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41. 发明授权

US06307021B1 Human apoptosis regulator 失效
标题翻译：人类凋亡调节因子
公开(公告)号：US06307021B1
公开(公告)日：2001-10-23
申请号：US09199892
申请日：1998-11-24
申请人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C07K100
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a human apoptosis regulator protein (APRG) and polynucleotides which identify and encode APRG. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding APRG and a method for producing APRG. The invention also provides for agonists, antibodies, or antagonists specifically binding APRG, and their use, in the prevention and treatment of diseases associated with expression of APRG. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding APRG for the treatment of diseases associated with the expression of APRG. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding APRG.
摘要翻译：本发明提供了鉴定和编码APRG的人细胞凋亡调节蛋白（APRG）和多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码APRG的核酸序列和生产APRG的方法。本发明还提供了特异性结合APRG的激动剂，抗体或拮抗剂及其在预防和治疗与APRG表达相关的疾病中的用途。此外，本发明提供了反义分子用于编码APRG的多核苷酸用于治疗与APRG表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合APRG的抗体的诊断测定法。

42. 发明授权

US5847093A Human apoptosis regulator 失效
标题翻译：人类凋亡调节因子
公开(公告)号：US5847093A
公开(公告)日：1998-12-08
申请号：US773910
申请日：1996-12-27
申请人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P7/06 , A61P9/06 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P43/00 , C07K14/47 , C07K16/18 , C12N15/12 , C12P21/02 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a human apoptosis regulator protein (APRG) and polynucleotides which identify and encode APRG. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding APRG and a method for producing APRG. The invention also provides for agonists, antibodies, or antagonists specifically binding APRG, and their use, in the prevention and treatment of diseases associated with expression of APRG. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding APRG for the treatment of diseases associated with the expression of APRG. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding APRG.
摘要翻译：本发明提供了鉴定和编码APRG的人细胞凋亡调节蛋白（APRG）和多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码APRG的核酸序列和生产APRG的方法。本发明还提供了特异性结合APRG的激动剂，抗体或拮抗剂及其在预防和治疗与APRG表达相关的疾病中的用途。此外，本发明提供了反义分子用于编码APRG的多核苷酸用于治疗与APRG表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合APRG的抗体的诊断测定法。

43. 发明授权

US5814451A Subunits of NADH dehydrogenase 失效
公开(公告)号：US5814451A
公开(公告)日：1998-09-29
申请号：US785065
申请日：1997-01-17
申请人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
IPC分类号： A61K38/00 , C12N9/02 , C12N15/53 , C12P21/08 , C12Q1/68 , C12N9/06
CPC分类号： C12N9/0036 , A61K38/00
摘要： The present invention provides four NADH dehydrogenase subunits (designated individually as NDS-1, NDS-2, NDS-3, and NDS-4 and collectively as NDS) and polynucleotides which identify and encode NDS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NDS and a method for producing NDS. The invention also provides for use of NDS and agonists, antibodies, or antagonists specifically binding NDS, in the prevention and treatment of diseases associated with expression of NDS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NDS for the treatment of diseases associated with the expression of NDS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NDS.

44. 发明授权

US5985635A Nucleic acids encoding novel human serine/threonine protein kinases 失效
标题翻译：编码新型人丝氨酸/苏氨酸蛋白激酶的核酸
公开(公告)号：US5985635A
公开(公告)日：1999-11-16
申请号：US749902
申请日：1996-11-15
申请人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
IPC分类号： A61K38/00 , C12N9/12 , C12N15/54
CPC分类号： C12N9/1205 , C12Y207/01037 , A61K38/00
摘要： The present invention provides human serine/threonine kinase (HSTK) and polynucleotides which identify and encode HSTK. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HSTK and a method for producing HSTK. The invention also provides for use of HSTK and agonists, antibodies, or antagonists specifically binding HSTK, in the prevention and treatment of diseases associated with expression of HSTK. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HSTK for the treatment of diseases associated with the expression of HSTK. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HSTK.
摘要翻译：本发明提供了人类丝氨酸/苏氨酸激酶（HSTK）和识别和编码HSTK的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HSTK的核酸序列和产生HSTK的方法。本发明还提供使用HSTK和特异性结合HSTK的激动剂，抗体或拮抗剂来预防和治疗与HSTK表达相关的疾病。另外，本发明提供了反义分子用于编码HSTK的多核苷酸用于治疗与HSTK表达有关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HSTK的抗体的诊断测定法。

45. 发明授权

US5869291A Rab proteins 失效
公开(公告)号：US5869291A
公开(公告)日：1999-02-09
申请号：US773423
申请日：1996-12-27
申请人： Jennifer L. Hillman , Surya K. Goli , Olga Bandman
发明人： Jennifer L. Hillman , Surya K. Goli , Olga Bandman
IPC分类号： A61K38/00 , C12N9/16 , C12Q1/68 , C07H21/04 , C12N1/20 , C12N15/63
CPC分类号： C12Q1/6883 , C12N9/16 , A61K38/00 , C12Q2600/158
摘要： The present invention provides three Rab proteins (designated individually as HRABS-1, HRABS-2, and HRABS-3, and collectively as HRABS) and polynucleotides which identify and encode HRABS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HRABS and a method for producing HRABS. The invention also provides for use of HRABS and agonists, antibodies, or antagonists specifically binding HRABS, in the prevention and treatment of diseases associated with expression of HRABS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HRABS for the treatment of diseases associated with the expression of HRABS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HRABS.

46. 发明授权

US6020474A ATP synthase subunits 失效
公开(公告)号：US6020474A
公开(公告)日：2000-02-01
申请号：US783974
申请日：1997-01-15
申请人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
发明人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C12N1/21 , C12N9/14 , C07H21/02 , C07H21/04
CPC分类号： C12N9/14 , A61K38/00
摘要： The present invention provides two ATP synthase subunits (designated individually as Asy-1 and Asy-2, and collectively as Asy) and polynucleotides which identify and encode Asy. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Asy and a method for producing Asy. The invention also provides for use of Asy and agonists, antibodies, or antagonists specifically binding Asy, in the prevention and treatment of diseases associated with expression of Asy. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Asy for the treatment of diseases associated with the expression of Asy. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Asy.

47. 发明授权

US5854022A Polynucleotides encoding a CD53-like transmembrane protein 失效
标题翻译：编码CD53样跨膜蛋白的多核苷酸
公开(公告)号：US5854022A
公开(公告)日：1998-12-29
申请号：US855140
申请日：1997-05-13
申请人： Jennifer L. Hillman , Olga Bandman , Surya K. Goli , Karl J. Guegler
发明人： Jennifer L. Hillman , Olga Bandman , Surya K. Goli , Karl J. Guegler
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/70596 , A61K38/00
摘要： The present invention provides a human transmembrane protein (ONMO) and polynucleotides which identify and encode ONMO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing ONMO and for treating or preventing disorders associated with expression of ONMO.
摘要翻译：本发明提供了人跨膜蛋白（ONMO）和识别和编码ONMO的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。此外，本发明提供了用于生产ONMO和用于治疗或预防与ONMO表达相关的病症的方法。

48. 发明授权

US06531575B1 ATP synthase subunits 失效
标题翻译： ATP合酶亚基
公开(公告)号：US06531575B1
公开(公告)日：2003-03-11
申请号：US09546306
申请日：2000-04-10
申请人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
发明人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
IPC分类号： C07K100
CPC分类号： C12N9/14 , A61K38/00
摘要： The present invention provides two ATP synthase subunits (designated individually as Asy-1 and Asy-2, and collectively as Asy) and polynucleotides which identify and encode Asy. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Asy and a method for producing Asy. The invention also provides for use of Asy and agonists, antibodies, or antagonists specifically binding Asy, in the prevention and treatment of diseases associated with expression of Asy. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Asy for the treatment of diseases associated with the expression of Asy. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Asy.
摘要翻译：本发明提供两个ATP合成酶亚单位（分别命名为Asy-1和Asy-2，统称为Asy）和识别和编码Asy的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码Asy的核酸序列和产生Asy的方法。本发明还提供了用于预防和治疗与Asy表达相关的疾病的Asy和特异性结合Asy的激动剂，抗体或拮抗剂。另外，本发明提供反义分子用于编码Asy的多核苷酸用于治疗与Asy表达相关的疾病。本发明还提供利用多核苷酸或其片段或其互补体和特异性结合Asy的抗体的诊断测定法。

49. 发明授权

US6103874A Human KDEL receptor 失效
标题翻译：人类KDEL受体
公开(公告)号：US6103874A
公开(公告)日：2000-08-15
申请号：US133735
申请日：1998-08-13
申请人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
发明人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/06 , A61P5/14 , A61P43/00 , C07K14/705 , C07K16/28 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/566 , C07K14/00 , A61K38/16 , C07H21/04
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a novel human KDEL receptor (NHKR) and polynucleotides which identify and encode NHKR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHKR and a method for producing NHKR. The invention also provides for agonists, antibodies, or antagonists specifically binding NHKR, and their use, in the prevention and treatment of diseases associated with expression of NHKR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHKR for the treatment of diseases associated with the expression of NHKR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHKR.
摘要翻译：本发明提供了一种新的人KDEL受体（NHKR）和识别并编码NHKR的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码NHKR的核酸序列和生产NHKR的方法。本发明还提供了特异性结合NHKR的激动剂，抗体或拮抗剂及其在预防和治疗与NHKR表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码NHKR的多核苷酸用于治疗与NHKR表达有关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHKR的抗体的诊断测定法。

50. 发明授权

US5863898A Human lim proteins 失效
标题翻译：人体蛋白质
公开(公告)号：US5863898A
公开(公告)日：1999-01-26
申请号：US739485
申请日：1996-10-28
申请人： Surya K. Goli , Jennifer L. Hillman , Olga Bandman
发明人： Surya K. Goli , Jennifer L. Hillman , Olga Bandman
IPC分类号： A61K38/00 , C07K14/47 , C07K14/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides three human LIM proteins (designated individually as HLIM-1, HLIM-2, and HLIM-3, and collectively as HLIM) and polynucleotides which identify and encode HLIM. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HLIM and a method for producing HLIM. The invention also provides for use of HLIM and agonists, antibodies, or antagonists specifically binding HLIM, in the prevention and treatment of diseases associated with expression of HLIM. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HLIM for the treatment of diseases associated with the expression of HLIM. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HLIM.
摘要翻译：本发明提供了三种人LIM蛋白（分别命名为HLIM-1，HLIM-2和HLIM-3，并且共同称为HLIM）和鉴定和编码HLIM的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码HLIM的核酸序列的宿主细胞和生产HLIM的方法。本发明还提供了用于预防和治疗与HLIM表达相关的疾病的HLIM和特异性结合HLIM的激动剂，抗体或拮抗剂。另外，本发明提供反义分子用于编码HLIM的多核苷酸用于治疗与HLIM表达相关的疾病。本发明还提供了利用多核苷酸或其片段或其补体以及特异性结合HLIM的抗体的诊断测定法。

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