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41. 发明授权

US07156095B2 Hybrid microprocessor controlled ventilator unit 有权
标题翻译：混合微处理器控制的呼吸机单元
公开(公告)号：US07156095B2
公开(公告)日：2007-01-02
申请号：US10140888
申请日：2002-05-09
申请人： Richard J. Melker , Michael J. Banner , Samsun Lampotang , Paul B. Blanch , Neil R. Euliano , Ronald G. Carovano
发明人： Richard J. Melker , Michael J. Banner , Samsun Lampotang , Paul B. Blanch , Neil R. Euliano , Ronald G. Carovano
IPC分类号： A61M16/00 , A62B7/00
CPC分类号： A61M16/206 , A61M16/0051 , A61M16/026 , A61M16/0858 , A61M16/203 , A61M16/205 , A61M16/208 , A61M16/209 , A61M2016/0021 , A61M2016/0027 , A61M2205/16
摘要： A method and apparatus for operating a ventilator in a primary electronic mode or in a back-up pneumatic mode during primary electronic mode failure. A method and apparatus for operating a ventilator in an advanced mode, having a number of ventilatory modes, or in a basic mode, having a limited number of ventilatory modes is also disclosed.
摘要翻译：一种用于在初级电子模式故障期间以主电子模式或备用气动模式操作呼吸机的方法和装置。还公开了一种用于以具有有限数量的通气模式的具有多个通气模式或以基本模式操作高级模式的呼吸机的方法和装置。

42. 发明授权

US07127278B2 Specially configured lip/cheek pulse oximeter/photoplethysmography probes, selectively with sampler for capnography, and covering sleeves for same 有权
标题翻译：特别配置的唇/颊脉搏血氧计/光电容积描记测量头，选择性地用于二氧化碳检查的取样器，同时覆盖袖子
公开(公告)号：US07127278B2
公开(公告)日：2006-10-24
申请号：US10751308
申请日：2004-01-02
申请人： Richard J. Melker , Joachim S. Gravenstein , George Worley
发明人： Richard J. Melker , Joachim S. Gravenstein , George Worley
IPC分类号： A61B5/00
CPC分类号： A61B5/0295 , A61B5/0205 , A61B5/02416 , A61B5/02427 , A61B5/0261 , A61B5/036 , A61B5/087 , A61B5/0873 , A61B5/14551 , A61B5/14552 , A61B5/4818 , A61B5/4836 , A61B5/6819 , A61B5/682 , A61B5/6826 , A61B5/6829 , A61B5/7278 , A61B5/7282 , A61B2560/0276 , A61B2562/247 , A61M16/0003 , A61M16/0051 , A61M16/0057 , A61M16/021 , A61M16/0666 , A61M16/0672 , A61M16/08 , A61M16/20 , A61M2202/0208 , A61M2202/03 , A61M2205/3561 , A61M2205/3569 , A61M2210/0618 , A61M2210/0625 , A61M2210/0662 , A61M2230/06 , A61M2230/205 , A61M2230/30 , A61M2230/42 , A61M2230/432 , A61M2230/005 , A61M2202/0007
摘要： The present invention relates to novel lip/cheek probes for detection of pulse-based differences in light absorbence across the vascularized tissue of a lip or cheek of a patient. These probes are fabricated to provide signals to estimate arterial oxygen saturation, and/or to obtain other photoplethysmographic data. The present invention also relates to a combined probe/cannula. The present invention also relates to other devices that combine a pulse oximeter probe with a device supplying oxygen or other oxygen-containing gas to a person in need thereof, and to sampling means for exhaled carbon dioxide in combination with the novel lip/cheek probes. In certain embodiments, an additional limitation of a control means to adjust the flow rate of such gas is provided, where such control is directed by the blood oxygen saturation data obtained from the pulse oximeter probe.
摘要翻译：本发明涉及用于检测穿过患者的唇部或脸颊的血管化组织的基于脉搏的差异的新型唇/颊探针。制造这些探针以提供信号以估计动脉血氧饱和度和/或获得其它光电体积描记数据。本发明还涉及组合的探针/套管。本发明还涉及将脉搏血氧计探针与向有需要的人提供氧气或其它含氧气体的装置组合的其它装置，以及与新型唇/颊探头组合的呼出二氧化碳的取样装置。在某些实施例中，提供了调节这种气体的流速的控制装置的附加限制，其中这种控制由从脉搏血氧计探针获得的血氧饱和度数据指示。

43. 发明授权

US06981947B2 Method and apparatus for monitoring respiratory gases during anesthesia 失效
公开(公告)号：US06981947B2
公开(公告)日：2006-01-03
申请号：US10178877
申请日：2002-06-24
申请人： Richard J. Melker
发明人： Richard J. Melker
IPC分类号： A61B5/08
CPC分类号： A61B5/4821 , A61B5/08 , A61B5/082 , A61B5/0836 , A61B5/7267 , A61M5/142 , A61M5/1723 , A61M16/0051 , A61M16/01 , A61M16/026 , A61M2016/1035 , A61M2230/437
摘要： A method and system is provided for monitoring delivery of anesthesia (inhalational and intravenous) and detecting the depth of anesthesia wherein at least one anesthetic agent is absorbed in patient's bloodstream during the administration of anesthesia, which includes sampling inspired and expired gas; analyzing the gas for concentration of at least one substance indicative of the anesthetic agent using sensor technology such as free (unmetabolized) anesthetic agent or its metabolites; determining the effect of the agent based on that concentration; and determining depth of anesthesia based thereon.

44. 发明授权

US6139821A Materials and methods utilizing a temporary visual indicator 失效
标题翻译：使用临时视觉指标的材料和方法
公开(公告)号：US6139821A
公开(公告)日：2000-10-31
申请号：US362164
申请日：1999-07-27
申请人： Ronnie S. Fuerst , Christopher D. Batich , Richard J. Melker
发明人： Ronnie S. Fuerst , Christopher D. Batich , Richard J. Melker
IPC分类号： A61K6/00 , A61K8/04 , A61K8/49 , A61K31/34 , A61Q17/04 , C09D7/00 , C11D3/40 , G01N31/22 , A61K7/42 , A61K7/44 , A61K31/74
CPC分类号： G01N31/221 , A61K6/0017 , A61K6/0058 , A61K8/046 , A61K8/4973 , A61Q17/04 , C09D7/00 , C11D3/40 , A61K2800/45 , Y10T428/13 , Y10T428/1352 , Y10T428/1397
摘要： This invention relates to novel compositions containing temporary visual indicators and methods for using these compositions. Specifically, this invention relates to a sunscreen composition containing an indicator that is visible when the substance is applied to the skin, but becomes invisible shortly after application. The continued presence of the indicator allows the indicator to be reactivated temporarily to the visible form so that a user can verify the presence of the sunscreen. The visible indicator ensures that the sunscreen is applied evenly and completely to the area to be protected, but becomes invisible so as not to interfere with the action of the sunscreen or discolor the skin.
摘要翻译：本发明涉及含有临时视觉指示剂和使用这些组合物的方法的新型组合物。具体地说，本发明涉及一种防晒组合物，其含有当该物质施用于皮肤时可见的指示剂，但在施用后不久即可看见。指示器的持续存在允许指示器临时重新启动到可见形式，使得用户可以验证防晒剂的存在。可视指示器确保防晒霜均匀且完全地涂覆到要保护的区域，但变得不可见，以免干扰防晒霜的作用或使皮肤变色。

45. 发明授权

US5328480A Vascular wire guiode introducer and method of use 失效
标题翻译：血管线导引器及其使用方法
公开(公告)号：US5328480A
公开(公告)日：1994-07-12
申请号：US959287
申请日：1992-10-09
申请人： Richard J. Melker , Frank J. Fischer, Jr.
发明人： Richard J. Melker , Frank J. Fischer, Jr.
IPC分类号： A61M5/178
CPC分类号： A61M25/09041
摘要： Multi-lumen wire guide introducer and method of inserting a wire guide or the like into the introducer prior to positioning the introducer in a vessel of the vascular system of a patient. The multi-lumen wire guide introducer comprises a tubular member formed of a semi-rigid plastic material such as a radiopaque polytetrafluoroethylene with first and second adjacent lumens extending longitudinally therein. In one aspect, the tubular member includes a tapered outer surface extending proximally from the distal end of the member and centered about the first lumen. The second lumen includes an opening in the tapered outer surface of the tubular member for extending a wire guide therefrom and into the blood vessel. In another aspect, the tubular member has proximal and distal portions with a first lumen extending longitudinally therethrough. The proximal portion includes a second lumen extending longitudinally therein and communicating with the first lumen prior to the distal portion. A method for positioning the multi-lumen introducer in the blood vessel of a patient includes the steps of providing and inserting a hollow needle through the first lumen, providing and inserting a wire guide in the second lumen, inserting the needle and tubular member into the blood vessel of a patient, advancing the wire guide from the second lumen into the blood vessel, and removing the needle and tubular member from the blood vessel when the wire guide is in place.
摘要翻译：多腔引导引导器以及在将导引器定位在患者的血管系统的血管内之前将引线管等插入导引器中的方法。多腔导线引导器包括由半刚性塑料材料形成的管状构件，例如不透射线的聚四氟乙烯，其中第一和第二相邻管腔在其中纵向延伸。在一个方面，管状构件包括从构件的远端向近侧延伸并且围绕第一内腔居中的锥形外表面。第二管腔包括在管状构件的锥形外表面中的开口，用于将线引导件从其延伸进入血管。在另一方面，管状构件具有近端部分和远端部分，其中第一内腔纵向延伸穿过其中。近端部分包括在其中纵向延伸并且在远侧部分之前与第一内腔连通的第二腔。用于将多腔引导器定位在患者的血管中的方法包括以下步骤：通过第一内腔提供并插入空心针，在第二腔中提供并插入线引导件，将针管和管状构件插入患者的血管，将线引导件从第二内腔推进到血管中，并且当导线器就位时从血管中移除针管和管状构件。

46. 发明授权

US5242410A Wireless high flow intravascular sheath introducer and method 失效
标题翻译：无线高流量血管内导管器及方法
公开(公告)号：US5242410A
公开(公告)日：1993-09-07
申请号：US873665
申请日：1992-04-23
申请人： Richard J. Melker
发明人： Richard J. Melker
IPC分类号： A61M25/06
CPC分类号： A61M25/06
摘要： A wireless high flow sheath introducer for intravascular access and a method for using such an introducer. The invention comprises a large bore flow sheath having a nested, coaxial, tapered dilator which dilates a vein to a size sufficient for introduction of the large bore flow sheath, and a needle nested within the tapered dilator and coaxial therewith for initially piercing the target vessel. The present invention also provides a method of using such an instrument.
摘要翻译：一种用于血管内通路的无线高流量护套引导器和使用这种导引器的方法。本发明包括具有嵌套的同轴锥形扩张器的大口径流动鞘，其将静脉扩张到足以引入大孔流动鞘的尺寸，以及嵌套在锥形扩张器内并与之同轴的针，用于最初刺穿靶容器。本发明还提供了使用这种仪器的方法。

47. 发明授权

US10390715B2 Photoplethysmography sensors 有权
公开(公告)号：US10390715B2
公开(公告)日：2019-08-27
申请号：US13650310
申请日：2012-10-12
申请人： David Rich , Richard J. Melker , Andrew Kersey , Matt Culen
发明人： David Rich , Richard J. Melker , Andrew Kersey , Matt Culen
IPC分类号： A61B5/0205 , A61B5/024 , A61B5/026 , A61B5/1455 , A61B5/00 , A61B5/087
摘要： Provided according to embodiments of the invention are photoplethysmography (PPG) sensors, systems and accessories, and methods of making and using the same. In some embodiments of the invention, the PPG sensors include a clip body that includes a first end portion and a second end portion; a flex circuit attached or adjacent to the clip body, and an elastomeric sleeve that envelops (1) at least part of the first end portion and at least part of the flex circuit attached or adjacent thereto; or (2) at least part of the second end portion and at least part of the flex circuit attached or adjacent thereto.

48. 发明授权

US09717836B2 Method for monitoring blood flow and volume using photoplethysmography 有权
公开(公告)号：US09717836B2
公开(公告)日：2017-08-01
申请号：US13191790
申请日：2011-07-27
申请人： Richard J. Melker
发明人： Richard J. Melker
IPC分类号： A61M37/00 , A61B5/00 , A61M1/34 , A61B5/02 , A61B5/026 , A61B5/0295 , A61M1/36 , A61M5/00 , A61B1/04 , A61K31/47
CPC分类号： A61M1/34 , A61B5/02007 , A61B5/0261 , A61B5/0295 , A61B5/6819 , A61M1/3403 , A61M1/341 , A61M1/3609 , A61M2205/3306 , A61M2205/50
摘要： Disclosed herein are methods, systems and devices to monitor vascular volume status utilizing at least one oximetry/photoplethysmography sensor. The methods, systems and devices provide an alternative to conventional vascular volume monitoring methods while enabling reliable, non-invasive, and automatic monitoring of vascular volume to avert patient hypotension. The methods, systems and devices may be employed in the context of both inpatient and outpatient facilities and may also be incorporated into conventional monitoring devices, techniques and equipment.

49. 发明申请

US20170049391A1 Monitoring Asthma And Other Respiratory Disorders With Calibrated Photoplethysmography Devices And Methods Of Using The Same 审中-公开
标题翻译：通过校准的Photoplethysmography设备监测哮喘和其他呼吸系统疾病及其使用方法
公开(公告)号：US20170049391A1
公开(公告)日：2017-02-23
申请号：US15186726
申请日：2016-06-20
申请人： Richard J. Melker
发明人： Richard J. Melker
IPC分类号： A61B5/00 , A61B5/0205
CPC分类号： A61B5/4884 , A61B5/0205 , A61B5/02416 , A61B5/08 , A61B5/085 , A61B5/1073 , A61B5/14551 , A61B5/14552 , A61B5/411 , A61B5/4836 , A61B2560/0223 , A61M16/0069 , A61M16/1005 , A61M2205/3303 , A61M2205/3306 , A61M2205/502 , A61M2230/205
摘要： Provided according to embodiments of the invention are methods of monitoring air obstruction in an individual that include obtaining at least one calibration photoplethysmography (PPG) signal stream from the individual while the individual spontaneously breathes through at least one resistor having a known resistance; using a processing device to determine changes in the at least one calibration PPG signal stream in response to an increase in resistance to the individual's breathing; obtaining a monitoring PPG signal stream from the individual during spontaneous breathing; and using the monitored PPG signal stream to determine a calibrated resistance value, and using the calibrated resistance value to determine a level of obstruction of the individual's breathing. Related devices are also provided herein.
摘要翻译：根据本发明的实施例提供的是监测个体中的空气阻塞的方法，包括在个体通过具有已知电阻的至少一个电阻器自发呼吸时获得来自个体的至少一个校准光谱体积描记术（PPG）信号流; 使用处理装置来响应于对个人呼吸的抵抗力的增加来确定至少一个校准PPG信号流的变化; 在自发呼吸期间从个体获得监测PPG信号流; 并且使用监测的PPG信号流来确定校准的电阻值，并且使用校准的电阻值来确定个体呼吸的阻塞水平。本文还提供了相关设备。

50. 发明授权

US09155826B2 Method for using photoplethysmography to optimize fluid removal during renal replacement therapy by hemodialysis or hemofiltration 有权
标题翻译：在血液透析或血液滤过肾脏置换治疗期间使用光电容积描记法优化流体去除的方法
公开(公告)号：US09155826B2
公开(公告)日：2015-10-13
申请号：US12985435
申请日：2011-01-06
申请人： Edward Allan Ross , Richard J. Melker
发明人： Edward Allan Ross , Richard J. Melker
IPC分类号： A61M37/00 , A61B5/00 , A61M1/34 , A61B5/02 , A61B5/026 , A61B5/0295 , A61M1/36 , A61M5/00 , A61B1/00 , A61B5/04
CPC分类号： A61M1/34 , A61B5/02007 , A61B5/0261 , A61B5/0295 , A61B5/6819 , A61M1/3403 , A61M1/341 , A61M1/3609 , A61M2205/3306 , A61M2205/50
摘要： Disclosed herein are methods, systems and devices to monitor vascular volume status during renal replacement therapy utilizing at least one oximetry/photoplethysmography sensor. The methods, systems and devices provide an alternative to conventional vascular volume monitoring methods during renal replacement therapy while enabling reliable, non-invasive, and automatic monitoring of vascular volume to avert patient hypotension. The methods, systems and devices may be employed in the context of both inpatient and outpatient dialysis facilities and may also be incorporated into conventional hemodialysis and hemofiltration techniques and equipment.
摘要翻译：本文公开了使用至少一种血氧定量/光电容积描记传感器在肾脏替代治疗期间监测血管体积状态的方法，系统和装置。在肾脏替代治疗期间，方法，系统和装置提供常规血管容积监测方法的替代方案，同时实现血管容积的可靠，非侵入和自动监测以避免患者低血压。方法，系统和装置可以在住院和门诊透析设备的上下文中使用，并且还可以并入常规血液透析和血液滤过技术和设备中。

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