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41. 发明授权

US07893068B2 Physiologically active substances 有权
标题翻译：生理活性物质
公开(公告)号：US07893068B2
公开(公告)日：2011-02-22
申请号：US11927564
申请日：2007-10-29
申请人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
发明人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
IPC分类号： A61K31/496 , A61K31/365 , C07D313/00 , C07D405/12 , A61P19/02 , A61P29/00 , A61P35/00 , A61P9/10
CPC分类号： A61K31/336 , A61K31/366 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D407/06
摘要： The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
摘要翻译：本发明涉及由式（I）表示的化合物：其中R3，R6，R7和R21彼此相同或不同，各自表示羟基等），其药理学上可接受的盐或它们的水合物。本发明的化合物（I）抑制血管生成，特别是在缺氧条件下抑制VEGF的产生，可用作治疗实体癌的治疗剂。

42. 发明授权

US07476483B2 Carrier for electrophotographic developer and two-component electrophotographic developer 失效
标题翻译：用于电子照相显影剂和双组分电子照相显影剂的载体
公开(公告)号：US07476483B2
公开(公告)日：2009-01-13
申请号：US11296630
申请日：2005-12-07
申请人： Yoichi Kamikoriyama , Kenji Suzuoka , Takashi Nakashima , Kazuya Kinoshita , Yuji Sato , Hiromichi Kobayashi , Takeshi Gondo , Takashi Hikichi
发明人： Yoichi Kamikoriyama , Kenji Suzuoka , Takashi Nakashima , Kazuya Kinoshita , Yuji Sato , Hiromichi Kobayashi , Takeshi Gondo , Takashi Hikichi
IPC分类号： G03G9/107
CPC分类号： G03G9/1135 , G03G9/107 , G03G9/1075 , G03G9/113 , G03G9/1133 , G03G9/1136
摘要： A carrier for electrophotographic developer comprises a resin carrier core comprising a binder resin and magnetic powder dispersed in the binder resin, and a coating layer comprising a coating resin on a surface of the core, the binder resin being a silicone resin obtained by curing of a polysiloxane compound (A) having an epoxy group and a polysiloxane compound (B) having a group capable of reacting with the epoxy group, due to a ring-opening addition reaction; the binder resin containing a functional group which is an epoxy group and/or a group capable of reacting with an epoxy group; the coating resin containing a functional group capable of reacting with the functional group of the binder resin; the functional group of the coating resin and the function group of the binder resin forming a chemical bond.
摘要翻译：用于电子照相显影剂的载体包括：树脂载体芯，其包含分散在粘合剂树脂中的粘合剂树脂和磁粉，以及在芯的表面上包含涂布树脂的涂层，粘合剂树脂是通过固化由于开环加成反应，具有环氧基的聚硅氧烷化合物（A）和具有与环氧基反应的基团的聚硅氧烷化合物（B）含有作为环氧基的官能团和/或能够与环氧基反应的基团的粘合剂树脂; 所述涂料树脂含有能够与所述粘合剂树脂的官能团反应的官能团; 涂层树脂的官能团和粘合剂树脂的官能团形成化学键。

43. 发明授权

US07371293B2 Cold finished seamless steel tubes 有权
标题翻译：冷成品无缝钢管
公开(公告)号：US07371293B2
公开(公告)日：2008-05-13
申请号：US11039954
申请日：2005-01-24
申请人： Takashi Nakashima , Kouichi Kuroda , Kenichi Beppu
发明人： Takashi Nakashima , Kouichi Kuroda , Kenichi Beppu
IPC分类号： C22C38/18 , C22C38/00 , C21D8/10
CPC分类号： C21D9/08 , B21D3/04 , Y10T428/12458
摘要： Cold finished seamless steel tubes are made such that the residual stress F to be generated at the stage of the correction process after cold working is controlled to be 30 MPa or more and the scattering thereof is 30 MPa or less, when measured by Crampton method. Further, by adjusting the average grain size of spheroidized carbides, the dimensional change which emerges in lathe turning of the outside and inside diameter of relevant steel tubes due to the residual strain can be suppressed, and the strict roundness as well as the excellent machinability can be secured at the final processing stage of the work pieces for bearing parts. Consequently, steel tubes with high dimensional accuracy and less dimensional change at the final steps such as lathe turning, heat treatment and the like, can be made for use as bearing parts.
摘要翻译：制成冷成品无缝钢管，使得在通过Crampton法测量时，在冷加工后的校正处理阶段中产生的残余应力F被控制为30MPa以上，散射为30MPa以下。此外，通过调整球状碳化物的平均粒径，可以抑制由于残留应变而导致的相关钢管的外径和内径的车削转弯引起的尺寸变化，严格的圆度以及优异的机械加工性在轴承零件的工件的最终加工阶段被固定。因此，可以在诸如车床车削，热处理等的最终步骤中具有高尺寸精度和较小尺寸变化的钢管用作轴承部件。

44. 发明授权

US07348492B1 Flexible wiring board and electrical device using the same 失效
标题翻译：柔性接线板和电器使用相同
公开(公告)号：US07348492B1
公开(公告)日：2008-03-25
申请号：US09712227
申请日：2000-11-15
申请人： Noriko Kawai , Takashi Nakashima , Hirokazu Yoshida
发明人： Noriko Kawai , Takashi Nakashima , Hirokazu Yoshida
IPC分类号： H05K1/00
CPC分类号： H05K3/361 , G02F1/13452 , H01L2924/0002 , H05K3/243 , H05K3/281 , H05K2201/0191 , H05K2201/0989 , H05K2201/10136 , H01L2924/00
摘要： A flexible wiring board is obtained as follows. A copper foil pattern is formed on the both surfaces of a base polymer film made of polyimide, etc. The copper foil pattern of the both sides, except for an end portion of the copper foil pattern of one surface, is covered entirely with an insulative protecting film made of polyimide, etc., for protecting the copper foil pattern, and the insulative protecting film and the copper foil pattern are bonded with each other by an insulative protecting film adhesive layer. On the exposed end portion of the copper foil pattern on one surface is formed a plated layer to be connected to an electrical component. The thickness of the insulative protecting film which is bonded with the surface on which the plated layer is formed is set to be thinner than the base polymer film. As a result, it is ensured that insulation failure of the insulative protecting film is prevented, and wire breakage of wiring when bent can easily be prevented.
摘要翻译：如下获得柔性布线板。在由聚酰亚胺等制成的基础聚合物膜的两面形成铜箔图案。除了一个表面的铜箔图案的端部之外，两面的铜箔图案全部被绝缘覆盖保护由聚酰亚胺制成的膜等，用于保护铜箔图案，并且绝缘保护膜和铜箔图案通过绝缘保护膜粘合剂层彼此接合。在一个表面上的铜箔图案的露出端部形成有与电气部件连接的镀层。与形成有镀层的表面接合的绝缘保护膜的厚度设定为比基体聚合物膜薄。其结果，能够防止绝缘保护膜的绝缘破坏，能够容易地防止弯曲时的布线断线。

45. 发明授权

US07288355B2 Carrier for electrophotography developers, developer prepared by using the carrier and method for forming image 失效
标题翻译：用于电子照相显影剂的载体，通过使用载体制备的显影剂和形成图像的方法
公开(公告)号：US07288355B2
公开(公告)日：2007-10-30
申请号：US10861083
申请日：2004-06-04
申请人： Yoichi Kamikoriyama , Kenji Suzuoka , Takashi Nakashima , Kazuya Kinoshita , Yuji Sato , Hiromichi Kobayashi , Takeshi Gondo , Takashi Hikichi
发明人： Yoichi Kamikoriyama , Kenji Suzuoka , Takashi Nakashima , Kazuya Kinoshita , Yuji Sato , Hiromichi Kobayashi , Takeshi Gondo , Takashi Hikichi
IPC分类号： G03G9/107
CPC分类号： G03G9/107 , G03G9/1131 , G03G9/1132 , G03G9/1135 , G03G9/1136 , G03G9/1137 , G03G9/1139
摘要： Provided are a carrier for electrophotography developers prepared by generating a slight amount of byproducts such as water, alcohol, etc, which carrier is free from release of a magnetic powder, has excellent mechanical strength and durability, and good environmental stability, and further can restrain occurrence of toner spent condition and has favorable fluidity and excellent capability of imparting charging to a toner, a two-component developer comprising the carrier and a method for forming an image using the developer. The carrier for electrophotography developers comprises a magnetic powder dispersed binder resin, the binder resin material comprises (A) a polysiloxane compound having an epoxy group as a functional group and (B) a polysiloxane compound having a group capable of ring-opening addition reaction with the epoxy group of the polysiloxane compound (A), and the binder resin is a silicone resin prepared by curing with ring-opening addition reaction of the epoxy resin. The developer comprises the carrier for electrophotography developers and the toner particle. The method for forming an image comprises developing a static latent image by the developer with an alternating electric field.
摘要翻译：提供了通过产生少量副产物如水，醇等的电子照相显影剂的载体，其载体不释放磁粉，具有优异的机械强度和耐久性，以及良好的环境稳定性，并且还可以抑制调色剂消耗状况的发生，并且具有良好的流动性和对调色剂充电的优异能力，包含载体的双组分显影剂和使用显影剂形成图像的方法。用于电子照相显影剂的载体包括磁粉分散的粘合剂树脂，粘合剂树脂材料包含（A）具有环氧基作为官能团的聚硅氧烷化合物和（B）具有能够开环加成反应的基团的聚硅氧烷化合物聚硅氧烷化合物（A）的环氧基和粘合剂树脂是通过环氧树脂的开环加成反应固化而制备的有机硅树脂。显影剂包括用于电子照相显影剂的载体和调色剂颗粒。形成图像的方法包括用交变电场显影显影剂的静电潜像。

46. 发明申请

US20050245514A1 Novel physiologically active substances 有权
标题翻译：新型生理活性物质
公开(公告)号：US20050245514A1
公开(公告)日：2005-11-03
申请号：US10522731
申请日：2003-07-31
申请人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Kanada , Susumu Takeda , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Tomohiro Sameshima
发明人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Kanada , Susumu Takeda , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Tomohiro Sameshima
IPC分类号： C07D313/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D407/06 , C12P17/08 , C12P17/16 , A61K31/5377 , A61K31/365 , A61K31/4025 , A61K31/452 , A61K31/496 , C07D413/02 , C07D45/02
CPC分类号： C07D407/06 , C07D313/00 , C12P17/08 , C12P17/16 , C12P17/162
摘要： Compounds represented by the following general formula (I), pharmacologically acceptable salts thereof or hydrates of the same: (I) wherein W represents and R3, R7, R16, R17, R20, R21 and R21′ are the same or different and each represents hydrogen, etc. Because of inhibiting angiogenesis and inhibiting the production of VEGF particularly in hypoxia, the compounds (I) are useful as remedies for solid cancer.
摘要翻译：由以下通式（I）表示的化合物，其药学上可接受的盐或其水合物：其中W表示和R 3，R 7，R 7， SUP> 16，R 17，R 20，R 21和R 21'是相同或不同，各自表示氢等。由于抑制血管生成并抑制VEGF的产生，特别是在缺氧中，所以化合物（I）可用作固体癌的治疗方法。

47. 发明授权

US06750526B2 Semiconductor device with trench isolation having reduced leak current 失效
标题翻译：具有沟槽隔离的半导体器件具有减小的漏电流
公开(公告)号：US06750526B2
公开(公告)日：2004-06-15
申请号：US10152008
申请日：2002-05-22
申请人： Takashi Nakashima
发明人： Takashi Nakashima
IPC分类号： H01L2900
CPC分类号： H01L29/66272 , H01L21/763 , H01L29/1004 , H01L29/7322
摘要： An N− type epitaxial layer is formed on a P− type silicon substrate. Trenches are created so as to penetrate N− type epitaxial layer and so as to reach to a predetermined depth of P− type silicon substrate. Thermal oxide films are formed on the sidewalls of trenches. Buried polysilicon films are formed so as to fill in trenches. Thermal oxide films are formed having an approximately constant film thickness ranging from the bottoms to the edges of the openings of trenches so as not to give stress to N− type epitaxial layers. Thereby, a semiconductor device wherein a leak current is prevented can be gained.
摘要翻译：在P型硅衬底上形成N +型外延层。产生沟槽以穿透N +型外延层，并达到P型硅衬底的预定深度。在沟槽的侧壁上形成热氧化膜。形成埋入的多晶硅膜以便填充沟槽。形成具有从底部到沟槽开口边缘的大致恒定膜厚的热氧化膜，以便不对N型外延层施加应力。由此，可以获得防止泄漏电流的半导体装置。

48. 发明授权

US06594218B2 Disk device having disk transferring mechanism capable of being made thin 失效
标题翻译：具有能够变薄的盘传送机构的盘装置
公开(公告)号：US06594218B2
公开(公告)日：2003-07-15
申请号：US09804433
申请日：2001-03-12
申请人： Hideo Kikuchi , Takashi Nakashima , Hitoshi Ikeda
发明人： Hideo Kikuchi , Takashi Nakashima , Hitoshi Ikeda
IPC分类号： G11B1704
CPC分类号： G11B17/0434
摘要： There is provided a disk device wherein an insertion/ejection slot for a disk, and two upper and lower disk D transferring paths connected to the insertion/ejection slot are provided; between the upper transferring path and the lower transferring path, a transferring roller for transferring the disk is disposed; an upper roller portion and a lower roller portion of the transferring roller are disposed so as to face the upper and lower transferring paths, respectively; in the upper roller portion and the lower roller portion, there are provided pressing members, having pressing surfaces to be arranged so as to oppose to each other; and the disk is caught between the pressing surface and the upper roller portion, or between the pressing surface and the lower roller portion to rotate the transferring roller thereby transferring the disk.
摘要翻译：提供了一种盘装置，其中提供了用于盘的插入/弹出槽，以及连接到插入/弹出槽的两个上，下盘D传送路径。在上传送路径和下传送路径之间设置用于传送盘的传送辊; 转印辊的上辊部分和下辊部分分别设置成面对上下传送路径; 在上辊部分和下辊部分中，设置有按压表面彼此相对的按压表面的按压部件; 并且盘被夹在按压表面和上辊部分之间，或者在按压表面和下辊部分之间，以转动转印辊，从而转印盘。

49. 发明授权

US06510136B1 Method and apparatus for setting a signaling virtual channel for an ATM exchange system 失效
标题翻译：用于设置ATM交换系统的信令虚拟信道的方法和装置
公开(公告)号：US06510136B1
公开(公告)日：2003-01-21
申请号：US09270328
申请日：1999-03-16
申请人： Makoto Tanaka , Shoji Fuwa , Fumiyasu Tanaka , Hiroaki Yamazaki , Atsushi Niwa , Takashi Nakashima
发明人： Makoto Tanaka , Shoji Fuwa , Fumiyasu Tanaka , Hiroaki Yamazaki , Atsushi Niwa , Takashi Nakashima
IPC分类号： G01R3108
CPC分类号： H04Q11/0478 , H04L2012/563 , H04L2012/5632
摘要： A signaling virtual channel (SVC) is established only when it is necessary so that a bandwidth reserved for a signaling channel for transmitting signaling information is usable for transmitting communication information. The SVC is established between a subscriber terminal and an asynchronous transfer mode (ATM) exchange system by selecting the virtual path identifier (VPI) and the virtual channel identifier (VCI) for signaling only when a request for a call connection is made by the subscriber terminal or only when a notification of reception of a call is sent to the subscriber terminal. A communication path between the subscriber terminal and the ATM exchange system is established for transmitting communication information by transmitting communication call setting information through the SVC. The SVC is released after an establishing operation of the communication path is completed.
摘要翻译：信号虚拟信道（SVC）仅在必要时建立，使得为发送信令信息的信令信道预留的带宽可用于发送通信信息。 SVC通过选择虚拟路径标识符（VPI）和虚拟信道标识符（VCI）来建立在用户终端和异步传输模式（ATM）交换系统之间，仅当订户进行呼叫连接的请求时才进行信令或者仅当向用户终端发送接收通知的通知时。建立用户终端和ATM交换系统之间的通信路径，用于通过SVC发送通信呼叫设置信息来发送通信信息。在通信路径的建立操作完成之后释放SVC。

50. 发明授权

US06345030B1 Disk apparatus 失效
标题翻译：磁盘设备
公开(公告)号：US06345030B1
公开(公告)日：2002-02-05
申请号：US09199946
申请日：1998-11-25
申请人： Toshihiro Sakurai , Takashi Nakashima
发明人： Toshihiro Sakurai , Takashi Nakashima
IPC分类号： G11B1704
CPC分类号： G11B17/0434 , G11B17/0285 , G11B17/0288 , G11B17/051
摘要： When a second disc is inserted, recording and/or reproducing operation of information on or from a first disc is stopped, and a moving member is moved in the X1-direction. This movement allows a clamp chassis to be moved upward and unclamped, and the second disc is carried into a disc apparatus by a transfer roller and is supported by disc guides. Then, the first and the second discs are supported by the disc guides and are moved upward and then, the first disc is carried out of an insertion opening by the transfer roller. In the course of the movement of the drive chassis to the upper position, the second disc is placed on a turntable, and is chucked and clamped by a clamper. Therefore, it is possible to exchange the second disc with the first disc only by inserting the second disc.
摘要翻译：当插入第二盘时，停止在第一盘上或从第一盘的信息的记录和/或再现操作，并且移动部件沿X1方向移动。该移动允许夹具底盘向上移动并松开，并且第二盘通过转印辊被携带到盘装置中，并由盘引导件支撑。然后，第一和第二盘由盘引导件支撑并向上移动，然后第一盘由转印辊从插入孔中移出。在驱动机架移动到上部位置的过程中，第二个盘被放置在转台上，被夹持器卡住并夹紧。因此，可以仅通过插入第二盘来将第二盘与第一盘交换。

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