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41. 发明申请

US20110067475A1 Process for Producing High-Alloy Seamless Tube 有权
标题翻译：生产高合金无缝管的工艺
公开(公告)号：US20110067475A1
公开(公告)日：2011-03-24
申请号：US12954223
申请日：2010-11-24
申请人： Hiroaki Murakami , Tomio Yamakawa , Tadashi Douhara , Masayuki Sagara
发明人： Hiroaki Murakami , Tomio Yamakawa , Tadashi Douhara , Masayuki Sagara
IPC分类号： B21C23/00
CPC分类号： C21D8/10 , B21C23/085 , B21C25/02 , C21D6/001 , C21D6/002 , C21D7/13 , C21D9/08 , C21D9/14 , C22C19/05 , C22C19/055 , C22C30/00 , C22F1/10
摘要： A starting material to be extruded made of a high alloy comprising, in mass %, Cr: 20 to 30% and Ni: more than 22% and 60% or less is heated to a temperature predetermined according to the contents of Mo and W and is subjected to a hot-extrusion process, the heating temperature T (° C.) satisfying a relationship of Formula (1), (2), or (3), which is expressed in terms of the average cross-sectional area A (mm2) of the starting material to be extruded, the extrusion ratio EL (−), and the extrusion speed V (mm/s). As a result, a high-alloy seamless tube can be produced without generating cracking and/or seam flaws. When 0%≦Mo+0.5W
摘要翻译：将以质量％计含有Cr：20〜30％，Ni：22％以上且60％以下的高合金挤出的原料加热至根据Mo，W的含量而预先确定的温度，进行热挤压加工，满足式（1），（2）或（3）的关系的加热温度T（℃），其以平均截面积A（ mm2），挤出比EL（ - ）和挤出速度V（mm / s）。结果，可以生产高合金无缝管而不产生开裂和/或接缝缺陷。当0％＆nlE; Mo + 0.5W <4％时：T＆nlE; 1343-0.001322×A-1.059×EL-0.129×V（1）当4％＆nlE; Mo + 0.5W <7％时：T＆nlE; 1316-0.001322× A-1.059×EL-0.129×V（2）当7％＆nlE; Mo + 0.5W：T＆nlE; 1289-0.001322×A-1.059×EL-0.129×V（3）

42. 发明授权

US07795458B2 Salt of (2S, 3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl] carbamoyl] oxirane-2-carboxylic acid 有权
标题翻译：（2S，3S）-3 - [[（1S）-1-异丁氧基甲基-3-甲基丁基]氨基甲酰基]环氧乙烷-2-羧酸
公开(公告)号：US07795458B2
公开(公告)日：2010-09-14
申请号：US12545665
申请日：2009-08-21
申请人： Atsushi Tendo , Toshihiro Takahashi , Tomio Yamakawa , Kazuki Okai , Susumu Nihashi
发明人： Atsushi Tendo , Toshihiro Takahashi , Tomio Yamakawa , Kazuki Okai , Susumu Nihashi
IPC分类号： C07D303/48
CPC分类号： C07D303/48
摘要： The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet) 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm−1.
摘要翻译：本发明涉及用（2S，3S）-3 - [[（1S）-1-异丁氧基甲基-3-甲基丁基]氨基甲酰基]环氧乙烷-2-羧酸[以下称为羧酸] 所述羧酸与选自哌嗪，金刚烷胺等的有机胺反应。本发明还涉及提供羧酸的结晶钠盐。钠盐可用作制备药物的材料并改善储存稳定性，具有以下特征：DSC：在170至175℃的温度范围内观察到的放热峰，重量减少; 和红外吸收光谱（KBr片剂）3255,2950,2860,1670,1630,1550,1460,1435,1395,1365,1310,1260,1110,890cm-1的特征吸收带。

43. 发明申请

US20100175450A1 METHOD OF PRODUCING SEAMLESS METAL TUBE AND PUNCH FOR USE THEREIN 有权
标题翻译：生产无缝金属管的方法和用于其的PUNCH
公开(公告)号：US20100175450A1
公开(公告)日：2010-07-15
申请号：US12748744
申请日：2010-03-29
申请人： Kazuhiro Shimoda , Tomio Yamakawa , Koji Muramatsu , Yuji Inoue
发明人： Kazuhiro Shimoda , Tomio Yamakawa , Koji Muramatsu , Yuji Inoue
IPC分类号： B21B19/04 , B21D28/34
CPC分类号： B21B23/00 , B21B19/04 , B21J5/10
摘要： A hole 30 is formed in the center of the rear end face 20 of a round billet 10. The hole 30 has a predetermined depth from the rear end face 20 and a plurality of grooves 31 are provided in the side surface thereof. Each groove 31 extends in the depth direction of the hole 30. Piercing and rolling of the round billet 10 having the hole 30 is performed using a piercing mill having a plug. During piercing and rolling, the bottom surface of the hole 30 is broken through by the plug and a protrusion which is to be the starting point of burrs is formed, and the protrusion is absorbed by the groove 31 as the plug advances. Consequently, formation of burrs at the rear end of a hollow shell after piercing-rolling thereof can be suppressed.
摘要翻译：在圆坯10的后端面20的中央形成有孔30.孔30具有从后端面20的预定深度，在其侧面设有多个槽31。每个槽31在孔30的深度方向上延伸。具有孔30的圆坯10的穿孔和轧制使用具有塞子的穿孔机进行。在穿刺和滚动期间，孔30的底表面被插塞断开，并且形成作为毛刺起点的突起，并且当插头前进时突起被凹槽31吸收。因此，可以抑制在穿孔轧制之后在中空壳的后端形成毛刺。

44. 发明授权

US07739892B2 Method of manufacturing seamless pipes 有权
标题翻译：制造无缝管的方法
公开(公告)号：US07739892B2
公开(公告)日：2010-06-22
申请号：US12453568
申请日：2009-05-15
申请人： Tomio Yamakawa , Kazuhiro Shimoda
发明人： Tomio Yamakawa , Kazuhiro Shimoda
IPC分类号： B21B19/04
CPC分类号： B21B19/04 , B21B25/00
摘要： Seamless pipes excellent in quality features with high productivity is made by a by carrying out piercing-rolling using a piercer provided with a pair of inclined rolls. The piercing-rolling is carried out under conditions such that the plug tip draft (TDFT) or the root of the product of the plug tip draft (TDFT) are controlled along with the number of billet revolutions (N), namely (TDFT×N)0.5. In addition, positions of the inclined rolls are controlled in connection with the gorge draft (GDFT) indicating the ratio of the roll gap (Rg) which is minimal in the gorge section between the inclined rolls to the billet outside diameter (Bd). The piercing-rolling is carried out using a plug having a particular shape.
摘要翻译：通过使用设置有一对倾斜辊的穿孔机进行穿孔轧制，可以实现高生产率的质量特性优良的无缝管。穿孔轧制在条件下进行，使得塞子末梢吃水深度（TDFT）或塞子末端吃水深度（TDFT）的产物根数与坯锭转数（N）一起被控制，即（TDFT×N ）0.5。此外，倾斜辊的位置与峡谷吃水（GDFT）相关联地控制，表示倾斜辊之间的峡谷部分中的辊间隙（Rg）与坯料外径（Bd）之间的最小比例。使用具有特定形状的塞子进行穿孔轧制。

45. 发明申请

US20100107714A1 PUSHER DEVICE FOR PIERCING AND ROLLING AND METHOD OF MANUFACTURING SEAMLESS PIPE OR TUBE USING THE SAME 有权
标题翻译：用于碾压和滚压的推动装置及使用其制造无缝管或管的方法
公开(公告)号：US20100107714A1
公开(公告)日：2010-05-06
申请号：US12685869
申请日：2010-01-12
申请人： Tomio Yamakawa , Kazuhiro Shimoda
发明人： Tomio Yamakawa , Kazuhiro Shimoda
IPC分类号： B21B19/04 , B21B39/06
CPC分类号： B21B19/04 , B21B23/00 , B21B39/06 , B21B2261/08 , B21B2261/10
摘要： A pusher device 4 includes a cylinder device 30 and a pusher mandrel 34. The cylinder device 30 includes a cylinder shaft 32. The pusher mandrel 34 is attached to the tip end of the cylinder shaft 32. The tip end of the pusher mandrel 34 is abutted against the rear end of a billet 20. The cross sectional area Sp of the pusher mandrel 34 and the cross sectional area Sb of the billet 20 satisfy Expression (1). The length Lp of the pusher mandrel 34 and the cross sectional area Sp of the pusher mandrel 34 satisfy Expression (2). The moving distance Lc of the tip end of the cylinder shaft 32 during piercing and rolling and the outer diameter Dc of the cylinder shaft 32 satisfy Expression (3). Therefore, the pusher device 4 can restrain the wall thickness deviation of the tip end part of a produced hollow shell. 0.3≦Sp/Sb (1) Lp/Sp≦1.2 (2) Lc/Dc≦45 (3)
摘要翻译：推动装置4包括气缸装置30和推动心轴34.气缸装置30包括气缸轴32.推动心轴34附接到气缸轴32的末端。推动心轴34的尖端是抵靠坯料20的后端。挤压心轴34的截面面积Sp和坯料20的横截面积Sb满足式（1）。推动心轴34的长度Lp和推动心轴34的横截面面积Sp满足式（2）。穿孔轧制时的圆筒轴32的前端的移动距离Lc和圆筒轴32的外径Dc满足式（3）。因此，推动装置4能够抑制制造的中空壳的前端部的壁厚偏差。 0.3＆nlE; Sp / Sb（1）Lp / Sp＆nlE; 1.2（2）Lc / Dc＆nlE; 45（3）

46. 发明申请

US20090218014A1 Method for Producing Duplex Stainless Steel Seamless Pipe 有权
标题翻译：生产双相不锈钢无缝管的方法
公开(公告)号：US20090218014A1
公开(公告)日：2009-09-03
申请号：US12225545
申请日：2007-03-23
申请人： Naoya Hirase , Tetsuya Nakanishi , Kazuhiro Shimoda , Hirokazu Okada , Tomio Yamakawa , Yasuyoshi Hidaka
发明人： Naoya Hirase , Tetsuya Nakanishi , Kazuhiro Shimoda , Hirokazu Okada , Tomio Yamakawa , Yasuyoshi Hidaka
IPC分类号： C21D8/10
CPC分类号： B21B23/00 , B21B19/04 , C21D1/70 , C21D1/74 , C21D9/08 , C22C38/001 , C22C38/02 , C22C38/04 , C22C38/44
摘要： The present invention is to provide a method for producing duplex stainless steel seamless pipe in which a duplex stainless steel billet can be inhibited from generating an oxide scale on the surface thereof during heating and the generation of outer surface flaw can also be prevented. The billet is heated in the a heating furnace for 1.5 hours or more and 4.0 hours or less at a heating temperature of 1250° C. or more and 1320° C. or less while regulating the average concentration of sulfur dioxide (SO2) gas in the atmosphere within the furnace to 0.01 volume % or less.
摘要翻译：本发明提供一种双相不锈钢无缝管的制造方法，其中可以抑制双相不锈钢坯料在加热时在其表面上产生氧化皮，并且还可以防止外表面缺陷的产生。在1250℃以上1320℃以下的加热温度下，在加热炉中将钢坯加热1.5小时以上4.0小时以上，同时调节二氧化硫（SO2）气体的平均浓度炉内气氛为0.01体积％以下。

47. 发明申请

US20090149452A1 XANTHINE OXIDASE INHIBITOR 审中-公开
标题翻译： XANTHINE氧化酶抑制剂
公开(公告)号：US20090149452A1
公开(公告)日：2009-06-11
申请号：US11994099
申请日：2006-06-29
申请人： Takeshi Nishino , Shinichi Yoshida , Atsushi Tendo , Tomio Yamakawa , Tadashi Kobayashi , Yoriko Shinohara
发明人： Takeshi Nishino , Shinichi Yoshida , Atsushi Tendo , Tomio Yamakawa , Tadashi Kobayashi , Yoriko Shinohara
IPC分类号： A61K31/519 , C07D513/04 , A61K31/5377 , A61P7/00 , A61K31/541
CPC分类号： C07D473/00 , C07D498/04 , C07D513/04
摘要： A compound represented by the following formula (I) is used as a xanthine oxidase inhibitor: in which R1 is phenyl or pyridyl each optionally having, as a substituent, C1-8 alkyl, C1-8 haloalkyl, C1-8 alkoxy, carboxyl, halogeno, hydroxyl, nitro, cyano, amino, etc.; R2 is cyano, nitro, etc.; X is oxygen, sulfur, etc.; and Y is sulfur, NH, etc.
摘要翻译：使用由下式（I）表示的化合物作为黄嘌呤氧化酶抑制剂：其中R1是苯基或吡啶基，其各自任选具有C1-8烷基，C1-8烷基，C1-8烷氧基，羧基，卤代，羟基，硝基，氰基，氨基等; R2是氰基，硝基等; X是氧，硫等; Y为硫，NH等

48. 发明申请

US20080314109A1 Plug for use in piercing mill 有权
标题翻译：插头用于穿孔机
公开(公告)号：US20080314109A1
公开(公告)日：2008-12-25
申请号：US12155657
申请日：2008-06-06
申请人： Kazuhiro Shimoda , Tomio Yamakawa
发明人： Kazuhiro Shimoda , Tomio Yamakawa
IPC分类号： B21B19/04
CPC分类号： B21B25/00 , B21B19/04
摘要： A plug has a tip end portion, a taper portion, and a middle portion. The surface of the tip end portion is a spherical surface whose radius of curvature is R1 and length is L1 that is shorter than R1. The outer diameter of the taper portion on the front end side is D1, and the outer diameter on the back end side is D2 that is larger than D1, and the length is L2. The plug satisfies Expression (1), Expression (2) if 0
摘要翻译：插头具有尖端部分，锥形部分和中间部分。前端部的表面是曲率半径为R1，长度为L1的比R1短的球面。前端侧的锥形部的外径为D1，后端侧的外径为D2，D1的长度为L2。如果0 0.5D1 <？in-line-formula description =“In-line Formulas”end =“lead”？> 1.0 ？in-line-formula description =“In-line Formulas”end =“tail”？>

49. 发明申请

US20080009525A1 Activator of peroxisome proliferator-activated receptor delta 有权
标题翻译：过氧化物酶体增殖物激活受体δ的活化剂
公开(公告)号：US20080009525A1
公开(公告)日：2008-01-10
申请号：US11888493
申请日：2007-07-31
申请人： Shogo Sakuma , Tomio Yamakawa , Takashi Kanda , Seiichiro Masui
发明人： Shogo Sakuma , Tomio Yamakawa , Takashi Kanda , Seiichiro Masui
IPC分类号： A61K31/4439 , A61K31/422 , C07D263/02 , C07D403/00 , C07D417/00 , C07D413/00 , C07D277/04 , A61K31/427
CPC分类号： C07D263/62 , C07D263/32 , C07D277/24
摘要： A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having halogen, halogen, hydroxyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C1-8 alkylene chain, etc.; Y represents C(═O), CH═CH, etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, C1-8 alkyl, etc.; and R8 represents hydrogen or C1-8 alkyl; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-δ activator which contains the compound or salt as the active ingredient.
摘要翻译：由以下通式（I）表示的化合物：（其中R 1表示苯基等，其可以具有选自C 1-8烷基的取代基具有卤素，卤素，羟基等的C 1-8烷基; R 2表示C 1-8烷基等; A 表示氧，硫等; X表示C 1-8亚烷基链等; Y表示C（-O），CH-CH等; R 3 O R 4，R 5和R 5各自表示氢，C 1-8烷基等; B表示CH或氮; Z表示氧或硫; R 6和R 7各自表示氢，C 1-8烷基等;和R 8， / SUP>表示氢或C 1-8烷基，条件是R 3，R 4和R 4中的至少一个， 5不是氢）或化合物的盐; 和含有该化合物或盐作为活性成分的PPAR-δ活化剂。

50. 发明申请

US20070293512A1 Condensed Pyrimidine Deriviative and Xanthine Oxidase Inhibitor 有权
标题翻译：缩合嘧啶衍生物和黄嘌呤氧化酶抑制剂
公开(公告)号：US20070293512A1
公开(公告)日：2007-12-20
申请号：US11629277
申请日：2005-06-13
申请人： Shinichi Yoshida , Kunio Kobayashi , Nobutaka Mochiduki , Tomio Yamakawa , Tadashi Kobayashi , Yoriko Shinohara
发明人： Shinichi Yoshida , Kunio Kobayashi , Nobutaka Mochiduki , Tomio Yamakawa , Tadashi Kobayashi , Yoriko Shinohara
IPC分类号： A61K31/519 , A61P7/00 , C07D495/04 , C07D498/04
CPC分类号： C07D513/04 , C07D498/04
摘要： The invention relates to compounds of the following formula (I) or their salts: in which R1 is a group of phenyl, naphthyl, pyridyl or the like which may have a substituent such as an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, carboxyl, halogen, hydroxyl, nitro, or cyano; R2 is cyano, nitro, or the like; R3 is hydroxyl or the like; X is oxygen, sulfur, or the like; and Y is oxygen or sulfur, and a xanthine oxidase inhibitor containing the compound.
摘要翻译：本发明涉及下式（I）化合物或其盐：其中R 1是苯基，萘基，吡啶基等可以具有取代基的基团，例如具有 1-8个碳原子，具有1-8个碳原子的烷氧基，具有2-8个碳原子的烷氧基羰基，羧基，卤素，羟基，硝基或氰基; R 2是氰基，硝基等; R 3是羟基等; X是氧，硫等; Y为氧或硫，含有该化合物的黄嘌呤氧化酶抑制剂。

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