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    • 41. 发明授权
    • Method and device for removing a toxic substance from blood
    • 从血液中除去有毒物质的方法和装置
    • US5397354A
    • 1995-03-14
    • US168050
    • 1993-12-15
    • Peter J. WilkSteven J. Gruber
    • Peter J. WilkSteven J. Gruber
    • A61F2/02A61M1/16A61M5/142A61M27/00A61M39/02A61F2/04
    • A61F2/022A61M1/1678A61M5/14276A61M27/002A61M39/0208Y10S623/917
    • A method for removing a toxic substance from a patient utilizes a filtering device defining a first fluid flow path and a second fluid flow path. The filtering device also includes a semipermeable membrane separating the first fluid flow path and the second fluid flow path from one another, the membrane being selectively permeable to the toxic substance. The filtering device additionally includes a reservoir and a pump, the reservoir being located along the second fluid flow path between the membrane and the second inlet port. The filtering device is inserted into the patient so that it is totally surrounded by the patient, the filtering device is connected to a blood vessel of the patient so that blood from the artery is shunted along the first fluid flow path. An outlet end of the second fluid flow path is connected to the urinary bladder of the patient. The inlet end of the second fluid flow path is disposed at the skin surface of the patient to enable a periodic refilling of the reservoir with a working fluid. Upon installation of the filtering device in the patient, the pump is operated to transfer working fluid along the second fluid flow path from the reservoir to the urinary bladder of the patient while blood flows along the first fluid flow path, thereby enabling transfer of the toxic substance from the patient's blood through the membrane to the working fluid in the second fluid flow path.
    • 用于从患者去除有毒物质的方法利用限定第一流体流动路径和第二流体流动路径的过滤装置。 过滤装置还包括将第一流体流动路径和第二流体流动路径彼此分开的半透膜,该膜对有毒物质是选择性渗透的。 过滤装置还包括储存器和泵,储存器沿着膜和第二入口之间的第二流体流动路径定位。 将过滤装置插入到患者体内,使其完全被患者包围,过滤装置与患者的血管连接,使得来自动脉的血液沿着第一流体流动路径分流。 第二流体流路的出口端连接到患者的膀胱。 第二流体流动路径的入口端设置在患者的皮肤表面,以便能够利用工作流体对储存器进行周期性重新填充。 当将过滤装置安装在患者体内时,泵被操作以沿着第二流体流动路径将工作流体从储存器传送到患者的膀胱,同时血液沿着第一流体流动路径流动,由此能够转移有毒的 物质从患者的血液通过膜到第二流体流动路径中的工作流体。
    • 44. 发明授权
    • Laparoscopic and endoscopic instrument guiding method and apparatus
    • 腹腔镜和内窥镜仪器引导方法和装置
    • US5386818A
    • 1995-02-07
    • US59629
    • 1993-05-10
    • Cary W. SchneebaumPeter J. Wilk
    • Cary W. SchneebaumPeter J. Wilk
    • A61B1/018A61B1/313A61B10/00A61B10/06A61B17/00A61B17/22A61B17/28A61B1/00
    • A61B1/3132A61B1/018A61B10/06A61B2017/003A61B2017/22072A61B2017/2905A61B2017/2927
    • In an endoscopic or laparoscopic instrument assembly, an elongate tubular instrument guide is inserted into a biopsy channel of an endoscope or laparoscope. The tubular instrument guide is provided with a distal end portion having a spring bias tending to form the distal end portion into an arcuate configuration. The tubular instrument guide is longitudinally slidable in the biopsy channel, whereby the distal end portion may be alternately maintained in a relatively straightened configuration in a distal end of the biopsy channel and moved outside of the biopsy channel to assume the arcuate configuration. An elongate flexible endoscopic or laparoscopic instrument is slidably inserted into the tubular instrument guide so that an operative tip at a distal end of the instrument may project outwardly from the distal end portion upon an ejection of at least a part of the distal end portion of the tubular instrument guide from the biopsy channel.
    • 在内窥镜或腹腔镜仪器组件中,将细长的管状器械引导件插入到内窥镜或腹腔镜的活检通道中。 管状仪器引导件设置有具有倾斜以形成弓形构造的远端部分的弹簧偏压的远端部分。 管状器械引导件可在活检通道中纵向滑动,由此远端部分可以在活检通道的远端中交替地保持相对矫直的构造,并移动到活检通道的外部以呈现弓形构型。 细长的柔性内窥镜或腹腔镜器械可滑动地插入到管状器械引导件中,使得当器械的远端部分的至少一部分的弹出时,器械的远端处的操作尖端可从远端部分向外突出 来自活检通道的管状仪器指导。
    • 46. 发明授权
    • Method and apparatus for inhibiting catheter sepsis
    • 抑制导管脓毒症的方法和装置
    • US5338308A
    • 1994-08-16
    • US85748
    • 1993-06-30
    • Peter J. Wilk
    • Peter J. Wilk
    • A61M25/02
    • A61M25/02A61M2025/0266Y10S128/26
    • An assembly for inhibiting catheter sepsis comprises an intravenous catheter inserted through a skin surface at an insertion point, a patch attached to the skin surface about the insertion point so as to cover a region of the skin surface and a segment of the catheter at the skin surface, and an ancillary tube having a distal end portion disposed between the patch and the skin surface upon an application of the patch to the skin surface. In the distal end portion, the ancillary tube has an outlet port which is located between the patch and the skin surface upon application of the patch to the skin surface. The ancillary tube has an inlet port spaced in a proximal direction from the outlet port so that the inlet port is accessible via a needle upon application of the patch to the skin surface.
    • 用于抑制导管败血症的组件包括插入穿过皮肤表面的插入点的静脉导管,围绕插入点附接到皮肤表面的贴片,以覆盖皮肤表面的一部分和皮肤的导管部分 表面和辅助管,其中在将贴片施加到皮肤表面上时,其具有设置在贴片和皮肤表面之间的远端部分。 在远端部分中,辅助管具有出口端口,当将贴片施加到皮肤表面时,该出口端口位于贴片和皮肤表面之间。 辅助管具有从出口端口沿近端方向隔开的入口端口,使得当将贴片施加到皮肤表面时,入口端口可通过针头接近。
    • 50. 发明授权
    • Method and device for obtaining continued transdermal access
    • 用于获得持续经皮摄取的方法和装置
    • US5282788A
    • 1994-02-01
    • US853987
    • 1992-03-20
    • Peter J. WilkNaomi L. Nakao
    • Peter J. WilkNaomi L. Nakao
    • A61M1/00A61M25/04A61M25/06A61M31/00
    • A61M1/0062A61M25/04A61M25/06A61M27/00A61M1/0009A61M2202/048
    • An assembly for use in drainage of an abscess comprises an outer tubular member provided in a distal end portion with a plurality of longitudinal slits. The distal end portion of the tubular member has a spring bias tending to form the distal end portion into a substantially spherical expanded configuration to anchor the distal end portion of the tubular member in an abscess. An inner tubular member or obturator is inserted into the outer tubular member and has a distal end provided with a cutting edge projecting from the outer tubular member. Locking components on the obturator and the outer tubular member serve to maintain the latter in a stretched out cylindrical configuration enabling insertion of the distal end portion into an abscess. A needle on the distal end of the tubular member serves to inject a quantity of anesthetic into the patient at the abscess site. A similar structure is disclosed in an intravenous catheter assembly.
    • 用于引流脓肿的组件包括设置在具有多个纵向狭缝的远端部分中的外管状构件。 管状构件的远端部分具有弹簧偏置,倾向于将远端部分形成为大致球形的扩张构型,以将管状构件的远端部分锚定在脓肿中。 内部管状构件或闭塞器插入到外部管状构件中,并且具有设置有从外部管状构件突出的切削刃的远端。 在闭塞器和外部管状构件上的锁定部件用于将后者保持在伸出的圆柱形构造中,从而能够将远端部分插入脓肿。 在管状构件的远端上的针用于在脓肿部位向患者注入一定量的麻醉剂。 在静脉导管组件中公开了类似的结构。