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41. 发明授权

US5116989A Fluorescent poly(arylpyridine) rare earth chelates 失效
标题翻译：荧光聚（芳基吡啶）稀土螯合物
公开(公告)号：US5116989A
公开(公告)日：1992-05-26
申请号：US339287
申请日：1989-05-30
申请人： Ron L. Hale , Dennis W. Solas
发明人： Ron L. Hale , Dennis W. Solas
IPC分类号： C07D213/79 , C07D213/81 , C07D401/14
CPC分类号： C07D213/79 , C07D213/81 , C07D401/14
摘要： A class of fluorescent rare earth chelates and the ligands upon which they are based whose molecular structure incorporates a plurality of substituted arylpyridine diacid units attached to a central template structure is disclosed. These ligands function as efficient energy transfer groups in fluorescent tagging reagents and tracers.
摘要翻译：公开了一类荧光稀土螯合物及其所属的配体，其分子结构包含连接至中心模板结构的多个取代的芳基吡啶二酸单元。这些配体在荧光标记试剂和示踪剂中起到有效的能量转移基团的作用。

42. 发明授权

US08288372B2 Method for treating headache with loxapine 有权
标题翻译：用洛沙平治疗头痛的方法
公开(公告)号：US08288372B2
公开(公告)日：2012-10-16
申请号：US10719540
申请日：2003-11-20
申请人： Ron L. Hale , Patrik Munzar , Joshua D. Rabinowitz
发明人： Ron L. Hale , Patrik Munzar , Joshua D. Rabinowitz
IPC分类号： A61K31/553 , A61K31/55
CPC分类号： A61K9/007 , A61K9/0073 , A61K31/553
摘要： Loxapine, amoxapine, or salts or prodrugs of either, is effective in alleviating pain, particularly headache pain such as migraine, cluster headaches and tension headaches. Preferably the loxapine or amoxapine is administered systemically, most preferably by inhalation.
摘要翻译：洛沙平，阿莫沙平或其盐或前药均有效减轻疼痛，特别是头痛，如偏头痛，丛集性头痛和紧张性头痛。优选地，全身施用洛沙平或阿莫沙平，最优选通过吸入给药。

43. 发明授权

US07981401B2 Diuretic aerosols and methods of making and using them 有权
标题翻译：利尿剂及其使用方法
公开(公告)号：US07981401B2
公开(公告)日：2011-07-19
申请号：US11670892
申请日：2007-02-02
申请人： Nathan R. Every , Ron L. Hale , Amy T. Lu , Joshua D. Rabinowitz
发明人： Nathan R. Every , Ron L. Hale , Amy T. Lu , Joshua D. Rabinowitz
IPC分类号： A61K9/12 , A61K9/00 , A61K31/18 , A61K31/05 , A61K31/20 , A61K31/415 , A61K31/40 , A61K31/50 , A61K31/58 , A61K31/522
CPC分类号： A61K9/0073 , A61K9/007 , A61K31/58
摘要： Described herein are diuretic condensation aerosols and methods of making and using them. Kits for delivering a condensation aerosol are also described. The diuretic aerosols typically comprise diuretic condensation aerosol particles that comprise a diuretic compound. In some variations the diuretic compound is selected from the group consisting of bumetanide, ethacrynic acid, furosemide, muzolimine, spironolactone, torsemide, triamterene, tripamide, BG 9928, and BG 9719. Methods of treating edema using the described aerosols are also provided. In general, the methods typically comprise the step of administering a therapeutically effective amount of diuretic condensation aerosol to a person with edema. The diuretic condensation aerosol may be administered in a single inhalation, or may be administered in more than one inhalation. Methods of forming a diuretic condensation aerosol are also described. The methods typically comprise the steps of providing a diuretic composition, vaporizing the composition to form a vapor, and then condensing the diuretic composition vapor.
摘要翻译：本文描述的是利尿凝结气溶胶及其制备和使用方法。还描述了用于递送冷凝气雾剂的组件。利尿剂气溶胶通常包含利尿剂缩合气溶胶颗粒，其包含利尿剂。在一些变体中，利尿剂化合物选自布美他尼，依西醋酸，呋塞米，多佐立胺，螺内酯，托塞米明，扑热息痛，三酰胺，BG 9928和BG 9719.还提供了使用所述气溶胶治疗水肿的方法。通常，所述方法通常包括向具有水肿的人施用治疗有效量的利尿冷凝气雾剂的步骤。利尿冷凝气雾剂可以在单次吸入中施用，或者可以在多于一次的吸入中施用。还描述了形成利尿冷凝气雾剂的方法。所述方法通常包括提供利尿组合物，蒸发组合物以形成蒸气，然后冷凝利尿组合物蒸气的步骤。

44. 发明申请

US20100055048A1 ACUTE TREATMENT OF HEADACHE WITH PHENOTHIAZINE ANTIPSYCHOTICS 审中-公开
标题翻译：用苯并噻唑类抗生素治疗头痛
公开(公告)号：US20100055048A1
公开(公告)日：2010-03-04
申请号：US12615185
申请日：2009-11-09
申请人： Ron L. Hale , Peter M. LIoyd , Amy T. Lu , Patrik Munzar , Joshua D. Rabinowitz , Roman Skowronski
发明人： Ron L. Hale , Peter M. LIoyd , Amy T. Lu , Patrik Munzar , Joshua D. Rabinowitz , Roman Skowronski
IPC分类号： A61K9/12 , A61K31/445 , A61K31/4439 , A61K31/382 , A61K31/496 , A61K31/553 , A61K31/5377 , A61K31/454 , A61K31/5415 , A61P29/00
CPC分类号： A61K31/553 , A61K9/007 , A61K9/0073 , A61K31/382 , A61K31/4439 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , A61M15/00 , A61M15/0028 , A61M15/0033 , A61M2202/064 , A61M2205/075
摘要： Methods of treating headache with antipsychotics are provided. A kit for treating headache is also provided, comprising an antipsychotic and a device for rapid delivery of the antipsychotic.
摘要翻译：提供了使用抗精神病药治疗头痛的方法。还提供了用于治疗头痛的试剂盒，其包含抗精神病药和用于快速递送抗精神病药的装置。

45. 发明申请

US20080299048A1 MIXED DRUG AEROSOL COMPOSITIONS 审中-公开
标题翻译：混合药物气溶胶组合物
公开(公告)号：US20080299048A1
公开(公告)日：2008-12-04
申请号：US11964630
申请日：2007-12-26
申请人： Ron L. Hale , Kathleen Simis , Amy T. Lu , Joshua D. Rabinowitz , Krishnamohan Sharma , William Shen , Justin Virgili
发明人： Ron L. Hale , Kathleen Simis , Amy T. Lu , Joshua D. Rabinowitz , Krishnamohan Sharma , William Shen , Justin Virgili
IPC分类号： A61K9/12
CPC分类号： A61K31/137 , A61K9/0073 , A61K31/138 , A61K31/23 , A61K31/40 , A61K31/404 , A61K31/54 , A61K31/5415
摘要： The present invention pertains to aerosols which comprise a first compound which is physiologically active and a second compound which is different from the first compound. Such aerosols may be produced “on demand” and can be used to control drug release, to improve vaporizability, or to reduce, modify or eliminate undesirable taste associated with a drug aerosol. The present invention also pertains to methods for producing such aerosols.
摘要翻译：本发明涉及包含生理活性的第一化合物和不同于第一化合物的第二化合物的气溶胶。这种气溶胶可以“按要求”生产，并可用于控制药物释放，改善可燃性，或减少，改变或消除与药物气溶胶相关的不良味道。本发明还涉及生产这种气溶胶的方法。

46. 发明授权

US5607691A Compositions and methods for enhanced drug delivery 失效
标题翻译：用于增强药物递送的组合物和方法
公开(公告)号：US5607691A
公开(公告)日：1997-03-04
申请号：US449188
申请日：1995-05-24
申请人： Ron L. Hale , Amy Lu , Dennis Solas , Harold E. Selick , Kevin R. Oldenburg , Alejandro C. Zaffaroni
发明人： Ron L. Hale , Amy Lu , Dennis Solas , Harold E. Selick , Kevin R. Oldenburg , Alejandro C. Zaffaroni
IPC分类号： A61K9/00 , A61K9/127 , A61K47/48 , A61K9/70 , A61K31/00
CPC分类号： A61K31/70 , A61K31/568 , A61K47/4803 , A61K47/48992 , A61K9/0009 , A61K9/1272
摘要： The present invention relates to methods of delivering pharmaceutical agents across membranes, including the skin layer or mucosal membranes of a patient. A pharmaceutical agent is covalently bonded to a chemical modifier, via a physiologically cleavable bond, such that the membrane transport and delivery of the agent is enhanced.
摘要翻译：本发明涉及通过膜（包括患者的皮肤层或粘膜）递送药剂的方法。药剂通过生理上可切割的键共价结合到化学改性剂上，使得药物的膜输送和递送得到增强。

47. 发明申请

US20090180968A1 Metal Coordination Complexes Of Volatile Drugs 审中-公开
标题翻译：挥发性药物的金属配位络合物
公开(公告)号：US20090180968A1
公开(公告)日：2009-07-16
申请号：US12352582
申请日：2009-01-12
申请人： Ron L. Hale , C.V. Krishnamohan Sharma , Mingzu Lei
发明人： Ron L. Hale , C.V. Krishnamohan Sharma , Mingzu Lei
IPC分类号： A61K9/72
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/7007 , A61K31/428 , A61K31/465 , A61K31/57 , A61K31/573 , A61K31/58 , A61M11/042 , A61M11/047 , A61M15/0031 , A61M15/0045 , A61M15/06 , A61M2202/064 , A61M2205/8268
摘要： The present disclosure provides a drug delivery device comprising a housing defining an airway, wherein the airway comprises at least one air inlet and a mouthpiece having at least one air outlet, at least one heated metal substrate disposed within the airway, at least one drug disposed on the at least one heated metal substrate. Drugs that can be complexed with metals or metal salts and could be deposited as thin films on heated metal substrate for generating thermal condensation aerosols are particularly suited. The metal substrate could be electrically or chemically heated. Further, the chemically heated metal source could be activated by an igniter that generates heat or spark.
摘要翻译：本公开提供了一种药物递送装置，其包括限定气道的壳体，其中所述气道包括至少一个空气入口和具有至少一个空气出口的口器，设置在所述气道内的至少一个加热的金属基底，设置有至少一种药物在所述至少一个加热的金属基底上。可以与金属或金属盐络合的药物，并且可以作为薄膜沉积在加热的金属基底上以产生热凝结气溶胶是特别合适的。金属基底可以电或化学加热。此外，化学加热的金属源可以由产生热量或火花的点火器激活。

48. 发明授权

US06242268B1 Homogeneous fluorassay methods employing fluorescent background rejection and water-soluble rare earth metal chelates 失效
标题翻译：使用荧光背景排斥和水溶性稀土金属螯合物的均匀氟化法
公开(公告)号：US06242268B1
公开(公告)日：2001-06-05
申请号：US09184330
申请日：1998-11-02
申请人： Irwin Wieder , Ron L. Hale
发明人： Irwin Wieder , Ron L. Hale
IPC分类号： G01N33536
CPC分类号： G01N33/542 , G01N33/533 , G01N2458/40
摘要： Homogeneous assays for determining quantitatively the extent of a specific binding reaction can be carried out effectively on very dilute solutions using measurements of fluorescence if a fluorescence measurement scheme that is capable of rejecting short-lived background fluorescence is employed and if the fluorescent group being measured has the following properties: a. the group being measured must be a rare earth metal chelate complex combination; b. the chelate must be water-soluble; c. the complex combination must also be stable in extremely dilute aqueous solutions, that is, the measured chelate must have at least one ligand having a metal-to-ligand binding constant of at least about 1013M−1 or greater and it must have a fluorescent emission that is long-lived compared to the longest decay lifetime of ambient substances and have a half life of from 0.01 to 50 msec.
摘要翻译：如果使用能够抑制短寿命背景荧光的荧光测量方案，并且如果被测量的荧光基团具有荧光测定方法，则可以使用荧光测量在非常稀的溶液上有效地进行特异性结合反应的程度的均匀测定以下属性：a。测量的组必须是稀土金属螯合物组合; b。螯合物必须是水溶性的; C。复杂组合也必须在非常稀的水溶液中稳定，即所测量的螯合物必须具有至少一种具有至少约1013M-1或更大的金属与配体结合常数的配体，并且必须具有荧光发射与环境物质的最长衰变寿命相比，寿命长，并且半衰期为0.01至50毫秒。

49. 发明授权

US5830769A Homogeneous fluorassay methods employing fluorescent background rejection and water-soluble rare earth metal chelates 失效
标题翻译：使用荧光背景排斥和水溶性稀土金属螯合物的均匀氟化法
公开(公告)号：US5830769A
公开(公告)日：1998-11-03
申请号：US732871
申请日：1996-10-15
申请人： Irwin Wieder , Ron L. Hale
发明人： Irwin Wieder , Ron L. Hale
IPC分类号： G01N33/533
CPC分类号： G01N33/533 , Y10S436/80
摘要： Homogeneous assays for determining quantitatively the extent of a specific binding reaction can be carried out effectively on very dilute solutions using measurements of fluorescence if a fluorescence measurement scheme that is capable of rejecting short-lived background fluorescence is employed and if the fluorescent group being measured has the following properties: a. the group being measured must be a rare earth metal chelate complex combination; b. the chelate must be water-soluble; c. the complex combination must also be stable in extremely dilute aqueous solutions, that is, the measured chelate must have at least one ligand having a metal-to-ligand binding constant of at least about 10.sup.13 M.sup.-1 or greater and it must have a fluorescent emission that is long-lived compared to the longest decay lifetime of ambient substances and have a half life of from 0.01 to 50 msec.
摘要翻译：如果使用能够抑制短寿命背景荧光的荧光测量方案，并且如果被测量的荧光基团具有荧光测定方法，则可以使用荧光测量在非常稀的溶液上有效地进行特异性结合反应的程度的均匀测定以下属性：a。测量的组必须是稀土金属螯合物组合; b。螯合物必须是水溶性的; C。复杂组合也必须在非常稀的水溶液中稳定，即所测量的螯合物必须具有至少一种具有至少约1013M-1或更大的金属与配体结合常数的配体，并且必须具有荧光发射与环境物质的最长衰变寿命相比，寿命长，并且半衰期为0.01至50毫秒。

50. 发明申请

US20100065052A1 Heating Units 审中-公开
标题翻译：加热单元
公开(公告)号：US20100065052A1
公开(公告)日：2010-03-18
申请号：US12211247
申请日：2008-09-16
申请人： C.V. Krishnamohan Sharma , Mingzu Lei , Karen Wang , Hoi Sze Lau , Ron L. Hale , Reynaldo Quintana , Pravin Soni
发明人： C.V. Krishnamohan Sharma , Mingzu Lei , Karen Wang , Hoi Sze Lau , Ron L. Hale , Reynaldo Quintana , Pravin Soni
IPC分类号： A61M15/00 , B32B37/06 , B32B37/12
CPC分类号： A61M11/041 , A61M11/047 , A61M11/048 , A61M15/0003 , A61M31/00 , A61M35/00
摘要： A heating unit comprises a substrate having a first surface and a second surface. A chemical reactant material capable of undergoing an exothermic reaction is disposed on at least a portion of the first surface of the substrate. An igniter is in proximity with the chemical reactant material. A layer of adhesive material overlays at least a portion of at least one of the chemical reactant material and the first surface of the substrate. Other embodiments of the heating unit include a first and a second substrate, each having first and second surfaces positioned with the first surfaces opposing each other in a sandwich construction. A chemical reactant material is disposed on at least a portion of the first surface of at least one of the substrates. The first and the second substrates are sealed together to define a cavity containing the chemical reactant material and an igniter is provided in proximity with the chemical reactant material.
摘要翻译：加热单元包括具有第一表面和第二表面的基底。能够经受放热反应的化学反应物质被设置在基板的第一表面的至少一部分上。点火器靠近化学反应物料。一层粘合剂材料覆盖至少一部分化学反应物质和基材的第一表面的至少一部分。加热单元的其它实施例包括第一和第二基板，每个基板具有第一和第二表面，其中第一表面和第二表面以夹层结构彼此相对。化学反应物料设置在至少一个基底的第一表面的至少一部分上。将第一和第二基板密封在一起以限定包含化学反应物料的空腔，并且靠近化学反应物料提供点火器。

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