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41. 发明公开

EP2970572A1 COMPOSITIONS AND DEVICES OF POLY-4-HYDROXYBUTYRATE 有权
标题翻译： ZUSAMMENSETZUNGEN UND VORRICHTUNGEN AUS POLY-4-HYDROXYBUTYRAT
公开(公告)号：EP2970572A1
公开(公告)日：2016-01-20
申请号：EP14723154.2
申请日：2014-03-11
申请人： Tepha, Inc.
发明人： MARTIN, David, P. , GUO, Kai , WILLIAMS, Simon, F.
IPC分类号： C08G63/08 , C08G63/90
CPC分类号： A61L15/26 , A61L17/105 , A61L27/18 , A61L27/34 , A61L29/06 , A61L29/085 , A61L31/06 , A61L31/10 , C08G63/06 , C08G63/90 , C08L67/04
摘要： Compositions of P4HB with high purity have been developed. The compositions are prepared by washing P4HB biomass prior to solvent extraction, and precipitating P4HB from solution. The same solvent is preferably used to wash the P4HB biomass, and as a non-solvent to precipitate the polymer from a P4HB solvent solution. The highly pure P4HB compositions are suitable for preparing implants. The implants may be used for the repair of soft and hard tissues.
摘要翻译：已经开发了高纯度的P4HB组合物。通过在溶剂萃取之前洗涤P4HB生物质并从溶液中沉淀出P4HB来制备组合物。优选使用相同的溶剂来洗涤P4HB生物质，并且作为非溶剂以从P4HB溶剂溶液中沉淀聚合物。高纯度的P4HB组合物适用于制备植入物。植入物可用于修复软组织和硬组织。

42. 发明公开

EP1991287A2 POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS 有权
标题翻译：聚合物，可生物降解和活性释放支架和涂料
公开(公告)号：EP1991287A2
公开(公告)日：2008-11-19
申请号：EP07763697.5
申请日：2007-02-06
申请人： Tepha, Inc.
发明人： SCHMITZ, Klaus-Peter , BEHREND, Detlef , STERNBERG, Katrin , GRABOW, Niels , MARTIN, David, P. , WILLIAMS, Simon, F.
IPC分类号： A61L31/04 , A61L31/14
CPC分类号： C08L67/04 , A61K47/34 , A61L15/26 , A61L17/105 , A61L17/12 , A61L27/18 , A61L27/26 , A61L29/049 , A61L29/06 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/18 , C08G63/06 , C08K3/014 , C08K5/0016 , C08K5/005 , C08K5/0083 , C08L2666/18
摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.

43. 发明授权

EP1212052B1 THERAPEUTIC USES OF POLYMERS AND OLIGOMERS COMPRISING GAMMA-HYDROXYBUTYRATE 有权
标题翻译：聚合物伽玛羟基丁酸治疗用途CONTAIN
公开(公告)号：EP1212052B1
公开(公告)日：2005-04-13
申请号：EP00963475.9
申请日：2000-09-14
申请人： Tepha, Inc. , Metabolix, Inc.
发明人： WILLIAMS, Simon, F. , MARTIN, David, P.
IPC分类号： A61K31/19 , A61K31/765 , A61P25/00 , A61P25/18
CPC分类号： A61K31/19 , A61K31/765
摘要： Oligomers and polymer compositions are provided which comprise GHB and produce GHB after administration in vivo. Devices for the storage and delivery of these polymers and oligomers are also provided. These oligomers and polymer compositions are useful in a variety of applications. The compositions can be used therapeutically, for example, in the treatment of patients with narcolepsy, chronic schizophrenia, catatonic schizophrenia, atypical psychoses, chronic brain syndrome, neurosis, alcoholism, drug addiction and withdrawal, Parkinson's disease and other neuropharmacological illnesses, hypertension, ischemia, circulatory collapse, radiation exposure, cancer, and myocardial infarction. Other uses for the compositions include anesthesia induction, sedation, growth hormone production, heightened sexual desire, anorectic effects, euphoria, smooth muscle relaxation, muscle mass production, and sleep, including rapid eye movement sleep. In a still further embodiment, the oligomers and polymers may be used to produce absence seizures.

44. 发明公开

EP4337141A1 NIPPLE RECONSTRUCTION IMPLANT 审中-实审
公开(公告)号：EP4337141A1
公开(公告)日：2024-03-20
申请号：EP22726888.5
申请日：2022-05-09
申请人： Tepha, Inc.
发明人： LIMEM, Skander , SARIIBRAHIMOGLU, Kemal , SCOTT, Jeffrey Robert , WILLIAMS, Simon, F. , BUTLER, Timothy John , HOHL LOPEZ, German Oswaldo
IPC分类号： A61F2/12 , A61F2/00 , A61L27/14

45. 发明授权

EP3183012B1 THERMOFORMED POLY-4-HYDROXYBUTYRATE MEDICAL IMPLANTS 有权
标题翻译：热成型聚-4-羟基丁酸酯医疗植入物
公开(公告)号：EP3183012B1
公开(公告)日：2017-12-20
申请号：EP14758251.4
申请日：2014-08-20
申请人： Tepha, Inc.
发明人： BERNASCONI, Matthew , CONNELLY, Dennis, W. , RIZK, Said , MARTIN, David, P. , WILLIAMS, Simon, F.
IPC分类号： A61L27/18 , A61L29/06 , A61L31/06 , A61L15/26
CPC分类号： A61L15/26 , A61L27/18 , A61L27/48 , A61L29/06 , A61L29/126 , A61L31/06 , A61L31/126 , A61L31/129 , C08L67/04

46. 发明公开

EP3183012A1 THERMOFORMED POLY-4-HYDROXYBUTYRATE MEDICAL IMPLANTS 有权
标题翻译：热成型聚-4-羟基丁酸酯医疗植入物
公开(公告)号：EP3183012A1
公开(公告)日：2017-06-28
申请号：EP14758251.4
申请日：2014-08-20
申请人： Tepha, Inc.
发明人： BERNASCONI, Matthew , CONNELLY, Dennis, W. , RIZK, Said , MARTIN, David, P. , WILLIAMS, Simon, F.
IPC分类号： A61L27/18 , A61L29/06 , A61L31/06 , A61L15/26
CPC分类号： A61L15/26 , A61L27/18 , A61L27/48 , A61L29/06 , A61L29/126 , A61L31/06 , A61L31/126 , A61L31/129 , C08L67/04
摘要： Methods to produce thermoforms from P4HB homopolymer and blends thereof have been developed. These thermoforms are produced from films and sheets including P4HB, wherein the intrinsic viscosity of the P4HB is less than 3.5 dl/g, but greater than 0.35 dl/g, and the thermoforms are produced at a temperature equal to or greater than the softening point of P4HB, and more preferably at a temperature higher than the melting point of P4HB. A preferred embodiment includes a P4HB thermoform wherein a film or sheet including a P4HB polymer is thermoformed at a temperature between its melting point and 150 °C. In a particularly preferred embodiment the thermoform is a laminate made from a P4HB film and a P4HB mesh.
摘要翻译：已经开发了由P4HB均聚物及其混合物生产热定型的方法。这些热成型体由包括P4HB的膜和片制成，其中P4HB的特性粘度小于3.5dl / g，但大于0.35dl / g，并且热成型体在等于或大于软化点的P4HB，更优选在高于P4HB的熔点的温度下进行。一个优选实施方案包括P4HB热成型物，其中包含P4HB聚合物的膜或片在其熔点与150℃之间的温度下热成型。在特别优选的实施方式中，热成型件是由P4HB膜和P4HB网制成的层压件。

47. 发明公开

EP3062995A1 PULTRUSION OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF 有权
标题翻译：聚合物聚合-4-羟基丁酸酯共聚物
公开(公告)号：EP3062995A1
公开(公告)日：2016-09-07
申请号：EP14803273.3
申请日：2014-10-31
申请人： Tepha, Inc.
发明人： GANATRA, Amit , SHAH, Bhavin , RIZK, Said , MARTIN, David, P. , WILLIAMS, Simon, F.
IPC分类号： B29C70/52 , A61L27/14 , A61L27/40 , A61L31/04 , A61L27/18 , A61L31/06 , C08L67/04
CPC分类号： A61L27/18 , A61L27/26 , A61L31/041 , A61L31/06 , B29C70/52 , C08G63/06 , C08L67/04
摘要： Compositions of P4HB (poly-4-hydroxybutyrate) and copolymers thereof, have been developed for pultrusion, as well as processes to produce profiles from these compositions by pultrusion. These pultrusion processes provide profiles without causing structural damage to the surface of the profile. The profiles may be used in medical applications. These compositions include P4HB, and copolymers thereof, having intrinsic viscosities less than 3.2 dl/g but greater than 0.8 dl/g. The profile may be formed using conditions such as: pull rate of 0.1 to 100 mm/min, die temperature of up to 95°C, rod stock temperature up to 95°C, draw ratio of up to 100X, pulling force of greater than 10 MPa, and clamping pressure at least 10 % higher than the pulling force. Preferably, the profile is formed by pulling the rod stock through a series of dies placed at intervals with the hole sizes decreasing in diameter by 0.1 to 10 mm.
摘要翻译： P4HB（聚-4-羟基丁酸酯）及其共聚物的组合物已被开发用于拉挤成型，以及通过拉挤成型从这些组合物生产型材的方法。这些拉挤成型工艺提供型材，而不会对轮廓的表面造成结构损坏。型材可用于医疗应用。这些组合物包括其特性粘度小于3.2dl / g但大于0.8dl / g的P4HB及其共聚物。外形可以采用以下条件形成：拉伸速度为0.1〜100mm / min，模具温度可达95℃，棒料温度可达95℃，拉伸比可达100×，拉力大于10MPa，并且夹紧压力比拉力高至少10％。优选地，通过将棒材拉伸通过一系列模具而形成，所述一系列模具以直径减小0.1至10mm的孔的间隔间隔放置。

48. 发明公开

EP2968669A1 ULTRAFINE ELECTROSPUN FIBERS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF 有权
标题翻译：高分子聚醚醚酮聚合物聚四氢呋喃
公开(公告)号：EP2968669A1
公开(公告)日：2016-01-20
申请号：EP14723153.4
申请日：2014-03-11
申请人： Tepha, Inc.
发明人： MARTIN, David, P. , GUO, Kai , RIZK, Said , WILLIAMS, Simon, F.
IPC分类号： A61L27/18 , C08L67/04 , D01D5/00
CPC分类号： A61L31/14 , A61F2/28 , A61L15/26 , A61L15/425 , A61L17/105 , A61L17/145 , A61L27/34 , A61L27/56 , A61L31/10 , A61L31/146 , A61L2400/12 , D01D5/0038 , D01F6/625 , Y10T428/249953 , Y10T428/298 , Y10T442/10 , Y10T442/681 , C08L67/04
摘要： Methods to produce structures containing ultrafine fibers with average diameters from 10 nm to 10 μm and more preferably from 50 nm to 5 μm, have been developed. These methods produce ultrafine fibers without substantial loss of the polymer's weight average molecular weight. The ultrafine electrospun fibers have an unexpectedly higher degree of molecular orientation, and higher melt temperature than fibers derived by dry spinning. In the preferred embodiment, the polymer comprises 4-hydroxybutyrate. The ultrafine fibers are preferably derived by electrospinning. A solution of the polymer is dissolved in a solvent, pumped through a spinneret, subjected to an electric field, and ultrafine fibers with a high degree of molecular orientation are collected. These structures of ultrafine fibers can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：已经开发了产生包含平均直径为10nm至10μm，更优选为50nm至5μm的超细纤维的结构的方法。这些方法产生超细纤维，而不会显着损失聚合物的重均分子量。超细电纺纤维具有意想不到的较高程度的分子取向，并且比通过干纺得到的纤维具有更高的熔融温度。在优选的实施方案中，聚合物包含4-羟基丁酸酯。超细纤维优选通过静电纺丝衍生。将聚合物溶液溶解在溶剂中，泵送通过喷丝头，进行电场，并收集高分子取向的超细纤维。超细纤维的这些结构可以用于各种目的，包括制造医疗装置。

49. 发明授权

EP1638615B1 POLYHYDROXYALKANOATE MEDICAL TEXTILES AND FIBERS 有权转让
标题翻译：医用纺织品和纤维聚羟基脂肪酸酯
公开(公告)号：EP1638615B1
公开(公告)日：2014-10-29
申请号：EP04760859.1
申请日：2004-04-30
申请人： Tepha, Inc.
发明人： MARTIN, David, P. , RIZK, Said , AHUJA, Ajay , WILLIAMS, Simon, F.
IPC分类号： A61L27/18 , A61L31/06 , A61F2/00 , D01F6/62 , D01F6/84
CPC分类号： A61F2/0063 , A61F2002/0068 , A61L27/18 , A61L27/48 , A61L31/06 , B29C47/0004 , B29C47/0014 , B29C71/0072 , B29K2067/00 , B29L2031/753 , D01D5/088 , D01D5/098 , D01D5/16 , D01F6/62 , D01F6/625 , D01F6/84 , D02G3/02 , Y10T428/1362 , Y10T428/1369 , Y10T428/249922 , Y10T442/10 , Y10T442/183 , Y10T442/184 , Y10T442/2525 , C08L67/04

50. 发明授权

EP1993621B1 TOUGHENED POLYLACTIC ACID POLYMERS AND COPOLYMERS 有权转让
标题翻译：增强的聚乳酸聚合物和共聚物
公开(公告)号：EP1993621B1
公开(公告)日：2011-08-17
申请号：EP07763255.2
申请日：2007-02-06
申请人： Tepha, Inc.
发明人： RIZK, Said , MARTIN, David, P. , HO, Kicherl , GANATRA, Amit , WILLIAMS, Simon, F.
IPC分类号： A61L15/22 , A61L17/12 , A61L27/26 , A61L29/04 , A61L31/04 , C08L67/04
CPC分类号： C08L67/04 , A61K47/34 , A61L15/26 , A61L17/105 , A61L17/12 , A61L27/18 , A61L27/26 , A61L29/049 , A61L29/06 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/18 , C08G63/06 , C08K3/014 , C08K5/0016 , C08K5/005 , C08K5/0083 , C08L2666/18
摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.

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