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41. 发明申请

US20060205934A1 Compositions, splice variants and methods relating to breast specific genes and proteins 审中-公开
标题翻译：与乳腺特异性基因和蛋白质相关的组合物，剪接变体和方法
公开(公告)号：US20060205934A1
公开(公告)日：2006-09-14
申请号：US10538001
申请日：2003-12-05
申请人： Roberto Macina , Leah Turner , Yongming Sun
发明人： Roberto Macina , Leah Turner , Yongming Sun
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30
CPC分类号： C12Q1/6886 , A61K39/00 , A61K48/00 , C07K14/47 , C12Q2600/112 , G01N33/57415
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，识别乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

42. 发明申请

US20050181413A1 Compositions and methods relating to ovary specific genes and proteins 审中-公开
标题翻译：与卵巢特异性基因和蛋白质有关的组成和方法
公开(公告)号：US20050181413A1
公开(公告)日：2005-08-18
申请号：US11057447
申请日：2005-02-14
申请人： Susana Salceda , Roberto Macina , Herve Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu
发明人： Susana Salceda , Roberto Macina , Herve Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu
IPC分类号： G01N33/53 , A61K39/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/566 , G01N33/574 , G01N33/68 , C07H21/04 , C07K14/72
CPC分类号： C07K14/47 , A61K39/00 , A61K2039/505 , A61K2039/53 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , G01N33/57449 , G01N33/68
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic ovary cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovary tissue, identifying ovary tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovary tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗卵巢组织中的卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化卵巢组织的生产。

43. 发明申请

US20050152837A1 Novel method of diagnosing, monitoring, staging, imaging and treating cancer 失效
标题翻译：诊断，监测，分期，成像和治疗癌症的新方法
公开(公告)号：US20050152837A1
公开(公告)日：2005-07-14
申请号：US11068678
申请日：2005-02-28
申请人： Herve Recipon , Roberto Macina , Sei-Yu Chen , Yongming Sun
发明人： Herve Recipon , Roberto Macina , Sei-Yu Chen , Yongming Sun
IPC分类号： A61K39/00 , A61K49/16 , A61K51/10 , C07K16/30 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/574 , A61K51/00 , A61K49/00
CPC分类号： G01N33/57423 , A61K39/0011 , A61K49/16 , A61K51/1054 , A61K2039/505 , C07K16/3023 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/574
摘要： The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating cancer.
摘要翻译：本发明提供了检测，诊断，监测，分期，预后，成像和治疗癌症的新方法。

44. 发明申请

US20050147556A1 Method of diagnosing, monitoring, staging, imaging and treating prostate cancer 有权
公开(公告)号：US20050147556A1
公开(公告)日：2005-07-07
申请号：US10929973
申请日：2004-08-30
申请人： Shujath Ali , Yongming Sun , Susana Salceda , Herve Recipon , Robert Cafferkey
发明人： Shujath Ali , Yongming Sun , Susana Salceda , Herve Recipon , Robert Cafferkey
IPC分类号： C07K14/47 , A61K51/00 , C07K16/30 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/4748 , A61K2039/505
摘要： The present invention provides a new method for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating prostate cancer.

45. 发明申请

US20050136473A1 Compositions and methods relating to breast specific genes and proteins 审中-公开
公开(公告)号：US20050136473A1
公开(公告)日：2005-06-23
申请号：US11057807
申请日：2005-02-14
申请人： Yongming Sun , Herve Recipon , Susana Salceda , Chenghua Liu , Leah Turner
发明人： Yongming Sun , Herve Recipon , Susana Salceda , Chenghua Liu , Leah Turner
IPC分类号： A61K39/00 , C07K14/47 , C12P21/04 , C12Q1/68 , C07H21/04 , G01N33/574
CPC分类号： C07K14/47 , A61K39/00 , A61K2039/505
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

46. 发明申请

US20050079483A1 Novel method of diagnosing, monitoring, and staging prostate cancer 失效
标题翻译：诊断，监测和分期前列腺癌的新方法
公开(公告)号：US20050079483A1
公开(公告)日：2005-04-14
申请号：US10939560
申请日：2004-09-13
申请人： Shujath Ali , Susana Salceda , Yongming Sun , Robert Cafferkey
发明人： Shujath Ali , Susana Salceda , Yongming Sun , Robert Cafferkey
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156
摘要： The present invention provides a new method for detecting, diagnosing, monitoring, staging and prognosticating prostate cancer.
摘要翻译：本发明提供了一种用于检测，诊断，监测，分期和预测前列腺癌的新方法。

47. 发明申请

US20050037419A1 Compositions and methods relating to lung specific genes and proteins 审中-公开
公开(公告)号：US20050037419A1
公开(公告)日：2005-02-17
申请号：US10958862
申请日：2004-10-05
申请人： Herve Recipon , Yongming Sun , Sei-Yu Chen , Chenghua Liu , Leah Turner
发明人： Herve Recipon , Yongming Sun , Sei-Yu Chen , Chenghua Liu , Leah Turner
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P11/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/574 , C07H21/04 , C12N9/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.

48. 发明授权

US06846650B2 Compositions and methods relating to lung specific genes and proteins 失效
标题翻译：与肺特异性基因和蛋白质有关的组成和方法
公开(公告)号：US06846650B2
公开(公告)日：2005-01-25
申请号：US10002344
申请日：2001-10-25
申请人： Herve E. Recipon , Yongming Sun , Sei-Yu Chen , Chenghua Liu , Leah R. Turner
发明人： Herve E. Recipon , Yongming Sun , Sei-Yu Chen , Chenghua Liu , Leah R. Turner
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P11/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/574 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，识别肺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。

49. 发明授权

US06737040B1 Method and antibody for imaging breast cancer 失效
标题翻译：用于成像乳腺癌的方法和抗体
公开(公告)号：US06737040B1
公开(公告)日：2004-05-18
申请号：US09762027
申请日：2001-08-06
申请人： Yongming Sun , Herve Recipon , Robert Cafferkey
发明人： Yongming Sun , Herve Recipon , Robert Cafferkey
IPC分类号： A61K4900
CPC分类号： G01N33/57415 , A61K49/16 , A61K51/1051 , C07K16/3015
摘要： The present invention provides a new method of detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating breast cancer.
摘要翻译：本发明提供了检测，诊断，监测，分期，预后，成像和治疗乳腺癌的新方法。

50. 发明申请

US20120319311A1 UV STERILIZATION CHAMBER FOR A HUMIDIFIER 审中-公开
标题翻译：一种除湿器紫外杀菌室
公开(公告)号：US20120319311A1
公开(公告)日：2012-12-20
申请号：US13002598
申请日：2010-10-20
申请人： Francis C Nutter , Zhijing Wang , Robert Zhao , Edisen Lu , Yongming Sun , Sean Wang , Christopher S. Kanel
发明人： Francis C Nutter , Zhijing Wang , Robert Zhao , Edisen Lu , Yongming Sun , Sean Wang , Christopher S. Kanel
IPC分类号： F24F6/02 , A61L2/10
CPC分类号： F24F13/00 , C02F1/32 , F24F6/02 , F24F6/043 , F24F13/20 , F24F2003/1667 , F24F2006/006 , F24F2006/008
摘要： A UV sterilization chamber is provided to a humidifier having a water reservoir, a humidifying element and a pathway for directing water provided by the water reservoir to the humidifying element of the humidifier. The pathway is provided in a humidifier base, over which a humidifier enclosure is removably placed. The UV sterilization chamber includes a serpentine portion of the pathway and a UV radiation source positioned for illuminating the portion of the pathway with UV light. Upwardly-directed projections in the base border a perimeter of the pathway; and a downwardly-directed projection of the UV radiation source extends between the upwardly-directed projections when the enclosure is mated with the base, thereby locating the UV radiation source over the portion of the pathway. A switch disables the UV radiation source when the enclosure is removed from the base.
摘要翻译： UV加压器设置在具有储水器，加湿元件和用于将由储水器提供的水引导到加湿器的加湿元件的通道的加湿器中。该通道设置在加湿器基座中，加湿器外壳可移除地放置在该加湿器基座上。 UV消毒室包括路径的蛇形部分和定位成用UV光照射路径部分的UV辐射源。在基部边界中的向上指向的突起在通路的周边; 并且当外壳与基座配合时，UV辐射源的向下指向的突出部在向上指向的突起之间延伸，从而将UV辐射源定位在路径的该部分上。当外壳从基座上拆下时，开关会禁用紫外线辐射源。

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