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41. 发明申请

US20090326512A1 ENDOVASCULAR TUMESCENT INFUSION APPARATUS AND METHOD 审中-公开
标题翻译：内分泌肿瘤输注装置及方法
公开(公告)号：US20090326512A1
公开(公告)日：2009-12-31
申请号：US12550708
申请日：2009-08-31
申请人： William M. Appling , Robert Torrance Andrews
发明人： William M. Appling , Robert Torrance Andrews
IPC分类号： A61M5/168 , A61M19/00
CPC分类号： A61M5/158 , A61M5/14 , A61M39/22
摘要： A tumescent fluid infusion apparatus for use in treatment of a vascular disease includes a needle attached to a valve device. The valve device is designed to receive tumescent fluid from a fluid source. When the valve device is in an open position, it administers the tumescent fluid from the fluid source through the needle channel to allow a single hand of a user to control the needle insertion and the infusion of the tumescent fluid to free the other hand for operating a probe such as an ultrasound probe to eliminate the requirement of a second operator. The infusion apparatus also allows a user to control the amount of infused fluid without requiring syringe changes.
摘要翻译：用于治疗血管疾病的肿胀液输注装置包括附接到阀装置的针。阀装置设计成从流体源接收肿胀流体。当阀装置处于打开位置时，其通过针通道从流体源管理肿胀流体，以允许使用者的单手控制针插入并且输注肿胀液以释放另一只手用于操作诸如超声波探头的探针，以消除第二操作者的要求。输液装置还允许使用者在不需要注射器改变的情况下控制输注流体的量。

42. 发明申请

US20090264875A1 Method of Treating a Blood Vessel with an Optical Fiber Having a Spacer 有权
标题翻译：用具有间隔物的光纤处理血管的方法
公开(公告)号：US20090264875A1
公开(公告)日：2009-10-22
申请号：US12496515
申请日：2009-07-01
申请人： William M. Appling , Eamonn Hobbs
发明人： William M. Appling , Eamonn Hobbs
IPC分类号： A61B18/22
CPC分类号： A61B18/22 , A61B18/24 , A61B2017/22068 , A61B2018/00285
摘要： An endovascular laser treatment device designed to be used with an optical fiber to treat venous diseases such as varicose veins is provided. The device includes a expandable separator that positions the distal end of the optical fiber away from the inner wall of the blood vessel during delivery of laser energy to provide an even distribution of thermal energy around the vessel, thereby avoiding vessel perforation and incomplete vessel collapse.
摘要翻译：提供了一种设计用于光纤治疗静脉曲张静脉疾病的血管内激光治疗装置。该装置包括可扩张的分离器，其在输送激光能量期间将光纤的远端远离血管的内壁定位，以在血管周围提供均匀的热能分布，从而避免血管穿孔和不完全的血管塌陷。

43. 发明授权

US07575563B2 Blood treatment catheter assembly 有权
标题翻译：血液处理导管总成
公开(公告)号：US07575563B2
公开(公告)日：2009-08-18
申请号：US11263361
申请日：2005-10-31
申请人： William M. Appling
发明人： William M. Appling
IPC分类号： A61M37/00 , A61M3/00 , A61M5/178 , A61M25/00
CPC分类号： A61M25/0068 , A61M1/3661 , A61M25/007 , A61M2025/0031 , A61M2025/0034 , A61M2025/0037 , A61M2025/0188
摘要： A blood treatment catheter pre-assembled with a stiffening tube is provided. The catheter includes a withdrawal lumen and a supply lumen each having distal split tube unjoined segments and an intermediate joined segment. The split tube segment of the supply lumen is provided with a sidewall aperture. The stiffening tube extends through the withdrawal split tip tube, out the distal end of the withdrawal tube, through the aperture of the supply split tip tube and through the split tip supply tube distal of the aperture, out the distal end of the split tip supply tube. When the stiffening tube is positioned inside the catheter, the aperture is adjacent to the withdrawal tube distal opening so as to minimize stiffening tube exposure and to provide a smooth exterior profile. In a preferred design, the tubes and their lumens, over their common length, are semi-circular to provide a circular profile for the catheter.
摘要翻译：提供了预先装配有加强管的血液处理导管。导管包括取出腔和供应腔，每个腔具有远端分裂管未接合段和中间连接区段。供应管腔的分裂管段设置有侧壁孔。加强管通过提取分离尖端管延伸穿过抽出管的远端，穿过供应分流尖端管的孔并且穿过孔的远端的分裂尖端供应管，从分流尖端供应的远端延伸管。当加强管定位在导管内时，孔与抽出管远端开口相邻，以便使加强管暴露最小化并提供光滑的外形。在优选的设计中，管和它们的腔在其公共长度上是半圆形的，以为导管提供圆形轮廓。

44. 发明申请

US20090038752A1 REINFORCED BALLOON FOR A CATHETER 审中-公开
标题翻译：用于导管的加强型气球
公开(公告)号：US20090038752A1
公开(公告)日：2009-02-12
申请号：US11658391
申请日：2006-02-08
申请人： Adel Weng , William M. Appling
发明人： Adel Weng , William M. Appling
IPC分类号： A61M25/10 , B32B37/06 , C09J5/06
CPC分类号： A61M25/10 , A61M25/1029 , A61M25/1034 , A61M25/104 , A61M2025/1084
摘要： An inflatable balloon, and method of making same, for a medical catheter includes a base layer or non-compliant balloon substrate, a reinforcing layer, an adhesive. layer adhering the reinforcing layer to the non-compliant balloon substrate, and a top coat layer. The reinforcing layer is a single ply matrix of interwoven strands applied to the non-compliant balloon substrate. There are preferably three sets of strands in the single ply matrix. One set of strands extends in a longitudinal direction. Another set of strands extends circumferentially in a helical fashion with a clockwise orientation at an angle of approximately 65° with the strands that extend in the longitudinal direction. The third set of strands extends circumferentially in a helical fashion with a counter-clockwise orientation at an angle of approximately 65° with the strands that extend in the longitudinal direction. The three sets of strands are interwoven with one another by a braiding machine so as to provide a single ply of interwoven strands to achieve a uniform, reproducible reinforcing matrix.
摘要翻译：用于医疗导管的可膨胀气囊及其制造方法包括基底层或非顺应性球囊基底，增强层，粘合剂。将增强层粘附到不顺应性球囊基底和顶涂层。加强层是施加到非顺应性气囊基底上的交织股线的单层基体。在单层基质中优选有三组股线。一组股线沿纵向方向延伸。另一组股线以螺旋形的方式以与大致65°的角度的顺时针方向以沿长度方向延伸的线条周向延伸。第三组股线以螺旋方式沿逆时针方向以大约65°的角度延伸，并且沿长度方向延伸的股线。三组股线通过编织机彼此交织，以提供单层交织股线，以实现均匀的，可再生的增强基体。

45. 发明授权

US07396358B2 Device and method for converting a balloon catheter into a cutting balloon catheter 有权
标题翻译：将球囊导管转换成切割气囊导管的装置和方法
公开(公告)号：US07396358B2
公开(公告)日：2008-07-08
申请号：US11293543
申请日：2005-12-02
申请人： William M. Appling , Israel Schur , Giorgio di Palma
发明人： William M. Appling , Israel Schur , Giorgio di Palma
IPC分类号： A61B17/22
CPC分类号： A61B17/320725 , A61B17/32075
摘要： A lesion treating device for converting a standard balloon catheter into a cutting balloon catheter is provided. The device includes a longitudinal housing such as a tube which is sized to be inserted into a lumen of the balloon catheter and cutting wires disposed within the longitudinal housing in an undeployed position. When the longitudinal housing is moved relative to the cutting wires, the cutting wires extend out of the longitudinal housing. The balloon of the balloon catheter is then moved under the deployed cutting wires and inflated to convert the standard balloon catheter into the cutting balloon catheter.
摘要翻译：提供了一种用于将标准气囊导管转换成切割气囊导管的病变处理装置。该装置包括诸如管的纵向壳体，其尺寸设置成插入气囊导管的内腔中，并且在未展开的位置中将设置在纵向壳体内的切割线切割。当纵向壳体相对于切割线移动时，切割线延伸出纵向壳体。然后气囊导管的气球在展开的切割线下移动并充气以将标准气囊导管转换成切割气囊导管。

46. 发明授权

US07131981B2 Device and method for converting a balloon catheter into a cutting balloon catheter 有权
标题翻译：将球囊导管转换成切割气囊导管的装置和方法
公开(公告)号：US07131981B2
公开(公告)日：2006-11-07
申请号：US10640716
申请日：2003-08-13
申请人： William M. Appling , Israel Schur , Giorgio di Palma
发明人： William M. Appling , Israel Schur , Giorgio di Palma
IPC分类号： A61B17/22 , A61M29/00
CPC分类号： A61B17/320725 , A61B17/32075
摘要： A lesion treating device for converting a standard balloon catheter into a cutting balloon catheter is provided. The device includes a longitudinal housing such as a tube which is sized to be inserted into a lumen of the balloon catheter and cutting wires disposed within the longitudinal housing in an undeployed position. When the longitudinal housing is moved relative to the cutting wires, the cutting wires extend out of the longitudinal housing. The balloon of the balloon catheter is then moved under the deployed cutting wires and inflated to convert the standard balloon catheter into the cutting balloon catheter.
摘要翻译：提供了一种用于将标准气囊导管转换成切割气囊导管的病变处理装置。该装置包括诸如管的纵向壳体，其尺寸设置成插入气囊导管的内腔中，并且在未展开的位置中将设置在纵向壳体内的切割线切割。当纵向壳体相对于切割线移动时，切割线延伸出纵向壳体。然后气囊导管的气球在展开的切割线下移动并充气以将标准气囊导管转换成切割气囊导管。

47. 发明授权

US07001424B2 Convertible blood clot filter 有权
公开(公告)号：US07001424B2
公开(公告)日：2006-02-21
申请号：US10379986
申请日：2003-03-05
申请人： Nilesh Patel , Kenneth P. Moresco , William M. Appling
发明人： Nilesh Patel , Kenneth P. Moresco , William M. Appling
IPC分类号： A61F2/06 , A61M29/00
CPC分类号： A61F2/01 , A61F2002/016 , A61F2230/005 , A61F2230/0067
摘要： A vena cava blood clot filter is described that is attached to the walls of the vena cava by barbed anchors. In its filtering state, the filter is cone shaped which causes the blood to be filtered. The cone shape is formed by an appropriate restraining mechanism. When it is desired to stop filtering, the restraining mechanism is released and the filter takes a cylindrical shape. The cylindrical shaped filter will then line the vena cava wall and cease filtration of the blood.

48. 发明授权

US06966886B2 Blood treatment catheter assembly 有权
标题翻译：血液处理导管总成
公开(公告)号：US06966886B2
公开(公告)日：2005-11-22
申请号：US10331667
申请日：2002-12-27
申请人： William M. Appling
发明人： William M. Appling
IPC分类号： A61M1/14 , A61M25/00 , A61M37/00 , A61M3/00 , A61M5/178
CPC分类号： A61M25/0026 , A61M1/3661 , A61M25/0071 , A61M2025/0031 , A61M2025/0037 , A61M2025/0063
摘要： A blood treatment catheter pre-assembled with a stiffening tube is provided. The catheter includes a withdrawal lumen and a supply lumen each having distal split tube unjoined segments and an intermediate joined segment. The split tube segment of the supply lumen is provided with a sidewall aperture. The stiffening tube extends through the withdrawal split tip tube, out the distal end of the withdrawal tube, through the aperture of the supply split tip tube and through the split tip supply tube distal of the aperture, out the distal end of the split tip supply tube. When the stiffening tube is positioned inside the catheter, the aperture is adjacent to the withdrawal tube distal opening so as to minimize stiffening tube exposure and to provide a smooth exterior profile.
摘要翻译：提供了预先装配有加强管的血液处理导管。导管包括取出腔和供应腔，每个腔具有远端分裂管未接合段和中间连接区段。供应管腔的分裂管段设置有侧壁孔。加强管通过提取分离尖端管延伸穿过抽出管的远端，穿过供应分流尖端管的孔并且穿过孔的远端的分裂尖端供应管，从分流尖端供应的远端延伸管。当加强管定位在导管内时，孔与抽出管远端开口相邻，以便使加强管暴露最小化并提供光滑的外形。

49. 发明授权

US06283950B1 Occluding wire assembly 失效
标题翻译：封闭线组件
公开(公告)号：US06283950B1
公开(公告)日：2001-09-04
申请号：US09095640
申请日：1998-06-11
申请人： William M. Appling
发明人： William M. Appling
IPC分类号： A61M2501
CPC分类号： A61M25/0075 , A61M25/0097 , A61M2025/0079
摘要： A catheter assembly for introducing material into the vascular system has an elongated catheter body forming a lumen with a hole at its distal end thereof, a catheter hub positioned at the proximal end of the catheter body and an occluding wire hub detachably connected with the catheter hub. The occluding wire hub has a cavity and an opening therethrough for communication with the lumen in order to provide for the introduction of infusion fluid into the lumen. An occluding wire, having a proximal end and a distal end, is positioned so that it extends from the occluding wire hub through the catheter hub and the lumen. The distal end of the occluding wire has an occluding region adapted to engage the distal end hole. The proximal end of the occluding wire terminates within the occluding wire hub and has an anchor positioned within the hub cavity to prevent removal of the wire from the occluding wire hub when the occluding wire hub is disconnected and removed from the catheter body. The anchor, which is contained within the hub cavity, is movable between a proximal position and a distal position within the cavity. A compression spring has a distal end fixed to the occluding wire and a proximal end positioned within said occluding wire hub to thereby urge the wire in the distal direction into an occluding position.
摘要翻译：用于将材料引入血管系统的导管组件具有细长的导管主体，其在其远端处形成具有孔的内腔，定位在导管主体的近端处的导管套管和可拆卸地连接到导管座的闭塞线毂。闭塞线轮毂具有空腔和穿过其中的与所述内腔连通的开口，以便将输注液引入管腔。具有近端和远端的闭塞线被定位成使得其从闭塞的线毂延伸穿过导管毂和腔。闭塞线的远端具有适于接合远端孔的闭塞区域。闭塞线的近端终止于封闭的线毂内，并且具有定位在轮毂腔内的锚固件，以防止当闭塞线轮毂从导管主体断开并移除时将线从闭塞线毂中移除。容纳在轮毂腔内的锚固件可在空腔内的近端位置和远端位置之间移动。压缩弹簧具有固定到闭塞线的远端和位于所述阻塞线毂内的近端，从而将线沿远端方向推动到闭塞位置。

50. 发明授权

US5034005A Radiopaque marker 失效
标题翻译：不透射线的标记
公开(公告)号：US5034005A
公开(公告)日：1991-07-23
申请号：US549959
申请日：1990-07-09
申请人： William M. Appling
发明人： William M. Appling
IPC分类号： A61M25/01
CPC分类号： A61M25/0108
摘要： A radiopaque marker usable with catheters is provided. The marker is shaped and dimensioned to fit within a catheter lumen. The marker has an annular sidewall which defines a marker lumen. The marker has a proximal end and a distal end. It further includes securing barbs to prevent the marker from exiting from the catheter lumen.
摘要翻译：提供可用于导管的不透射线的标记。标记的形状和尺寸适合于导管内腔。标记具有限定标记腔的环形侧壁。标记具有近端和远端。它还包括固定倒钩以防止标记物从导管腔排出。

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