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41. 发明授权

US4953727A Piston and shaft assembly of railroad end-of-car cushioning devices and method of repairing same 失效
标题翻译：铁路终端缓冲装置的活塞和轴组件及其修理方法
公开(公告)号：US4953727A
公开(公告)日：1990-09-04
申请号：US374954
申请日：1989-07-03
申请人： Howard E. Tonn , Robert Davidson , David B. Shultz , Keith R. Miller
发明人： Howard E. Tonn , Robert Davidson , David B. Shultz , Keith R. Miller
IPC分类号： B61G9/08
CPC分类号： B61G9/08
摘要： This invention concerns an end-of-car hydraulic cushioning device for use on rail cars and a method of repairing such devices. The cushioning device has a piston and shaft assembly which is subject to train action forces. The piston and shaft are connected by means of a threaded engagement which prevents relative axial movements between the two parts. Rotational movement of the piston on the shaft is prevented by a hardened steel pin disposed in aligned, radial holes formed in the piston and shaft. The pin and holes are sized to provide clearance between the piston and pin. This permits piston metal deformation to occur during high speed impacts without catastrophically stressing the steel pin. A filler rod retains the pin in the radial holes.
摘要翻译：本发明涉及一种用于轨道车辆的汽车终端液压缓冲装置和修理这种装置的方法。缓冲装置具有经受列车作用力的活塞和轴组件。活塞和轴通过螺纹接合连接，防止两部分之间的相对轴向移动。通过设置在形成于活塞和轴中的排列的径向孔中的硬化钢销来防止活塞在轴上的旋转运动。销和孔的尺寸设置成在活塞和销之间提供间隙。这样可以在高速冲击时发生活塞金属变形，而不会对钢销造成灾难性的压力。填充杆将销保持在径向孔中。

42. 发明授权

US08883483B2 Combinatorial DNA library for producing modified N-glycans in lower eukaryotes 有权
标题翻译：用于在低等真核生物中生产修饰的N-聚糖的组合DNA文库
公开(公告)号：US08883483B2
公开(公告)日：2014-11-11
申请号：US13156804
申请日：2011-06-09
申请人： Tillman U. Gerngross , Stefan Wildt , Byung-kwon Choi , Juergen Nett , Piotr Bobrowicz , Stephen Hamilton , Robert Davidson
发明人： Tillman U. Gerngross , Stefan Wildt , Byung-kwon Choi , Juergen Nett , Piotr Bobrowicz , Stephen Hamilton , Robert Davidson
IPC分类号： C12N15/04 , C12N1/16 , C07K14/47 , C12N9/10 , C12N15/10 , C12N15/79
CPC分类号： C12P21/005 , C07K14/47 , C12N9/1051 , C12N15/1082 , C12N15/79
摘要： The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The invention provides nucleic acid molecules and combinatorial libraries which can be used to successfully target and express mammalian enzymatic activities such as those involved in glycosylation to intracellular compartments in a eukaryotic host cell. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. Host cells with modified oligosaccharides are created or selected. N-glycans made in the engineered host cells have a Man5GlcNAc2 core structure which may then be modified further by heterologous expression of one or more enzymes, e.g., glycosyltransferases, sugar transporters and mannosidases, to yield human-like glycoproteins. For the production of therapeutic proteins, this method may be adapted to engineer cell lines in which any desired glycosylation structure may be obtained.
摘要翻译：本发明涉及具有修饰的寡糖的真核宿主细胞，其可以通过异源表达一组糖基转移酶，糖转运体和甘露糖苷酶进一步修饰，以成为用于产生哺乳动物例如人治疗性糖蛋白的宿主菌株。本发明提供核酸分子和组合文库，其可用于成功靶向和表达哺乳动物酶活性，例如参与糖基化的真核宿主细胞中的细胞内区室的那些。该方法提供了可用于表达和靶向参与糖基化的任何所需基因的工程化宿主细胞。建立或选择具有修饰寡糖的宿主细胞。在工程化宿主细胞中制备的N-聚糖具有Man5GlcNAc2核心结构，然后可以通过异源表达一种或多种酶，例如糖基转移酶，糖转运蛋白和甘露糖苷酶来进一步修饰，以产生人样糖蛋白。为了生产治疗性蛋白质，该方法可适用于工程化可能获得任何所需糖基化结构的细胞系。

43. 发明申请

US20140012700A1 METHODS FOR AND APPARATUS FOR PROVIDING ADVICE BASED UPON EMOTIONAL MOTIVATORS 审中-公开
标题翻译：用于提供基于意图激励器的建议的方法和装置
公开(公告)号：US20140012700A1
公开(公告)日：2014-01-09
申请号：US13924468
申请日：2013-06-21
申请人： Robert Davidson , Fanny Chung Davidson , Belinda Womack
发明人： Robert Davidson , Fanny Chung Davidson , Belinda Womack
IPC分类号： G06Q30/06
CPC分类号： G06Q30/0631 , G06Q30/0241 , G06Q30/06
摘要： The present invention provides methods and apparatus for associating Products with Emotional Qualifiers and Purchasers with Emotional Motivators. The associations may then be used to provide advice on a decision to Purchase or other decision.
摘要翻译：本发明提供了将产品与情绪限定词和购买者与情绪动机相关联的方法和装置。然后可以将协会用于就购买决定或其他决定提供建议。

44. 发明申请

US20090124000A1 Recombinant Vectors 有权
标题翻译：重组载体
公开(公告)号：US20090124000A1
公开(公告)日：2009-05-14
申请号：US12227203
申请日：2007-05-18
申请人： Juergen Nett , Robert Davidson
发明人： Juergen Nett , Robert Davidson
IPC分类号： C12N15/81
CPC分类号： C12N15/815 , C12N15/905
摘要： Methods and materials are provided for integrating heterologous nucleic acids into the genome of a cell or virus without disrupting expression of genes adjacent to the insertion site.
摘要翻译：提供的方法和材料用于将异源核酸整合到细胞或病毒的基因组中，而不会破坏与插入位点相邻的基因的表达。

45. 发明申请

US20080139470A1 Erythropoietin compositions 有权
标题翻译：红细胞生成素组成
公开(公告)号：US20080139470A1
公开(公告)日：2008-06-12
申请号：US11804510
申请日：2007-05-18
申请人： Natarajan Sethuraman , Juergen Nett , Robert Davidson
发明人： Natarajan Sethuraman , Juergen Nett , Robert Davidson
IPC分类号： A61K38/00 , C07K14/505 , C12P21/04 , A61P7/00
CPC分类号： C07K14/505 , C12P21/005
摘要： Methods and materials are provided for the production of compositions of erythropoietin protein, wherein said compositions comprise a pre-selected N-linked glycosylation pattern as the predominant N-glycoform.
摘要翻译：提供了用于生产促红细胞生成素蛋白质组合物的方法和材料，其中所述组合物包含预先选择的N-连接的糖基化模式作为主要的N-糖基型。

46. 发明申请

US20070275040A1 METHOD AND APPARATUS FOR MINIMIZING HEAT, MOISTURE, AND SHEAR DAMAGE TO MEDICANTS AND OTHER COMPOSITIONS DURING INCORPORATION OF SAME WITH EDIBLE FILMS 有权
标题翻译：在与可食用薄膜共同使用的情况下，将药物和其他组合物的热量，水分和剪切损伤最小化的方法和装置
公开(公告)号：US20070275040A1
公开(公告)日：2007-11-29
申请号：US11836758
申请日：2007-08-09
申请人： Robert Davidson
发明人： Robert Davidson
IPC分类号： A61K9/50
CPC分类号： A61K9/006 , A61K9/0051 , A61K9/0056 , A61K9/7007 , A61K31/167 , A61K31/43 , A61K33/06 , A61K47/36 , A61K47/38
摘要： A medicant composition is provided. The composition includes a film layer and a powder matrix layer. The powder matrix layer includes a medicant. The powder matrix layer is applied to the film layer by admixing particulate to form a powder matrix and by then applying the powder matrix to the film layer by any desired method. The composition of the powder matrix is varied to alter the dissolution rate of the medicant, the adhesion of the medicant composition, and other physical properties of the powder matrix. The powder matrix layer can be cured.
摘要翻译：提供了一种药物组合物。该组合物包括膜层和粉末基质层。粉末基质层包括药物。通过将颗粒混合以形成粉末基质，然后通过任何所需的方法将粉末基质施加到膜层，将粉末基质层施加到膜层。改变粉末基质的组成以改变药物的溶解速率，药物组合物的粘附性和粉末基质的其它物理性质。粉末基质层可以固化。

47. 发明申请

US20070235434A1 Method and Apparatus For Pulse Welding 有权
标题翻译：脉冲焊接方法与装置
公开(公告)号：US20070235434A1
公开(公告)日：2007-10-11
申请号：US11278344
申请日：2006-03-31
申请人： Robert Davidson , David Almy , Richard Schuh
发明人： Robert Davidson , David Almy , Richard Schuh
IPC分类号： B23K9/09
CPC分类号： B23K9/092 , B23K9/093
摘要： A method and system for pulse welding provides an output pulse waveform. The waveform has at least a frequency from a range of available frequencies not limited to harmonic frequencies. The waveform provides power suitable for welding, and has a plurality of background portions alternating with a plurality of peak portions. A transition down occurs from the peak portion to the background portion with a first acceleration and a transition up occurs from the background portion to the peak portion with a second acceleration. At least one of the first and second accelerations are non-zero over at least most of the transition. The waveform is preferably created by switching an inverter. Both accelerations may be non-zero, and each transition may have two accelerations, one negative closer to the peak, and one positive closer to the background. The accelerations may be constant with opposite polarity. Preferably the process is current controlled during the transitions. The process frequency may be fixed or varying.
摘要翻译：脉冲焊接的方法和系统提供输出脉冲波形。该波形至少有一个频率范围内的可用频率不限于谐波频率。波形提供适合于焊接的功率，并且具有与多个峰部交替的多个背景部分。从第一加速度的峰部分到背景部分发生转变下降，并且以第二加速度从背景部分到峰部分发生转变。第一和第二加速度中的至少一个在至少大部分转换中都是非零的。该波形优选地通过切换逆变器来产生。两个加速度可以是非零，并且每个转变可以具有两个加速度，一个靠近峰值的加速度，另一个加速度更靠近背景。加速度可以是相反极性的恒定。优选地，该过程在过渡期间是电流控制的。过程频率可以是固定的或变化的。

48. 发明申请

US20060081578A1 Method and apparatus for welding 有权
公开(公告)号：US20060081578A1
公开(公告)日：2006-04-20
申请号：US11286960
申请日：2005-11-23
申请人： Todd Holverson , James Uecker , Robert Davidson , Richard Hutchison
发明人： Todd Holverson , James Uecker , Robert Davidson , Richard Hutchison
IPC分类号： B23K9/09
CPC分类号： B23K9/0008 , B23K9/067 , B23K9/073 , B23K9/09 , B23K9/095
摘要： A method and apparatus for welding include initiating a pulse welding process includes initiating a welding arc by providing CC type welding power, maintaining the arc by providing CV type power. Then, pulse type welding power is provided. The method and system can be used to start short circuit, or other welding processes by providing short circuit power, or welding power of a given mode, instead of providing pulse power. Also, in one alternative, a method and system of initiating a pulse, short circuit, or given welding process includes initiating a welding arc by providing CC type welding power at least until a pseudo-equilibrium for the arc is established. Then, providing welding power in a pulse, short circuit, or the given mode.

49. 发明申请

US20050208617A1 N-acetylglucosamintransferase III expression in lower eukaryotes 失效
标题翻译： N-乙酰葡萄糖转移酶III在低等真核生物中的表达
公开(公告)号：US20050208617A1
公开(公告)日：2005-09-22
申请号：US10680963
申请日：2003-10-07
申请人： Piotr Bobrowicz , Stephen Hamilton , Tilman Gerngross , Stefan Wildt , Byung-Kwon Choi , Juergen Nett , Robert Davidson
发明人： Piotr Bobrowicz , Stephen Hamilton , Tilman Gerngross , Stefan Wildt , Byung-Kwon Choi , Juergen Nett , Robert Davidson
IPC分类号： A61K38/00 , C07K14/39 , C07K14/47 , C12N1/18 , C12N9/10 , C12N15/12 , C12N15/74 , C12P21/00 , C12P21/06
CPC分类号： C07K14/39 , A61K38/00 , C07K2319/05 , C12N9/1051 , C12P21/005 , Y02A50/396
摘要： The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. Host cells with modified lipid-linked oligosaccharides are created or selected. N-glycans made in the engineered host cells exhibit GnTIII activity, which produce bisected N-glycan structures and may be modified further by heterologous expression of one or more enzymes, e.g., glycosyltransferases, sugar transporters and mannosidases, to yield human-like glycoproteins. For the production of therapeutic proteins, this method may be adapted to engineer cell lines in which any desired glycosylation structure may be obtained.
摘要翻译：本发明涉及具有修饰的寡糖的真核宿主细胞，其可以通过异源表达一组糖基转移酶，糖转运体和甘露糖苷酶进一步修饰，以成为用于产生哺乳动物例如人治疗性糖蛋白的宿主菌株。该方法提供了可用于表达和靶向参与糖基化的任何所需基因的工程化宿主细胞。制备或选择具有修饰的脂质连接寡糖的宿主细胞。在工程化的宿主细胞中制备的N-聚糖表现出GnTIII活性，其产生二等分的N-聚糖结构，并且可以通过异源表达一种或多种酶（例如糖基转移酶，糖转运蛋白和甘露糖苷酶）进一步修饰，以产生人样糖蛋白。为了生产治疗性蛋白质，该方法可适用于工程化可能获得任何所需糖基化结构的细胞系。

50. 发明申请

US20050185568A1 Storage device 审中-公开
标题翻译：储存设备
公开(公告)号：US20050185568A1
公开(公告)日：2005-08-25
申请号：US10784622
申请日：2004-02-23
申请人： Robert Davidson
发明人： Robert Davidson
IPC分类号： G11B9/00 , G11B9/10 , G11B11/08 , G11C16/00
CPC分类号： B82Y10/00 , G11B9/10 , G11B9/14 , G11B9/1409 , G11B9/1463 , G11B9/1472 , G11B11/08
摘要： The present invention provides a storage device. The storage device comprises a field emitter, a storage medium having a storage area being in one of at least three states to represent information stored at the storage area, and a read circuit for sensing the state of the storage area and providing an output signal representative of the sensed status.
摘要翻译：本发明提供一种存储装置。存储装置包括场发射器，具有存储区域处于至少三种状态之一以表示存储在存储区域中的信息的存储介质，以及读取电路，用于感测存储区域的状态并提供输出信号代表的感觉状态。

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