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41. 发明授权

US06696301B2 Method for determination of 5-hydroxycreatinine 失效
标题翻译： 5-羟基肌氨酸的测定方法
公开(公告)号：US06696301B2
公开(公告)日：2004-02-24
申请号：US09968823
申请日：2001-10-02
申请人： Ko Nakamura , Katsumi Kawano
发明人： Ko Nakamura , Katsumi Kawano
IPC分类号： G01N3300
CPC分类号： C07D233/88 , Y10S436/811 , Y10S436/815 , Y10T436/17 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides a highly sensitive and practical method for the determination of and the separation of 5-hydroxycreatinine from a sample of bodily fluid. The method of the present invention is useful as a method for the testing of renal dysfunction, such as uremia, chronic nephritis and closure of the urinary tract, etc. A separation solvent of pH 4.1 to 4.6 is used in a high performance liquid chromatography step that is carried out using a strongly acidic cation-exchange resin, such as a styrene-divinylbenzene resin. The determination sensitivity is a concentration of only about 0.02 &mgr;M, whereby 5-hydroxycreatinine in blood of healthy persons can be determined for the first time. Moreover, only one separation solvent, such as a citrate, need be used and the cycle time for analysis is only about 14 minutes per measurement. Thus, a practitioner using one set of HPLC equipment is able to carry out about 100 determinations per day.
摘要翻译：本发明提供了用于从体液样品中测定和分离5-羟基肌氨酸的高灵敏度和实用的方法。本发明的方法可用作肾功能障碍如尿毒症，慢性肾炎和尿路闭塞等的测试方法。在高效液相色谱步骤中使用pH 4.1至4.6的分离溶剂其使用强酸性阳离子交换树脂如苯乙烯 - 二乙烯基苯树脂进行。测定灵敏度仅为0.02微克浓度，可以首次测定健康人血液中的5-羟基肌氨酸。此外，仅需要使用一种分离溶剂，例如柠檬酸盐，并且每次测量的分析循环时间仅为约14分钟。因此，使用一套HPLC设备的从业者能够每天进行约100次测定。

42. 发明授权

US5446021A Agricultural and horticultural compositions inducing resistance in plants against salt- and water-stress 失效
标题翻译：农业和园艺组合物在植物中诱导抗盐胁迫和水分胁迫
公开(公告)号：US5446021A
公开(公告)日：1995-08-29
申请号：US240534
申请日：1994-05-10
申请人： Masaharu Kurohashi , Ko Nakamura , Kazuharu Ienaga
发明人： Masaharu Kurohashi , Ko Nakamura , Kazuharu Ienaga
IPC分类号： A01N43/90 , C07K5/12 , A61K38/12
CPC分类号： A01N43/90 , C07K5/12
摘要： The present invention relates to an agricultural and horticultural composition inducing resistance in plants against salt- and water-stresses which comprises as an active ingredient an effective amount of at least one cyclic dipeptide of the following formula (I) or an agriculturally or horticulturally acceptable salt thereof; ##STR1## wherein each of R.sub.1 and R.sub.2, which may be the same or different, is a hydrogen atom or lower alkyl group, or R.sub.1 and R.sub.2 are joined to form pyrrolidine ring which may optionally have hydroxy group, and R.sub.3 is a hydrogen atom or hydroxy group.
摘要翻译：本发明涉及一种诱导植物对抗盐胁迫和水分胁迫的抗性的农业和园艺组合物，其包含作为活性成分的有效量的至少一种下式（I）的环状二肽或农业上或园艺上可接受的盐的; （I）其中R 1和R 2可以相同或不同，其中R 1和R 2各自为氢原子或低级烷基，或R 1和R 2连接形成可任选具有羟基的吡咯烷环，R 3为氢原子或羟基。

43. 发明授权

US4683240A Pharmaceutical composition containing an imidazolidinetrione derivative or pharmaceutically acceptable salt thereof 失效
标题翻译：含有咪唑啉四酮衍生物或其药学上可接受的盐的药物组合物
公开(公告)号：US4683240A
公开(公告)日：1987-07-28
申请号：US826607
申请日：1986-02-06
申请人： Kazuharu Ienaga , Ko Nakamura , Akira Ishii
发明人： Kazuharu Ienaga , Ko Nakamura , Akira Ishii
IPC分类号： A61K31/415 , C07D233/96
CPC分类号： C07D233/96 , A61K31/415 , Y10S514/824 , Y10S514/866
摘要： Pharmaceutical compositions containing imidazolidinetrione derivatives or pharmaceutically acceptable salts thereof having hypoglycemic and hypolipidemic effects. The compositions comprise as an active ingredient at least one imidazolidinetrione derivative of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2, which may be the same or different, is hydrogen, an alkyl group, a cycloalkyl group or ##STR2## and each of R.sub.3 and R.sub.4, which may be the same or different, is hydrogen, halogen, a nitro group, a lower alkyl group or a lower alkoxy group.
摘要翻译：含有具有低血糖和降血脂作用的咪唑烷四酮衍生物或其药学上可接受的盐的药物组合物。所述组合物包含至少一种下式的咪唑烷四酮衍生物作为活性成分：其中R 1和R 2可以相同或不同，分别为氢，烷基，环烷基或者每个可以相同或不同的R 3和R 4是氢，卤素，硝基，低级烷基或低级烷氧基。

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