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    • 41. 发明授权
    • Method and apparatus for NMR imaging
    • NMR成像方法和装置
    • US4905699A
    • 1990-03-06
    • US92303
    • 1987-09-02
    • Koichi SanoTetsuo YokoyamaHideaki Koizumi
    • Koichi SanoTetsuo YokoyamaHideaki Koizumi
    • A61B5/055
    • A61B5/055A61B5/7257
    • In order to permit the detection of a respiratory motion and an imaging synchronized with the respiration by an NMR imaging apparatus itself without any special hardware, a sequence for detecting the respiratory motion is repeated for a short time immediately before the measurement of an image signal to detect the position and speed of the respiratory motion, and a desired image signal is measured in synchronism with the detected position. Alternatively, the respiratory motion is detected immediately after the measurement of an image signal, and the measured image signal is corrected in accordance with the detected amount to obtain a desired image signal synchronized with the respiration.
    • 为了允许通过NMR成像设备本身检测呼吸运动和与呼吸同步的成像,而没有任何特殊的硬件,用于检测呼吸运动的顺序在测量图像信号之前的短时间内被重复到 检测呼吸运动的位置和速度,并且与检测到的位置同步地测量期望的图像信号。 或者,在测量图像信号之后立即检测呼吸运动,并且根据检测到的量校正测量的图像信号,以获得与呼吸同步的期望的图像信号。
    • 43. 发明授权
    • Method of measuring sectional shape and a system therefor
    • 测量截面形状的方法及其系统
    • US4835385A
    • 1989-05-30
    • US76216
    • 1987-07-22
    • Makoto KatoTetsuo YokoyamaToshihiro Furuya
    • Makoto KatoTetsuo YokoyamaToshihiro Furuya
    • G01B15/00G01B15/04H01J37/22H01J37/28
    • G01B15/04
    • A method and system for measuring sectional shape to system the sectional shape of a subject on a plane that includes a direction that couples light sources or detectors, relying upon intensities of the same subject taken or irradiated from one direction wherein a calculation is carried out using a function that is not affected by the change of surface material of the subject in order to find a gradient component of a surface element in the direction which couples the light sources or the detectors, and the sectional shape of the subject on a plane that includes the direction coupling the light sources and the surface element, is determined relying upon the gradient component, making it possible to correctly obtain the sectional shape even when there exist different materials on the subject. Distortion in the measured result caused by the shadow of the surface topography is corrected by repeating the procedure; i.e., (1) estimating the shadow produced by the calculated sectional shape, (2) estimating the signals of when the shadow is removed, and (3) calculating the sectional shape from the signals from which effect of the shadow has been removed. Therefore, the sectional shape is obtained correctly even when there exists great unevenness on the surface of the subject.
    • 一种用于测量截面形状的方法和系统,以在包括将光源或检测器耦合的方向的平面上依赖于从一个方向拍摄或照射的相同被摄体的强度的平面的系统截面形状,其中使用 不影响被检体的表面材料的变化的功能,以便在耦合光源或检测器的方向上找到表面元件的梯度分量,以及主体的截面形状在包括 根据梯度分量来确定耦合光源和表面元件的方向,使得即使当在对象上存在不同的材料时也可以正确地获得截面形状。 通过重复该过程来校正由表面形貌的阴影引起的测量结果的失真; 即,(1)估计由计算出的截面形状产生的阴影,(2)估计阴影被去除时的信号,以及(3)从已经去除了影子的影响的信号计算截面形状。 因此,即使在被检体的表面上存在大的不均匀性,也能够正确地获得截面形状。
    • 47. 发明授权
    • Instrument and method for analysis of mannose 6-phosphate
    • 用于甘露糖6-磷酸的分析仪器和方法
    • US08906692B2
    • 2014-12-09
    • US14007977
    • 2012-03-26
    • Tetsuo Yokoyama
    • Tetsuo Yokoyama
    • G01N30/02G01N21/64G01N30/30G01N30/74G01N30/84G01N30/88
    • G01N21/6486G01N30/30G01N30/74G01N30/84G01N30/88G01N2030/3007G01N2030/8435G01N2030/8836Y10T436/143333
    • Disclosed are an apparatus and method for separation analysis of mannose-6-phosphate (M6P) by post-column fluorescence detection method. The apparatus is based on chromatography, and includes a column with a solid phase having affinity for phosphate, a flow path for the eluate, a heater installed on the flow path for M6P and a basic amino acid to react by heating the eluate in the flow path, and a fluorescence detector installed downstream of the heater for continuously irradiating the eluate with excitation light and measuring the intensity of the emission, and may include in the flow path a supply channel for addition of a basic amino acid between the column and the heater. The method is characterized in that it uses the apparatus and a second mobile phase consisting of a second buffer containing phosphate of predetermined concentration and adjusted to a predetermined pH.
    • 公开了通过柱后荧光检测方法分离甘露糖-6-磷酸(M6P)的装置和方法。 该装置基于色谱法,并且包括具有对磷酸盐具有亲和力的固相的柱,洗脱液的流动路径,安装在用于M6P的流动路径上的加热器和通过加热流体中的洗脱液进行反应的碱性氨基酸 路径和安装在加热器下游的荧光检测器,用于用激发光连续照射洗脱液并测量发射强度,并且可以在流路中包括在柱和加热器之间添加碱性氨基酸的供应通道 。 该方法的特征在于其使用该装置和由含有预定浓度的磷酸盐并调节至预定pH的第二缓冲液组成的第二流动相。
    • 48. 发明申请
    • INSTRUMENT AND METHOD FOR ANALYSIS OF MANNOSE 6-PHOSPHATE
    • 用于分析6-PHOSPHOSE的仪器和方法
    • US20140051175A1
    • 2014-02-20
    • US14007977
    • 2012-03-26
    • Tetsuo Yokoyama
    • Tetsuo Yokoyama
    • G01N21/64
    • G01N21/6486G01N30/30G01N30/74G01N30/84G01N30/88G01N2030/3007G01N2030/8435G01N2030/8836Y10T436/143333
    • Disclosed are an apparatus and method for separation analysis of mannose-6-phosphate (M6P) by post-column fluorescence detection method. The apparatus is based on chromatography, and includes a column with a solid phase having affinity for phosphate, a flow path for the eluate, a heater installed on the flow path for M6P and a basic amino acid to react by heating the eluate in the flow path, and a fluorescence detector installed downstream of the heater for continuously irradiating the eluate with excitation light and measuring the intensity of the emission, and may include in the flow path a supply channel for addition of a basic amino acid between the column and the heater. The method is characterized in that it uses the apparatus and a second mobile phase consisting of a second buffer containing phosphate of predetermined concentration and adjusted to a predetermined pH.
    • 公开了通过柱后荧光检测方法分离甘露糖-6-磷酸(M6P)的装置和方法。 该装置基于色谱法,并且包括具有对磷酸盐具有亲和力的固相的柱,洗脱液的流动路径,安装在用于M6P的流动路径上的加热器和通过加热流体中的洗脱液进行反应的碱性氨基酸 路径和安装在加热器下游的荧光检测器,用于用激发光连续照射洗脱液并测量发射强度,并且可以在流路中包括在柱和加热器之间添加碱性氨基酸的供应通道 。 该方法的特征在于其使用该装置和由含有预定浓度的磷酸盐并调节至预定pH的第二缓冲液组成的第二流动相。