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41. 发明申请

US20070031825A1 Methods and compositions for detecting BK virus 有权
标题翻译：检测BK病毒的方法和组合物
公开(公告)号：US20070031825A1
公开(公告)日：2007-02-08
申请号：US11246904
申请日：2005-10-06
申请人： Fan Chen , Lilly Kong , Jules Chen , Mehrdad Jannatipour
发明人： Fan Chen , Lilly Kong , Jules Chen , Mehrdad Jannatipour
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/701 , C12N2710/22011 , C12Q2600/158
摘要： The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of a BK virus in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region of BK viral genomes. The invention also features compositions, including primers, probes, and kits, for use in the methods of the invention.
摘要翻译：本发明提供用于样品中BK病毒的快速，灵敏和高度特异性核酸（例如基于DNA）检测的方法和组合物。通常，所述方法涉及检测具有BK病毒基因组的保守区的靶序列的靶核酸。本发明还包括用于本发明方法的组合物，包括引物，探针和试剂盒。

42. 发明授权

US07163790B2 Parallel polymorphism scoring by amplification and error correction 失效
公开(公告)号：US07163790B2
公开(公告)日：2007-01-16
申请号：US10306828
申请日：2002-11-27
申请人： Yan Wang , Michael Finney , Fan Chen
发明人： Yan Wang , Michael Finney , Fan Chen
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6858 , C07K2319/80 , C12Q1/6823 , C12Q1/6869 , C12Q2535/125 , C12Q2521/319 , C12Q2521/101 , C12Q2565/537
摘要： This invention provides a method of detecting polymorphisms, e.g., single nucleotide polymorphisms (SNPs), by amplification and error correction. The invention encompasses methods of performing amplification and error correction using an improved generation of nucleic acid polymerases, and methods of multiplexing the assay. The improvement to the polymerases is the joining of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a manner that enhances the ability of the enzyme to bind and catalytically modify the nucleic acid.

43. 发明授权

US10465252B2 Bordetella detection assay 有权
公开(公告)号：US10465252B2
公开(公告)日：2019-11-05
申请号：US12116364
申请日：2008-05-07
申请人： Michelle M. Tabb , Ming-Chou Lee , Lilly I. Kong , Ning Lu , Michael Aye , Fan Chen , Jules Chen
发明人： Michelle M. Tabb , Ming-Chou Lee , Lilly I. Kong , Ning Lu , Michael Aye , Fan Chen , Jules Chen
IPC分类号： C12Q1/689
摘要： Disclosed herein are methods and compositions for detecting Bordetella pertussis and Bordetella parapertussis by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.

44. 发明授权

US08525428B2 Power supply apparatus and method for a backlight system 有权
标题翻译：用于背光系统的电源装置和方法
公开(公告)号：US08525428B2
公开(公告)日：2013-09-03
申请号：US12986960
申请日：2011-01-07
申请人： Fan Chen , Xin Wu , Chaoqun Sun , Qanqing Wu
发明人： Fan Chen , Xin Wu , Chaoqun Sun , Qanqing Wu
IPC分类号： H05B37/02 , H05B39/04 , H05B41/36 , H05B39/02 , H05B41/16 , H05B41/24 , H05B37/00 , H05B39/00 , H05B41/00 , G01F1/00 , H02M3/335
CPC分类号： H02M3/337 , G09G3/34 , G09G2330/00 , H02M2001/007
摘要： A power supply system includes a transformer having a primary winding on its primary side for coupling to a power source and one or more secondary windings on its secondary side. A first control circuit is disposed on the primary side of the transformer for controlling a current flow in the primary winding. A second control circuit disposed on the secondary side of the transformer, and the second control circuit is configured to provide a regulated output voltage. In the power supply system, the first control circuit is configured to generate a control signal for controlling the current flow in the primary winding without using a feedback control signal from the secondary side of the transformer.
摘要翻译：电源系统包括：变压器，其初级侧具有用于耦合到电源的初级绕组和其次级侧上的一个或多个次级绕组。第一控制电路设置在变压器的初级侧，用于控制初级绕组中的电流。设置在变压器次级侧的第二控制电路，第二控制电路被配置为提供稳定的输出电压。在电源系统中，第一控制电路被配置为产生用于控制初级绕组中的电流的控制信号，而不使用来自变压器的次级侧的反馈控制信号。

45. 发明授权

US08378457B2 Silicon-germanium heterojunction bipolar transistor 有权
标题翻译：硅 - 锗异质结双极晶体管
公开(公告)号：US08378457B2
公开(公告)日：2013-02-19
申请号：US13239250
申请日：2011-09-21
申请人： Fan Chen , Xiongbin Chen , Wensheng Qian , Zhengliang Zhou
发明人： Fan Chen , Xiongbin Chen , Wensheng Qian , Zhengliang Zhou
IPC分类号： H01L27/102
CPC分类号： H01L29/7378 , H01L21/26513 , H01L29/0821 , H01L29/41708
摘要： A SiGe HBT formed on a silicon substrate is disclosed. An active area is isolated by field oxide regions; a collector region is formed in the active area and extends into the bottom of the field oxide regions; pseudo buried layers are formed at the bottom of the field oxide regions, wherein each pseudo buried layer is separated by a lateral distance from the active area and connected to a lateral extension part of the collector region; first deep hole contacts are formed on top of the pseudo buried layers in the field oxide regions to pick up collector electrodes; a plurality of second deep hole contacts with a floating structure, are formed in the field oxide region on top of a lateral extension part of the collector region, wherein N-type implantation regions are formed at the bottom of the second deep hole contacts.
摘要翻译：公开了一种形成在硅衬底上的SiGe HBT。有源区域由场氧化物区域隔离; 在有源区域中形成集电极区域并延伸到场氧化物区域的底部; 伪掩埋层形成在场氧化物区域的底部，其中每个伪掩埋层与有源区域的横向距离分离并连接到集电极区域的横向延伸部分; 第一深孔触点形成在场氧化物区域中的伪掩埋层的顶部上以拾取集电极; 在集电区域的横向延伸部分的顶部上的场氧化物区域中形成多个具有浮动结构的第二深孔触点，其中在第二深孔触点的底部形成有N型注入区域。

46. 发明申请

US20110159659A1 Novel Manufacturing Approach for Collector and N Type Buried Layer Of Bipolar Transistor 有权
标题翻译：双极晶体管集电极和N型埋层的新型制造方法
公开(公告)号：US20110159659A1
公开(公告)日：2011-06-30
申请号：US12979907
申请日：2010-12-28
申请人： Tzuyin CHIU , TungYuan Chu , YungChieh Fan , Wensheng Qian , Fan Chen , Jiong Xu , Haifang Zhang
发明人： Tzuyin CHIU , TungYuan Chu , YungChieh Fan , Wensheng Qian , Fan Chen , Jiong Xu , Haifang Zhang
IPC分类号： H01L21/331 , B82Y40/00
CPC分类号： H01L29/7371 , H01L21/76237 , H01L21/76264 , H01L29/0653 , H01L29/0821 , H01L29/66272
摘要： This invention disclosed a novel manufacturing approach of collector and buried layer of a bipolar transistor. One aspect of the invention is that an oxide-nitride-oxide (ONO) sandwich structure is employed instead of oxide-nitride dual layer structure before trench etching. Another aspect is, through the formation of silicon oxide spacer in trench sidewall and silicon oxide remaining in trench bottom in the deposition and etch back process, the new structure hard mask can effectively protect active region from impurity implanted in ion implantation process.
摘要翻译：本发明公开了双极晶体管的集电极和掩埋层的新颖制造方法。本发明的一个方面是在沟槽蚀刻之前采用氧化物 - 氮化物 - 氧化物（ONO）夹层结构代替氧化氮化物双层结构。另一方面是，通过在沉积和回蚀工艺中在沟槽侧壁中形成氧化硅隔离物和保留在沟槽底部的氧化硅，新的结构硬掩模可以有效地保护有源区域免于植入离子注入过程中的杂质。

47. 发明申请

US20110156163A1 Structure of electrode pick up in LOCOS 审中-公开
标题翻译： LOCOS中电极拾取的结构
公开(公告)号：US20110156163A1
公开(公告)日：2011-06-30
申请号：US12979802
申请日：2010-12-28
申请人： Tzuyin CHIU , TungYuan Chu , YungChieh Fan , Wensheng Qian , Jiong Xu , Fan Chen , Haifang Zhang
发明人： Tzuyin CHIU , TungYuan Chu , YungChieh Fan , Wensheng Qian , Jiong Xu , Fan Chen , Haifang Zhang
IPC分类号： H01L23/535 , H01L23/48
CPC分类号： H01L29/1004 , H01L21/743 , H01L21/76208 , H01L23/535 , H01L29/0821 , H01L29/66287 , H01L29/732 , H01L2924/0002 , H01L2924/00
摘要： This invention disclosed a kind of electrode picking up structure in LOCOS isolation process. The active region is isolated by local oxide of silicon (LOCOS). A pseudo buried layer under the bottom of LOCOS is formed. The pseudo-buried layer extends into active region and connects to doping region one which needs to be picked up by an electrode. This is achieved by deep trench contacts which etch through LOCOS and get in touch with pseudo buried layer. This invention can reduce the device size, pick up electrode resistance, collector parasitic capacitance, and increase device cut off frequency.
摘要翻译：本发明公开了LOCOS隔离工艺中的一种电极拾取结构。有源区由硅的局部氧化物（LOCOS）隔离。形成LOCOS底部的伪掩埋层。伪掩埋层延伸到有源区并连接到需要被电极拾取的掺杂区。这是通过深沟槽接触实现的，其通过LOCOS蚀刻并与伪掩埋层接触。本发明可以减小器件尺寸，拾取电极电阻，集电极寄生电容，并增加器件截止频率。

48. 发明申请

US20090181360A1 MULTIPLEX DETECTION ASSAY FOR INFLUENZA AND RSV VIRUSES 有权
标题翻译：用于流感病毒和RSV病毒的多重检测测定
公开(公告)号：US20090181360A1
公开(公告)日：2009-07-16
申请号：US11963699
申请日：2007-12-21
申请人： Jules Chen , Lilly I. Kong , Ming-Chou Lee , Fan Chen , Michelle M. Tabb , Michael Aye
发明人： Jules Chen , Lilly I. Kong , Ming-Chou Lee , Fan Chen , Michelle M. Tabb , Michael Aye
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701
摘要： The present invention generally relates to a molecular test of Influenza A, Influenza B, Respiratory Syncytial Virus A, and Respiratory Syncytial Virus B in order to identify patients with a viral infection. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a sample containing one or more target nucleic acids from the M gene of Influenza A, Influenza B, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B.
摘要翻译：本发明一般涉及A型流感，B型流感，呼吸道合胞病毒A和呼吸道合胞病毒B的分子检测，以鉴定病毒感染患者。因此，公开了方法和组合物以确定含有来自A型流感，B型流感，呼吸道合胞病毒A和/或呼吸道合胞病毒B的M基因的一种或多种靶核酸的样品中病毒病原体的存在或不存在。

49. 发明申请

US20070009954A1 Parallel polymorphism scoring by amplification and error correction 审中-公开
标题翻译：平行多态性通过放大和纠错得分
公开(公告)号：US20070009954A1
公开(公告)日：2007-01-11
申请号：US11521754
申请日：2006-09-15
申请人： Yan Wang , Michael Finney , Fan Chen
发明人： Yan Wang , Michael Finney , Fan Chen
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6858 , C07K2319/80 , C12Q1/6823 , C12Q1/6869 , C12Q2535/125 , C12Q2521/319 , C12Q2521/101 , C12Q2565/537
摘要： This invention provides a method of detecting polymorphisms, e.g., single nucleotide polymorphisms (SNPs), by amplification and error correction. The invention encompasses methods of performing amplification and error correction using an improved generation of nucleic acid polymerases, and methods of multiplexing the assay. The improvement to the polymerases is the joining of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a manner that enhances the ability of the enzyme to bind and catalytically modify the nucleic acid.
摘要翻译：本发明提供了通过扩增和错误校正来检测多态性（例如单核苷酸多态性（SNP））的方法。本发明包括使用改进的核酸聚合酶的产生来进行扩增和纠错的方法，以及多重测定的方法。对聚合酶的改进是以提高酶结合和催化修饰核酸的能力的方式连接序列非特异性核酸结合结构域与酶。

50. 发明申请

US20060051749A1 Polymorphism and haplotype scoring by differential amplification of polymorphisms 审中-公开
标题翻译：多态性差异扩增多态性和单倍型评分
公开(公告)号：US20060051749A1
公开(公告)日：2006-03-09
申请号：US10496702
申请日：2002-11-27
申请人： Yan Wang , Lei Xi , Michael Finney , Fan Chen
发明人： Yan Wang , Lei Xi , Michael Finney , Fan Chen
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6858 , C12Q2561/113 , C12Q2545/114 , C12Q2537/143 , C12Q2535/125 , C12Q2531/113
摘要： The current invention provides a method of performing DNA polymorphism assays. The assay combines allele-specific PCR with technology used for quantitative PCR. The method can be used to score the presence of absence of particular polymorphisms in a DNA sample. In a further aspect of the invention, the method is used to score the presence or absence of particular haplotypes in a DNA sample.
摘要翻译：本发明提供了进行DNA多态性测定的方法。该测定将等位基因特异性PCR与用于定量PCR的技术相结合。该方法可用于评估DNA样品中特定多态性缺失的存在。在本发明的另一方面，该方法用于评估DNA样品中特定单元型的存在或不存在。

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