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41. 发明申请

US20050260724A1 Methods for the preparation of para-hydroxycinnamic acid and cinnamic acid at alkaline PH 有权
标题翻译：在碱性PH下制备对羟基肉桂酸和肉桂酸的方法
公开(公告)号：US20050260724A1
公开(公告)日：2005-11-24
申请号：US11105259
申请日：2005-04-13
申请人： Arie Ben-Bassat , Fateme Sariaslani , Lisa Huang , Ranjan Patnaik , David Lowe
发明人： Arie Ben-Bassat , Fateme Sariaslani , Lisa Huang , Ranjan Patnaik , David Lowe
IPC分类号： C12N1/21 , C12P7/40 , C12P7/42 , C12P13/22
CPC分类号： C12P7/42 , C12P7/40
摘要： Methods for the microbial production of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) are provided. Microbes producing either tyrosine or phenylalanine are grown in the presence of either tyrosine ammonium lyase or phenylalanine ammonium lyase respectively where some part of the fermentation is accomplished at alkaline pH. The process results in greater yields and higher rates of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) production as compared with fermentation exclusively at physiological pH.
摘要翻译：提供了对羟基肉桂酸（pHCA）和肉桂酸（CA）的微生物生产方法。生产酪氨酸或苯丙氨酸的微生物分别在酪氨酸裂解酶或苯丙氨酸铵裂解酶的存在下生长，其中部分发酵在碱性pH下完成。与仅在生理pH下的发酵相比，该方法产生较高的产率和较高的对羟基肉桂酸（PHCA）和肉桂酸（CA）产率。

42. 发明申请

US20050148406A1 Golf club head with peripheral weighting 有权
公开(公告)号：US20050148406A1
公开(公告)日：2005-07-07
申请号：US11069284
申请日：2005-02-28
申请人： Steven Mahaffey , Thomas Greene , David Lowe
发明人： Steven Mahaffey , Thomas Greene , David Lowe
IPC分类号： A61M27/00 , A63B53/04 , G02B6/036 , G02B6/42
CPC分类号： A63B53/0466 , A63B60/02 , A63B2053/0433 , A63B2053/0491 , A63B2225/01
摘要： A golf club head with low peripheral and rearward weighting includes C-shaped and annular weights connected with at least one of the rear and bottom surfaces, respectively, of the head. The weighting within the peripheral weights is adjustable between the heel, rear, and toe portions of the head to customize the weight distribution of the head in accordance with a golfer's swing. The added weight and its orientation increases the moment of inertia of the head and reduces the rotation thereof.

43. 发明申请

US20050132422A1 Transgenic flies expressing Abeta42-Iowa 审中-公开
标题翻译：表达Abeta42-Iowa的转基因苍蝇
公开(公告)号：US20050132422A1
公开(公告)日：2005-06-16
申请号：US10969894
申请日：2004-10-21
申请人： David Lowe , Gerhard Koenig , Christopher Cummings
发明人： David Lowe , Gerhard Koenig , Christopher Cummings
IPC分类号： A01K67/00 , A01K67/033 , C12N15/85 , G01N33/00
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0312 , C12N15/8509
摘要： The present invention discloses a transgenic fly that expresses the Iowa mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Iowa peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
摘要翻译：本发明公开了表达人淀粉样蛋白-β前体蛋白（APP）的人Aβ42肽的爱荷华突变体版本的转基因飞行物，以及表达Tau蛋白和人Abeta42爱荷华双重转基因飞蝇人淀粉样蛋白-β前体蛋白质（APP）的肽。本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。

44. 发明授权

US06890267B2 Golf club head with peripheral weighting 有权
公开(公告)号：US06890267B2
公开(公告)日：2005-05-10
申请号：US10798147
申请日：2004-03-11
申请人： Steven J. Mahaffey , Thomas M. Greene , David Lowe
发明人： Steven J. Mahaffey , Thomas M. Greene , David Lowe
IPC分类号： A61M27/00 , A63B53/04 , G02B6/036 , G02B6/42
CPC分类号： A63B53/0466 , A63B60/02 , A63B2053/0433 , A63B2053/0491 , A63B2225/01
摘要： A golf club head with low peripheral and rearward weighting includes C-shaped and annular weights connected with at least one of the rear and bottom surfaces, respectively, of the head. The weighting within the peripheral weights is adjustable between the heel, rear, and toe portions of the head to customize the weight distribution of the head in accordance with a golfer's swing. The added weight and its orientation increases the moment of inertia of the head and reduces the rotation thereof.

45. 发明授权

US06860818B2 Golf club head with peripheral weighting 有权
标题翻译：高尔夫球杆头与周边加权
公开(公告)号：US06860818B2
公开(公告)日：2005-03-01
申请号：US10379146
申请日：2003-03-04
申请人： Steven J. Mahaffey , Thomas M. Greene , David Lowe
发明人： Steven J. Mahaffey , Thomas M. Greene , David Lowe
IPC分类号： A61M27/00 , A63B53/04 , G02B6/036 , G02B6/42
CPC分类号： A63B53/0466 , A63B60/02 , A63B2053/0433 , A63B2053/0491 , A63B2225/01
摘要： A golf club head with low peripheral and rearward weighting includes C-shaped and annular weights connected with at least one of the rear and bottom surfaces, respectively, of the head. The weighting within the peripheral weights is adjustable between the heel, rear, and toe portions of the head to customize the weight distribution of the head in accordance with a golfer's swing. The added weight and its orientation increases the moment of inertia of the head and reduces the rotation thereof.
摘要翻译：具有低外围和后加重的高尔夫球杆头包括分别与头部的后表面和底表面中的至少一个连接的C形和环形重物。外围重量之间的重量可以在头部的后跟，后部和脚趾部分之间调节，以根据高尔夫球手的摆动来定制头部的重量分布。增加的重量和其取向增加了头部的惯性矩并且减小了其旋转。

46. 发明授权

US06777823B1 Integrated continuous power system assemblies having multiple nozzle block segments 失效
标题翻译：具有多个喷嘴块段的集成连续动力系统组件
公开(公告)号：US06777823B1
公开(公告)日：2004-08-17
申请号：US09861739
申请日：2001-05-21
申请人： Gail Roberts , Philip Keene , David Lowe , James Hunt , Joseph F. Pinkerton , David B. Clifton
发明人： Gail Roberts , Philip Keene , David Lowe , James Hunt , Joseph F. Pinkerton , David B. Clifton
IPC分类号： H02K718
CPC分类号： F01D15/10 , F02C6/14 , F05D2220/64 , F05D2250/82 , F05D2250/84 , H02K7/025 , H02K7/1823 , Y02E60/16
摘要： A continuous power system assembly is provided that includes an integrated shaft-driven unit. The unit contains a turbine, an alternator, a flywheel and a feed pump, all of which are coupled to the shaft. During various modes of operation, any of the turbine, alternator or flywheel may provide the torque used to drive the shaft. When the alternator is not providing the necessary torque to drive the shaft, it is operated as a generator that provides back-up power to a load. The present invention also includes a unique nozzle design that improves the ease with the nozzles may be manufactured in comparison to known designs. The nozzle is manufactured as two halves which are mated as part of the manufacturing process. The individual nozzles may, because only half of the nozzle segments exist on either half of the nozzle block, be easily manufactured using conventional machining.
摘要翻译：提供了连续的电力系统组件，其包括集成的轴驱动单元。该单元包含涡轮机，交流发电机，飞轮和进料泵，所有这些都联接到轴上。在各种操作模式下，涡轮机，交流发电机或飞轮中的任何一个可以提供用于驱动轴的扭矩。当交流发电机不提供必要的扭矩来驱动轴时，它作为一个发电机运行，为负载提供备用电力。本发明还包括独特的喷嘴设计，其改进了与已知设计相比可以制造喷嘴的容易性。喷嘴被制造成两半，其被配合为制造过程的一部分。由于只有一半的喷嘴段存在于喷嘴块的任一半上，所以各个喷嘴可以使用传统的加工容易地制造。

47. 发明授权

US6009473A Using callbacks to effectively manage resources 失效
标题翻译：使用回调来有效地管理资源
公开(公告)号：US6009473A
公开(公告)日：1999-12-28
申请号：US846715
申请日：1997-04-30
申请人： David Lowe
发明人： David Lowe
IPC分类号： H04L5/14 , H04L12/20
CPC分类号： H04L5/1446 , Y02B60/31
摘要： A method for sharing a resource among a plurality of clients is provided. A request is received by a client requesting access to a shared resource. A usage rate is determined for the client. The usage rate of clients are reduced by transmitting a request for a usage reduction to the clients. The request for the usage reduction is initiated independent of a receipt of a message from the clients whose usage rates are being reduced. If a requested usage reduction would reduce a client below a minimum usage rate, then the usage rate of the client is set to the minimum usage rate. The minimum usage rate can be established by the client or by configuration data. The usage rate of a non-real-time client is adjusted based on a uniform rate. If the uniform rate is higher than a maximum usage rate, then the usage rate of a non-real-time client is adjusted to the maximum usage rate. The maximum usage rate can be established by the client or by configuration data.
摘要翻译：提供了一种用于在多个客户端之间共享资源的方法。请求访问共享资源的客户端接收到请求。确定客户端的使用率。通过向客户端发送使用减少请求来减少客户端的使用率。独立于从使用率降低的客户端的消息的接收开始执行使用减少的请求。如果所请求的使用减少将使客户端降低到最低使用率之下，则将客户端的使用率设置为最小使用率。最小使用率可以由客户端或配置数据建立。非实时客户端的使用率根据均匀率进行调整。如果统一率高于最大使用率，则将非实时客户端的使用率调整为最大使用率。最大使用率可由客户端或配置数据建立。

48. 发明授权

US09101503B2 Apparatus having variable strut length and methods of use 有权
标题翻译：具有可变支柱长度和使用方法的装置
公开(公告)号：US09101503B2
公开(公告)日：2015-08-11
申请号：US12043513
申请日：2008-03-06
申请人： David Lowe , Craig Bonsignore , David W. Snow , Timothy Robinson , Joshua P. Wiesman , Dawn Henderson , Nathan Maier
发明人： David Lowe , Craig Bonsignore , David W. Snow , Timothy Robinson , Joshua P. Wiesman , Dawn Henderson , Nathan Maier
IPC分类号： A61F2/06 , A61F2/915 , A61F2/91 , A61F2/966 , A61F2/89
CPC分类号： A61F2/915 , A61F2/89 , A61F2/91 , A61F2/966 , A61F2002/91508 , A61F2002/91533 , A61F2002/91541 , A61F2002/9155 , A61F2002/91558
摘要： A tubular prosthesis has a plurality of tubular rings that are radially expandable from a contracted configuration to an expanded configuration. Each ring comprises a plurality of axially oriented struts that are interconnected so as to form a circumferential series of at least one high peak and at least one low peak. The high and low peaks have apices that are oriented in the same axial direction. The apices of the high and low peaks are also oriented in the same direction and the apices of the high peaks are axially offset from the apices of the low peaks. A bridge member couples a pair of adjacent tubular rings together. The bridge member has a first end connected to a first low peak in a first tubular ring and a second end connected to either a high or low peak in an adjacent tubular ring.
摘要翻译：管状假体具有多个管状环，其从收缩构型可扩展至扩张构型。每个环包括多个轴向取向的支柱，其互连以形成至少一个高峰值和至少一个低峰值的圆周系列。高低峰具有相同轴向取向的顶点。高峰和低峰的顶点也定向在相同的方向，并且高峰的顶点从低峰的顶点轴向偏移。桥构件将一对相邻的管状环连接在一起。桥构件具有连接到第一管状环中的第一低峰的第一端和连接到相邻管状环中的高峰或低峰的第二端。

49. 发明授权

US08806055B2 System and method for stream processing utilizing totipotent morphogenic stem cells 有权
标题翻译：使用全能形态干细胞的流处理系统和方法
公开(公告)号：US08806055B2
公开(公告)日：2014-08-12
申请号：US13212514
申请日：2011-08-18
申请人： Kenneth Sabir , David Lowe
发明人： Kenneth Sabir , David Lowe
IPC分类号： G06F15/16
CPC分类号： H04L69/40 , H04L67/1002 , H04W4/70
摘要： A method, computer program product, and system for de-centralized stream processing is provided. The method may include providing a plurality of processing nodes each of said processing nodes configured to transmit and receive a stream of data. The method may further include restricting a subset of the plurality of processing nodes from differentiating into a role. The method may also include identifying a failure at one of the processing nodes and replacing the failed node with one of the processing nodes from the restricted subset.
摘要翻译：提供了一种用于去集中式流处理的方法，计算机程序产品和系统。该方法可以包括提供多个处理节点，每个处理节点被配置成发送和接收数据流。该方法还可以包括将多个处理节点的子集限制为一个角色。该方法还可以包括在处理节点之一处识别出故障，并且从受限子集中用处理节点之一替换故障节点。

50. 发明授权

US08801861B2 Cleaning apparatus with brush head disengager 有权
标题翻译：带刷头分离器的清洁装置
公开(公告)号：US08801861B2
公开(公告)日：2014-08-12
申请号：US13499819
申请日：2010-10-06
申请人： Aaron D. Cobabe , W. Kenneth Thiess , David Lowe , David O. Meyers
发明人： Aaron D. Cobabe , W. Kenneth Thiess , David Lowe , David O. Meyers
IPC分类号： B08B1/04 , A46B13/02 , B08B1/00 , A46B13/00
CPC分类号： B08B1/002 , A46B13/008 , A46B13/02 , A46B2200/3033 , A47L13/10 , A47L25/00 , B08B1/04
摘要： A cleaning apparatus includes an elongated housing bounding a chamber with a motor disposed therein. A drive shaft is at least partially disposed within the chamber of the housing, the drive shaft being coupled with the motor such that during selective operation of the motor the drive shaft is rotated. A hub having a rotational axis about which the hub rotates is coupled with the drive shaft such that rotation of the drive shaft facilitates rotation of the hub. A cleaning head is removably coupled with the hub such that rotation of the hub causes rotation of the cleaning head. A disengaging system is movable between a first position where the cleaning head is securely engaged to the hub and a second position where the cleaning head is freely removable from the hub.
摘要翻译：清洁设备包括细长的壳体，其围绕设置在其中的电动机的一个室。驱动轴至少部分地设置在壳体的腔室内，驱动轴与马达联接，使得在马达的选择性操作期间驱动轴旋转。具有轮毂旋转的旋转轴线的毂与驱动轴联接，使得驱动轴的旋转有助于轮毂的旋转。清洁头可拆卸地与轮毂联接，使得毂的旋转引起清洁头的旋转。分离系统可以在清洁头牢固地接合到轮毂的第一位置和清洁头可自由地从轮毂移除的第二位置之间移动。

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