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41. 发明专利

JPH10236963A CALCIUM CHANNEL ANTAGONIST 失效
公开(公告)号：JPH10236963A
公开(公告)日：1998-09-08
申请号：JP4178797
申请日：1997-02-26
申请人： SAGAMI CHEM RES
发明人： KAMIMURA DAISUKE , YAMADA KAORU
IPC分类号： A61K35/24 , A61K35/38 , A61K35/55 , A61P9/00 , A61P9/12 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To obtain the subject new antagonist inhibiting inflow of calcium to cell by using an extract of salivary gland of shrew as an active ingredient. SOLUTION: This antagonist contains an extract of salivary gland of shrew as an active ingredient. An insectivore such as Sorex unguiculatus Dobson or Sorex shinto saevus Thomas is exemplified as the shrew. A lower alcohol such as ethanol or ketone such as acetone is exemplified as organic solvent used for extraction. When an auxiliary for production such as excipient and disintegrator is used, formulating amount of an extract of salivary gland is preferably 0.2-10wt.%. The daily dose of the extract is preferably 1-1,000mg when an adult is treated as the concentrate of the extract and the extract is preferably administered in 2-3 divided portions.

42. 发明专利

JPH0967211A AGENT FOR INHIBITING PROLIFERATION OF ADHESIVE BACTERIUM CONTAINING BENZOIC ACID DERIVATIVE AS ACTIVE COMPONENT 失效
公开(公告)号：JPH0967211A
公开(公告)日：1997-03-11
申请号：JP22486395
申请日：1995-09-01
申请人： SAGAMI CHEM RES
发明人： KAMIMURA DAISUKE , YAMADA AKIHIRO , YAZAWA KAZUYOSHI , TSUZUKI HITOMI
IPC分类号： A01N37/10
摘要： PROBLEM TO BE SOLVED: To obtain an agent for inhibiting the proliferation of adhesive bacteria by using a specific compound exhibiting a remarkable growth inhibiting activity in vitro against adhesive bacterium causing biological fouling. SOLUTION: This agent contains benzoic acid or its derivative expressed by the formula (R and R are each independently H, an alkyl, an alkoxy, OH, a halogen or nitro) as an active component. Examples of the compound of the formula are 2-nitrobenzoic acid, 2-chlorobenzoic acid, 2,4-dichlorobenzoic acid, anthranylic acid, salicylic acid and 3-hydroxybenzoic acid. Among these compounds, salicylic acid exhibits strong proliferation inhibiting activity against Rhodospirillum sarexigens. The adhesive bacterium is e.g. Rhodospirillum, Cyclobacterium or Hyphomicrobium.

43. 发明专利

JPH08245625A NEW LACTAM 失效
公开(公告)号：JPH08245625A
公开(公告)日：1996-09-24
申请号：JP4952295
申请日：1995-03-09
申请人： SAGAMI CHEM RES
发明人： KAMIMURA DAISUKE , YAMADA KAORU , TSUJI TOMOKO
IPC分类号： C12P17/18 , A61K31/40 , A61P35/00 , C07D487/08 , C12R1/465
摘要： PURPOSE: To obtain the subject lactam expressed by a specific formula, having growth-inhibiting activity against a mouse lymphemia cell, easily and steadily producible from a microorganism and useful as an antitumor agent, etc. CONSTITUTION: This lactam is expressed by the formula (R is H or a protecting group of OH; R and R are each H or a lower alkyl). The lactam can be obtained e.g. by culturing a marine actinomyces, especially a microorganism belonging to Streptomyces (FERM-P-13915) in a 3/4-concentration artificial seawater medium (pH7.4) at 35 deg.C for 7 days under aerobic conditions and extracting the cultured microbial bodies or the supernatant of the cultured mixture with an organic solvent (e.g. chloroform) followed by separation by chromatography.

44. 发明专利

JPH07304667A VENOUS CELL ADHESIVE MOLECULE-1 PRODUCTION INHIBITOR 失效
公开(公告)号：JPH07304667A
公开(公告)日：1995-11-21
申请号：JP9623794
申请日：1994-05-10
申请人： SAGAMI CHEM RES
发明人： KAMIMURA DAISUKE , YAMADA KAORU , RI HEIRITSU , NUMAO OSANORI
IPC分类号： C07D493/14 , A61K31/165 , A61K31/365 , A61P9/10 , A61P29/00 , A61P35/00 , A61P37/06
摘要： PURPOSE:To obtain a new medicinal agent presenting no cytotoxicity, highly inhibiting the production of venous cell adhesive molecule-1 (VCAM-1) by human venous endothelial cells, thus useful as a metastasis inhibitor, anti-inflammatory agent, medicine for e.g. arteriosclerosis. CONSTITUTION:This VCAM-1 production inhibitor contains, as active ingredient, jolkinolide B of formula I or an alaninol derivative of formula II. The jolkinolide B of formula I is obtained by isolation from Euphorbia jolkini Boiss. followed by purification, the alaninol derivative of formula II from Euphorbia fischeriana Steud. The dose of the above compounds each is normally about 0.01-500mg/kg a day, and it is preferable that these compounds each be contained, as the active ingredient, at ca.0.01-99.99wt.% in the corresponding preparation.

45. 发明专利

JPH07300481A NOVEL COMPOUND D ORIGINATING FROM PINNA 失效
公开(公告)号：JPH07300481A
公开(公告)日：1995-11-14
申请号：JP14621594
申请日：1994-06-28
申请人： SAGAMI CHEM RES
发明人： KAMIMURA DAISUKE , SHIYUU TOU , HAINO TAKEHARU
IPC分类号： C07D491/22 , A61K31/55 , A61K35/56 , A61K35/618 , A61P35/00
摘要： PURPOSE:To obtain a new compound which originates from Pinna shells and can be expected to be usefulness as an anti-tumor agent because it has a strong proliferation-inhibitory effect against mouse lymphocytic leukemia cells P388, a cancer cell. CONSTITUTION:The compound originating from pinna plants has partial structures of formula I and formula II and a compositional formula, C45H67NO10, preferably has a structural formula of formula IV. The compound preferably has 781 molecular weight and is positive to the Dragendorff's test. The compound is obtained by breaking finely and extracting internal organs of shells in Pinna (SUEHIRO GAI) in an organic solvent and subjected to chromatography.

46. 发明专利

JPH06199867A NEW ZOANTHAMINE DERIVATIVE 失效
公开(公告)号：JPH06199867A
公开(公告)日：1994-07-19
申请号：JP8388793
申请日：1993-03-19
申请人： SAGAMI CHEM RES
发明人： KAMIMURA DAISUKE , NAGATSU AKITO , YAMADA KAORU
IPC分类号： A61K31/435 , A61P35/00 , C07D498/22
摘要： PURPOSE:To obtain the subject new compounds, capable of manifesting in vitro inhibiting activity against the proliferation of a cancerous cell P388 and useful as an antitumor agent. CONSTITUTION:This compounds of formulas I to III (R is H or OH-protecting group), e.g. cyclozoanthamine of formula IV. The compounds of formulas I to III are obtained by pulverizing a coelenterate, e.g. a zoanthidean polyp of the genus Zoanthus in an organic solvent, extracting the compounds therefrom and further separating the extracted compounds by chromatography.

47. 发明专利

JPH05213988A NEW SESTERTERPENOID 失效
公开(公告)号：JPH05213988A
公开(公告)日：1993-08-24
申请号：JP4044592
申请日：1992-01-31
申请人： SAGAMI CHEM RES
发明人： KAMIMURA DAISUKE , YAMADA KAORU
IPC分类号： A61K31/56 , A61P35/00 , C07J73/00
摘要： PURPOSE:To obtain a new sesterterpenoid exhibiting in vitro proliferation- inhibiting activity to mouse lymphogenous leukemic cell P388, reduced in side effects and expected in utilization as an antitumo agent by extracting and purifying a sponges Porifera. CONSTITUTION:Ircinia fasciculata which is a kind of sponges Porifera is finely cut with scissors and mixed with ethanol and pulverized with a blender and the resultant immersed liquid is cooled in the immersed state for 10 day and then filtered while sucking with Buchner funnel and brawn filtrate is concentrated with a rotary evaporator under reduced pressure and water is added to the concentrate and the concentrate is extracted with ethyl acetate and the ethyl acetate layer is concentrated to afford a black oily crude extract, which is then purified by a silica gel column chromatography, etc., to provide the objective new sesterterpenoid expressed by the formula (R is H or protecting group of hydroxyl group), exhibiting in vitro proliferation-inhibiting activity to cancer cell P388 and expected for utilization as an antitumor agent.

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