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41. 发明授权

US08428316B2 Coronary reconstruction from rotational X-ray projection sequence 失效
标题翻译：旋转X射线投影序列冠状动脉重建
公开(公告)号：US08428316B2
公开(公告)日：2013-04-23
申请号：US12275714
申请日：2008-11-21
申请人： Yiyong Sun , Rui Liao , Luc Duong , Frank Sauer , Chenyang Xu
发明人： Yiyong Sun , Rui Liao , Luc Duong , Frank Sauer , Chenyang Xu
IPC分类号： A61B6/03
CPC分类号： G06T7/55 , G06T7/136 , G06T2207/10116 , G06T2207/20044 , G06T2207/30101 , G06T2207/30172
摘要： A method for three-dimensional reconstruction of a branched object from a rotational sequence of images of the branched object includes segmenting the branched object from each image of the sequence, extracting centerlines of the branched object, performing symbolic reconstruction via a stereo correspondence matching between the centerlines from different views of the sequence of images using a graph cut-based optimization, and creating a three-dimensional tomographic reconstruction of the branched object compensated for motion of the branched object between the images of the sequence.
摘要翻译：从分支对象的图像的旋转顺序对分支对象进行三维重建的方法包括从分支对象的每个图像分割分支对象，提取分支对象的中心线，通过在对象之间的立体对应匹配进行符号重建使用基于图切割优化的图像序列的不同视图的中心线，以及创建分支对象的三维断层重建，以补偿分支对象在序列图像之间的运动。

42. 发明申请

US20130060132A1 AUTOMATIC DETECTION OF CONTRAST INJECTION 有权
标题翻译：自动检测对比度注射
公开(公告)号：US20130060132A1
公开(公告)日：2013-03-07
申请号：US13532923
申请日：2012-06-26
申请人： Rui Liao , Yinxiao Liu , Xudong Lv
发明人： Rui Liao , Yinxiao Liu , Xudong Lv
IPC分类号： G06K9/00 , A61B6/00
CPC分类号： A61B6/12 , A61B6/032 , A61B6/469 , A61B6/481 , A61B6/487 , A61B6/503 , A61B6/5264 , A61B8/12 , G06K2209/057 , G06T7/0016 , G06T7/20 , G06T2207/10016 , G06T2207/10121 , G06T2207/30104
摘要： A method for automatically detecting the presence of a contrast agent in an x-ray image includes acquiring a preliminary x-ray image. A background image is estimated. The contrast agent is administered. A plurality of image frames is acquired. The background image is subtracted from each image frame. An image having a highest image intensity is selected. A predefined shape model is fitted to the selected image using a semi-global optimization strategy. The fitting of the shape model is used to fit the shape model to each of the subtracted images. A feature value is calculated for each image frame based on pixel intensities of each pixel fitted to the shape model for the corresponding subtracted image. An image frame of peak contrast is determined by selecting the image frame with the greatest feature value.
摘要翻译：用于自动检测x射线图像中的造影剂的存在的方法包括获取初步x射线图像。估计背景图像。施用造影剂。获取多个图像帧。从每个图像帧中减去背景图像。选择具有最高图像强度的图像。使用半全局优化策略将预定义的形状模型拟合到所选择的图像。形状模型的拟合用于将形状模型拟合到每个相减的图像。基于适合于相应减法图像的形状模型的每个像素的像素强度，针对每个图像帧计算特征值。通过选择具有最大特征值的图像帧来确定峰值对比度的图像帧。

43. 发明申请

US20130058555A1 AUTOMATIC POSE INITIALIZATION FOR ACCURATE 2-D/3-D REGISTRATION APPLIED TO ABDOMINAL AORTIC ANEURYSM ENDOVASCULAR REPAIR 有权
标题翻译：适用于ABDOMINAL AORTIC ANEURYSM ENDOVASCULAR REPAIR的精确二维/三维注册的自动位置初始化
公开(公告)号：US20130058555A1
公开(公告)日：2013-03-07
申请号：US13473049
申请日：2012-05-16
申请人： Shun Miao , Joseph Lucas , Rui Liao
发明人： Shun Miao , Joseph Lucas , Rui Liao
IPC分类号： G06K9/00
CPC分类号： G06K9/00214 , G06K9/6203
摘要： A method for automatically initializing pose for registration of 2D fluoroscopic abdominal aortic images with a 3D model of an abdominal aorta includes detecting a 2D iliac bifurcation and a 2D renal artery bifurcation from a sequence of 2D fluoroscopic abdominal aortic images, detecting a spinal centerline in a 2D fluoroscopic spine image, providing a 3D iliac bifurcation and a 3D renal artery bifurcation from a 3D image volume of the patient's abdomen, and a 3D spinal centerline from the 3D image volume of the patient's abdomen, and determining pose parameters {x, y, z, θ}, where (x, y) denotes the translation on a table plane, z denotes a depth of the table, and θ is a rotation about the z axis, by minimizing a cost function of the 2D and 3D iliac bifurcations, the 2D and 3D renal artery bifurcation, and the 2D and 3D spinal centerlines.
摘要翻译：用于自动初始化用于腹部主动脉3D模型的2D荧光透视腹主动脉图像配准的姿势的方法包括从2D荧光透视腹主动脉图像序列检测2D髂骨分叉和2D肾动脉分叉，检测脊髓中心线 2D透视脊柱图像，从患者腹部的3D图像体积提供3D髂骨分叉和3D肾动脉分叉，以及来自患者腹部的3D图像体积的3D脊柱中心线，以及确定姿势参数{x，y， z，＆thetas;}，其中（x，y）表示平面上的平移，z表示表的深度，＆thetas; 通过最小化2D和3D髂骨分叉，2D和3D肾动脉分叉以及2D和3D脊髓中心线的成本函数，围绕z轴旋转。

44. 发明申请

US20120163686A1 SYSTEM AND METHOD FOR 2-D/3-D REGISTRATION BETWEEN 3-D VOLUME AND 2-D ANGIOGRAPHY 有权
标题翻译：三维体积与二维图像之间二维/三维注册的系统与方法
公开(公告)号：US20120163686A1
公开(公告)日：2012-06-28
申请号：US13222034
申请日：2011-08-31
申请人： Rui Liao , Shun Miao
发明人： Rui Liao , Shun Miao
IPC分类号： G06K9/00
CPC分类号： G06T7/33 , G06T2207/10072 , G06T2207/10124 , G06T2207/20224 , G06T2207/30048
摘要： A method for registering a 2-D DSA image to a 3-D image volume includes calculating a coarse similarity measure between a 2-D DRR of an aorta and a cardiac DSA image, and a 2-D DRR of a coronary artery and the cardiac DSA image, for a plurality of poses over a range of 2-D translations. Several DRR-pose combinations with largest similarity measures are selected as refinement candidates. The similarity measure is calculated between the refinement candidate DRRs and the DSA, for a plurality of poses over a range of 3-D translations and in-plane rotations. One or more DRR-pose combinations with largest similarity measures are selected as final candidates. The similarity measure between the final candidate DRRs the DSA are calculated for a plurality of poses over a range of 3D translations and 3D rotations, and a DRR-pose combination with a largest similarity measure is selected as a final registration result.
摘要翻译：将2-D DSA图像记录到3-D图像体积的方法包括计算主动脉的2-D DRR与心脏DSA图像和冠状动脉的2-D DRR之间的粗略相似性度量，心脏DSA图像，用于在2-D翻译的范围内的多个姿势。选择具有最大相似性度量的几种DRR姿势组合作为细化候选。对于在3D平移和平面内旋转的范围内的多个姿态，在细化候选DRR和DSA之间计算相似性度量。选择具有最大相似性度量的一个或多个DRR姿势组合作为最终候选。在3D平移和3D旋转的范围内针对多个姿态计算最终候选DRR之间的相似性度量，并且选择具有最大相似性度量的DRR姿势组合作为最终注册结果。

45. 发明申请

US20120134553A1 Spatio-Temporal Analysis for Automatic Contrast Injection Detection on Angiography During Trans-Catheter Aortic Valve Implantation 有权
标题翻译：跨导管主动脉瓣植入时血管造影自动对比注射检测的时空分析
公开(公告)号：US20120134553A1
公开(公告)日：2012-05-31
申请号：US13283793
申请日：2011-10-28
申请人： Rui Liao , Michelle Xiaohong Yan , Wei You
发明人： Rui Liao , Michelle Xiaohong Yan , Wei You
IPC分类号： G06K9/00
CPC分类号： G06T7/0016 , G06K2209/05 , G06T2207/10121 , G06T2207/30104
摘要： A method that includes generating a contrast feature curve for a medical image sequence including a plurality of frames, where the contrast feature curve represents contrast feature values of the frames. The method further includes detecting a peak in the contrast feature curve, and determining whether the peak corresponds to at least one of contrast injection in an aortic root, contrast injection in a balloon, and a non-contrast injected region.
摘要翻译：一种方法，其包括生成包括多个帧的医学图像序列的对比度特征曲线，其中所述对比度特征曲线表示所述帧的对比特征值。该方法还包括检测对比度特征曲线中的峰值，以及确定该峰值是否对应于主动脉根部中的对比度注入，气球中的对比度注入和非对比度注入区域中的至少一种。

46. 发明申请

US20110069063A1 CATHETER RF ABLATION USING SEGMENTATION-BASED 2D-3D REGISTRATION 有权
标题翻译：使用基于分段的2D-3D注册的导管射频消除
公开(公告)号：US20110069063A1
公开(公告)日：2011-03-24
申请号：US12821235
申请日：2010-06-23
申请人： Rui Liao , Norbert Strobel , Chenyang Xu
发明人： Rui Liao , Norbert Strobel , Chenyang Xu
IPC分类号： G06T15/00 , G06K9/00 , G06K9/32
CPC分类号： A61B6/5235 , A61B6/487 , A61B6/504 , A61B6/5247 , A61B18/1492 , A61B90/37 , A61B2090/364 , A61B2090/376 , A61B2090/3764 , G06T3/0068 , G06T7/33 , G06T2207/10072 , G06T2207/10121 , G06T2207/20041 , G06T2207/30048
摘要： A method for registering a two-dimensional image of a cardiocirculatory structure and a three-dimensional image of the cardiocirculatory structure includes acquiring a three-dimensional image including the cardiocirculatory structure using a first imaging modality. The acquired three-dimensional image is projected into two-dimensions to produce a two-dimensional projection image of the cardiocirculatory structure. A structure of interest is segmented either from the three-dimensional image prior to projection or from the projection image subsequent to projection. A two-dimensional image of the cardiocirculatory structure is acquired using a second imaging modality. The structure of interest is segmented from the acquired two-dimensional image. A first distance map is generated based on the two-dimensional projection image and a second distance map is generated based on the acquired two-dimensional image. A registration of the three-dimensional image and the two-dimensional image is performed by minimizing a difference between the first and second distance maps.
摘要翻译：用于记录心脏循环结构的二维图像和心脏循环结构的三维图像的方法包括使用第一成像模式获取包括心脏循环结构的三维图像。所获取的三维图像被投影成二维以产生心脏循环结构的二维投影图像。感兴趣的结构或者从投影之前的三维图像或投影之后的投影图像分割。使用第二成像模式获取心脏循环结构的二维图像。感兴趣的结构从获得的二维图像中分割出来。基于二维投影图像生成第一距离图，并且基于所获取的二维图像生成第二距离图。通过最小化第一和第二距离图之间的差异来执行三维图像和二维图像的配准。

47. 发明申请

US20100310140A1 METHOD OF COMPENSATION OF RESPIRATORY MOTION IN CARDIAC IMAGING 有权
标题翻译：心脏成像中呼吸运动的补偿方法
公开(公告)号：US20100310140A1
公开(公告)日：2010-12-09
申请号：US12767908
申请日：2010-04-27
申请人： Matthias Schneider , Hari Sundar , Rui Liao , Chenyang Xu
发明人： Matthias Schneider , Hari Sundar , Rui Liao , Chenyang Xu
IPC分类号： G06K9/00 , G06T15/00
CPC分类号： G06K9/6247 , G06K2209/05 , G06T7/277 , G06T7/35 , G06T2207/10081 , G06T2207/10121 , G06T2207/20081 , G06T2207/30048
摘要： A method (10) for respiratory motion compensation by applying principle component analysis (PCA) on cardiac imaging samples obtained using 2D/3D registration of a pre-operative 3D segmentation of the coronary arteries.
摘要翻译：一种用于呼吸运动补偿的方法（10），其通过对冠状动脉的术前3D分割的2D / 3D登记获得的心脏成像样本应用主成分分析（PCA）。

48. 发明申请

US20100061611A1 CO-REGISTRATION OF CORONARY ARTERY COMPUTED TOMOGRAPHY AND FLUOROSCOPIC SEQUENCE 审中-公开
标题翻译：冠状动脉计算机断层扫描和荧光序列的共同注册
公开(公告)号：US20100061611A1
公开(公告)日：2010-03-11
申请号：US12545922
申请日：2009-08-24
申请人： Chenyang Xu , Hari Sundar , Luc Duong , Rui Liao , Andreas Meyer , Ulrich Bill
发明人： Chenyang Xu , Hari Sundar , Luc Duong , Rui Liao , Andreas Meyer , Ulrich Bill
IPC分类号： G06K9/00 , G06T15/00 , G01N23/00
CPC分类号： G06T19/00 , G06T7/136 , G06T7/187 , G06T7/337 , G06T7/38 , G06T2207/20101 , G06T2207/30101
摘要： A method for displaying real-time imagery of coronary arteries including a chronic total occlusion (CTO) includes acquiring three-dimensional image data of coronary arteries using a three-dimensional medical imaging device, wherein the three-dimensional image data includes imagery of the CTO. A radiocontrast agent is administered to a patient. Real-time image data of the coronary arteries are acquired using one or more fluoroscopes. The real-time image data does not include imagery of the CTO and down-stream vessel structure. The three-dimensional image data is co-registered with the real-time image data using an image processing device within a vicinity of the CTO. The co-registered image data are displayed in real-time using a display device to accurately illustrate the location of the CTO within the context of the real-time image data.
摘要翻译：用于显示包括慢性完全闭塞（CTO）在内的冠状动脉的实时图像的方法包括采用三维医学成像装置获取冠状动脉的三维图像数据，其中三维图像数据包括CTO的图像。向患者施用放射性对比剂。使用一个或多个荧光检查器获取冠状动脉的实时图像数据。实时图像数据不包括CTO和下游血管结构的图像。使用CTO附近的图像处理装置将三维图像数据与实时图像数据共同对准。使用显示装置实时显示共同登记的图像数据，以准确地示出CTO在实时图像数据的上下文中的位置。

49. 发明申请

US20090163800A1 TOOLS AND METHODS FOR VISUALIZATION AND MOTION COMPENSATION DURING ELECTROPHYSIOLOGY PROCEDURES 审中-公开
标题翻译：电生理过程中可视化和运动补偿的工具和方法
公开(公告)号：US20090163800A1
公开(公告)日：2009-06-25
申请号：US12335738
申请日：2008-12-16
申请人： Chenyang Xu , Rui Liao , Liron Yatziv , Norbert Strobel
发明人： Chenyang Xu , Rui Liao , Liron Yatziv , Norbert Strobel
IPC分类号： A61B6/00 , A61B5/05
CPC分类号： A61B6/12 , A61B5/0422 , A61B6/466 , A61B6/503 , A61B6/504 , A61B6/5235 , A61B6/541 , A61B6/566 , A61B90/36 , A61B2017/00703 , A61B2090/376
摘要： A method for real-time cardiac visualization includes acquiring fluoroscope imagery from two planes. The location of at least one electrophysiology (EP) device is marked within the fluoroscope imagery from each of the two planes. The location information for the at least one EP device is combined within each of the acquired fluoroscope images from the two planes to determine a 3D location for the at least one EP device. The fluoroscope imagery from at least one of the two planes is displayed with a visual aid superimposed thereon. The visual aid is based on the 3D location of the EP device.
摘要翻译：一种用于实时心脏可视化的方法包括从两个平面获取荧光成像。至少一个电生理学（EP）装置的位置被标记在两个平面中的每一个的荧光图像内。用于至少一个EP设备的位置信息在来自两个平面的所获取的荧光镜图像的每个中组合，以确定用于至少一个EP设备的3D位置。来自两个平面中的至少一个的荧光图像以其上叠加的视觉辅助物显示。视觉辅助是基于EP设备的3D位置。

50. 发明申请

US20080275467A1 Intraoperative guidance for endovascular interventions via three-dimensional path planning, x-ray fluoroscopy, and image overlay 审中-公开
标题翻译：通过三维路径规划，X射线透视和图像叠加进行血管内干预的术中指导
公开(公告)号：US20080275467A1
公开(公告)日：2008-11-06
申请号：US12110415
申请日：2008-04-28
申请人： Rui Liao , Ashraf Mohamed , Yiyong Sun , Chenyang Xu
发明人： Rui Liao , Ashraf Mohamed , Yiyong Sun , Chenyang Xu
IPC分类号： A61B17/00
CPC分类号： A61B6/5235 , A61B5/055 , A61B6/032 , A61B6/12 , A61B6/466 , A61B6/481 , A61B6/504 , A61B17/12022 , A61B34/10 , A61B90/36 , A61B2017/1205 , A61B2090/364 , A61F2/95
摘要： A method for planning a path for an endovascular intervention includes acquiring and displaying 3D angiographic images; selecting a target on the displayed images; extracting a skeleton of a vascular tree from the displayed images; extracting a symbolic vessel path to the target based on the skeleton of the vascular tree; and overlaying and displaying the symbolic vessel path on 2D fluoroscopic images for guiding the endovascular intervention.
摘要翻译：用于规划血管内干预的路径的方法包括获取和显示3D血管造影图像; 在显示的图像上选择目标; 从所显示的图像中提取血管树的骨架; 基于血管树的骨架提取到目标的符号血管路径; 并在2D荧光镜图像上叠加和显示符号血管路径，用于引导血管内介入。

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