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41. 发明申请

US20110251248A1 GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS 有权
标题翻译： GLUCAGON受体拮抗剂化合物
公开(公告)号：US20110251248A1
公开(公告)日：2011-10-13
申请号：US13140260
申请日：2009-12-09
申请人： Songnian Lin , Xibin Liao , Roman Kats-Kagan , John E. Stelmach , Emma R. Parmee
发明人： Songnian Lin , Xibin Liao , Roman Kats-Kagan , John E. Stelmach , Emma R. Parmee
IPC分类号： A61K31/41 , A61K31/197 , C07C233/87 , A61K31/166 , A61P3/10 , C07C309/70 , A61K31/255 , C07C255/60 , A61K31/277 , C07C229/36 , C07D257/04
CPC分类号： C07C233/83 , C07C235/42 , C07C255/57 , C07C309/15 , C07C317/44 , C07C323/62
摘要： Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了胰高血糖素受体拮抗剂化合物。该化合物可用于治疗2型糖尿病及相关病症。还包括药物组合物和治疗方法。

42. 发明授权

US07803951B2 Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use 有权
标题翻译：胰高血糖素受体拮抗剂化合物，含有这些化合物的组合物和使用方法
公开(公告)号：US07803951B2
公开(公告)日：2010-09-28
申请号：US11887125
申请日：2006-03-24
申请人： Rui Liang , Emma R. Parmee
发明人： Rui Liang , Emma R. Parmee
IPC分类号： C07D257/00 , A61K31/41
CPC分类号： C07C323/44 , C07C237/48 , C07C275/30 , C07C275/34 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D257/06 , C07D311/68 , C07D317/60 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12
摘要： Substituted aryl and heteroaryl derivatives are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了取代的芳基和杂芳基衍生物。该化合物可用于治疗2型糖尿病及相关病症。还包括药物组合物和治疗方法。

43. 发明申请

US20090176854A1 PYRAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE 有权
标题翻译：吡唑衍生物，含有这些化合物的组合物和使用方法
公开(公告)号：US20090176854A1
公开(公告)日：2009-07-09
申请号：US12405600
申请日：2009-03-17
申请人： Emma R. Parmee , Yusheng Xiong , Jian Guo , Rui Liang , Linda Brockunier
发明人： Emma R. Parmee , Yusheng Xiong , Jian Guo , Rui Liang , Linda Brockunier
IPC分类号： A61K31/415 , A61P3/06
CPC分类号： C07D231/12 , C07D405/04
摘要： Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了具有连接的萘基的吡唑。该化合物可用于治疗2型糖尿病及相关病症。还包括药物组合物和治疗方法。

44. 发明申请

US20080108620A1 Substituted Pyrazoles, Compositions Containing such Compounds and Methods of Use 有权
标题翻译：取代吡唑，含有这些化合物的组合物和使用方法
公开(公告)号：US20080108620A1
公开(公告)日：2008-05-08
申请号：US11632198
申请日：2005-07-19
申请人： Linda Brockunier , Jian Guo , Rui Liang , Emma R. Parmee , Subharekha Raghavan , George Scott Tria , Yusheng Xiong
发明人： Linda Brockunier , Jian Guo , Rui Liang , Emma R. Parmee , Subharekha Raghavan , George Scott Tria , Yusheng Xiong
IPC分类号： A61K31/4155 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K31/498 , A61P3/10 , A61P9/10 , C07D401/04 , C07D403/04 , C07D405/02 , C07D413/04 , C07D417/04
CPC分类号： C07D401/04 , C07D403/04 , C07D405/04 , C07D407/04 , C07D413/04 , C07D417/04
摘要： The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
摘要翻译：本发明涉及取代的吡唑，含有这些化合物的组合物和处理方法。该化合物是胰高血糖素受体拮抗剂，因此可用于治疗，预防或延缓2型糖尿病的发作。

45. 发明授权

US07332520B2 Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权
标题翻译：熔融吲哚作为二肽基肽酶抑制剂用于治疗或预防糖尿病
公开(公告)号：US07332520B2
公开(公告)日：2008-02-19
申请号：US10558931
申请日：2004-06-02
申请人： Scott D. Edmondson , Anthony Mastracchio , Emma R. Parmee
发明人： Scott D. Edmondson , Anthony Mastracchio , Emma R. Parmee
IPC分类号： A61K31/403 , C07D209/82 , C07D403/02
CPC分类号： C07D209/88 , C07D209/86 , C07D403/06 , C07D417/06
摘要： The present invention is directed to fused indole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译：本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的稠合吲哚衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如作为糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

46. 发明授权

US06699871B2 Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权
标题翻译： β-氨基杂环二肽基肽酶抑制剂，用于治疗或预防糖尿病
公开(公告)号：US06699871B2
公开(公告)日：2004-03-02
申请号：US10189603
申请日：2002-07-05
申请人： Scott D. Edmondson , Michael H. Fisher , Dooseop Kim , Malcolm Maccoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
发明人： Scott D. Edmondson , Michael H. Fisher , Dooseop Kim , Malcolm Maccoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
IPC分类号： C07D48704
CPC分类号： A61K31/4985 , A61K31/498 , A61K38/28 , A61K45/06 , C07D487/04 , Y10S514/866 , A61K2300/00
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译：本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）抑制剂的化合物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病特别是2型糖尿病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

47. 发明授权

US6043253A Fused piperidine substituted arylsulfonamides as .beta.3-agonists 失效
标题翻译：将哌啶取代的芳基磺酰胺作为β3-激动剂
公开(公告)号：US6043253A
公开(公告)日：2000-03-28
申请号：US257707
申请日：1999-02-25
申请人： Linda Brockunier , Ann E. Weber , Emma R. Parmee
发明人： Linda Brockunier , Ann E. Weber , Emma R. Parmee
IPC分类号： C07D217/16 , C07D217/18 , C07D217/00 , A61K31/47
CPC分类号： C07D217/18 , C07D217/16
摘要： Fused piperidine substituted arylsulfonamides are .beta..sub.3 adrenergic receptor agonists with very little .beta..sub.1 and .beta..sub.2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compounds can be used to reduced neurogenic inflammation or as antidepressant agents. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for decreasing gut motility are also disclosed.
摘要翻译：融合的哌啶取代的芳基磺酰胺是具有非常少的β1和β2肾上腺素能受体活性的β3肾上腺素能受体激动剂，因此这些化合物能够增加细胞中的脂肪分解和能量消耗。因此，这些化合物在治疗II型糖尿病和肥胖中具有有效的活性。该化合物也可用于降低甘油三酯水平和胆固醇水平或提高高密度脂蛋白水平或降低肠道运动性。此外，该化合物可用于减少神经源性炎症或作为抗抑郁剂。还公开了使用该化合物治疗糖尿病和肥胖以及降低甘油三酯水平和胆固醇水平或提高高密度脂蛋白水平或降低肠蠕动的组合物和方法。

48. 发明授权

US08809579B2 Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use 有权
标题翻译：胰高血糖素受体拮抗剂化合物，含有这些化合物的组合物和使用方法
公开(公告)号：US08809579B2
公开(公告)日：2014-08-19
申请号：US13148577
申请日：2010-02-03
申请人： Roman Kats-Kagan , Christian P. Stevenson , Xibin Liao , Qinghong Fu , Emma R. Parmee , Songnian Lin
发明人： Roman Kats-Kagan , Christian P. Stevenson , Xibin Liao , Qinghong Fu , Emma R. Parmee , Songnian Lin
IPC分类号： C07C229/00 , A01N43/04
CPC分类号： C07C235/42 , C07C235/46 , C07C255/54 , C07D213/64 , C07D215/233 , C07D277/64 , C07D333/16
摘要： Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了胰高血糖素受体拮抗剂化合物。该化合物可用于治疗2型糖尿病及相关病症。还包括药物组合物和治疗方法。

49. 发明授权

US08741910B2 Soluble guanylate cyclase activators 有权
标题翻译：可溶性鸟苷酸环化酶活化剂
公开(公告)号：US08741910B2
公开(公告)日：2014-06-03
申请号：US13127334
申请日：2009-11-16
申请人： Linda L. Brockunier , Jian Guo , Emma R. Parmee , Subharekha Raghavan , Keith Rosauer , Darby Schmidt , John E. Stelmach
发明人： Linda L. Brockunier , Jian Guo , Emma R. Parmee , Subharekha Raghavan , Keith Rosauer , Darby Schmidt , John E. Stelmach
IPC分类号： A61K31/519 , C07D471/04 , C07D487/04 , A61P9/12 , A61P9/04
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： Compounds of Formula I are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of the Formula I, to their use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of the Formula I.
摘要翻译：式I的化合物能够调节人体的环鸟苷酸（“cGMP”）的产生，并且通常适用于治疗和预防与扰乱的cGMP平衡相关的疾病。本发明还涉及制备式I化合物的方法，其用于治疗和预防上述疾病和用于制备用于该目的的药物以及包含式I化合物的药物制剂。

50. 发明授权

US08445538B2 Glucagon receptor antagonist compounds 有权
标题翻译：胰高血糖素受体拮抗剂化合物
公开(公告)号：US08445538B2
公开(公告)日：2013-05-21
申请号：US13140260
申请日：2009-12-09
申请人： Songnian Lin , Xibin Liao , Roman Kats-Kagan , John E. Stelmach , Emma R. Parmee
发明人： Songnian Lin , Xibin Liao , Roman Kats-Kagan , John E. Stelmach , Emma R. Parmee
IPC分类号： A61K31/165 , C07C237/22
CPC分类号： C07C233/83 , C07C235/42 , C07C255/57 , C07C309/15 , C07C317/44 , C07C323/62
摘要： Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了胰高血糖素受体拮抗剂化合物。该化合物可用于治疗2型糖尿病及相关病症。还包括药物组合物和治疗方法。

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