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41. 发明申请

US20210403457A1 2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS 有权
公开(公告)号：US20210403457A1
公开(公告)日：2021-12-30
申请号：US17347639
申请日：2021-06-15
申请人： Merck Sharp & Dohme Corp.
发明人： Ashok Arasappan , Ian M. Bell , Christopher James Bungard , Christopher S. Burgey , Jason M. Cox , Michael J. Kelly, III , Mark E. Layton , Hong Liu , Jian Liu , James J. Perkins , Akshay A. Shah , Michael David VanHeyst , Zhe Wu
IPC分类号： C07D403/12 , C07D233/32 , C07D401/14 , C07D401/12 , C07D405/12 , C07D417/12 , C07D417/14 , C07D413/12 , C07D513/04 , C07D471/08 , C07D471/04
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

42. 发明申请

US20190218224A1 COMPOUNDS USEFUL FOR ALTERING THE LEVELS OF BILE ACIDS FOR THE TREATMENT OF DIABETES AND CARDIOMETABOLC DISEASE 审中-公开
公开(公告)号：US20190218224A1
公开(公告)日：2019-07-18
申请号：US16324604
申请日：2017-08-10
申请人： Merck Sharp & Dohme Corp.
发明人： John P. Caldwell , Mary Ann Caplen , Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Claire Lankin , Derun Li , Hong Liu , Amy McCracken , Brian McKittrick , Ashwin Rao , Jayaram Tagat , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu , Tianyuan Zhang
IPC分类号： C07D487/04 , C07D519/00 , C07D498/04
CPC分类号： C07D487/04 , C07D498/04 , C07D519/00
摘要： Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.

43. 发明申请

US20160009682A1 COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY 有权
标题翻译：化合物抑制富含重复激素激酶活性
公开(公告)号：US20160009682A1
公开(公告)日：2016-01-14
申请号：US14772589
申请日：2014-02-27
申请人： MERCK SHARP & DOHME CORP.
发明人： Michael Miller , Kallol Basu , Duane DeMong , Jack Scott , Hong Liu , Xing Dai , Joel M. Harris , Bernard Neustadt , Andrew Stamford , Marc Poirier , John A. McCauley , Thomas Greshock , Heather Stevenson , John Sanders , Jonathan Kern
IPC分类号： C07D401/04 , C07D491/113 , C07D413/14 , C07D405/14 , C07D487/10 , C07D487/04 , C07D471/10 , C07D491/04 , C07D409/14 , C07D417/14 , C07D498/04 , C07D498/08 , C07D451/02 , C07D491/107 , C07D491/08 , C07D491/056 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/056 , C07D491/08 , C07D491/10 , C07D491/107 , C07D491/113 , C07D498/04 , C07D498/08
摘要： The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
摘要翻译：本发明涉及作为LRRK2激酶的有效抑制剂的吲唑化合物，可用于治疗或预防其中涉及LRRK2激酶的疾病，例如帕金森病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及LRRK-2激酶的疾病中的用途。

44. 发明授权

US11246340B2 Tobacco heater with straight through heating tube 有权
公开(公告)号：US11246340B2
公开(公告)日：2022-02-15
申请号：US16390019
申请日：2019-04-22
申请人： Gongyun Long , Hong Liu
发明人： Gongyun Long , Hong Liu
IPC分类号： A24F1/32 , A24F7/02 , E05C19/16 , H05B3/44 , A24F15/015 , A24F40/20 , A24F40/40 , A24F9/02
摘要： A tobacco heater with straight through heating tube, comprising a housing with a replaceable battery and a control PCB board; the housing has a mouthpiece; each side of the housing is hinged with an openable seagull door; inside the door is a heating tube at the middle housing; between the mouthpiece and the tube is an airflow path; inside each door is a compress tool for blocking the tobacco; the tube is electrically connected to the board. An openable seagull door is hinged on both sides of the housing to block the tube formed on the inner side of the door in the housing middle to form a straight through tobacco heating container. Tobaccos can be quickly and easily loaded by opening the doors, and the heater can be powered on when closed doors; opening doors, the tobacco heating residues can be easily and quickly cleaned after using.

45. 发明授权

US09894447B2 Hearing device and a method of selecting an optimal transceiver channel in a wireless network 有权
公开(公告)号：US09894447B2
公开(公告)日：2018-02-13
申请号：US13825966
申请日：2011-10-14
申请人： Hong Liu , Brian Dam Pedersen
发明人： Hong Liu , Brian Dam Pedersen
IPC分类号： H04R25/00 , H04L1/00
CPC分类号： H04R25/50 , H04L1/0033 , H04L43/0823 , H04R25/552 , H04R25/554 , H04R2225/51 , H04W72/0453 , H04W72/085
摘要： A method in a wireless network comprising a plurality of frequency channels and a receiving participant, the method includes: receiving data on a first subset of the plurality of frequency channels, wherein the frequency channels in the first subset are utilized at least once; receiving data on a second subset of the plurality of frequency channels; determining packet error rates for the respective frequency channels in the first and the second subsets; and selecting one of the plurality of frequency channel as an optimal frequency channel based on a result from the act of determining.

46. 发明授权

US09567694B2 Elastic fabric comprising a polyurethane elastic fiber made from a polyether based polyol 有权
标题翻译：包含由聚醚基多元醇制成的聚氨酯弹性纤维的弹性织物
公开(公告)号：US09567694B2
公开(公告)日：2017-02-14
申请号：US14119985
申请日：2012-05-24
申请人： Shingo Itoh , Toshihiro Tanaka , Hong Liu
发明人： Shingo Itoh , Toshihiro Tanaka , Hong Liu
IPC分类号： D01F6/70 , D03D15/08 , D04B1/18
CPC分类号： D01F6/70 , D03D15/08 , D04B1/18 , Y02P70/633 , Y10T428/249921
摘要： To provide elastic fabric that has comfortable wear and fit even in thin and light fabric by using a high-powered polyurethane elastic fiber that has at least 1.5 times the active force and recovery per unit fineness at the time of 100 to 200% elongation compared to conventional polyurethane elastic fiber. Resolution means an elastic fabric comprising a polyurethane elastic fiber made of a polyol, with a molecular weight between 450 and 1600 with a ratio of weight average molecular weight to number average molecular weight of at least 1.8, an organic diisocyanate compound, and a diamine compound.
摘要翻译：通过使用高功率聚氨酯弹性纤维来提供即使在薄而轻的织物中也具有舒适的磨损和适应性的弹性织物，该高功率聚氨酯弹性纤维具有至少1.5倍的活性作用力，并且在100至200％伸长时的单位细度恢复率相比，常规聚氨酯弹性纤维。分辨率是指包含由多元醇制成的聚氨酯弹性纤维的弹性织物，其分子量为450至1600，重均分子量与数均分子量之比至少为1.8，有机二异氰酸酯化合物和二胺化合物。

47. 发明授权

US09435059B2 Fusible bicomponent spandex 有权
标题翻译：易熔双组份氨纶
公开(公告)号：US09435059B2
公开(公告)日：2016-09-06
申请号：US13124438
申请日：2009-10-19
申请人： Steven W. Smith , Hong Liu , Willem Bakker , Gregory P. Weeks , Juan Cera
发明人： Steven W. Smith , Hong Liu , Willem Bakker , Gregory P. Weeks , Juan Cera
IPC分类号： D04B1/18 , D01F1/10 , D01F6/70 , D01F8/16 , D02G3/32 , D03D15/08 , D04B1/16
CPC分类号： D04B1/18 , D01F1/10 , D01F6/70 , D01F8/16 , D02G3/326 , D03D15/08 , D04B1/16 , D10B2401/041
摘要： Included are multiple component elastic fibers prepared by a solution-spinning process such as dry spinning or wet spinner of spandex fibers including polyurethaneurea and polyurethane compositions. These fibers have a cross-section including at least two separate regions with definable boundaries wherein at least one region defined by the boundaries of the cross-section includes a polyurethaneurea or polyurethane composition. One region of the fiber includes a fusibility improvement additive to enhance adhesion to itself or to a substrate.
摘要翻译：包括通过溶液纺丝方法制备的多组分弹性纤维，例如干纺丝或氨纶纤维的湿纺丝，包括聚氨酯脲和聚氨酯组合物。这些纤维具有横截面，其包括具有可限定边界的至少两个分开的区域，其中由横截面的边界限定的至少一个区域包括聚氨酯脲或聚氨酯组合物。纤维的一个区域包括可熔融性改进添加剂以增强对其自身或底物的粘合性。

48. 发明授权

US09194594B2 Multiple tanks water thermal storage system and its using method 有权
标题翻译：多水箱蓄热系统及其使用方法
公开(公告)号：US09194594B2
公开(公告)日：2015-11-24
申请号：US12519409
申请日：2007-12-28
申请人： Hong Liu , Yuanquan Jiang , Zhangwei Hou
发明人： Hong Liu , Yuanquan Jiang , Zhangwei Hou
IPC分类号： G05D23/00 , F24F5/00 , F28D20/00
CPC分类号： F24F5/0017 , F28D20/0034 , F28D20/0039 , Y02E60/142 , Y02E60/147
摘要： A multiple-tank water thermal storage system and its using method belong to energy saving technology. The multiple-tank water thermal storage system includes at least two water tanks. There are an upper diffuser (2) and a lower diffuser (5) provided in each said water tank. The upper and lower diffusers (2, 5) are connected with a chiller (heater) unit (4) and a heat exchanger (11) after connecting in parallel, respectively. Control valves (8) are set on pipes of the upper and the lower diffusers (2, 5), respectively. A thermal energy-charging pump (1) is set on the water-inlet pipe of chiller (heater) unit (4). A thermal energy-releasing pump (10) is set on the water-inlet pipe of the heat exchanger (11), and temperature sensors (6) are set in the water tanks.
摘要翻译：多槽水热储存系统及其使用方法属于节能技术。多箱水热储存系统至少包括两个水箱。在每个所述水箱中设置有上扩散器（2）和下扩散器（5）。分别连接并联的上下扩散器（2,5）与冷却器（加热器）单元（4）和热交换器（11）连接。控制阀（8）分别设置在上部和下部扩散器（2,5）的管道上。在热水器（加热器）单元（4）的入水管上设置热能充气泵（1）。热能释放泵（10）设置在热交换器（11）的入水管上，温度传感器（6）设置在水箱中。

49. 发明授权

US08867915B1 Dynamic data center network with optical circuit switch 有权
标题翻译：动态数据中心网络采用光电开关
公开(公告)号：US08867915B1
公开(公告)日：2014-10-21
申请号：US13342784
申请日：2012-01-03
申请人： Amin Vahdat , Xiaoxue Zhao , Paul Germano , Bikash Koley , Hong Liu
发明人： Amin Vahdat , Xiaoxue Zhao , Paul Germano , Bikash Koley , Hong Liu
IPC分类号： H04J14/00
CPC分类号： H04B10/27 , H04Q11/0005 , H04Q11/0071 , H04Q2011/0052 , H04Q2011/0083 , H04Q2213/1301
摘要： A system and method of providing a dynamic optical network topology according to topology determinations made by a network control is disclosed. The system and method includes optical ports on an optical circuit switch system operably connected to a plurality of server groups, and optical ports on the optical circuit switch system operably connected to a plurality of packet processing nodes. The system and method also includes at least one memory and at least one processor to execute network control software to receive input comprising a bandwidth request, determine an output comprising a preferred optical link topology for the optical circuit switch system based on the received input, convert the optical link topology for the optical circuit switch system into optical circuit switch port mapping, and send the optical circuit switch port mapping to the optical circuit switch system and to the packet processing nodes.
摘要翻译：公开了根据由网络控制进行的拓扑确定提供动态光网络拓扑的系统和方法。该系统和方法包括可操作地连接到多个服务器组的光学电路交换系统上的光学端口和可操作地连接到多个分组处理节点的光学电路交换系统上的光学端口。该系统和方法还包括至少一个存储器和至少一个处理器，用于执行网络控制软件以接收包括带宽请求的输入，基于所接收的输入确定包括用于光电路交换系统的优选光链路拓扑的输出，转换将光电开关系统的光链路拓扑转换成光电路交换机端口映射，并将光电路交换机端口映射发送给光电路交换系统和分组处理节点。

50. 发明授权

US08781322B2 Migratable wavelength division multiplexing passive optical network 有权
标题翻译：可移动波分复用无源光网络
公开(公告)号：US08781322B2
公开(公告)日：2014-07-15
申请号：US13205055
申请日：2011-08-08
申请人： Cedric F. Lam , Hong Liu
发明人： Cedric F. Lam , Hong Liu
IPC分类号： H04J14/00
CPC分类号： H04J14/0282 , H04J14/0232 , H04J14/0235 , H04J14/0246 , H04J14/0247 , H04J14/025 , H04J14/0252 , H04J14/0265
摘要： A hybrid passive optical network (“PON”) includes a time-division multiplexing (“TDM”) optical line terminal (“OLT”) and a wavelength-division multiplexing (“WDM”) OLT. The TDM OLT communicates with a first group of customer premises (“CPs”) via TDM signals while the WDM OLT communicates with a second group of CPs via WDM signals. A remote node power splitter is coupled to receive the TDM and WDM signals and broadcast both the TDM signals and the WDM signals on all of its ports facing towards the CPs. Optical filters are disposed between the remote node power splitter and the second group of CPs. Each optical filter is configured to pass a sub-group of the WDM signals while blocking other WDM signals such that each of the second group of CPs receives its own allocation of WDM signals but does not receive WDM signals allocated to other CPs of the second group of CPs.
摘要翻译：混合无源光网络（“PON”）包括时分复用（“TDM”）光线路终端（“OLT”）和波分复用（“WDM”）OLT。 TDM OLT经由TDM信号与第一组客户端（“CP”）通信，而WDM OLT经由WDM信号与第二组CPC通信。远程节点功率分配器被耦合以接收TDM和WDM信号，并且在其面向CP的所有端口上广播TDM信号和WDM信号。光学滤波器设置在远程节点功率分配器和第二组CP之间。每个滤光器被配置成通过WDM信号的子组同时阻挡其它WDM信号，使得第二组CP中的每一个接收到其自己的WDM信号分配，但是不接收分配给第二组的其他CP的WDM信号的CP。

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