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41. 发明申请

WO1997021429A1 RADIATION-PROTECTIVE PHOSPHOLIPID 审中-公开
标题翻译：放射性保护性磷脂
公开(公告)号：WO1997021429A1
公开(公告)日：1997-06-19
申请号：PCT/IL1996000175
申请日：1996-12-10
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , TIROSH, Oren , KOHEN, Ron , KATZHENDLER, Joshua , BARENHOLZ, Yechezkel
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： A61K09/127
CPC分类号： C08G65/3353 , A61K8/14 , A61K9/1272 , A61Q17/04 , C07F9/10
摘要： Novel ether-linked phospholipids derivatized with polyethylene glycol at the polar head group are disclosed. Lipid bilayers containing these phospholipids show high oxidative stability. Also disclosed is the use of PEG-derivatized ether-linked lipids in moisturizing and radiation-protective cosmetic compositions.
摘要翻译：公开了在极性头基团上用聚乙二醇衍生的新型醚连接磷脂。含有这些磷脂的脂质双层显示出高的氧化稳定性。还公开了在保湿和辐射保护的化妆品组合物中使用PEG衍生的醚连接的脂质。

42. 发明申请

WO1997019179A1 PSEUDOMONAS EXOTOXIN - MYELIN BASIC PROTEIN CHIMERIC PROTEINS 审中-公开
标题翻译： PSEUDOMONAS EXOTOXIN - MYELIN BASIC PROTEIN CHIMERIC PROTEINS
公开(公告)号：WO1997019179A1
公开(公告)日：1997-05-29
申请号：PCT/IL1996000151
申请日：1996-11-17
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , LORBERBOUM-GALSKI, Haya , STEINBERGER, Ida , BERAUD, Eveline , MARIANOVSKY, Irina , YARKONI, Shai
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： C12N15/62
CPC分类号： C07K14/21 , A61K38/00 , C07K14/4713 , C07K2319/00 , Y10S424/81 , Y10S514/885 , Y10S514/903 , Y10S530/868
摘要： A chimeric protein comprising a Pseudomonas aeruginosa exotoxin (PE) moiety linked to a myelin basic protein (MBP) moiety is disclosed. The MBP moiety is selected from the group comprising: (a) MBP; (b) amino acids 69-88 of guinea-pig myelin basic protein or an antigenic portion thereof; (c) amino acids 84-102 of human myelin basic protein or an antigenic portion thereof; (d) amino acids 143-168 of human myelin basic protein or an antigenic portion thereof; and (e) an amino acid sequence in which one or more amino acids have been deleted, added, substituted or mutated in the amino acid sequences of (a), (b), (c) or (d), the modified sequence of (e) retaining at least 75 % homology with the amino acid sequences of (a), (b), (c) or (d), respectively. The chimeric protein is useful in treating autoimmune diseases, and especially multiple sclerosis.
摘要翻译：公开了包含与髓磷脂碱性蛋白（MBP）部分连接的铜绿假单胞菌外毒素（PE）部分的嵌合蛋白质。 MBP部分选自：（a）MBP; （b）豚鼠髓磷脂碱性蛋白质的氨基酸69-88或其抗原部分; （c）人髓磷脂碱性蛋白质的氨基酸84-102或其抗原部分; （d）人髓磷脂碱性蛋白质的氨基酸143-168或其抗原部分; 在（a），（b），（c）或（d）的氨基酸序列中缺失，添加，取代或突变的一个或多个氨基酸的氨基酸序列，（e）分别与（a），（b），（c）或（d）的氨基酸序列保持至少75％的同源性。嵌合蛋白可用于治疗自身免疫疾病，特别是多发性硬化。

43. 发明申请

WO1997010514A1 NEAR-FIELD RESISTIVITY MICROSCOPE 审中-公开
标题翻译：近场电阻显微镜
公开(公告)号：WO1997010514A1
公开(公告)日：1997-03-20
申请号：PCT/IL1996000106
申请日：1996-09-10
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , DAVIDOV, Dan , GOLOSOVSKY, Michael
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： G01R27/26
CPC分类号： G01R27/02 , G01R1/06772 , Y10S977/862 , Y10S977/875 , Y10S977/89 , Y10S977/901
摘要： A microwave microscope comprising a microwave waveguide having a probe end positioned closely above the surface to probed such that the surface is in the near field of the microwave radiation. The end of the probe facing the surface is covered with a metallic foil or a conducting film deposited over a dielectric layer and having a rectangular slit formed therein. The long dimension of the slit is nearly resonant with the microwave, that is, just slightly longer than one-half of the microwave wavelength. The short dimension is substantially shorter than long dimension and is chosen such that the slitted end is transparent to the microwave. Thereby, substantial microwave power is emitted through the slit with fine resolution that is determined by the short dimension of the slit. The probe is scanned across the surface in the direction of the short slit dimension, and its resolution is approximately equal to the short slit dimension. Preferably, the end is convexly curved along the direction of the long slit dimension so that only a portion of the slit is in the near field, thereby reducing the effective lateral dimension.
摘要翻译：一种微波显微镜，包括微波波导，其具有位于表面附近的探针端，以被探测，使得表面处于微波辐射的近场中。面向表面的探针的端部被沉积在电介质层上并且在其中形成有矩形狭缝的金属箔或导电膜覆盖。狭缝的长尺寸几乎与微波共振，即略微长于微波波长的一半。短尺寸基本上比长尺寸短，并且被选择成使得狭缝端对微波是透明的。因此，通过狭缝的短尺寸确定的细分辨率通过狭缝发射大量的微波功率。探针沿着短狭缝尺寸的方向扫描表面，其分辨率近似等于短狭缝尺寸。优选地，端部沿着长狭缝尺寸的方向凸起地弯曲，使得仅狭缝的一部分处于近场，从而降低了有效的横向尺寸。

44. 发明申请

WO1996039095A1 OCULAR INSERTS 审中-公开
公开(公告)号：WO1996039095A1
公开(公告)日：1996-12-12
申请号：PCT/IB1996000554
申请日：1996-06-04
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , DOMB, Abraham, J.
IPC分类号： A61F02/00
CPC分类号： A61K9/0051 , A01N37/14 , A01N37/20 , A01N39/02 , A01N39/04 , A01N49/00 , A61F2/16 , A61F9/0017 , A61F2210/0004 , A61F2250/0067 , A61K47/48038 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/542 , A61K47/58 , A61K47/59 , A61K47/593
摘要： Absorbable ocular inserts fabricated of materials that are biologically inert, biodegradable, non-allergenic, and insoluble in tear liquid, and a method for delivering substances to the eye using the ocular insert, are disclosed. In embodiment A of the invention, the insert and method include the covalent attachment of a carboxylic acid-containing substance to be delivered to a polymer that contains pendent carboxylic acid groups, through anhydride linkages. The drug is released over time by hydrolysis of the anhydride bonds. In embodiment B of the invention, a substance to be delivered (whether or not it contains a carboxylic acid group) is dispersed within an anhydride polymer or copolymer matrix and the mixture is formed into an appropriately shaped article for ocular delivery. In embodiment C of the invention, the insert and method include the covalent attachment of a carboxylic acid-containing substance to be delivered to a polymer that contains pendent carboxylic acid groups through methylene diester bonds which degrade in vivo over time.
摘要翻译：公开了由生物惰性，可生物降解，非致敏性和不溶于泪液的材料制成的吸收性眼部插入物，以及使用眼部插入物将物质输送到眼睛的方法。在本发明的实施方案A中，插入物和方法包括通过酸酐键将待递送到含有羧酸基团的聚合物共价连接。随着时间的推移，药物通过酸酐键的水解释放。在本发明的实施方案B中，待递送物质（无论其含有羧酸基团）是否分散在酸酐聚合物或共聚物基质中，并将该混合物形成适当成型的用于眼睛输送的制品。在本发明的实施方案C中，插入物和方法包括通过在体内随时间而降解的通过亚甲基二酯键将要递送到含有侧挂羧酸基团的聚合物中的含羧酸物质的共价连接。

45. 发明申请

WO1996028014A1 LYCOPENE CYCLASE GENE 审中-公开
标题翻译： LYCOPENE CYCLASE基因
公开(公告)号：WO1996028014A1
公开(公告)日：1996-09-19
申请号：PCT/US1996003044
申请日：1996-03-05
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HIRSCHBERG, Joseph , CUNNINGHAM, Francis, Xavier, Jr. , GANTT, Elisabeth
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： A01H05/00
CPC分类号： C12N9/0004 , C12N15/825 , C12N15/8274
摘要： A purified and isolated DNA sequence encoding lycopene cyclase.
摘要翻译：纯化和分离的编码番茄红素环化酶的DNA序列。

46. 发明申请

WO1996013193A2 NON-INVASIVE DEVICE AND METHOD FOR QUANTITATIVE DETERMINATION OF OXIDANTS AND/OR ANTIOXIDANTS IN THE SKIN 审中-公开
标题翻译：非侵入性装置和用于定量测定皮肤中的氧化物和/或抗氧化剂的方法
公开(公告)号：WO1996013193A2
公开(公告)日：1996-05-09
申请号：PCT/US1995013550
申请日：1995-10-10
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I. , KOHEN, Ron , FANBERSTEIN, David , TIROSH, Oren
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I.
IPC分类号： A61B00/00
CPC分类号： A61B5/1477 , A61B5/14542 , A61B5/442
摘要： A non-invasive device for the quantitative determination of the level of oxidants and/or antioxidants in the skin of a subject includes a reference electrode and a working electrode which are connected to an electrical voltage measuring device; and a test solution container which is open at a bottom side thereof and which is placed on the skin of the subject and is sealingly but releasably affixed to the skin, is filled with a test solution, and which permits contact between the test solution and the skin. The test solution container further includes a top opening through which the electrodes are immersed in the test solution.
摘要翻译：用于定量测定受试者皮肤中氧化剂和/或抗氧化剂水平的非侵入性装置包括连接到电压测量装置的参比电极和工作电极; 以及在其底侧开口并被放置在被检体的皮肤上并且密封地但可剥离地固定在皮肤上的试液容器，填充有试验溶液，并且允许试验溶液与皮肤。测试溶液容器还包括顶部开口，电极浸入测试溶液中。

47. 发明申请

WO1996009326A1 REVERSIBLE AND CONTROLLABLE CLOSING AND OPENING OF THE GUEST-BINDING CAVITY OF CYCLODEXTRIN DERIVATIVES AND RELATED HOST MOLECULES 审中-公开
标题翻译：环糊精衍生物和相关主体分子的结合孔的可逆和可控关闭和开放
公开(公告)号：WO1996009326A1
公开(公告)日：1996-03-28
申请号：PCT/US1995011883
申请日：1995-09-18
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , ARAD-YELLIN, Rina , GREEN, Bernard, S.
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： C08B30/18
CPC分类号： B82Y5/00 , A61K47/6951 , C08B37/0012
摘要： A method for trapping a guest in and releasing the guest from the interior of a cyclic compound, which includes the steps of first contacting the cyclic compound and the guest so as to allow the guest to enter the interior of the cyclic compound, then activating the cyclic compound to bring about the entrapment of the guest in the interior of the cyclic compound. Subsequently, the cyclic compound is further activated to release the guest from the interior of the cyclic compounds. The cyclic compound includes a cyclic structure and one or more substituents which are chemically bonded to the cyclic structure and which, upon activation, react with the cyclic structure or with another substituent to form a bridge which at least partially blocks access to the interior of the cyclic compound. Upon further activation, the bridge opens to unblock access to the interior of the cyclic compound, thereby releasing the guest.
摘要翻译：一种用于将客体从环状化合物的内部捕获和释放客体的方法，其包括以下步骤：首先使环状化合物和客体接触，以使客人进入环状化合物的内部，然后激活环状化合物引起游离物在环状化合物的内部的捕获。随后，循环化合物被进一步活化以从环状化合物的内部释放客体。环状化合物包括环状结构和一个或多个化学键合到环状结构的取代基，并且其在活化时与环状结构或与另一个取代基反应以形成桥，其至少部分阻止进入到环状化合物。在进一步激活时，桥开通以解除对循环组合物内部的通路，从而释放客人。

48. 发明申请

WO1996005212A1 WATER-SOLUBLE POLYENE CONJUGATE 审中-公开
标题翻译：水溶性聚酯共混物
公开(公告)号：WO1996005212A1
公开(公告)日：1996-02-22
申请号：PCT/US1995010522
申请日：1995-08-16
申请人： HELFGOTT & KARAS, P.C. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
发明人： HELFGOTT & KARAS, P.C. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , LINDEN, Galina , DOMB, Abraham, J. , POLACHECK, Itzhack , BENITA, Shimon
IPC分类号： C07H17/08
CPC分类号： C08B37/006 , A61K47/61 , C08B37/0021
摘要： A method for producing a substantially stable water-soluble polysaccharide conjugate of a polyene antibiotic is described. The method comprises the following steps: (a) activating the polysaccharide to a dialdehyde by periodate oxidation; (b) purifying the dialdehyde from interfering anions and by-products; (c) coupling the polyene to the purified dialdehyde by Schiff base formation to form the conjugate; and (d) purifying the conjugate. In a preferred embodiment, the conjugate of step (c) is reduced to an amine conjugate by a reducing agent prior to purification. Also described are imine and amine polysaccharide conjugates of the polyene Nystatin.
摘要翻译：描述了一种制备多烯抗生素基本上稳定的水溶性多糖缀合物的方法。该方法包括以下步骤：（a）通过高碘酸氧化活化多糖至二醛; （b）从干扰阴离子和副产物中纯化二醛; （c）通过希夫碱形成将多烯偶联到纯化的二醛以形成缀合物; 和（d）纯化缀合物。在优选的实施方案中，步骤（c）的缀合物在纯化之前通过还原剂还原成胺缀合物。还描述了多烯制霉菌素的亚胺和胺多糖缀合物。

49. 发明申请

WO1995034288A1 METHODS OF TREATING HYPERTENSION AND OF IMPROVING IMPAIRED RENAL FUNCTION 审中-公开
标题翻译：治疗高血压和改善不良后期功能的方法
公开(公告)号：WO1995034288A1
公开(公告)日：1995-12-21
申请号：PCT/US1995007243
申请日：1995-06-09
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KURTZ, Seymour , BARENHOLZ, Yechezkel , GREENFELD, Ziv , SHMEEDA, Hilary
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KURTZ, Seymour
IPC分类号： A61K09/127
CPC分类号： A61K31/685 , A61K9/127
摘要： A method of treating hypertension and related symptoms thereof is described. A suspension of small, unilamellar vesicles composed primarily of phospholipids similar in nature to those of egg phosphatidylcholine is administered parenterally to a subject in need of such treatment repeatedly and over an extended period of time of at least several days, until a significant drop in blood pressure is observed. A method of improving renal function is also disclosed. In the treatment method, a suspension of liposomes is administered parenterally to a subject in need of such improvement repeatedly and over an extended period of time of at least several days, until a significant improvement in renal function is observed, as evidenced by an improvement in glomerular filtration rate characterized by a drop in plasma creatinine concentration of at least 10 percent.
摘要翻译：描述了治疗高血压及其相关症状的方法。主要由本质上与卵磷脂酰胆碱类似的磷脂组成的小的单层囊泡的悬浮液经胃肠外给予需要这种治疗的受试者，并且持续至少数天的延长的时间，直到血液显着下降观察压力。还公开了改善肾功能的方法。在治疗方法中，将脂质体的悬浮液肠胃外给予反复需要这样改善的受试者，并且持续至少数天的延长时间，直到观察到肾功能的显着改善，这通过改善肾小球滤过率的特征在于血肌酐浓度下降至少10％。

50. 发明申请

WO1995021814A1 NOVEL DERIVATIVES OF TETRAMETHYLCYCLOPROPANE 审中-公开
标题翻译：四氢呋喃的新衍生物
公开(公告)号：WO1995021814A1
公开(公告)日：1995-08-17
申请号：PCT/US1995001388
申请日：1995-02-08
申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , STERLING, Jeff , HERZIG, Yaacov , BIALER, Meir , HAJ-YEHIA, Abdullah , YAGEN, Boris
发明人： TEVA PHARMACEUTICAL INDUSTRIES LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： C07C233/58
CPC分类号： C07C237/22 , C07C233/58
摘要： The present invention relates to derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid (TMCA) of general formula (I), wherein R is a lower alkyl group (C1-C6), an aryl group, an aralkyl group or an amide of general formula (II), where R1 and R2 are the same or different and may be a hydrogen, a lower alkyl group (C1-C6), an aryl group or an aralkyl group, and n=0-3, to their racemic mixtures and the D and L enantiomers. The invention also relates to processes for the preparation of said compounds and for pharmaceutical preparations comprising same. The new compounds show improved activity against epilepsy.
摘要翻译：本发明涉及通式（I）的2,2,3,3-四甲基环丙烷羧酸（TMCA）的衍生物，其中R是低级烷基（C1-C6），芳基，芳烷基或酰胺，其中R 1和R 2相同或不同，并且可以是氢，低级烷基（C 1 -C 6），芳基或芳烷基，并且n = 0-3。外消旋混合物和D和L对映异构体。本发明还涉及制备所述化合物和包含其的药物制剂的方法。新化合物显示改善的针对癫痫的活性。

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