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41. 发明授权

US08457371B2 Method and apparatus for mapping a structure 有权
标题翻译：用于映射结构的方法和装置
公开(公告)号：US08457371B2
公开(公告)日：2013-06-04
申请号：US12117549
申请日：2008-05-08
申请人： H. Toby Markowitz , Karl Evan Nowak , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Victoria Interrante , Phillip Falkner
发明人： H. Toby Markowitz , Karl Evan Nowak , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Victoria Interrante , Phillip Falkner
IPC分类号： G06K9/00 , A61B5/05
CPC分类号： A61B5/063 , A61B5/0215 , A61B5/0422 , A61B5/053 , A61B5/0536 , A61B5/06 , A61B5/066 , A61B5/742 , A61B6/12 , A61B34/20 , A61B2034/2046 , A61B2034/2051 , A61B2034/2072 , G06K2209/05 , G06K2209/057
摘要： An area of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of an area or volume can be determined based upon the sensing of the plurality of points without the use of an imaging device. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以利用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者的区域。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用成像装置来确定面积或体积的图。然后可以相对于映射数据导航可植入医疗装置。

42. 发明授权

US08380295B2 Detection of waveform artifact 有权
标题翻译：检测波形伪影
公开(公告)号：US08380295B2
公开(公告)日：2013-02-19
申请号：US12609455
申请日：2009-10-30
申请人： Saul E. Greenhut , Mustafa Karamanoglu , Karen J. Kleckner , Tommy D. Bennett , Scott W. Davie
发明人： Saul E. Greenhut , Mustafa Karamanoglu , Karen J. Kleckner , Tommy D. Bennett , Scott W. Davie
IPC分类号： A61B5/04
CPC分类号： A61N1/3702
摘要： An implantable medical device system including a physiological sensor detects signal artifact in a signal waveform acquired by the sensor. Features of individual waveforms in the sensor signal are extracted. Sample waveforms are classified by expert observation into at least two classes including an artifact class. A distribution range for each of the extracted features from the sample waveforms is determined for each of the classes. Waveform classification criteria are established in response to the determined distribution ranges.
摘要翻译：包括生理传感器的可植入医疗装置系统检测由传感器获取的信号波形中的信号伪影。提取传感器信号中各波形的特征。通过专家观察将样本波形分类为至少两个类，包括神器类。为每个类别确定来自采样波形的每个提取特征的分布范围。响应于确定的分布范围建立波形分类标准。

43. 发明申请

US20130030496A1 TRANSVENOUS METHOD TO INDUCE RESPIRATION 有权
标题翻译：诱导呼吸的转移方法
公开(公告)号：US20130030496A1
公开(公告)日：2013-01-31
申请号：US13192116
申请日：2011-07-27
申请人： Mustafa Karamanoglu , Vincent E. Splett , Nancy J. Rakow , Linnea R. Lentz
发明人： Mustafa Karamanoglu , Vincent E. Splett , Nancy J. Rakow , Linnea R. Lentz
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61B5/042 , A61B5/0452 , A61B5/0538 , A61N1/36185 , A61N1/371 , A61N1/37241
摘要： A system and method for delivering a nerve stimulation therapy determines whether a cardiac EGM signal can be sensed by a bipolar pair of electrodes selected from a number of electrodes positioned for stimulating a nerve. In response to not being able to sense a cardiac signal using the bipolar pair, stimulation of the nerve using a selected pair of the electrodes is enabled.
摘要翻译：用于递送神经刺激疗法的系统和方法确定心脏EGM信号是否可以被选自用于刺激神经的多个电极的双极电极对感测。响应于不能使用双极对感测心脏信号，使得能够使用所选择的一对电极刺激神经。

44. 发明申请

US20130030495A1 METHOD AND APPARATUS TO DETECT SUBCEREBRAL ISCHEMIA 有权
标题翻译：方法和装置检测苏木精
公开(公告)号：US20130030495A1
公开(公告)日：2013-01-31
申请号：US13192029
申请日：2011-07-27
申请人： Mustafa Karamanoglu , Vincent E. Splett , Nancy J. Rakow , Linnea R. Lentz
发明人： Mustafa Karamanoglu , Vincent E. Splett , Nancy J. Rakow , Linnea R. Lentz
IPC分类号： A61B5/08 , A61N1/36
CPC分类号： A61B5/686 , A61B5/0538 , A61B5/0809 , A61B5/14503 , A61N1/3611 , A61N1/36135
摘要： A medical device and associated method detect ischemia using stimulation delivered to induce respiration. A spontaneous breathing response to the stimulation-induced respiration is determined. Ischemia is detected in response to the spontaneous breathing response. The spontaneous breathing response is measured as a response to adjusting a parameter controlling the stimulation.
摘要翻译：医疗装置和相关方法使用递送的刺激来检测缺血以诱导呼吸。确定对刺激诱发的呼吸的自发呼吸反应。根据自发性呼吸反应检测到缺血。测量自发呼吸响应作为调整控制刺激的参数的响应。

45. 发明授权

US08340751B2 Method and apparatus for determining tracking a virtual point defined relative to a tracked member 有权
标题翻译：用于确定跟踪相对于被跟踪的成员定义的虚拟点的方法和装置
公开(公告)号：US08340751B2
公开(公告)日：2012-12-25
申请号：US12422689
申请日：2009-04-13
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/042
CPC分类号： A61B5/0422 , A61B5/0215 , A61B5/053 , A61B5/06 , A61B5/062 , A61B5/066 , A61B5/068 , A61B6/12 , A61B34/20 , A61B2034/2046 , A61B2034/2051 , A61B2034/2072 , G06K9/00201 , G06K2209/057
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

46. 发明申请

US20120197088A1 DETECTION OF WAVEFORM ARTIFACT 有权
标题翻译：检测波浪文艺
公开(公告)号：US20120197088A1
公开(公告)日：2012-08-02
申请号：US13017307
申请日：2011-01-31
申请人： Mustafa Karamanoglu , Karen J. Kleckner , Tommy D. Bennett
发明人： Mustafa Karamanoglu , Karen J. Kleckner , Tommy D. Bennett
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： G06F19/3406 , A61B5/02116 , A61B5/02125 , A61B5/7217 , A61B5/7239 , G06K9/0053 , G16H40/63
摘要： A medical device system including a physiological sensor is configured to perform a method for detecting signal artifact in a signal waveform acquired by the sensor. A signal waveform is sensed in a patient using the physiological sensor and a fiducial point associated with the sensed waveform is identified. A point value is established using the fiducial point. Signal artifact is detected in response to the established point value and an established threshold, and at least a portion of the signal waveform is rejected in response to detecting signal artifact.
摘要翻译：包括生理传感器的医疗装置系统被配置为执行用于检测由传感器获取的信号波形中的信号伪影的方法。使用生理传感器在患者中感测到信号波形，并且识别与感测波形相关联的基准点。使用基准点建立点值。响应于建立的点值和建立的阈值检测信号伪像，并且响应于检测到信号伪影而拒绝信号波形的至少一部分。

47. 发明申请

US20110160787A1 OPTIMIZATION OF AV DELAY USING VENTRICULAR PRESSURE SIGNAL 审中-公开
标题翻译：使用心室压力信号优化AV延迟
公开(公告)号：US20110160787A1
公开(公告)日：2011-06-30
申请号：US12751440
申请日：2010-03-31
申请人： Saul E. Greenhut , Mustafa Karamanoglu
发明人： Saul E. Greenhut , Mustafa Karamanoglu
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61N1/3682
摘要： An implantable medical device system including an intraventricular pressure sensor controls an atrioventricular (AV) delay based on the intraventricular pressure signal. An atrial kick pressure waveform corresponding to active contraction of an atrial chamber is detected from the intraventricular pressure signal. In one embodiment, a time interval corresponding to the atrial kick pressure waveform is measured. An AV delay is set in response to the measured time interval.
摘要翻译：包括心室内压力传感器的可植入医疗装置系统基于心室内压力信号来控制房室（AV）延迟。从心室内压力信号检测与心房的主动收缩对应的心房踢压力波形。在一个实施例中，测量对应于心房踢压力波形的时间间隔。响应于测量的时间间隔设置AV延迟。

48. 发明授权

US07935062B2 Derivation of flow contour from pressure waveform 有权
标题翻译：从压力波形推导流量轮廓
公开(公告)号：US07935062B2
公开(公告)日：2011-05-03
申请号：US11045574
申请日：2005-01-27
申请人： Mustafa Karamanoglu , Tommy D. Bennett
发明人： Mustafa Karamanoglu , Tommy D. Bennett
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/02108 , A61B5/029 , A61B5/7239
摘要： The present invention provides a system and method for estimating a blood flow waveform contour from a pressure signal. An arterial or ventricular pressure signal is acquired from a pressure sensor. Landmark points are identified on the pressure waveform that correspond to features of a flow waveform. In one embodiment, the landmark pressure waveform points correspond to the onset of flow, the peak flow, and the end of the systolic ejection phase. The landmark pressure waveform points define a contour that approximates the flow contour. Beat-by-beat flow contour estimation can be performed to allow computation of flow-related hemodynamic parameters such as stroke volume or cardiac output for use in patient monitoring and/or therapy management.
摘要翻译：本发明提供一种用于从压力信号估计血流波形轮廓的系统和方法。从压力传感器获取动脉或心室压力信号。在与流量波形的特征对应的压力波形上标识地标点。在一个实施例中，标记压力波形点对应于流动的开始，峰值流动和收缩期喷射阶段的结束。界标压力波形点定义近似流轮廓的轮廓。可以进行逐搏流轮廓估计，以允许计算流动相关的血液动力学参数，例如用于患者监测和/或治疗管理的中风体积或心输出量。

49. 发明申请

US20090267773A1 Multiple Sensor for Structure Identification 审中-公开
标题翻译：多传感器用于结构识别
公开(公告)号：US20090267773A1
公开(公告)日：2009-10-29
申请号：US12422708
申请日：2009-04-13
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： G08B23/00
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

50. 发明申请

US20090264778A1 Uni-Polar and Bi-Polar Switchable Tracking System between 有权
标题翻译：单极和双极可切换跟踪系统
公开(公告)号：US20090264778A1
公开(公告)日：2009-10-22
申请号：US12423521
申请日：2009-04-14
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ionana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ionana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/053 , A61B5/02 , A61B5/05
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

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