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41. 发明申请

US20080207552A1 Decoy compositions for treating and preventing brain diseases and disorders 审中-公开
标题翻译：用于治疗和预防脑部疾病和疾病的诱饵组合物
公开(公告)号：US20080207552A1
公开(公告)日：2008-08-28
申请号：US11982970
申请日：2007-11-05
申请人： Yoshiki Sawa , Ryuichi Morishita , Yasufumi Kaneda , Hikaru Matsuda , Toshiki Yoshimine
发明人： Yoshiki Sawa , Ryuichi Morishita , Yasufumi Kaneda , Hikaru Matsuda , Toshiki Yoshimine
IPC分类号： A61K31/7088 , A61P9/10
CPC分类号： A61K9/0019 , A61K9/127 , A61K31/711 , A61K48/005 , A61K48/0075 , C07K14/4705 , C12N15/1131 , C12N15/115 , C12N15/86 , C12N2310/13 , C12N2310/315 , C12N2760/18811
摘要： The present invention provides introduction of NF-κB decoy oligodeoxynucleotide into rat cranial nerve through a carotid artery during global brain ischemia. Polymerase chain reaction demonstrated that one hour after global brain ischemia, transfected NF-κB decoy oligodeoxynucleotide effectively suppressed expression of tumor necrosis factor α, interleukin 1β and intracellular adhesion molecule 1 messenger RNAs. Terminal deoxynucleotidyl transferase-mediated deoxyuridine nick-end labeling staining and immunohistochemistry using microtubule-associated protein 2 demonstrated that transfected NF-κB decoy oligodeoxynucleotide significantly attenuated neuronal damage seven days after global brain ischemia. Therapeutic transfection of NF-κB decoy oligodeoxynucleotide during brain ischemia may be effective for attenuation of neuronal damage, suggesting a strategy for protecting the cerebrum from global ischemia.
摘要翻译：本发明提供了在全脑缺血期间通过颈动脉将NF-κB诱饵寡脱氧核苷酸引入大鼠颅神经中。聚合酶链反应表明，全球脑缺血后1小时，转染的NF-κB诱饵寡脱氧核苷酸有效抑制肿瘤坏死因子α，白细胞介素1β和细胞内粘附分子1信使RNA的表达。末端脱氧核苷酸转移酶介导的脱氧尿苷切口末端标记染色和使用微管相关蛋白2的免疫组织化学证实，转染的NF-κB诱饵寡脱氧核苷酸在全脑缺血后7天显着减弱神经元损伤。在脑缺血期间，NF-κB诱饵寡脱氧核苷酸的治疗转染对于减少神经元损伤可能是有效的，这表明保护大脑免受全身缺血的策略。

42. 发明申请

US20070293447A1 Gene Therapy for Skin Disorders Using Needleless Syringes 审中-公开
标题翻译：使用无针注射器进行皮肤疾病的基因治疗
公开(公告)号：US20070293447A1
公开(公告)日：2007-12-20
申请号：US10570052
申请日：2004-08-27
申请人： Yasuo Kunugiza , Naruya Tomita , Hideki Yoshikawa , Yoshiaki Taniyama , Katsuto Tamai , Ryuichi Morishita
发明人： Yasuo Kunugiza , Naruya Tomita , Hideki Yoshikawa , Yoshiaki Taniyama , Katsuto Tamai , Ryuichi Morishita
IPC分类号： A61K31/70 , A61P17/02
CPC分类号： A61K9/0024 , A61K31/7088 , A61K48/0075
摘要： The present invention provides highly useful clinical methods for treating skin disorders, particularly intractable skin disorders. Specifically, the methods comprise injecting/subcutaneously introducing a 10 μg to 10 mg dose of a polynucleotide, such as a DNA, oligonucleotide, RNA, siRNA, and antisense, around a lesion associated with a skin disorder, such as a wound, cutaneous ulcer, or psoriasis, using a needleless syringe that injects a pharmaceutical liquid by using gas pressure or the elastic force of an elastic member to drive a piston.
摘要翻译：本发明提供用于治疗皮肤病症，特别是顽固性皮肤病症的非常有用的临床方法。具体地说，所述方法包括将注射/皮下注射10μg至10mg剂量的多核苷酸，例如DNA，寡核苷酸，RNA，siRNA和反义，在与皮肤病症如伤口，皮肤溃疡相关的病变周围或牛皮癣，使用无针注射器，其通过使用气体压力或弹性构件的弹力来驱动活塞而喷射药液。

43. 发明申请

US20060074036A1 Agents for gene therapy of cerebrovascular disorders 审中-公开
标题翻译：用于脑血管障碍基因治疗的药剂
公开(公告)号：US20060074036A1
公开(公告)日：2006-04-06
申请号：US10517154
申请日：2003-06-03
申请人： Ryuichi Morishita , Munehisa Shimamura
发明人： Ryuichi Morishita , Munehisa Shimamura
IPC分类号： A61K48/00 , A61K9/127
CPC分类号： A61K38/1833 , A61K48/00
摘要： The present invention provides novel methods for treating cerebrovascular disorders, in which HGF is overexpressed by introducing an HGF gene. The methods of this invention using an HGF gene enable active treatment of cerebrovascular disorders, such as cerebral infarction, by gene transfer, and enable the maintenance of neuronal function and the suppression of infarcted areas in patients for whom appropriate treatment methods were unavailable until now.
摘要翻译：本发明提供治疗脑血管障碍的新方法，其中HGF通过引入HGF基因而过表达。使用HGF基因的本发明的方法能够通过基因转移来有效治疗脑血管障碍，例如脑梗死，并且能够维持神经功能，并抑制患有适当治疗方法的患者的梗死区域。

44. 发明授权

US06936594B1 Gene therapy for cerebrovascular disorders 有权
标题翻译：基因治疗脑血管障碍
公开(公告)号：US06936594B1
公开(公告)日：2005-08-30
申请号：US09856374
申请日：2000-09-18
申请人： Ryuichi Morishita , Toshio Ogihara
发明人： Ryuichi Morishita , Toshio Ogihara
IPC分类号： A61K38/18 , A61K38/19 , A61K48/00 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/28 , A61P43/00 , A01N65/00 , A61K9/127 , C12N15/74
CPC分类号： A61K38/1833 , A61K38/1866 , A61K48/00
摘要： By introducing hepatocyte growth factor (HGF) gene and/or vascular endothelial growth factor (VEGF) gene into the subarachnoid space in humans, cerebrovascular disorders such as cerebrovascular obstruction, cerebral infarction, cerebral thrombosis, cerebral embolism, stroke, cerebral bleeding, moyamoya disease, cerebrovascular dementia, and Alzheimer's dementia can be effectively treated or prevented.
摘要翻译：通过将肝细胞生长因子（HGF）基因和/或血管内皮生长因子（VEGF）基因引入人类的蛛网膜下腔内，脑血管障碍如脑血管阻塞，脑梗塞，脑血栓形成，脑栓塞，中风，脑出血，moyamoya病，脑血管性痴呆和阿尔茨海默氏痴呆可以有效地治疗或预防。

45. 发明授权

US08647820B2 Circular dumbbell decoy oligodeoxynucleotides (CDODN) containing DNA bindings sites of transcription 有权
标题翻译：圆形哑铃诱饵寡脱氧核苷酸（CDODN）含有DNA结合位点的转录
公开(公告)号：US08647820B2
公开(公告)日：2014-02-11
申请号：US13036578
申请日：2011-02-28
申请人： In-Kyu Lee , Ryuichi Morishita
发明人： In-Kyu Lee , Ryuichi Morishita
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04 , A61K38/00
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/13 , C12N2310/53
摘要： The present invention provides a circular dumbbell oligodeoxynucleotide (CDODN) comprising two loop structures and a stem structure, wherein the stem structure comprises a nucleotide sequence capable of binding the DNA-binding domain of a transcriptional factor. The present invention further provides a pharmaceutical composition comprising said CDODN. The pharmaceutical composition can be used for treating and/or preventing a disease or disorder related to such a transcriptional factor. The present invention also provides a method for treating and/or preventing a disease or disorder related to such a transcriptional factor, comprising administering to the subject a therapeutically effective amount of a CDODN comprising two loop structures and a stem structure, wherein the stem structure comprises a nucleotide sequence capable of binding the DNA-binding domain of the transcriptional factor.
摘要翻译：本发明提供了包含两个环结构和茎结构的环状哑铃寡脱氧核苷酸（CDODN），其中所述茎结构包含能够结合转录因子的DNA结合结构域的核苷酸序列。本发明还提供了包含所述CDODN的药物组合物。药物组合物可用于治疗和/或预防与这种转录因子相关的疾病或病症。本发明还提供了用于治疗和/或预防与这种转录因子相关的疾病或病症的方法，包括向受试者施用治疗有效量的包含两个环结构和茎结构的CDODN，其中茎结构包括能够结合转录因子的DNA结合结构域的核苷酸序列。

46. 发明授权

US08372957B2 Antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved 有权
标题翻译：针对骨膜素的抗体，以及包含其用于预防或治疗涉及骨膜素的疾病的药物组合物
公开(公告)号：US08372957B2
公开(公告)日：2013-02-12
申请号：US13198618
申请日：2011-08-04
申请人： Yoshiaki Taniyama , Ryuichi Morishita , Naruto Katsuragi
发明人： Yoshiaki Taniyama , Ryuichi Morishita , Naruto Katsuragi
IPC分类号： C07K16/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/73
摘要： The present invention provides an antibody against a periostin isoform having anti-cell adhesive activity, especially an anti-periostin antibody having the ability to neutralize anti-cell adhesive properties, as well as a prophylactic or therapeutic agent for periostin-related diseases comprising the antibody. The present invention also provides methods for detecting and quantifying the periostin isoform in a sample by using the antibody, as well as a method for diagnosing periostin-related diseases comprising measuring the amount of the periostin isoform by the detection or quantification method.
摘要翻译：本发明提供具有抗细胞粘附活性的抗骨膜素同种型抗体，特别是具有中和抗细胞粘附性能的抗骨膜素抗体，以及包含抗体的骨膜素相关疾病的预防或治疗剂。本发明还提供了通过使用抗体检测和定量样品中骨膜素异构体的方法，以及用于诊断骨膜素相关疾病的方法，包括通过检测或定量方法测量骨膜素同种型的量。

47. 发明申请

US20120058572A1 ANTIBODY AGAINST PERIOSTIN, AND A PHARMACEUTICAL COMPOSITION COMPRISING IT FOR PREVENTING OR TREATING A DISEASE IN WHICH PERIOSTIN IS INVOLVED 有权
标题翻译：抗周期抗体，以及包含其用于预防或治疗周围疾病的疾病的药物组合物
公开(公告)号：US20120058572A1
公开(公告)日：2012-03-08
申请号：US13198618
申请日：2011-08-04
申请人： Yoshiaki TANIYAMA , Ryuichi Morishita , Naruto Katsuragi
发明人： Yoshiaki TANIYAMA , Ryuichi Morishita , Naruto Katsuragi
IPC分类号： G01N33/53 , C12N5/16 , C12P21/08 , C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/73
摘要： The present invention provides an antibody against a periostin isoform having anti-cell adhesive activity, especially an anti-periostin antibody having the ability to neutralize anti-cell adhesive properties, as well as a prophylactic or therapeutic agent for periostin-related diseases comprising the antibody. The present invention also provides methods for detecting and quantifying the periostin isoform in a sample by using the antibody, as well as a method for diagnosing periostin-related diseases comprising measuring the amount of the periostin isoform by the detection or quantification method.
摘要翻译：本发明提供具有抗细胞粘附活性的抗骨膜素同种型抗体，特别是具有中和抗细胞粘附性能的抗骨膜素抗体，以及包含抗体的骨膜素相关疾病的预防或治疗剂。本发明还提供了通过使用抗体检测和定量样品中骨膜素异构体的方法，以及用于诊断骨膜素相关疾病的方法，包括通过检测或定量方法测量骨膜素同种型的量。

48. 发明授权

US07595301B2 Staple type oligonucleotide and drug comprising the same 有权
标题翻译：短链型寡核苷酸和包含其的药物
公开(公告)号：US07595301B2
公开(公告)日：2009-09-29
申请号：US10568226
申请日：2004-09-29
申请人： Yasuo Kunugiza , Naruya Tomita , Hideo Hashimoto , Hideki Yoshikawa , Ryuichi Morishita
发明人： Yasuo Kunugiza , Naruya Tomita , Hideo Hashimoto , Hideki Yoshikawa , Ryuichi Morishita
IPC分类号： A61K48/00 , A61K31/70 , C07H21/02 , C07H21/04
CPC分类号： A61K31/713 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/53 , C12N2320/51
摘要： Conventional oligonucleotides are opened at both ends and thereby unstable. Their stability against catabolic enzymes is increased by phosphorothioate modification, but such phosphorothioate causes toxicity. The present invention provides oligonucleotides and medicaments in which these problems are improved. That is, it provides staple oligonucleotides and medicaments containing the same as the active ingredient. Specifically, it provides transcription factor inhibitors, antisense oligonucleotides and siRNAs. More specifically, it provides agents for preventing, treating or improving inflammation, autoimmune diseases, central diseases, reperfusion injury in ischaemic diseases, worsened prognosis after organ transplantation or organ surgery, or restenosis after PTCA. Further specifically, it provides agents for preventing, treating or improving arthritis, dermatitis, nephritis, hepatitis, renal failure, cystitis, prostatitis, urethritis, ulcerative colitis, Crohn disease, chronic rheumatoid arthritis, osteoarthritis, atopic dermatitis, contact dermatitis, psoriasis, cutaneous ulcer or decubitus.
摘要翻译：常规寡核苷酸在两端开放，从而不稳定。它们对分解代谢酶的稳定性通过硫代磷酸酯修饰而增加，但是这种硫代磷酸酯会引起毒性。本发明提供了改善这些问题的寡核苷酸和药物。也就是说，它提供含有与活性成分相同的主要寡核苷酸和药物。具体来说，它提供转录因子抑制剂，反义寡核苷酸和siRNA。更具体地说，它提供用于预防，治疗或改善炎症，自身免疫性疾病，中枢性疾病，缺血性疾病中的再灌注损伤，器官移植或器官手术后的预后恶化或PTCA后的再狭窄的药剂。更具体地说，它提供预防，治疗或改善关节炎，皮炎，肾炎，肝炎，肾衰竭，膀胱炎，前列腺炎，尿道炎，溃疡性结肠炎，克罗恩病，慢性类风湿性关节炎，骨关节炎，特应性皮炎，接触性皮炎，牛皮癣，皮肤溃疡或褥疮。

49. 发明申请

US20090082263A1 DRUG AND METHOD FOR IMPROVING BRAIN FUNCTION 审中-公开
标题翻译：用于改善脑功能的药物和方法
公开(公告)号：US20090082263A1
公开(公告)日：2009-03-26
申请号：US11658897
申请日：2005-07-29
申请人： Yasufumi Kaneda , Ryuichi Morishita , Munehisa Shimamura
发明人： Yasufumi Kaneda , Ryuichi Morishita , Munehisa Shimamura
IPC分类号： A61K38/18 , A61K31/7088 , C07K14/475
CPC分类号： A61K38/1858 , A01K67/027 , A61K38/1825 , A61K38/1833 , A61K48/00
摘要： It is intended to provide a novel remedy for improving the brain function or preventing the same from worsening and a novel administration method for the remedy. Namely, a composition for preventing the brain function from worsening or improving the brain function which contains a cell growth factor. It is preferred that this cell growth factor is one selected from the group consisting of vascular endothelial growth factors (VEGFs), fibroblast growth factors (FGFs) and hepatocyte growth factors (HGFs). A method for preventing the brain function from worsening or improving the brain function which comprises the step of administering a cell growth factor to a patient.
摘要翻译：旨在提供改善脑功能或防止其相同恶化的新颖的治疗方法以及用于治疗的新型治疗方法。即，用于防止脑功能恶化或改善包含细胞生长因子的脑功能的组合物。优选该细胞生长因子是选自血管内皮生长因子（VEGF），成纤维细胞生长因子（FGF）和肝细胞生长因子（HGF））中的一种。一种防止脑功能恶化或改善脑功能的方法，包括向患者施用细胞生长因子的步骤。

50. 发明申请

US20090074788A1 Antibody Against Periostin, and a Pharmaceutical Composition comprising it for Preventing or Treating a Disease in which Periostin is Involved 有权
标题翻译：抗骨质素的抗体和包含其用于预防或治疗其中涉及骨膜素的疾病的药物组合物
公开(公告)号：US20090074788A1
公开(公告)日：2009-03-19
申请号：US12147331
申请日：2008-06-26
申请人： Yoshiaki Taniyama , Ryuichi Morishita , Naruto Katsuragi
发明人： Yoshiaki Taniyama , Ryuichi Morishita , Naruto Katsuragi
IPC分类号： A61K39/395 , C07K16/00 , G01N33/68 , A61P25/00 , A61P1/18 , A61P31/12 , A61P35/00 , A61P11/00 , A61P9/00 , C12N5/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/73
摘要： The present invention provides an antibody against a periostin isoform having anti-cell adhesive activity, especially an anti-periostin antibody having the ability to neutralize anti-cell adhesive properties, as well as a prophylactic or therapeutic agent for periostin-related diseases comprising the antibody. The present invention also provides methods for detecting and quantifying the periostin isoform in a sample by using the antibody, as well as a method for diagnosing periostin-related diseases comprising measuring the amount of the periostin isoform by the detection or quantification method.
摘要翻译：本发明提供具有抗细胞粘附活性的抗骨膜素同种型抗体，特别是具有中和抗细胞粘附性能的抗骨膜素抗体，以及包含抗体的骨膜素相关疾病的预防或治疗剂。本发明还提供了通过使用抗体检测和定量样品中骨膜素异构体的方法，以及用于诊断骨膜素相关疾病的方法，包括通过检测或定量方法测量骨膜素同种型的量。

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