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41. 发明申请

US20080153751A1 Albumin Fusion Proteins 有权
公开(公告)号：US20080153751A1
公开(公告)日：2008-06-26
申请号：US11929828
申请日：2007-10-30
申请人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
发明人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
IPC分类号： A61K38/00 , C07K16/00 , C07H21/04 , C12N5/00 , A61P43/00 , C12N5/02 , C12P21/04
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

42. 发明申请

US20080146503A1 Albumin Fusion Proteins 有权
公开(公告)号：US20080146503A1
公开(公告)日：2008-06-19
申请号：US11772643
申请日：2007-07-02
申请人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
发明人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
IPC分类号： A61K38/00 , A61P43/00 , C07K14/76 , C12N15/00 , C12N15/11 , C12N5/06
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

43. 发明授权

US07375192B2 Antibodies that specifically bind to chemokine beta-4 失效
标题翻译：特异性结合趋化因子β-4的抗体
公开(公告)号：US07375192B2
公开(公告)日：2008-05-20
申请号：US10513705
申请日：2003-04-30
申请人： Craig A. Rosen , Steven M. Ruben
发明人： Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K16/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies and related molecules that specifically bind to CK-B4. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including cancers, as well as immune system diseases and disorders including autoimmune diseases, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease. The invention also relates to nucleic acid molecules encoding anti-CK-B4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to CK-B4.
摘要翻译：本发明涉及特异性结合CK-B4的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症以及包括癌症在内的免疫系统疾病和病症，以及免疫系统疾病和病症，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏，牛皮癣，皮炎和炎性肠病。本发明还涉及编码抗CK-B4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症以及免疫系统疾病和病症的方法和组合物，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏牛皮癣，皮炎和炎性肠病，包括向动物，优选人类施用有效量的与CK-B4特异性结合的一种或多种抗体或其片段或变体或相关分子。

44. 发明授权

US07368244B2 Peptidoglycan recognition proteins 失效
标题翻译：肽聚糖识别蛋白
公开(公告)号：US07368244B2
公开(公告)日：2008-05-06
申请号：US11214796
申请日：2005-08-31
申请人： Paul E. Young , Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
发明人： Paul E. Young , Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
IPC分类号： C07H21/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention related to three novel peptidoglican recognition binding protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
摘要翻译：本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新型肽基识别结合蛋白。更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。图1A-B，图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。还提供了PGRP-K，PGRP-W和PGRP-C多肽。进一步提供载体，宿主细胞和用于制备其的重组方法。本发明还涉及PGRP-K，PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

45. 发明授权

US07361341B2 Methods of treating cancer using antibodies that immunospecifically bind to trail receptors 有权
标题翻译：使用免疫特异性结合尾静脉受体的抗体治疗癌症的方法
公开(公告)号：US07361341B2
公开(公告)日：2008-04-22
申请号：US11391384
申请日：2006-03-29
申请人： Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
发明人： Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
IPC分类号： A61K39/395 , G01N33/53 , C12P21/04 , C12P21/08 , C07K16/00 , C07H21/04
CPC分类号： C07K16/2878 , C07K2317/56 , C07K2317/622 , C07K2317/73
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.
摘要翻译：本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。这样的抗体具有例如用于治疗癌症和其它增殖性疾病的用途。本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或变体或相关分子，其免疫特异性结合TRAIL受体TR4。

46. 发明授权

US07196164B2 Secreted protein HHTLF25 失效
标题翻译：分泌蛋白HHTLF25
公开(公告)号：US07196164B2
公开(公告)日：2007-03-27
申请号：US09973278
申请日：2001-10-10
申请人： Craig A. Rosen , Steven M. Ruben , David W. LaFleur
发明人： Craig A. Rosen , Steven M. Ruben , David W. LaFleur
IPC分类号： C07K14/00 , C12Q1/68 , C07H21/02 , C12P21/02 , C07K16/00
CPC分类号： A01C23/024 , A61K38/00 , C07K14/47 , C12N9/00 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5058 , G01N33/5091 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

47. 发明授权

US07105644B2 Secreted protein HHTLF25 antibodies 失效
标题翻译：分泌蛋白HHTLF25抗体
公开(公告)号：US07105644B2
公开(公告)日：2006-09-12
申请号：US09983802
申请日：2001-10-25
申请人： Craig A. Rosen , Steven M. Ruben , David W. LaFleur
发明人： Craig A. Rosen , Steven M. Ruben , David W. LaFleur
IPC分类号： C07K16/24 , C12N5/12 , G01N33/53
CPC分类号： C12N9/00 , A61K38/00 , C07K14/47 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5058 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins. Disclosed embodiments of the invention also include antibodies that bind to secreted protein HHTLF25 and methods for making and using such antibodies.
摘要翻译：本发明涉及新型人分泌蛋白质和含有编码这种蛋白质的编码区基因的分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。本发明的公开的实施方案还包括结合分泌蛋白HHTLF25的抗体以及制备和使用该抗体的方法。

48. 发明授权

US07041802B2 Peptidoglycan recognition proteins 失效
标题翻译：肽聚糖识别蛋白
公开(公告)号：US07041802B2
公开(公告)日：2006-05-09
申请号：US10180454
申请日：2002-06-27
申请人： Paul E. Young , Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
发明人： Paul E. Young , Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
IPC分类号： C07K16/00 , C12P21/08 , C12N5/06 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to three novel peptidoglycan recognition binding proteins expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A–B, FIGS. 2A–C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
摘要翻译：本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新的肽聚糖识别结合蛋白。更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。图1A-B，图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。还提供了PGRP-K，PGRP-W和PGRP-C多肽。进一步提供载体，宿主细胞和用于制备其的重组方法。本发明还涉及PGRP-K，PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

49. 发明授权

US07001992B2 Antibodies to secreted protein HEMCM42 有权
标题翻译：抗体分泌蛋白HEMCM42
公开(公告)号：US07001992B2
公开(公告)日：2006-02-21
申请号：US10062831
申请日：2002-02-05
申请人： Steven M. Ruben , Craig A. Rosen , Gregory A. Endress
发明人： Steven M. Ruben , Craig A. Rosen , Gregory A. Endress
IPC分类号： C07K16/00
CPC分类号： C07K14/47 , A61K38/00 , C07K16/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

50. 发明授权

US06632920B1 36 human secreted proteins 失效
标题翻译： 36人分泌蛋白
公开(公告)号：US06632920B1
公开(公告)日：2003-10-14
申请号：US09716129
申请日：2000-11-17
申请人： Henrik S. Olsen , Steven M. Ruben , Craig A. Rosen , Laurie A. Brewer , Reinhard Ebner , Roxanne Duan , Kimberly Florence
发明人： Henrik S. Olsen , Steven M. Ruben , Craig A. Rosen , Laurie A. Brewer , Reinhard Ebner , Roxanne Duan , Kimberly Florence
IPC分类号： A61K3800
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00
摘要： The present invention relates to 36 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及36种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病的诊断和治疗方法。

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