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41. 发明授权

US08170650B2 Implantable tissue perfusion sensing system and method 有权
标题翻译：植入式组织灌注感应系统及方法
公开(公告)号：US08170650B2
公开(公告)日：2012-05-01
申请号：US12039242
申请日：2008-02-28
申请人： Can Cinbis , James K. Carney , William T. Donofrio , Robert M. Ecker
发明人： Can Cinbis , James K. Carney , William T. Donofrio , Robert M. Ecker
IPC分类号： A61B6/00
CPC分类号： A61B5/1459 , A61B5/0059 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/14542 , A61B5/7214 , A61N1/3925
摘要： A medical device for sensing cardiac events that includes a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor generates an ambient light measurement in response to ambient light detected by the detector, generates a plurality of light measurements in response to the emitted light detected by the detector, and adjusts the plurality of light measurements in response to the ambient light measurement.
摘要翻译：一种用于感测心脏事件的医疗装置，其包括能够发射多个波长的光的多个光源，以及检测器，用于检测发射的光。处理器响应于由检测器检测到的环境光产生环境光测量，响应于由检测器检测到的发射光产生多个光测量，并且响应于环境光测量来调整多个光测量。

42. 发明申请

US20120035490A1 WIRELESS CARDIAC PULSATILITY SENSING 有权
标题翻译：无线心脏脉搏传感
公开(公告)号：US20120035490A1
公开(公告)日：2012-02-09
申请号：US12852740
申请日：2010-08-09
申请人： Xiaonan Shen , Can Cinbis
发明人： Xiaonan Shen , Can Cinbis
IPC分类号： A61B5/0464 , A61B5/053
CPC分类号： A61B5/6846 , A61B5/0245 , A61B5/0538 , A61N1/3937 , A61N1/3956 , A61N1/3987
摘要： An implantable medical device system and associated method monitor changes in transimpedance in a body tissue due to changes in cardiac pulsatility. A first dipole is used to deliver a non-stimulating electrical current. The first dipole includes a first electrode and a second electrode adapted to be deployed along a first body location. A second dipole is used to measure a voltage resulting from the non-stimulating electrical current being conducted through a portion of a patient's body. The second dipole includes a third electrode and a fourth electrode different than the first electrode and the second electrode and adapted to be deployed along a second body location spaced apart from the first body location.
摘要翻译：可植入医疗装置系统和相关方法监测由于心脏搏动的变化而导致的身体组织中的跨阻抗变化。第一偶极子用于传递非刺激电流。第一偶极子包括适于沿着第一身体位置展开的第一电极和第二电极。使用第二偶极子来测量通过患者身体的一部分传导的非刺激性电流产生的电压。第二偶极子包括不同于第一电极和第二电极的第三电极和第四电极，并且适于沿着与第一主体位置间隔开的第二主体位置展开。

43. 发明授权

US08090432B2 Implantable tissue perfusion sensing system and method 有权
标题翻译：植入式组织灌注感应系统及方法
公开(公告)号：US08090432B2
公开(公告)日：2012-01-03
申请号：US12039294
申请日：2008-02-28
申请人： Can Cinbis , James K. Carney
发明人： Can Cinbis , James K. Carney
IPC分类号： A61B6/00
CPC分类号： A61B5/1459 , A61B5/0059 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/14542 , A61B5/7214 , A61N1/3925
摘要： A medical device for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, an isobestic blood volume index in response to determined light measurements of the plurality of light measurements from a first light source of the plurality of light sources emitting light at an isobestic wavelength, determines an oxygen index associated with light measurements of the plurality of light measurements from a light source of the plurality of light sources other than the first light source, and verifies the identifying of the cardiac event in response to the determined isobestic blood volume index and the determined oxygen index.
摘要翻译：一种用于感测心脏事件的医疗装置，其包括感测用于识别心脏事件的心脏信号的多个电极，能够发射多个波长的光的多个光源以及检测发射光的检测器。处理器响应于由检测器检测到的发射光来确定多个光测量值，响应于来自多个光源中的多个光源的确定的光测量而测量的异常血液体积指数异常波长，确定与来自除了第一光源之外的多个光源的光源的多个光测量的光测量相关联的氧指数，并且响应于所确定的异源血液来验证心脏事件的识别体积指数和确定的氧指数。

44. 发明申请

US20110160801A1 COMMUNICATION WITH AN IMPLANTABLE MEDICAL DEVICE DURING IMPLANTATION 有权
标题翻译：在植入期间与可植入医疗设备的通信
公开(公告)号：US20110160801A1
公开(公告)日：2011-06-30
申请号：US12732433
申请日：2010-03-26
申请人： H. Toby Markowitz , Can Cinbis
发明人： H. Toby Markowitz , Can Cinbis
IPC分类号： A61N1/08
CPC分类号： A61B5/0028 , A61B5/0031 , A61B2034/2053 , A61B2560/0271 , A61N1/37205 , A61N1/37217 , A61N1/37241 , A61N1/3756
摘要： A system and method are described for delivering an implantable medical device in a patient and through a catheter. The delivery catheter comprises telemetry means for communicatively coupling the implantable medical device with an external instrumentation during implantation.
摘要翻译：描述了用于将可植入医疗装置递送到患者体内并通过导管的系统和方法。递送导管包括用于在植入期间将可植入医疗装置与外部装置通信地连接的遥测装置。

45. 发明申请

US20110066206A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 有权
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：US20110066206A1
公开(公告)日：2011-03-17
申请号：US12845843
申请日：2010-07-29
申请人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
发明人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
IPC分类号： A61N1/365
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a monitoring module detecting a cardiac event in response to the sensed cardiac signals using first detection criteria, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the monitoring module, the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, determine a recovery index in response to the determined tissue oxygenation trend, and control one or both of detecting a cardiac event by the monitoring module and delivery of therapy by the therapy delivery module in response to the determined recovery index.
摘要翻译：一种用于递送疗法的方法和装置，其包括用于感测心脏信号并递送治疗的电极，监测模块，响应于使用第一检测标准的所感测到的心脏信号检测心脏事件，发射光并检测由与所述传感器相邻的组织体积以产生相应的检测到的光强度输出信号;控制模块，耦合到所述传感器以响应于递送所述治疗来控制所述传感器的光发射;以及控制器，耦合到所述监测模块，所述治疗递送模块以及所述传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于组织氧合测量确定组织氧合趋势，响应于所确定的组织氧合趋势确定恢复指数，并且控制一个或两个通过监测模块检测心脏事件并进行治疗 y由治疗递送模块响应于确定的恢复指数。

46. 发明申请

US20110066204A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 有权
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：US20110066204A1
公开(公告)日：2011-03-17
申请号：US12845818
申请日：2010-07-29
申请人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
发明人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
IPC分类号： A61B5/1455 , A61N1/365
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy; and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine a tissue oxygenation measurement in response to the output signal, and determine whether the delivered therapy was successful in restoring cardiac hemodynamic function in response to the tissue oxygenation measurement.
摘要翻译：一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器发射由邻近传感器的组织体积散射的光，以产生相应的检测到的光强度输出信号;控制模块，其耦合到所述传感器，以响应于递送所述治疗来控制所述传感器的光发射; 以及耦合到所述治疗递送模块和所述传感器的控制器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，并且确定所递送的治疗是否成功响应于所述组织氧合测量来恢复心脏血液动力学功能。

47. 发明申请

US20100318149A1 Shock Reduction Using Absolute Calibrated Tissue Oxygen Saturation and Total Hemoglobin Volume Fraction 有权
标题翻译：使用绝对校准的组织氧饱和度和总血红蛋白体积分数进行减震
公开(公告)号：US20100318149A1
公开(公告)日：2010-12-16
申请号：US12797793
申请日：2010-06-10
申请人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , James K. Carney
发明人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , James K. Carney
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61B5/02028 , A61B5/0215 , A61B5/042 , A61B5/1116 , A61B5/14542 , A61B5/1459 , A61N1/36557 , A61N1/3956
摘要： An implantable medical device that includes an optical sensor for providing a signal corresponding to light attenuation by a volume of blood perfused tissue, a control module coupled to the optical sensor controlling the light emitted by the optical sensor, a monitoring module receiving an optical sensor output signal and measuring light attenuation, a tissue electrode for stimulating the volume of blood perfused tissue, a pulse generator coupled to the tissue electrode for delivering electrical stimulation to the volume of blood-perfused tissue, and a processor coupled to the cardiac electrode and the monitoring module and configured to detect an arrhythmia in response to the depolarization signals, compute a tissue oxygenation measurement and control the pulse generator to deliver electrical stimulation to the volume of blood-perfused tissue in response to detecting the arrhythmia, and detect a hemodynamic status of the arrhythmia in response to at least one of a detected rate of tissue oxygenation decline and a detected rate of tissue oxygenation recovery.
摘要翻译：一种可植入医疗装置，其包括：光学传感器，用于通过一定量的血液灌注组织提供对应于光衰减的信号;耦合到所述光学传感器的控制模块，所述控制模块控制由所述光学传感器发射的光;监测模块，其接收光学传感器输出信号和测量光衰减的组织电极，用于刺激血液灌注组织的体积的组织电极，耦合到组织电极的脉冲发生器，用于向血液灌注组织的体积输送电刺激;以及处理器，其耦合到心脏电极和监测模块并且被配置为响应于去极化信号检测心律失常，计算组织氧合测量并控制脉冲发生器以响应于检测到心律失常而向血液灌注组织的体积递送电刺激，并且检测血液动力学状态响应于检测到的tis的速率中的至少一种的心律失常检测氧合反应的下降和组织氧合恢复率。

48. 发明申请

US20100030088A1 PHYSIOLOGICAL PARAMETER MONITORING WITH MINIMIZATION OF MOTION ARTIFACTS 有权
标题翻译：生物学参数监测与运动文学的最小化
公开(公告)号：US20100030088A1
公开(公告)日：2010-02-04
申请号：US12182847
申请日：2008-07-30
申请人： James Kevin Carney , Can Cinbis
发明人： James Kevin Carney , Can Cinbis
IPC分类号： A61B5/02
CPC分类号： A61B5/02427 , A61B5/14552 , A61B5/1459 , A61B5/6846 , A61B5/7207 , A61B5/7214 , A61B2562/0233 , A61B2562/043
摘要： An implanted system includes at least two optical sensors implanted proximate to an artery of a patient such that one optical sensor is upstream of another optical sensor. Arterial pulses of the patient may be detected based on electrical signals from at least one of the optical sensors. In addition, electrical signals from the optical sensors may be used to minimize the effects of motion artifacts on the detection of arterial pulses. For example, a detected pulse may be determined to be a spurious pulse if the optical sensors indicate the occurrence of the pulse within a predetermined range of time. As another example, a first optical sensor signal may be shifted in time relative to a second optical sensor signal, and the signals may be correlated. An arterial pulse may be detected at a time at which a peak or trough amplitude value of the correlated signal is observed.
摘要翻译：植入系统包括在患者的动脉附近植入的至少两个光学传感器，使得一个光学传感器在另一个光学传感器的上游。可以基于来自至少一个光学传感器的电信号来检测患者的动脉。此外，可以使用来自光学传感器的电信号来最小化运动假象对动脉脉冲检测的影响。例如，如果光学传感器指示在预定的时间范围内出现脉冲，则检测到的脉冲可以被确定为杂散脉冲。作为另一示例，第一光学传感器信号可以相对于第二光学传感器信号在时间上移位，并且信号可以相关。可以在观察到相关信号的峰值或谷值振幅值的时间检测到动脉脉冲。

49. 发明申请

US20090112275A1 IMPLANTABLE SYSTEM FOR FLOW MEASUREMENT INCLUDING CHARGE AMPLIFIER 有权
标题翻译：用于流量测量的可扩展系统，包括充电放大器
公开(公告)号：US20090112275A1
公开(公告)日：2009-04-30
申请号：US11930583
申请日：2007-10-31
申请人： Can Cinbis , Bozidar Ferek-Petric , Branko Breyer
发明人： Can Cinbis , Bozidar Ferek-Petric , Branko Breyer
IPC分类号： A61N1/37
CPC分类号： A61N1/056 , A61B5/027 , A61N1/08 , A61N1/36514 , A61N1/36571 , A61N1/375
摘要： An implantable medical device lead having a flow measurement sensor mounted thereon is provided with a capsule mounted proximate to the sensor. The capsule is used to house electrical circuitry corresponding to the sensor in order to prevent impedance on conductors of the lead, which gradually decreases over chronic periods, from directly affecting signal transmission between the sensor and the electrical circuitry. The electrical circuitry includes a charge amplifier used for processing signals from the sensor. In some cases, the amplifier can be initially calibrated and periodically tuned so as to have consistent functioning with the sensor over chronic periods.
摘要翻译：具有安装在其上的流量测量传感器的可植入医疗装置引线设置有靠近传感器安装的胶囊。胶囊用于容纳对应于传感器的电路，以便防止在慢性期逐渐减少的导线的阻抗直接影响传感器和电路之间的信号传输。电路包括用于处理来自传感器的信号的电荷放大器。在某些情况下，可以对放大器进行初始校准并定期调谐，以便在慢性期间与传感器具有一致的功能。

50. 发明申请

US20080208269A1 IMPLANTABLE TISSUE PERFUSION SENSING SYSTEM AND METHOD 有权
标题翻译：可植入组织渗透感应系统及方法
公开(公告)号：US20080208269A1
公开(公告)日：2008-08-28
申请号：US12039326
申请日：2008-02-28
申请人： Can Cinbis , James K. Carney
发明人： Can Cinbis , James K. Carney
IPC分类号： A61N1/00
CPC分类号： A61B5/1459 , A61B5/0059 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/14542 , A61B5/7214 , A61N1/3925
摘要： A medical device system for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, determines changes in perfusion in response to first changes in the plurality of light measurements in a direction indicative of a decrease in blood oxygenation and second changes in a direction indicative of a decrease in blood volume, and adjusts delivery of therapy by the device in response to the determined loss of perfusion.
摘要翻译：一种用于感测心脏事件的医疗装置系统，其包括感测用于识别心脏事件的心脏信号的多个电极，能够发射多个波长的光的多个光源和检测发射光的检测器。处理器响应于由检测器检测到的发射光来确定多个光测量值，响应于多个光测量中指示血氧饱和度降低的方向和方向上的第二变化的方向响应于第一变化来确定灌注变化指示血容量的减少，并且响应于确定的灌注损失来调整装置的治疗递送。

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