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41. 发明申请

WO2012177695A3 HYBRID POLYMERASES HAVING THE ABILITY TO PRODUCE LONG AMPLICONS 审中-公开
标题翻译：具有生产长寿命能力的混合聚合物
公开(公告)号：WO2012177695A3
公开(公告)日：2013-02-28
申请号：PCT/US2012043246
申请日：2012-06-20
申请人： BIO RAD LABORATORIES , WANG YAN , SULLIVAN JOHN
发明人： WANG YAN , SULLIVAN JOHN
IPC分类号： C12P19/34 , C07K16/00 , C12N9/96
CPC分类号： C12N9/1252 , C07K2319/80
摘要： The present invention provides DNA polymerases having increased efficiency of amplification of long amplicons. The present invention also provides for methods of amplifying target nucleic acid molecules with the DNA polymerases for increasing the efficiency of amplification of long amplicons.
摘要翻译：本发明提供具有增加的长扩增子效率的DNA聚合酶。本发明还提供了用DNA聚合酶扩增靶核酸分子以增加长扩增子扩增效率的方法。

42. 发明申请

WO0246869A9 CUSTOMER DATA COLLECTION 审中-公开
标题翻译：客户数据收集
公开(公告)号：WO0246869A9
公开(公告)日：2004-05-06
申请号：PCT/US0146375
申请日：2001-12-05
申请人： MYGARB INC , SULLIVAN JOHN , SULLIVAN TODD
发明人： SULLIVAN JOHN , SULLIVAN TODD
IPC分类号： G06F9/44 , G06Q30/00 , G06F17/60
CPC分类号： G06Q30/02 , G06Q30/0277 , G06Q30/0621 , G06Q30/0643
摘要： A method includes displaying a representation of a customizable merchandise item on a marketing screen (12), the screen having at least one response field for customer data (14) and at least one response field for a customization option (16), receiving selection data from the customer (18), the selection data usable for manufacturing the item, updating the displayed representation (26) based on the selection data and receiving a customer response (20), the response representing customer data (22).
摘要翻译：一种方法包括在营销屏幕（12）上显示可定制的商品项目的表示，该屏幕具有用于客户数据（14）的至少一个响应字段和用于定制选项（16）的至少一个响应字段，接收选择数据来自客户（18）的可选择数据可用于制造该项目，基于选择数据更新所显示的表示（26）并接收客户响应（20），所述响应表示客户数据（22）。

43. 发明专利

CA3015816C SYSTEMS AND METHODS FOR EX VIVO LUNG CARE 未知
公开(公告)号：CA3015816C
公开(公告)日：2022-12-13
申请号：CA3015816
申请日：2009-01-30
申请人： TRANSMEDICS INC
发明人： FISHMAN ROBERT , HAVENER ROBERT , FATTAH IHAB ABDEL , ABDELAZIM ANAS , NEWELL SCOTT , BISHOP TOM , KHAYAL TAMER , KYI STANLEY , TAYLOR RONALD , HARRIOTT DOUG , DE REMER MATTHEW , MURRAY PAUL , SULLIVAN JOHN , ANDERSON MARK , BRINGHAM RICHARD , VAN DRIEL MICHAEL , HASSANEIN WALEED
IPC分类号： A01N1/02 , C12M3/00 , C12Q1/00
摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

44. 发明专利

NZ739881A Aortic cannula for ex vivo organ care system 未知
公开(公告)号：NZ739881A
公开(公告)日：2021-10-29
申请号：NZ73988116
申请日：2016-09-07
申请人： TRANSMEDICS INC
发明人： HASSANEIN WALEED , BRINGHAM RICHARD , SULLIVAN JOHN , RITCHIE GREG , LAMBERT II VINCENT
IPC分类号： A61M39/10 , A01N1/02
摘要： An cannula for use in an ex vivo organ care system comprises a cannula body comprising a fitting adapted to connect to an organ care system, and an aorta interface to contact an aorta, and a pivotably mounted arm strap on which a spring applies pressure, contacts the aorta to hold the aorta on the aorta interface. The pivot mount allows the arm strap to uniformly contact the aorta to hold the aorta more securely on the aorta interface.

45. 发明专利

ES2839202T3 Sistema de cuidado de órganos ex vivo 未知
公开(公告)号：ES2839202T3
公开(公告)日：2021-07-05
申请号：ES15803127
申请日：2015-06-02
申请人： TRANSMEDICS INC
发明人： HASSANEIN WALEED , KHAYAL TAMER , ELBETANONY AHMED , BARNES JEFF , RITCHIE GREG , BRINGHAM RICHARD , ANDERSON MARK , SULLIVAN JOHN
IPC分类号： A01N1/02
摘要： Un circuito de perfusión para perfundir un hígado ex vivo que comprende: una bomba (106) para proporcionar un flujo de fluido pulsátil de un fluido de perfusión a través del circuito de perfusión (100); un intercambiador de gas (114); un divisor (105) en comunicación de fluido con la bomba (106), estando el divisor configurado para dividir el flujo de fluido pulsátil en una primera ramificación (315) y una segunda ramificación (313); donde la primera ramificación (315) comprende una interfaz de arteria hepática (162); donde la primera ramificación (315) está configurada para proporcionar una primera porción del fluido de perfusión a una arteria hepática del hígado a una presión alta entre 25-150 mmHg y un caudal bajo entre 0,25-1 l/min a través de la interfaz de arteria hepática (162); donde la primera ramificación (315) está en comunicación de presión de fluido con la bomba (106); donde la segunda ramificación (313) comprende una interfaz de vena porta (166); donde la segunda ramificación (313) está configurada para proporcionar una segunda porción del fluido de perfusión a una vena porta del hígado a una presión baja entre 1-25 mmHg y un caudal alto entre 0,75 y 2 l/min a través de la interfaz de vena porta (166); comprendiendo además la segunda ramificación (313) una pinza (190) ubicada entre el divisor (105) y la interfaz de vena porta (166), controlando selectivamente la pinza (190) el caudal del fluido de perfusión a la vena porta; comprendiendo además la segunda ramificación (313) una cámara de distensibilidad (186) configurada para reducir las características de flujo pulsátil del fluido de perfusión desde la bomba (106) a la vena porta; donde la bomba (106) está configurada para proporcionar el flujo de fluido pulsátil del fluido de perfusión y el circuito de perfusión está configurado para proporcionar: el flujo de fluido pulsátil del fluido de perfusión a través de la primera ramificación (315), incluida la interfaz de arteria hepática (162), para proporcionar la primera porción del fluido de perfusión a la arteria hepática del hígado a una presión alta entre 25-150 mmHg y un caudal bajo entre 0,25-1 l/min, y un flujo con una naturaleza pulsátil reducida a través de la segunda ramificación (313), incluida la interfaz de vena porta (166), para proporcionar la segunda porción del fluido de perfusión a la vena porta del hígado a una presión baja entre 1-25 mmHg y un caudal alto entre 0,75 y 2 l/min; un drenaje (2806) configurado para recibir el fluido de perfusión de una vena cava inferior del hígado; y un depósito (160) posicionado para que esté por debajo del hígado cuando está en uso, estando el depósito situado entre el drenaje (2806) y la bomba (106), estando el depósito (160) configurado para recibir el fluido de perfusión del drenaje (2806) y almacenar un volumen del fluido de perfusión.

46. 发明专利

DK3151663T3 EX VIVO-ORGANPLEJESYSTEM 未知
公开(公告)号：DK3151663T3
公开(公告)日：2020-11-30
申请号：DK15803127
申请日：2015-06-02
申请人： TRANSMEDICS INC
发明人： HASSANEIN WALEED H , BARNES JEFF , RITCHIE GREG , BRINGHAM RICHARD , ANDERSON MARK , SULLIVAN JOHN , ELBETANONY AHMED , KHAYAL TAMER I
IPC分类号： A01N1/02

47. 发明专利

NZ739110A Systems and methods for ex vivo lung care 未知
公开(公告)号：NZ739110A
公开(公告)日：2019-08-30
申请号：NZ73911009
申请日：2009-01-30
申请人： TRANSMEDICS INC
发明人： DE REMER MATTHEW , MURRAY PAUL , SULLIVAN JOHN , ANDERSON MARK , BRINGHAM RICHARD , VAN DRIEL MICHAEL , HASSANEIN WALEED , FISHMAN ROBERT , HAVENER ROBERT , ABDELAZIM ANAS , FATTAH IHAB ABDEL , NEWELL SCOTT , BISHOP TOM , KHAYAL TAMER , KYI STANLEY , TAYLOR RONALD , HARRIOTT DOUG
IPC分类号： A01N1/02 , A61M16/00
摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to re-breathe a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to re-oxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

48. 发明专利

AU2015271799B2 Ex vivo organ care system 未知
公开(公告)号：AU2015271799B2
公开(公告)日：2019-07-11
申请号：AU2015271799
申请日：2015-06-02
申请人： TRANSMEDICS INC
发明人： HASSANEIN WALEED H , KHAYAL TAMER I , ELBETANONY AHMED , BARNES JEFF , RITCHIE GREG , BRINGHAM RICHARD , ANDERSON MARK , SULLIVAN JOHN
IPC分类号： A01N1/02
摘要： The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiment, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions. The below summary is exemplary only, and not limiting. Other embodiment of the disclosed subject matter are possible. Embodiment of the disclosed subject matter can provide techniques relating to portable ex vivo organ care, such as ex vivo liver organ care. In some embodiment, the liver care system can maintain the liver at, or near, normal physiological conditions. To this end, the system can circulate an oxygenated, nutrient enriched perfusion fluid to the liver at or near physiological temperature, pressure, and flow rate.

49. 发明专利

CA2713443C SYSTEMS AND METHODS FOR EX VIVO LUNG CARE 未知
公开(公告)号：CA2713443C
公开(公告)日：2018-11-13
申请号：CA2713443
申请日：2009-01-30
申请人： TRANSMEDICS INC
发明人： FISHMAN ROBERT , HAVENER ROBERT , FATTAH IHAB ABDEL , ABDELAZIM ANAS , NEWELL SCOTT , BISHOP TOM , KHAYAL TAMER , KYI STANLEY , TAYLOR RONALD , HARRIOTT DOUG , DE REMER MATTHEW , MURRAY PAUL , SULLIVAN JOHN , ANDERSON MARK , BRINGHAM RICHARD , VAN DRIEL MICHAEL , HASSANEIN WALEED
IPC分类号： A01N1/02 , C12M3/00
摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

50. 发明专利

AU2015202735B2 SYSTEMS AND METHODS FOR EX VIVO LUNG CARE 未知
公开(公告)号：AU2015202735B2
公开(公告)日：2017-08-03
申请号：AU2015202735
申请日：2015-05-20
申请人： TRANSMEDICS INC
发明人： FISHMAN ROBERT , HAVENER ROBERT , FATTAH IHAB ABDEL , ABDELAZIM ANAS , NEWELL SCOTT , BISHOP TOM , KHAYAL TAMER , KYI STANLEY , TAYLOR RONALD , HARRIOTT DOUG , DE REMER MATTHEW , MURRAY PAUL , SULLIVAN JOHN , ANDERSON MARK , BRINGHAM RICHARD , VAN DRIEL MICHAEL , HASSANEIN WALEED
IPC分类号： A61M16/00
摘要： A lung chamber assembly (2204) comprising a housing (2802) having a bottom including at east one housing drain, and walls; a support surface (2810) for suppoing a tung the support surface (2810) defining a drain (2814) and drainage channel (2812lading to the drain (2814) for draining a perfusion fluid(250) exiting the lun; an openable lid (2810) that provides a sealatde connection to the walls of the housing; a first perusion interface for allowing a flow of the perfusion fluid into the lung; a ventilation interface that alows ventiation of the ung by a ventilator; and a second perfusion interface for allowing a flotw of the perfusion fluid away fror the lung:berein the first perfusion interface includes at least one connector portion (805)and at last one insertion tube (804) attached to a distal end of the connector portion (805) and disposed at an angle relatve to the connection portion (808,and wherein the inserion tube (804) is made of a bio inert material having a hardness between about 50 Shore A and 90 Shore A for suturing the insertion tube to a pulmonary artery, 2Q/Oan S

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