专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明授权

US5030654A Glutaramide diuretic agents 失效
标题翻译：戊酰胺利尿剂
公开(公告)号：US5030654A
公开(公告)日：1991-07-09
申请号：US354170
申请日：1989-05-19
申请人： Ian T. Barnish , John C. Danilewicz , Keith James , Gillian M. R. Samuels , Nicholas K. Terrett , Michael T. Williams , Martin J. Wythes
发明人： Ian T. Barnish , John C. Danilewicz , Keith James , Gillian M. R. Samuels , Nicholas K. Terrett , Michael T. Williams , Martin J. Wythes
IPC分类号： A61K31/16 , A61K31/335 , A61K31/395 , C07C235/52 , C07C235/82 , C07C237/24 , C07C311/01 , C07D207/30 , C07D209/46 , C07D213/02 , C07D213/56 , C07D231/00 , C07D233/00 , C07D235/00 , C07D237/00 , C07D239/00 , C07D241/12 , C07D261/10 , C07D277/36 , C07D277/46 , C07D295/00 , C07D295/185 , C07D307/04 , C07D307/16 , C07D307/68 , C07D309/02 , C07D319/00 , C07D321/02 , C07D321/08 , C07D321/12 , C07D333/34 , C07D521/00
CPC分类号： C07D241/12 , C07D209/46 , C07D213/56 , C07D231/12 , C07D233/56 , C07D249/08 , C07D261/10 , C07D277/36 , C07D277/46 , C07D295/185 , C07D307/16 , C07D307/68 , C07D321/08 , C07D333/34
摘要： A series of novel spiro-substituted glutaramide derivatives have been prepared, including the pharmaceutically acceptable salts thereof and bioprecursors therefor, wherein the spiro-substituent completes a 5- or 6-membered carbocycyclic ring and is located at the carbon atom adjacent to the carbamoyl group. These particular compounds are inhibitors of the neutral endopeptidase E.C.3.4.24.11 enzyme and are therefore useful in therapy as diuretic agents for the treatment of hypertension, heart failure, renal insufficiency and other disorders. Methods for preparing these compounds from known starting materials are provided.

42. 发明申请

US20150100329A1 COMPUTER IMPLEMENTED HEALTH CARE PAYMENT PROCESSING APPARATUS, SYSTEM, AND METHOD 审中-公开
标题翻译：计算机实施卫生保健处理装置，系统和方法
公开(公告)号：US20150100329A1
公开(公告)日：2015-04-09
申请号：US14046649
申请日：2013-10-04
申请人： Daniel W. Dreyfuss , Michael T. Williams
发明人： Daniel W. Dreyfuss , Michael T. Williams
IPC分类号： G06F19/00
CPC分类号： G06F19/328
摘要： Systems, methodologies, media, and other embodiments associated with a health care payment processing system are described. One exemplary system embodiment includes a computer implemented method of health care payment processing including receiving health care insurance information pertaining to a patient, the information including the patient's identity and health care insurance carrier information or health care exchange information, adding the health care insurance information to a premium assistor database, determining eligibility of the patient for health care insurance premium payment assistance based on a status of a health care insurance premium payment for verified health care insurance coverage, paying a health care insurance premium payment associated with the status of the health care insurance premium payment, verifying receipt of the health care insurance premium payment, and verifying receipt of a health care services payment from a health care insurance carrier.
摘要翻译：描述了与卫生保健支付处理系统相关联的系统，方法，媒体和其他实施例。一个示例性系统实施例包括计算机实现的医疗保健支付处理方法，包括接收与患者有关的医疗保险信息，包括患者身份信息和医疗保险运营商信息或医疗保健交换信息的信息，将医疗保险信息添加到一个优质的合作伙伴数据库，根据医疗保险保险费状况确定病人获得医疗保险费支付援助的资格，用于验证保健保险，支付与医疗保健状况相关的医疗保险费用保险费支付，确认收到医疗保险费缴费，并确认从医疗保险公司收到保健服务费。

43. 发明申请

US20110214391A1 LIGHTWEIGHT COMPOSITIONS AND ARTICLES CONTAINING SUCH 审中-公开
标题翻译：轻型组合物及其制品
公开(公告)号：US20110214391A1
公开(公告)日：2011-09-08
申请号：US13103354
申请日：2011-05-09
申请人： Tricia Guevara , Michael T. Williams , David A. Cowan , John K. Madish , Kolapo Adewale , Roger Moore , Mary Margaret Moore , Jay Bowman
发明人： Tricia Guevara , Michael T. Williams , David A. Cowan , John K. Madish , Kolapo Adewale , Roger Moore , Mary Margaret Moore , Jay Bowman
IPC分类号： E04C2/22
CPC分类号： C04B16/08 , C04B28/02 , C04B28/14 , C04B2111/00612 , C04B2111/0075 , C04B2111/10 , C04B2111/30 , C04B2111/40 , C04B2201/20 , E04B5/04 , E04B5/043 , E04C2/044 , E04C2002/045 , Y02W30/92 , Y10T428/249968 , C04B14/06 , C04B18/08 , C04B14/42 , C04B20/06 , C04B24/2623 , C04B24/2676
摘要： A lightweight cementitious composition containing from 22 to 90 volume percent of a cement composition and from 10 to 78 volume percent of particles having an average particle diameter of from 0.2 mm to 8 mm, a bulk density of from 0.03 g/cc to 0.64 g/cc, an aspect ratio of from 1 to 3, where after the lightweight cementitious composition is set it has a compressive strength of at least 1700 psi as tested according to ASTM C39. The cementitious composition can be used to make concrete masonry units, construction panels, road beds and other articles and can be included as a layer on wall panels and floor panels and can be used in insulated concrete forms. Aspects of the lightweight cementitious composition can be used to make lightweight structural units.
摘要翻译：一种轻质水泥组合物，其含有22至90体积％的水泥组合物和10至78体积％的平均粒径为0.2mm至8mm，堆积密度为0.03g / cc至0.64g / cc，纵横比为1至3，其中在轻质水泥组合物被设定之后，其具有至少1700psi的压缩强度，如根据ASTM C39测试的。水泥组合物可用于制造混凝土砌块单元，建筑面板，路面和其他物品，可以作为一层层叠在墙板和地板上，可用于绝缘混凝土形式。轻质水泥组合物的方面可用于制造轻质结构单元。

44. 发明申请

US20110003904A1 Lightweight Concrete Compositions 有权
标题翻译：轻质混凝土组合物
公开(公告)号：US20110003904A1
公开(公告)日：2011-01-06
申请号：US12881674
申请日：2010-09-14
申请人： Tricia Guevara , Michael T. Williams , Rick Hughes , Michael R. Kelley , John K. Madish , Kristen Van Buskirk
发明人： Tricia Guevara , Michael T. Williams , Rick Hughes , Michael R. Kelley , John K. Madish , Kristen Van Buskirk
IPC分类号： C08J9/22
CPC分类号： C04B28/02 , C04B16/08 , C04B16/082 , C04B38/009 , C04B38/08 , C04B2103/302 , C04B2111/00586 , C04B2111/0075 , C04B2111/40 , C04B2111/60 , C04B2201/20 , Y02W30/92 , Y02W30/94 , Y10S264/43 , C04B14/06 , C04B14/108 , C04B14/42 , C04B14/4693 , C04B40/0608 , C04B2103/54 , C04B14/386 , C04B16/0691 , C04B18/08 , C04B18/141 , C04B24/22 , C04B20/0048 , C04B20/0076 , C04B38/0067 , C04B2103/30 , C04B14/12 , C04B14/18 , C04B14/202 , C04B14/204 , C04B14/22 , C04B16/0675 , C04B2103/12 , C04B2103/22 , C04B2103/32 , C04B2103/50 , C04B2103/65 , C04B14/08 , C04B14/10 , C04B14/16 , C04B14/185 , C04B14/46 , C04B18/06 , C04B18/146 , C04B20/06 , C04B16/04 , C04B40/02 , C04B24/06 , C04B24/163 , C04B24/223 , C04B24/226
摘要： A lightweight ready-mix concrete composition that contains 8-20 volume percent cement, 11-50 volume percent sand, 10-31 volume percent prepuff particles, 9-40 volume percent coarse aggregate, and 10-22 volume percent water, where the sum of components used does not exceed 100 volume percent;. The prepuff particles have an average particle diameter of from 0.2 mm to 8 mm, a bulk density of from 0.02 g/cc to 0.64 g/cc, an aspect ratio of from 1 to 3. The slump value of the composition measured according to ASTM C 143 is from 2 to 8 inches. After the lightweight ready-mix concrete composition is set for 28 days, it has a compressive strength of at least 1400 psi as tested according to ASTM C39.
摘要翻译：一种轻质的预拌混凝土组合物，其含有8-20体积％的水泥，11-50体积百分比的砂，10-31体积百分比的前缀颗粒，9-40体积％的粗骨料和10-22体积百分比的水，其中总和的组分不超过100体积％。该稀释剂颗粒的平均粒径为0.2mm至8mm，堆积密度为0.02g / cc至0.64g / cc，纵横比为1至3。根据ASTM测量的组合物的坍落度值 C 143为2至8英寸。将轻质预拌混凝土组合物放置28天后，根据ASTM C39测试，其抗压强度至少为1400psi。

45. 发明申请

US20100064943A1 LIGHTWEIGHT CONCRETE COMPOSITIONS 有权
标题翻译：轻型混凝土组合物
公开(公告)号：US20100064943A1
公开(公告)日：2010-03-18
申请号：US12612097
申请日：2009-11-04
申请人： Tricia Guevara , Michael T. Williams , David A. Cowan , John K. Madish , Kolapo Adewale , Roger Moore , Mary Margaret Moore , Tobias Blain Hileman
发明人： Tricia Guevara , Michael T. Williams , David A. Cowan , John K. Madish , Kolapo Adewale , Roger Moore , Mary Margaret Moore , Tobias Blain Hileman
IPC分类号： C04B16/08 , C08J9/00
CPC分类号： C04B28/02 , C04B16/08 , C04B38/009 , C04B38/08 , C04B2111/0075 , C04B2111/40 , C04B2201/20 , Y02W30/92 , Y02W30/94 , C04B20/0048 , C04B20/0076 , C04B2103/30 , C04B14/06 , C04B14/08 , C04B14/10 , C04B14/12 , C04B14/16 , C04B14/185 , C04B14/204 , C04B14/22 , C04B14/386 , C04B14/42 , C04B14/46 , C04B16/0675 , C04B16/0691 , C04B18/06 , C04B18/08 , C04B18/141 , C04B18/146 , C04B20/06 , C04B16/04 , C04B16/082 , C04B38/0067 , C04B14/18 , C04B14/202 , C04B14/4693 , C04B2103/12 , C04B2103/22 , C04B2103/32 , C04B2103/50 , C04B2103/54 , C04B2103/65
摘要： A lightweight concrete composition containing from 10 to 90 volume percent of a cement composition, from 10 to 90 volume percent of particles having an average particle diameter of from 0.2 mm to 8 mm, a bulk density of from 0.03 g/cc to 0.64 g/cc, an aspect ratio of from 1 to 3, and from 0 to 50 volume percent of aggregate; where the sum of components used does not exceed 100 volume percent, and where after the lightweight concrete composition is set it has a compressive strength of at least 1700 psi as tested according to ASTM C39 after seven days. The concrete composition can be used to make concrete masonry units, construction panels, road beds and other articles.
摘要翻译：一种轻质混凝土组合物，其含有10至90体积％的水泥组合物，10至90体积％的平均粒径为0.2mm至8mm，堆积密度为0.03g / cc至0.64g / cc，纵横比为1至3，总重为0至50体积％; 其中使用的组分的总和不超过100体积％，并且在轻量级混凝土组合物被固定之后，其具有至少1700psi的抗压强度，如在七天后根据ASTM C39测试的。混凝土组成可用于制作混凝土砌块单元，建筑面板，路床等物品。

46. 发明授权

US07666258B2 Lightweight compositions and articles containing such 失效
公开(公告)号：US07666258B2
公开(公告)日：2010-02-23
申请号：US11361654
申请日：2006-02-24
申请人： Tricia Guevara , Michael T. Williams , David A. Cowan , John K. Madish , Kolapo Adewale , Roger Moore , Mary Margaret Moore, legal representative
发明人： Tricia Guevara , Michael T. Williams , David A. Cowan , John K. Madish , Kolapo Adewale , Roger Moore
IPC分类号： C04B16/08
CPC分类号： C04B16/08 , C04B28/02 , C04B28/14 , C04B2111/00612 , C04B2111/0075 , C04B2111/10 , C04B2111/30 , C04B2111/40 , C04B2201/20 , E04B5/04 , E04B5/043 , E04C2/044 , E04C2002/045 , Y02W30/92 , Y10T428/249968 , C04B14/06 , C04B18/08 , C04B14/42 , C04B20/06 , C04B24/2623 , C04B24/2676
摘要： A lightweight cementitious composition containing from 22 to 90 volume percent of a cement composition and from 10 to 78 volume percent of particles having an average particle diameter of from 0.2 mm to 8 mm, a bulk density of from 0.03 g/cc to 0.64 g/cc, an aspect ratio of from 1 to 3, where after the lightweight cementitious composition is set it has a compressive strength of at least 1700 psi as tested according to ASTM C39. The cementitious composition can be used to make concrete masonry units, construction panels, road beds and other articles and can be included as a layer on wall panels and floor panels and can be used in insulated concrete forms. Aspects of the lightweight cementitious composition can be used to make lightweight structural units.

47. 发明申请

US20090081446A1 METHOD OF PLACING CONCRETE 有权
标题翻译：浇筑混凝土的方法
公开(公告)号：US20090081446A1
公开(公告)日：2009-03-26
申请号：US12212046
申请日：2008-09-17
申请人： Daniel Woolfsmith , Michael T. Williams , Rick Hughes , Michael R. Kelley , John K. Madish , Kristen Van Buskirk , Tricia Guevara Ladely
发明人： Daniel Woolfsmith , Michael T. Williams , Rick Hughes , Michael R. Kelley , John K. Madish , Kristen Van Buskirk , Tricia Guevara Ladely
IPC分类号： B32B5/16
CPC分类号： C04B38/08 , C04B28/02 , C04B2111/00146 , Y02W30/92 , Y02W30/94 , Y10S106/01 , Y10S106/02 , Y10T428/25 , C04B14/06 , C04B16/082 , C04B18/08 , C04B20/0076 , C04B2103/302 , C04B14/08 , C04B14/10 , C04B14/12 , C04B14/14 , C04B14/16 , C04B14/18 , C04B14/202 , C04B14/22 , C04B14/386 , C04B14/42 , C04B14/4693 , C04B16/06 , C04B18/02 , C04B18/141 , C04B40/0028 , C04B2103/0088 , C04B2103/30
摘要： A method of placing a concrete compositions including a) combining 3-40 volume percent cement, 5-50 volume percent fine aggregate, 5-50 volume percent coarse aggregate, and 10-22 volume percent water; b) adding 1.5-40 volume percent of prepuff particles to form a concrete composition; and c) pumping the concrete composition to a point higher in elevation than the delivery point of the concrete to place the concrete. The concrete composition contains less than 30 volume percent of other light weighting aggregates and the prepuff particles have an average particle diameter of from 0.2 mm to 8 mm, a bulk density of from 0.02 g/cc to 0.64 g/cc, an aspect ratio of from 1 to 3. The slump value of the placed concrete measured according to ASTM C 143 is greater than 1 inch and the concrete has a density of from about 40 to about 135 lb./ft3.
摘要翻译：一种放置混凝土组合物的方法，包括a）将3-40体积％的水泥，5-50体积％的细骨料，5-50体积％的粗骨料和10-22体积百分比的水混合; b）加入1.5-40体积百分数的稀释剂颗粒以形成混凝土组合物; 和c）将混凝土组合物泵送到高于混凝土输送点的高度高处以放置混凝土。混凝土组合物含有少于30体积％的其它轻重量聚集体，并且所述预浸料颗粒的平均粒径为0.2mm至8mm，堆积密度为0.02g / cc至0.64g / cc，纵横比为从1到3.根据ASTM C 143测量的放置混凝土的坍落度值大于1英寸，混凝土的密度为约40至约135磅/英尺3。

48. 发明授权

US4839104A Process for preparing sertraline intermediates 失效
标题翻译：舍曲林中间体的制备方法
公开(公告)号：US4839104A
公开(公告)日：1989-06-13
申请号：US207579
申请日：1988-06-16
申请人： George J. Quallich , Michael T. Williams
发明人： George J. Quallich , Michael T. Williams
IPC分类号： C07C45/46 , C07C45/59 , C07C49/697 , C07C51/09 , C07C51/367 , C07D307/33
CPC分类号： C07D307/33 , C07C45/46 , C07C45/59 , C07C49/697 , C07C51/09 , C07C51/367
摘要： A novel three-step process for preparing 4-(3,4-dichlorophenyl)-4-phenylbutanoic acid is disclosed, which involves (1) reducing 4-(3,4-dichlorophenyl)-4-ketobutanoic acid to 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid; (2) then converting the intermediate hydroxy acid formed in the first step to 5-(3,4-dichlorophenyl)-dihydro-2(3H)-furanone, and (3) thereafter reacting the resulting gamma-butyrolactone compound with benzene in a Friedel-Crafts type reaction to form the desired final product. The latter compound is known to be useful as an intermediate leading to 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone and ultimately, to cis-(1S)(4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalene amine (sertraline), which is known to be a preferred anti-depressant agent in the field of medicinal chemistry. The aforementioned 5-(3,4-dichlorophenyl)-dihydro-2(3H)-furanone and 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid are both novel compounds. There is also disclosed a novel process for converting 5-(3,4-dichlorophenyl)-dihydro-2(3H)-furanone directly to 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone, as well as an alternate novel process for converting 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid directly to this same key intermediate.
摘要翻译：公开了一种制备4-（3,4-二氯苯基）-4-苯基丁酸的新型三步法，其包括（1）将4-（3,4-二氯苯基）-4-酮丁酸还原成4-（3 ，4-二氯苯基）-4-羟基丁酸; （2）然后将第一步中形成的中间体羟基酸转化为5-（3,4-二氯苯基） - 二氢-2（3H） - 呋喃酮，和（3）然后使所得的γ-丁内酯化合物与苯在 Friedel-Crafts型反应形成所需的最终产品。已知后一种化合物可用作导致4-（3,4-二氯苯基）-3,4-二氢-1（2H） - 萘酮的中间体，最终可用于顺式 - （1S）（4S）-N- 甲基-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘色胺（舍曲林），已知它是药物化学领域中优选的抗抑郁剂。上述5-（3,4-二氯苯基） - 二氢-2（3H） - 呋喃酮和4-（3,4-二氯苯基）-4-羟基丁酸都是新化合物。还公开了一种将5-（3,4-二氯苯基） - 二氢-2（3H） - 呋喃酮直接转化为4-（3,4-二氯苯基）-3,4-二氢-1（2H） - 萘酮，以及将4-（3,4-二氯苯基）-4-羟基丁酸直接转化为该相同关键中间体的替代新方法。

49. 发明授权

US4777288A Process for preparing a 4,4-diphenylbutanoic acid derivative 失效
标题翻译：制备4,4-二苯基丁酸衍生物的方法
公开(公告)号：US4777288A
公开(公告)日：1988-10-11
申请号：US60577
申请日：1987-06-11
申请人： George J. Quallich , Michael T. Williams
发明人： George J. Quallich , Michael T. Williams
IPC分类号： C07D307/82 , B01J27/125 , C07B61/00 , C07C45/00 , C07C45/45 , C07C45/46 , C07C45/59 , C07C49/697 , C07C51/00 , C07C51/09 , C07C51/347 , C07C51/353 , C07C51/367 , C07C57/58 , C07C59/56 , C07C67/00 , C07D307/30 , C07D307/33 , C07C63/33 , C07D307/26
CPC分类号： C07D307/33 , C07C45/46 , C07C45/59 , C07C49/697 , C07C51/09 , C07C51/367
摘要： A novel three-step process for preparing 4-(3,4-dichlorophenyl)-4-phenylbutanoic acid is disclosed, which involves (1) reducing 4-(3,4-dichlorophenyl)-4-ketobutanoic acid to 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid; (2) then converting the intermediate hydroxy acid formed in the first step to 5-(3,4-dichlorophenyl)-dihydro-2(3H)-furanone, and (3) thereafter reacting the resulting gamma-butyrolactone compound with benzene in a Friedel-Crafts type reaction to form the desired final product. The latter compound is known to be useful as an intermediate leading to cis-(1S)(4S)- -N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine (sertraline), which is known to be a preferred anti-depressant agent in the field of medicinal chemistry. The aforementioned 5-(3,4-dichlorophenyl)-dihydro-2(3H)-furanone and 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid are both novel compounds.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式