is a linking moiety for example -CO-NH2- and further values as defined in the specification; A is selected from phenyl; naphthyl; a 5-10 membered monocyclic or bicyclic heteroaryl ring containing up to 5 heteroatoms where the heteroatoms are independently selected from O, N and S; or a -S-S- dimer thereof when R =H; or an enantiomer, diastereoisomer, pharmaceutically acceptable salt, prodrug or solvate thereof together with a pharmaceutically acceptable diluent or carrier. A particular use is cancer therapy.
摘要翻译：包含式（I）的ras法呢基酯化抑制剂的药物组合物，其中R 1例如为H，以及说明书中所定义的其它值; R 2例如为H，如说明书中所定义的其它值; R 3例如为H或具有本说明书中定义的值的取代基; p为0-3，其中R 3可以相同或不同; L是例如-CO-NH 2的连接部分和如说明书中定义的进一步的值; A选自苯基; 萘; 含有多达5个杂原子的5-10元单环或双环杂芳基环，其中杂原子独立地选自O，N和S; 或当R 2 = H时，其-S-S-二聚体; 或其对映体，非对映异构体，药学上可接受的盐，前药或溶剂合物以及药学上可接受的稀释剂或载体。一个特别的用途是癌症治疗。

43. 发明申请

WO1997005910A1 NON-WOVEN COMPOSITION WITH ANTIMICROBIAL PROTECTION AND USE THEREOF 审中-公开
标题翻译：非织造组合物与抗微生物保护及其用途
公开(公告)号：WO1997005910A1
公开(公告)日：1997-02-20
申请号：PCT/GB1996001562
申请日：1996-06-28
申请人： ZENECA LIMITED , PAYNE, John, David , FAWKES, David, Melville
发明人： ZENECA LIMITED
IPC分类号： A61L15/20
CPC分类号： A61L15/46 , A61L15/20 , A61L2300/206 , A61L2300/404
摘要： A composition comprising a cellulosic non-woven material containing a mixture of polymeric biguanides such as poly(hexamethylene biguanide) together with an anionic polymer such as a polyacrylic acid super-absorbent and the use of such composition in disposable articles such as nappies.
摘要翻译：包含含有聚合双胍的混合物如聚（六亚甲基双胍）与阴离子聚合物如聚丙烯酸超吸收剂的纤维素非织造材料的组合物，以及在一次性制品如尿布中使用这种组合物。

44. 发明申请

WO1997005182A1 ANTI-MICROBIAL COATING COMPOSITIONS 审中-公开
标题翻译：抗微生物涂料组合物
公开(公告)号：WO1997005182A1
公开(公告)日：1997-02-13
申请号：PCT/GB1996001617
申请日：1996-07-08
申请人： ZENECA LIMITED , EASTWOOD, Ian, Michael , PADGET, John, Christopher , GERRARD, John, Jeffrey , YEATES, Terence
发明人： ZENECA LIMITED
IPC分类号： C08F246/00
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C08F246/00 , C09D5/14 , C09D5/165
摘要： A water-erodible organic polymer bearing anionic salt groups, at least a proportion of which has as counter ions a biologically active heterocyclic cation having a delocalised positive charge. The heterocyclic cation is preferably a bis-imidazolium cation and the anionic salt group is preferably derived from (meth)acrylic acid or 2-acrylamido-2-methyl-propane sulphonic acid.
摘要翻译：具有阴离子盐基团的水溶性有机聚合物，其至少一部分具有作为抗衡离子的具有离域正电荷的生物活性杂环阳离子。杂环阳离子优选为双咪唑阳离子，阴离子盐基优选衍生自（甲基）丙烯酸或2-丙烯酰胺基-2-甲基 - 丙磺酸。

45. 发明申请

WO1997004031A1 DYE MIXTURES 审中-公开
标题翻译： DYE混合物
公开(公告)号：WO1997004031A1
公开(公告)日：1997-02-06
申请号：PCT/GB1996001532
申请日：1996-06-26
申请人： ZENECA LIMITED , LEAVER, Alan, Thomas
发明人： ZENECA LIMITED
IPC分类号： C09B67/22
CPC分类号： C09B67/0034 , C09B57/00 , Y10S8/922 , Y10S8/934
摘要： A disperse dye mixture which comprises, on a weight basis, from 5 % to 70 % of the dye of Formula (1), from 5 % to 70 % of the dye of Formula (2), and from 0 % to 40 % of the dye of Formula (3), wherein each of R and R represents an alkylene group and each of R and R represents an alkyl group.
摘要翻译：一种分散染料混合物，其以重量计包含式（1）的染料的5％至70％，式（2）的染料的5％至70％，以及0％至40％的式（3）的染料，其中R和R 1各自表示亚烷基，R 2和R 3各自表示烷基。

46. 发明申请

WO1997004030A1 AZOTHIOPHENES 审中-公开
公开(公告)号：WO1997004030A1
公开(公告)日：1997-02-06
申请号：PCT/GB1996001533
申请日：1996-06-26
申请人： ZENECA LIMITED , LEAVER, Alan, Thomas
发明人： ZENECA LIMITED
IPC分类号： C09B29/033
CPC分类号： C09B67/0051 , C09B29/0059 , C09B67/0041 , Y10S8/922 , Y10S534/01
摘要： An azothiophene disperse dye of Formula (1) in which R, R , R and R each independently is alkyl or alkenyl.
摘要翻译：其中R 1，R 2，R 2和R 3各自独立地是烷基或烯基的式（1）的噻吩分散染料。

47. 发明申请

WO1997003132A1 STABILISED DYE COMPOSITION 审中-公开
标题翻译：稳定的染料组合物
公开(公告)号：WO1997003132A1
公开(公告)日：1997-01-30
申请号：PCT/GB1996001561
申请日：1996-06-28
申请人： ZENECA LIMITED , GREGORY, Peter , KENYON, Ronald, Wynford , WIGHT, Paul
发明人： ZENECA LIMITED
IPC分类号： C09B67/24
CPC分类号： C09B31/08 , C09B67/0072
摘要： A composition of a water-soluble bis-azo dye of formula (1) and an oxidising agent, wherein A is optionally substituted phenyl or optionally substituted naphthyl; B is optionally substituted phenylene or optionally substituted naphthylene; R is H or sulpho; R is H, optionally substituted alkyl, optionally substituted aryl or optionally substituted acyl; R is H, optionally substituted aryl, optionally substituted alkyl or a group, -D-E; D is optionally substituted C2-6-alkylene; and E is a group of formula (1a); R & R each independently is H or optionally substituted alkyl; and R is H, optionally substituted alkyl, optionally substituted aryl or optionally substituted acyl.
摘要翻译：式（1）的水溶性双偶氮染料和氧化剂的组合物，其中A是任选取代的苯基或任选取代的萘基; B是任选取代的亚苯基或任选取代的亚萘基; R 1是H或磺基; R 2是H，任选取代的烷基，任选取代的芳基或任选取代的酰基; R 3是H，任选取代的芳基，任选取代的烷基或基团，-D-E; D是任选取代的C 2-6 - 亚烷基; 和E是式（1a）的一组; R 4和R 5各自独立地为H或任选取代的烷基; 且R 6为H，任选取代的烷基，任选取代的芳基或任选取代的酰基。

48. 发明申请

WO1997002289A1 PEPTIDE INHIBITORS OF FIBRONECTINE 审中-公开
标题翻译：纤维蛋白抑肽酶
公开(公告)号：WO1997002289A1
公开(公告)日：1997-01-23
申请号：PCT/GB1996001580
申请日：1996-07-02
申请人： ZENECA LIMITED , DUTTA, Anand, Swaroop
发明人： ZENECA LIMITED
IPC分类号： C07K14/78
CPC分类号： C07K7/56 , A61K38/00
摘要： Cyclic dimeric peptides of formula (1) wherein: peptide 1 and peptide 2 independently represent a tetrapeptide of formula -AA1-AA2-AA3-AA4- juxtaposed in parallel or antiparallel orientation; AA1 is an L or D amino acid selected from Ile, Leu and amino analogues thereof selected from Pro, Gly, Tic and Phe; AA2 is an L amino acid selected from Leu and amino acid analogues thereof selected from Ile, Phe and Val; AA3 is an L amino acid selected from Asp, Glu and amino acid analogues thereof; AA4 is an L amino acid selected from Val and amino acid analogues thereof selected from Leu, Ile, Phe and Cha (cyclohexylalanine); L1 and L2 independently represent linking moieties for linking peptides 1 and 2 to form a cyclic dipeptide; or salts thereof. The cyclic dipeptides inhibit the interaction of vascular cell adhesion molecule-1 and fibronectin with integrin very late antigen 4 and have therapeutic applications such as in rheumatoid arthritis, asthma or multiple sclerosis.
摘要翻译：式（1）的环状二聚肽其中：肽1和肽2独立地表示并列或反平行取向并入的式-AA1-AA2-AA3-AA4的四肽; AA1是选自Ile，Leu及其选自Pro，Gly，Tic和Phe的氨基类似物的L或D或D 氨基酸; AA2是选自Leu和其选自Ile，Phe和Val的氨基酸类似物的L9氨基酸; AA3是选自Asp，Glu及其氨基酸类似物的一种氨基酸; AA4是选自Val和其氨基酸类似物的选自Leu，Ile，Phe和Cha（环己基丙氨酸）的L9A氨基酸; L1和L2独立地表示用于连接肽1和2的连接部分以形成环状二肽; 或其盐。环状二肽抑制血管细胞粘附分子-1和纤连蛋白与整联蛋白非常晚的抗原4的相互作用，并具有治疗应用，例如类风湿性关节炎，哮喘或多发性硬化。

49. 发明申请

WO1997000864A1 AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：芳香化合物和含有它们的药物组合物
公开(公告)号：WO1997000864A1
公开(公告)日：1997-01-09
申请号：PCT/GB1996001443
申请日：1996-06-17
申请人： ZENECA LIMITED , BREAULT, Gloria, Anne
发明人： ZENECA LIMITED
IPC分类号： C07D237/24
CPC分类号： C07D213/80 , C07D213/82 , C07D237/18 , C07D237/24 , C07D401/04 , C07D403/04 , C07D413/04 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of formula (I), wherein A is an optionally substituted, ring system provided that the -CH(R )N(R )B-R and -OD groups are positioned in a 1,2 relationship to one another on ring carbon atoms and the ring atom positioned ortho to the -OD linking group (and therefore in the 3-position relative to the -CHR NR linking group) is not substituted; B is an optionally substituted ring system; R is positioned on ring B in a 1,3 or 1,4 relationship with the -CH(R )N(R )- linking group and is as defined in the description; R is hydrogen, C1-6alkyl, optionally substituted by hydroxy, cyano or trifluoromethyl, C2-6alkenyl (provided the double bond is not in the 1-position), (C2-6alkynyl (provided the triple bond is not in the 1-position), phenylC1-3alkyl or pyridylC1-3alkyl; R is hydrogen, methyl or ethyl; D is hydrogen, an optionally substituted 5-7 membered carbocyclic ring containing one double bond, C1-3alkyl substituted by an optionally substituted 5-7 membered carbocyclic ring containing one double bond or D is of the formula -(CH2)nCH(R )C(R )=C(R )R and N-oxides of -NR where chemically possible; and S-oxides of sulphur containing rings where chemically possible; and pharmaceutically acceptable salts and in vivo hydrolysable esters and amides thereof; excluding 4-[5-carboxy-2-hydroxybenzylamino]benzoic acid, 4-[2,5-dihydroxybenzylamino]benzoic acid, 5-[2-hydroxybenzylamino]-2-hydroxybenzoic acid, 3-[2,5-dihydroxybenzylamino]benzoic acid, 4-[2,5-dihydroxybenzylamino]benzenecarboxamide, 3-[2-hydroxybenzylamino]benzoic acid, 4-[2,5-dihydroxybenzylamino]-2-hydroxybenzoic acid, 4-[hydroxybenzylamino]-2-hydroxybenzoic acid and 4[2-hydroxybenzylamino]benzoic acid. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）化合物，其中A是任选取代的环系，条件是-CH（R 3）N（R 2）BR 1和-OD基团位于在环碳原子上彼此相关，并且位于-OD连接基团（因此相对于-CHR 3 NR 2连接基团的3位）的环原子未被取代 ; B是任选取代的环系; R 1与-CH（R 3）N（R 2） - 连接基以1,3或1,4个关系位于环B上，并且如说明书中所定义; R 2是氢，任选被羟基，氰基或三氟甲基取代的C 1-6烷基，C 2-6烯基（提供双键不在1-位），（C 2-6炔基（条件是三键不在 1-位），苯基C 1-3烷基或吡啶基C 1-3烷基; R 3是氢，甲基或乙基; D是氢，任选取代的含有一个双键的5-7元碳环，被任选取代的C 1-3烷基含有一个双键的5-7元碳环或D具有式 - （CH 2）n CH（R 4）C（R 5）= C（R 6）R 7和N-氧化物其中化学上可能的是-NR 2，和其中化学可能的含硫环的S-氧化物;及其药学上可接受的盐和体内可水解的酯和酰胺;不包括4- [5-羧基-2-羟基苄基氨基]苯甲酸， 4- [2,5-二羟基苄基氨基]苯甲酸，5- [2-羟基苄基氨基] -2-羟基苯甲酸，3- [2,5-二羟基苄基氨基]苯甲酸，4- [2,5-二羟基苄基氨基]苯甲醛 de，3- [2-羟基苄基氨基]苯甲酸，4- [2,5-二羟基苄基氨基] -2-羟基苯甲酸，4- [羟基苄基氨基] -2-羟基苯甲酸和4 [2-羟基苄基氨基]苯甲酸。其制备方法，制备中的中间体，作为治疗剂的用途和含有它们的药物组合物。

50. 发明申请

WO1996039822A1 DRY WATER-DISPERSIBLE COMPOSITIONS OF MICROENCAPSULATED PESTICIDES 审中-公开
标题翻译：微乳化农药的干水分散组合物
公开(公告)号：WO1996039822A1
公开(公告)日：1996-12-19
申请号：PCT/GB1996001310
申请日：1996-06-03
申请人： ZENECA LIMITED
发明人： ZENECA LIMITED , SCHER, Herbert, Benson , CHEN, Jin, Ling , LO, Ray, Jia
IPC分类号： A01N25/14
CPC分类号： A01N25/28 , A01N25/14
摘要： Solid water-dispersible compositions containing microencapsulated pesticides are produced by spray-drying an aqueous suspension of said pesticides in the presence of a water-soluble polymer, preferably polyvinyl alcohol.
摘要翻译：通过在水溶性聚合物，优选聚乙烯醇存在下，将所述杀虫剂的水性悬浮液喷雾干燥来制备含微囊化农药的固体水分散性组合物。

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