专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明公开

EP1819341A4 IL-12 MODULATORY COMPOUNDS 审中-公开
标题翻译： IL-12-调节化合物
公开(公告)号：EP1819341A4
公开(公告)日：2011-06-29
申请号：EP05820870
申请日：2005-11-10
申请人： SYNTA PHARMACEUTICALS CORP
发明人： SUN LIJUN , KOSTIK ELENA , PRZEWLOKA TERESA , NG HOWARD P , CHIMMANAMADA DINESH , DEMKO ZACHARY
IPC分类号： A61K31/535 , A61P37/00 , C07D239/42 , C07D239/46 , C07D239/48 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D403/12 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14

42. 发明公开

EP1556140A4 NOVEL COMPOUNDS 审中-公开
标题翻译： NEUE VERBINDUNGEN
公开(公告)号：EP1556140A4
公开(公告)日：2006-04-19
申请号：EP03776373
申请日：2003-10-14
申请人： SYNTA PHARMACEUTICALS CORP
发明人： SUN LIJUN , ONO MITSUNORI , WADA YUMIKO , YING WEIWEN , PRZEWLOKA TERESA , KOSTIK ELENA
IPC分类号： A61P19/02 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P3/10 , A61P17/06 , C07D473/16 , C07D473/18 , C07D473/34
CPC分类号： C07D473/34 , C07D473/16 , C07D473/18
摘要： This invention features a compound of formula (I): R1 is aryl or heteroaryl; each of R2 and R4, independently, is H, halogen, CN, alkyl, ORa, or NRaRb; R3 is H, halogen, CN, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, ORa, OC(O)Ra, OC(O)NRaRb, NRaRb, NRaC(O)Rb, NRaS(O)Rb, NRaS(O)2Rb, NRaC(O)NRbRc NRaC(S)NRbR°, NRaC(NRb)NRcRd, NRaC(O)ORb, S(O)NTRaRt, S(O)2NRSRb, S(O)Ra, S(O)2Ra, C(O)Ra, C(O)ORa, or C(O)NRaRl; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; A is 0, S, S(O), S(O)2, or NW; B is N or CRC; X is 0, S, S(O), S(O)2, NR, or C(O); Y is a covalent bond, C(O), C=NR a, O, S, S(O), S(O)2, or NW; Z is N or CH; each of U and V, independently, is N or CR; and W is 0, S, or NR'; in which each of Ra, Rb, Re, and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl; Re is H, alkyl, aryl, acyl, or sufonyl; and Rf is H, alkyl., aryl, acyl, sulfonyl, alkoxyl, amino, ester, amide, CN, or halogen. The compound is useful for treating an interleukin- 12 overproduction-related disorder.
摘要翻译：本发明的特征在于式（I）的化合物：R 1是芳基或杂芳基; R 2和R 4中的每一个独立地为H，卤素，CN，烷基，ORa或NRaRb; （O）R a，OC（O）NR a R b，NR a R b，NR a C（O）R b，NR a S（O）R b，其中R b是H，卤素，CN，烷基，烯基，炔基，芳基，杂芳基，（O）2Rb，NRaC（O）NRbRc，NRaC（S）NRbR°，NRaC（NRb）NRcRd，NRaC（O）ORb，S（O）NTRaRt，S（O）2NRSRb，S（O）Ra，S O）2Ra，C（O）R a，C（O）ORa或C（O）NR a R 1; R5是H或烷基; n是0,1,2,3,4,5或6; A是O，S，S（O），S（O）2或NW; B是N或CRC; X是O，S，S（O），S（O）2，NR或C（O）; Y是共价键，C（O），C = NR a，O，S，S（O），S（O）2或NW; Z是N或CH; U和V中的每一个独立地是N或CR; 和W是0，S或NR'; 其中Ra，Rb，Re和Rd中的每一个独立地为H，烷基，芳基，杂芳基，环基或杂环基; Re是H，烷基，芳基，酰基或磺酰基; Rf为H，烷基，芳基，酰基，磺酰基，烷氧基，氨基，酯，酰胺，CN或卤素。该化合物可用于治疗白介素-12过量产生相关疾病。

43. 发明专利

HRP20140704T1 SPOJEVI TRIAZOLA KOJI MODULIRAJU HSP90 AKTIVNOST 未知
公开(公告)号：HRP20140704T1
公开(公告)日：2014-11-21
申请号：HRP20140704
申请日：2014-07-22
申请人： SYNTA PHARMACEUTICALS CORP
发明人： YING WEIWEN , PRZEWLOKA TERESA , CHAE JUNGHYUN , ZHANG SHIJIE , HAO LI , DU ZHENJIAN , JAMES DAVID , CHIMMANAMADA DINESH U , NG HOWARD P , FOLEY KEVIN , DEMKO ZACHARY , SUN LIJUN , ZHOU DAN , QIN SHUZHEN
IPC分类号： C07D249/12 , A61K31/4196 , A61P35/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04

44. 发明专利

DK2035396T3 TRIAZOLFORBINDELSER DER MODULERER HSP90-AKTIVITET 未知
公开(公告)号：DK2035396T3
公开(公告)日：2014-06-02
申请号：DK07795379
申请日：2007-05-25
申请人： SYNTA PHARMACEUTICALS CORP
发明人： YING WEIWEN , NG HOWARD P , PRZEWLOKA TERESA , CHAE JUNGHYUN , ZHANG SHIJIE , LI HAO , DU ZHENJIAN , CHIMMANAMADA DINESH U , FOLEY KEVIN , DEMKO ZACHARY , SUN LIJUN , ZHOU DAN , QIN SHUZHEN , JAMES DAVID
IPC分类号： C07D249/12 , A61K31/4196 , A61P35/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04

45. 发明专利

MX2009008547A COMPUESTOS DE TRIAZOL QUE SON UTILES EN EL TRATAMIENTO DE TRASTORNOS PROLIFERATIVOS TALES COMO CANCER. 未知
公开(公告)号：MX2009008547A
公开(公告)日：2010-01-15
申请号：MX2009008547
申请日：2008-02-08
申请人： SYNTA PHARMACEUTICALS CORP
发明人： SUN LIJUN , PRZEWLOKA TERESA , ZHANG SHIJIE , YING WEIWEN , JAMES DAVID , DEMKO ZACHARY , CHIMMANAMADA DINESH U , BURLISON JOSEPH A , SCHWEIZER STEFAN MICHAEL
IPC分类号： C07D249/08
摘要： La presente invención se refiere a compuestos de triazol sustituidos y composiciones que comprenden compuestos de triazol sustituidos; la invención además se refiere a métodos para inhibir la actividad de Hsp9O en un sujeto que necesita los mismos y métodos para prevenir o tratar trastornos hiperproliferativos, tales como cáncer, en un sujeto que necesita los mismos, que comprenden administrar al sujeto un compuesto de triazol sustituido de la invención, o una composición que comprende dicho compuesto.

46. 发明专利

CA2695995A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 未知
公开(公告)号：CA2695995A1
公开(公告)日：2009-02-19
申请号：CA2695995
申请日：2008-08-13
申请人： SYNTA PHARMACEUTICALS CORP
发明人： YING WEIWEN , SUN LIJUN , KOYA KEIZO , CHIMMANAMADA DINESH U , ZHANG SHIJIE , PRZEWLOKA TERESA , LI HAO
IPC分类号： C07F9/6518 , A61K31/4196 , A61K31/5355 , C07F9/6558
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

47. 发明专利

AU2008232354A1 Triazinone and diazinone derivatives useful as Hsp90 inhibitors 未知
公开(公告)号：AU2008232354A1
公开(公告)日：2008-10-02
申请号：AU2008232354
申请日：2008-03-24
申请人： SYNTA PHARMACEUTICALS CORP
发明人： FOLEY KEVIN , LEE CHI-WAN , SONG MINGHU , YING WEIWEN , QIN SHUZHEN , ZHOU DAN , DU ZHENJIAN , PRZEWLOKA TERESA
IPC分类号： C07D239/10 , A61K31/4168 , A61K31/4196 , C07D249/12

48. 发明专利

AU2007267859A1 Triazole compounds that modulate Hsp90 activity 未知
公开(公告)号：AU2007267859A1
公开(公告)日：2007-12-06
申请号：AU2007267859
申请日：2007-05-25
申请人： SYNTA PHARMACEUTICALS CORP
发明人： CHIMMANAMADA DINESH U , JAMES DAVID , SUN LIJUN , ZHANG SHIJIE , QIN SHUZHEN , DEMKO ZACHARY , PRZEWLOKA TERESA , FOLEY KEVIN , DU ZHENJIAN , NG HOWARD P , LI HAO , ZHOU DAN , YING WEIWEN , CHAE JUNGHYUN
IPC分类号： C07D249/12 , A61K31/4196 , A61P35/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

49. 发明专利

MX2007005940A COMPUESTOS DE TRIAZOL QUE MODULAN LA ACTIVIDAD HSP90. 未知
公开(公告)号：MX2007005940A
公开(公告)日：2007-06-19
申请号：MX2007005940
申请日：2005-11-17
申请人： SYNTA PHARMACEUTICALS CORP
发明人： NG HOWARD P , PRZEWLOKA TERESA , ZHANG SHIJIE , KOSTIK ELENA , YING WEIWEN , JAMES DAVID , CHAE JUNGHYUN , CHIMMANAMADA SINESH U , LEE CHI-WAN , FOLEY KEVIN , DU ZHENJIAN , BARSOUM JAMES
IPC分类号： A61K31/00 , C07D249/12 , A61P35/00 , C07D401/04 , C07D403/04 , C07D405/04
摘要： La presente invencion se refiere a compuestos de triazol sustituidos y a composiciones que comprenden compuestos de triazol sustituidos. La invencion se refiere asimismo a metodos para inhibir la actividad de Hsp90 en un sujeto que lo necesita y a metodos para prevenir o tratar trastornos hiperproliferativos, como el cancer, en un sujeto que lo necesita que comprende la administracion a dicho sujeto de un compuesto de triazol segun la invencion o una composicion que comprende dicho compuesto.

50. 发明专利

CA2545340A1 FUSED HETEROCYCLIC COMPOUNDS 未知
公开(公告)号：CA2545340A1
公开(公告)日：2005-05-26
申请号：CA2545340
申请日：2004-11-10
申请人： SYNTA PHARMACEUTICALS CORP
发明人： LI HAO , PRZEWLOKA TERESA , DEMKO ZACHARY , CHIMMANAMADA DINESH , WADA YUMIKO , SUN LIJUN , ONO MITSUNORI
IPC分类号： A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/541 , C07D239/84 , C07D239/88 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/04 , C07D413/14 , C07D471/04 , C07D475/06 , C07D491/04
摘要： This invention provides fused heterocyclic compounds, pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12 related disease and disorders.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式