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41. 发明授权

US09880129B2 Mass spectrometer 有权
公开(公告)号：US09880129B2
公开(公告)日：2018-01-30
申请号：US11568167
申请日：2005-04-20
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： H01J49/06 , G01N27/62
CPC分类号： G01N27/624 , H01J49/062
摘要： A mass spectrometer is disclosed comprising a FAIMS device comprising two parallel electrodes (9a, 9b) in series with an ion mobility separator (12) forming part of a mass spectrometer. Ions are separated in the FAIMS device (9a, 9b) according to their rate of change of ion mobility with electric field strength. The ions which are onwardly transmitted from the FAIMS device (9a, 9b) are then passed to an ion separator device (12) comprising a plurality of electrodes (12) and an optional ion trapping region (33). Ions are radially confined with the ion separator by application of an AC or RF voltage to the electrodes (12) and ions are separated according to their ion mobility by applying an axial DC voltage gradient which may remain constant as a function of time or which may vary with time.

42. 发明授权

US08809768B2 Mass spectrometer with bypass of a fragmentation device 有权
标题翻译：质谱仪旁路碎片装置
公开(公告)号：US08809768B2
公开(公告)日：2014-08-19
申请号：US12952619
申请日：2010-11-23
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： H01J49/00
CPC分类号： H01J49/0031 , H01J49/0027 , H01J49/0045 , H01J49/10 , H01J49/34
摘要： A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer.
摘要翻译：用于分析组分混合物的方法包括从组分形成前体离子，交替地使前体离子传递到并绕过碎裂装置，以从通过装置的前体离子形成产物离子并基本上形成来自前体离子的产物离子越过旁路器件，并且从从器件接收的产物离子和从器件旁路的前体离子获得质谱。用于分析样品的装置包括用于从样品的组分形成前体离子的离子源，用于从前体离子形成产物离子的碎裂装置，设置在碎裂装置上游的旁路装置，用于可切换的旁路碎片装置和质量分析器。

43. 发明授权

US07943900B2 Mass analysis using alternating fragmentation modes 有权
标题翻译：使用交替分片模式进行质量分析
公开(公告)号：US07943900B2
公开(公告)日：2011-05-17
申请号：US12272117
申请日：2008-11-17
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： B01D59/44
CPC分类号： H01J49/0031 , H01J49/0027 , H01J49/0045 , H01J49/10 , H01J49/34
摘要： A method for the analysis of mixtures of components includes separating or partially separating different components of a mixture of a sample by means that causes the components to elute sequentially over a period of time, forming precursor ions from the components in the eluent, repeatedly switching, altering or varying an Electron Transfer Dissociation fragmentation device back and forth between a hi-fragmentation mode and a low-fragmentation mode to alternately produce product ions from the precursor ions in the hi-fragmentation mode and to produce substantially fewer product ions in the low-fragmentation mode, and obtaining mass spectra during the period of time from the precursor and product ions received from the Electron Transfer Dissociation fragmentation device.
摘要翻译：用于分析组分混合物的方法包括通过使组分在一段时间内顺序洗脱的方式分离或部分分离样品混合物的组分，从洗脱液中的组分形成前体离子，重复切换，在高分裂模式和低碎裂模式之间来回地改变或改变电子转移离解断裂装置，以在高分裂模式中交替地从前体离子产生产物离子，并在低分散化模式中产生基本上更少的产物离子，从电子转移解离分离装置接收的前体和产物离子获得质谱。

44. 发明授权

US07851751B2 Mass analysis with alternating bypass of a fragmentation device 有权
标题翻译：用分段装置的交替旁路进行质量分析
公开(公告)号：US07851751B2
公开(公告)日：2010-12-14
申请号：US12272213
申请日：2008-11-17
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0031 , H01J49/0027 , H01J49/0045 , H01J49/10 , H01J49/34
摘要： A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer.
摘要翻译：用于分析组分混合物的方法包括从组分形成前体离子，交替地使前体离子传递到并绕过碎裂装置，以从通过装置的前体离子形成产物离子并基本上形成来自前体离子的产物离子越过旁路器件，并且从从器件接收的产物离子和从器件旁路的前体离子获得质谱。用于分析样品的装置包括用于从样品的组分形成前体离子的离子源，用于从前体离子形成产物离子的碎裂装置，设置在碎裂装置上游的旁路装置，用于可切换的旁路碎片装置和质量分析器。

45. 发明申请

US20090065690A1 MASS ANALYSIS WITH ALTERNATING BYPASS OF A FRAGMENTATION DEVICE 有权
标题翻译：具有分段设备旁路的质量分析
公开(公告)号：US20090065690A1
公开(公告)日：2009-03-12
申请号：US12272213
申请日：2008-11-17
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： B01D59/44
CPC分类号： H01J49/0031 , H01J49/0027 , H01J49/0045 , H01J49/10 , H01J49/34
摘要： A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer.
摘要翻译：用于分析组分混合物的方法包括从组分形成前体离子，交替地使前体离子传递到并绕过碎裂装置，以从通过装置的前体离子形成产物离子并基本上形成来自前体离子的产物离子越过旁路器件，并且从从器件接收的产物离子和从器件旁路的前体离子获得质谱。用于分析样品的装置包括用于从样品的组分形成前体离子的离子源，用于从前体离子形成产物离子的碎裂装置，设置在碎裂装置上游的旁路装置，用于可切换的旁路碎片装置和质量分析器。

46. 发明授权

US07427752B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07427752B2
公开(公告)日：2008-09-23
申请号：US10535053
申请日：2003-10-28
申请人： Gareth Rhys Jones , Robert Harold Bateman
发明人： Gareth Rhys Jones , Robert Harold Bateman
IPC分类号： H01J49/30 , H01J49/32
CPC分类号： H01J49/30
摘要： A magnetic sector mass spectrometer is disclosed comprising an ion detector (11) wherein a reflecting electrode (13) is used to divide an ion beam in the direction of mass dispersion into two separate ion beams. The two ion beams are directed onto two detectors which preferably comprise two or more conversion dynodes (15a, 15b) and two or more corresponding microchannel plate detectors (14a, 14b) to detect electrons produced by the conversion dynodes (15a, 15b). If the signal from the two detectors differs substantially then the ion beam can be determined to include interference ions. Conversely, if the signal from the two detectors is substantially the same then the ion beam can be determined to be substantially free from interference ions.
摘要翻译：公开了一种磁性扇形质谱仪，其包括离子检测器（11），其中使用反射电极（13）将质谱分散的离子束分成两个分离的离子束。两个离子束被引导到两个检测器上，优选地包括两个或更多个转换倍增极（15a，15b）和两个或更多个相应的微通道板检测器（14a，14b），以检测由转换倍增电极（15a）产生的电子，15 b）。如果来自两个检测器的信号基本相差，则可以确定离子束包括干涉离子。相反，如果来自两个检测器的信号基本相同，则可以确定离子束基本上不含干扰离子。

47. 发明授权

US07199363B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07199363B2
公开(公告)日：2007-04-03
申请号：US10964791
申请日：2004-10-14
申请人： Robert Harold Bateman , Jeffery Mark Brown , Daniel James Kenny
发明人： Robert Harold Bateman , Jeffery Mark Brown , Daniel James Kenny
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/405 , H01J49/0031
摘要： A mass spectrometer is disclosed comprising an ion source 4, a field free or drift region 5 and an ion mirror 7 comprising a reflectron. Metastable parent ions which spontaneously fragment by Post Source Decay whilst passing through the field free or drift region 5 are arranged to enter the ion mirror 7 and be reflected by the reflectron towards an ion detector 8 when the reflectron is maintained at a certain voltage. The process is then repeated with the reflectron being maintained at a slightly lower voltage. Two related sets of time of flight or mass spectral data are obtained for the two different voltage settings of the reflectron. From the two data sets the different times of flight for the same species of fragment ion can be determined. The mass to charge ratio of the parent ion which fragmented to produce the particular species of fragment ion can then be determined from the times of flight of the fragment ions.
摘要翻译：公开了一种质谱仪，其包括离子源4，无场或漂移区5以及包括反射镜的离子镜7。当通过场自由或漂移区域5时通过后源衰变自发分裂的亚稳态亲本离子被布置成当反射器保持在一定电压时进入离子反射镜7并被反射器反射离子检测器8。然后重复该过程，其中反射器保持在稍低的电压。对于反射镜的两个不同的电压设置，获得两组相关的飞行时间或质谱数据。从两个数据集可以确定相同种类的碎片离子的不同飞行时间。然后可以从片段离子的飞行时间确定碎片化以产生特定种类的碎片离子的母体离子的质荷比。

48. 发明授权

US07087897B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07087897B2
公开(公告)日：2006-08-08
申请号：US10797242
申请日：2004-03-10
申请人： Robert Harold Bateman , Jeff Brown
发明人： Robert Harold Bateman , Jeff Brown
IPC分类号： H01J49/40
CPC分类号： H01J49/401
摘要： A mass spectrometer is disclosed comprising an electric field region L2 wherein a time-varying electric field is applied thereto. In a mode of operation a pulse of ions 3 comprising ions having different mass to charge ratios passes through the electric field region L2 and the electric field is varied with time such that at least some of the ions 3 having different mass to charge ratios subsequently arrive at the extraction or acceleration region 10 of a Time of Flight mass analyser at substantially the same time.
摘要翻译：公开了一种质谱仪，其包括施加时变电场的电场区域L 2。在操作模式中，包含不同质荷比的离子的离子3的脉冲通过电场区L 2，并且电场随时间而变化，使得至少一些离子3 具有不同的质荷比随后在几乎相同的时间到达飞行时间质量分析仪的提取或加速区域10。

49. 发明授权

US07041972B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07041972B2
公开(公告)日：2006-05-09
申请号：US10841145
申请日：2004-05-07
申请人： Steve Bajic , Robert Harold Bateman
发明人： Steve Bajic , Robert Harold Bateman
IPC分类号： H01J49/10
CPC分类号： H01J49/168
摘要： An Atmospheric Pressure Chemical Ionisation ion source is disclosed wherein the current applied to a corona needle 2 is repeatedly varied between two or more settings during a single experimental run or acquisition. Two or more separate sets of mass spectral or mass analysed data are obtained. The ion source in one embodiment comprises a heated tube 1 arranged to discharge gas and analyte into a housing 7 enclosing corona needle 2. The housing 7 comprises a gas outlet port 3 via which analyte ions exit. According to another embodiment the corona needle does not have to be enclosed within a housing.
摘要翻译：公开了一种大气压化学电离离子源，其中施加到电晕针2上的电流在单个实验运行或采集期间在两个或多个设置之间重复变化。获得了两组或更多个分开的质谱分析数据。在一个实施例中，离子源包括被配置为将气体和分析物排放到包围电晕针2的壳体7中的加热管1。壳体7包括气体出口3，分析物离子通过该出口3离开。根据另一个实施例，电晕针不必被封闭在外壳内。

50. 发明授权

US06794642B2 Mass spectrometer 有权
公开(公告)号：US06794642B2
公开(公告)日：2004-09-21
申请号：US10636811
申请日：2003-08-08
申请人： Robert Harold Bateman , Jeff Brown
发明人： Robert Harold Bateman , Jeff Brown
IPC分类号： H01J4926
CPC分类号： H01J49/42 , H01J49/004
摘要： A mass spectrometer is disclosed comprising at least first and second ion traps which are arranged in series. A relatively high AC or RF voltage is applied to the electrodes forming the first ion trap in order to improve the trapping of energetic or high mass to charge ratio ions. The relatively high AC or RF voltage applied to the first ion trap also has the effect of raising the low mass cut-off of the first ion trap. The second ion trap, arranged downstream of the first ion trap, is arranged to have a lower low mass cut-off than the first ion trap, and hence ions which are not trapped in the first ion trap are trapped in the second ion trap.

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