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    • 43. 发明授权
    • 2-Oxo-1,3-oxazolo[4,5-h] quinolines useful as anti-allergy agents
    • 可用作抗过敏剂的2-氧代-1,3-恶唑并[4,5-h]喹啉
    • US4563463A
    • 1986-01-07
    • US667667
    • 1984-11-02
    • John H. MusserRichard E. Brown
    • John H. MusserRichard E. Brown
    • C07D215/28C07D498/04A61K31/47
    • C07D215/28
    • New quinoline compound, and the corresponding 1,2-; 1,3-; and 1,4-benzodiazines, the quinoline compounds being of the formulae: ##STR1## and salts thereof, wherein R is hydrogen, acyl, carboethoxy,(3-methoxyphen)acetyl,(2-phenyl)propionyl, dimethylcarbamoyl or methyl,R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl,Y is oxygen, sulfur, nitrogen or R.sub.3 N wherein R.sub.3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, aralkyl, acyl, aminoalkyl, or carboxyalkyl,Z is oxygen, sulfur or nitrogen,X is cyano, carbalkoxy, carboxyl, formyloximino, tetrazolyl, carbalkoxyalkyl or carboxyalkyl, andm is 0 or 1, are useful as medicinals, especially for treatment of asthma, and/or as intermediates in the preparation of compounds useful for treating asthma.
    • 新喹啉化合物及相应的1,2-; 1,3- 其中R为氢,酰基,乙酰乙氧基,(3-甲氧基苯基)乙酰基,(2-苯基)丙酰基,二甲基氨基甲酰基或甲基,R 1,R 2, 氰基,芳基,芳基/低级亚烷基,硝基,低级炔基,低级烯基,低级烷基亚磺酰基,低级烷基磺酰基,低级烷氧基羰基,低级烷基氨基,低级烷基氨基, 羧基,低级烷氧基,低级烷酰基或低级烯酰基,Y是氧,硫,氮或R3N,其中R3是氢,低级烷基,烯基,炔基,芳基,芳烷基,酰基,氨基烷基或羧基烷基,Z是氧,硫或 氮,X为氰基,烷氧羰基,羧基,甲酰肟基,四唑基,碳烷氧基烷基或羧基烷基,m为0或1,可用作药物,特别是用于治疗哮喘,和/或作为制备用于治疗哮喘的化合物的中间体 。