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41. 发明申请

US20130245018A1 Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use 有权
标题翻译：芳基 - 苯基磺酰氨基 - 环烷基化合物及其用途
公开(公告)号：US20130245018A1
公开(公告)日：2013-09-19
申请号：US13886799
申请日：2013-05-03
申请人： Iain Robert Greig , Rose Mary Sheridan , Raymond Fisher , Matthew John Tozer , Juha Andrew Clase , Andrew Smith , Andrew Robert Tuffnell , Robert Jurgen Van 't Hof
发明人： Iain Robert Greig , Rose Mary Sheridan , Raymond Fisher , Matthew John Tozer , Juha Andrew Clase , Andrew Smith , Andrew Robert Tuffnell , Robert Jurgen Van 't Hof
IPC分类号： C07C311/20 , C07D239/26 , C07D213/61 , C07D239/30 , C07D207/04 , C07D295/135
CPC分类号： A61K31/18 , A61K31/44 , A61K31/4418 , A61K31/505 , C07C311/20 , C07C311/28 , C07C311/29 , C07D207/04 , C07D213/34 , C07D213/52 , C07D213/61 , C07D239/26 , C07D239/30 , C07D295/135
摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc.
摘要翻译：本发明一般涉及治疗化合物领域，更具体地涉及下列通式的某些芳基 - 苯基 - 亚磺酰氨基 - 环烷基化合物（在本文中统称为“APSAC化合物”）。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内在治疗例如炎症和/或关节破坏和/或骨丢失中的用途; 由免疫系统的过度和/或不适当和/或延长的激活介导的疾病; 炎性和自身免疫性疾病，例如类风湿性关节炎，牛皮癣，牛皮癣关节炎，慢性阻塞性肺病（COPD），动脉粥样硬化，炎性肠病，强直性脊柱炎等; 与骨丢失相关的疾病，例如与类风湿性关节炎中的过度破骨细胞活性相关的骨丢失，骨质疏松症，癌症相关的骨病，佩吉特氏病等; 和癌症，如血液恶性肿瘤，实体瘤等。

42. 发明授权

US08515005B2 Tomosynthesis with shifting focal spot and oscillating collimator blades 有权
标题翻译：具有移动焦点和振荡准直器叶片的合成
公开(公告)号：US08515005B2
公开(公告)日：2013-08-20
申请号：US12849294
申请日：2010-08-03
申请人： Baorui Ren , Andrew Smith , Tom Farbizio , Zhenxue Jing , Jay Stein
发明人： Baorui Ren , Andrew Smith , Tom Farbizio , Zhenxue Jing , Jay Stein
IPC分类号： A61B6/04 , A61B6/00 , G21K5/10
CPC分类号： A61B6/06 , A61B6/025 , A61B6/03 , A61B6/035 , A61B6/502 , G21K1/02 , G21K1/04
摘要： In a tomosynthesis system a static focal spot is moved in a direction opposite to and generally synchronized with the directional movement of an x-ray source and X-ray collimator blades are moved during each exposure in synchronization with the shifting of the static focal spot. The synchronized movement of the static focal spot, x-ray tube and collimator blades helps keep the effective focal spot fixed in space relative to the breast, detector or both during the entire duration of the exposure and keeps the x-ray field on the detector and breast static. The shifting collimator blades follow an oscillating pattern over the multiple x-ray exposures of a tomosynthesis scan.
摘要翻译：在断层合成系统中，静态焦点沿着与X射线源的定向运动相反并且大体上与X射线源的定向运动相同的方向移动，并且与静态焦点的移动同步地在每次曝光期间移动X射线准直器叶片。静态焦点，X射线管和准直器刀片的同步运动有助于在曝光的整个持续时间内将有效焦斑保持在相对于乳房，检测器或两者的空间中，并将X射线场保持在检测器和乳房静电。移位准直器刀片遵循断层扫描合成扫描的多次X射线曝光的振荡模式。

43. 发明授权

US08469977B2 Endoscopic plication device and method 有权
标题翻译：内镜矫治装置及方法
公开(公告)号：US08469977B2
公开(公告)日：2013-06-25
申请号：US12785268
申请日：2010-05-21
申请人： Daniel J. Balbierz , Dave Cole , Samuel T. Crews , Brett Swope , Andrew Smith , John Lunsford , Fiona Sander
发明人： Daniel J. Balbierz , Dave Cole , Samuel T. Crews , Brett Swope , Andrew Smith , John Lunsford , Fiona Sander
IPC分类号： A61B17/72
CPC分类号： A61B17/1155 , A61B17/0218 , A61B17/068 , A61B17/072 , A61B17/07292 , A61B17/1114 , A61B17/115 , A61B17/1285 , A61B2017/00535 , A61B2017/00827 , A61B2017/07214 , A61B2017/07228 , A61B2017/1139 , A61B2017/1157 , A61B2017/306 , A61F5/0036
摘要： Described herein are endoscopic plicators passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. In the disclosed embodiments, the tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The disclosed plicators allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver sutures, staples or other means for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparoscopic intervention. After one or more plications is formed, medical devices may be coupled to the plication(s) for retention within the stomach.
摘要翻译：这里描述的是内窥镜检查器，其通过经腹部通过胃并用于通过从胃内部接合组织并将其向内抽吸来摧毁胃组织。在所公开的实施例中，将组织向内拉入真空室，使得胃外部的浆膜组织的部分彼此相对定位。所公开的调节器允许组织的相对部分彼此移动接触，并且优选地递送缝合线，缝钉或其它装置，用于保持组织切片之间的接触，至少在它们之间形成浆膜粘结。这些步骤中的每一个可以完全从胃内进行，因此可以消除对任何手术或腹腔镜干预的需要。在形成一个或多个脓肿之后，医疗装置可以连接到脓液以保持在胃中。

44. 发明申请

US20120263273A9 System and Method for Low Dose Tomosynthesis 有权
标题翻译：低剂量重组合的系统和方法
公开(公告)号：US20120263273A9
公开(公告)日：2012-10-18
申请号：US12397013
申请日：2009-03-03
申请人： Jay Stein , Andrew Smith , Zhenzue Jing , Loren Niklason
发明人： Jay Stein , Andrew Smith , Zhenzue Jing , Loren Niklason
IPC分类号： A61B6/04 , H05G1/42
CPC分类号： A61B6/025 , A61B6/405 , A61B6/4417 , A61B6/502 , A61B6/5235 , A61B6/5247 , A61B6/542 , A61B8/0825 , G01N23/046
摘要： A breast imaging system leverages the combined strengths of two-dimensional and three-dimensional imaging to provide a breast cancer screening with improved sensitivity, specificity and patient dosing. A tomosynthesis system supports the acquisition of three-dimensional images at a dosage lower than that used to acquire a two-dimensional image. The low-dose three-dimensional image may be used for mass detection, while the two-dimensional image may be used for calcification detection. Obtaining tomosynthesis data at low dose provides a number of advantages in addition to mass detection including the reduction in scan time and wear and tear on the x-ray tube. Such an arrangement provides a breast cancer screening system with high sensitivity and specificity and reduced patient dosing.
摘要翻译：乳房成像系统利用二维和三维成像的综合优势，提供具有改善的敏感性，特异性和患者给药的乳腺癌筛查。断层合成系统支持以比用于获取二维图像的剂量低的剂量获取三维图像。低剂量三维图像可以用于质量检测，而二维图像可以用于钙化检测。以低剂量获得断层合成数据除了质量检测之外还提供了许多优点，包括扫描时间的减少以及X射线管上的磨损和撕裂。这种布置提供了具有高灵敏度和特异性并减少患者给药的乳腺癌筛查系统。

45. 发明申请

US20120134146A1 LIGHTING APPARATUS 审中-公开
标题翻译：照明设备
公开(公告)号：US20120134146A1
公开(公告)日：2012-05-31
申请号：US13376638
申请日：2010-06-10
申请人： Andrew Smith
发明人： Andrew Smith
IPC分类号： F21S4/00 , F21V15/015 , F21V7/04
CPC分类号： F21V7/005 , F21V14/02 , F21V15/015 , F21V19/02 , F21Y2103/00
摘要： A lighting apparatus (1) with a housing (2), two parallel elongate lighting cells (5a, 5b) and a concave reflector (6) configured to focus light emitted from the two lighting cells (5a, 5b). The lighting cells (5a, 5b) are movable with respect to one another and with respect to the reflector (3), thereby to alter the spread and/or direction of the emitted light. The housing includes removable end caps (3) each with a receptacle (33) that receive the end portion (22) of the housing (2) and a clip (35) configured to connect the end cap (3) to the housing (2). The reflector (6) includes spaced brackets (60) and a resilient reflective sheet (61) received and retained by the brackets (60).
摘要翻译：一种具有壳体（2）的照明设备（1），两个平行的细长照明单元（5a，5b）和凹面反射器（6），其被配置为聚焦从两个照明单元（5a，5b）发射的光。照明单元（5a，5b）可相对于彼此和相对于反射器（3）移动，从而改变发射光的扩展和/或方向。壳体包括可移除的端盖（3），每个端盖具有容纳壳体（2）的端部（22）的容器（33）和构造成将端盖（3）连接到壳体（2）的夹子）。反射器（6）包括间隔开的支架（60）和由支架（60）容纳和保持的弹性反射片（61）。

46. 发明申请

US20120033868A1 DETECTING AND QUANTIFYING PATIENT MOTION DURING TOMOSYNTHESIS SCANS 有权
标题翻译：在TOMOSYNTHESIS扫描期间检测和定量患者运动
公开(公告)号：US20120033868A1
公开(公告)日：2012-02-09
申请号：US13198352
申请日：2011-08-04
申请人： Baorui Ren , Loren Niklason , Andrew Smith , Zhenxue Jing , Jay Stein
发明人： Baorui Ren , Loren Niklason , Andrew Smith , Zhenxue Jing , Jay Stein
IPC分类号： G06K9/00 , A61B6/00
CPC分类号： A61B6/5264 , A61B5/055 , A61B5/7207 , A61B6/025 , A61B6/035 , A61B6/0414 , A61B6/461 , A61B6/481 , A61B6/502 , A61B6/5223 , A61B8/13 , A61B8/5276 , G06F19/00 , G06T7/246 , G06T2207/10112 , G06T2207/30068
摘要： The effects of patient motion in tomosynthesis scan images are automatically detected and quantified. In at least one embodiment an indication of detection of the effects of patient motion in tomosynthesis scan images is provided shortly after the scan, e.g., before the patient is discharged or before the breast is decompressed. A patient motion score may be calculated as part of motion quantification. The score may be stored for subsequent retrieval. Images may be presented with reference features to help a technician confirm of the effects of motion in images.
摘要翻译：自动检测和量化在体层摄影扫描图像中患者运动的影响。在至少一个实施例中，在扫描之后不久，例如在患者被排出之前或在乳房被减压之前，提供了在层析合成扫描图像中患者运动的影响的检测指示。患者运动评分可以作为运动量化的一部分计算。该分数可以存储用于随后的检索。图像可以呈现参考特征，以帮助技术人员确认图像中运动的影响。

47. 发明申请

US20110216879A1 Full Field Mammography With Tissue Exposure Control, Tomosynthesis, And Dynamic Field Of View Processing 有权
标题翻译：全场乳腺X线摄影与组织暴露控制，Tomosynthesis和动态视野处理
公开(公告)号：US20110216879A1
公开(公告)日：2011-09-08
申请号：US13111618
申请日：2011-05-19
申请人： Zhenxue JING , Georgia Hitzke , Donald Kennedy , Andrew Smith , Jay A. Stein
发明人： Zhenxue JING , Georgia Hitzke , Donald Kennedy , Andrew Smith , Jay A. Stein
IPC分类号： A61B6/02 , A61B6/04
CPC分类号： A61B6/502 , A61B6/025 , A61B6/06 , A61B6/4035 , A61B6/4291 , A61B6/482
摘要： A mammography system using a tissue exposure control relying on estimates of the thickness of the compressed and immobilized breast and of breast density to automatically derive one or more technic factors. The system further uses a tomosynthesis arrangement that maintains the focus of an anti-scatter grid on the x-ray source and also maintains the field of view of the x-ray receptor. Finally, the system finds an outline that forms a reduced field of view that still encompasses the breast in the image, and uses for further processing, transmission or archival storage the data within said reduced field of view.
摘要翻译：依赖于压缩和固定的乳房的厚度的估计和乳房密度的使用组织暴露控制的乳房摄影系统自动导出一个或多个技术因素。该系统进一步使用将X射线源上的抗散射栅格的焦点保持在X射线受体的视野的层析合成装置。最后，系统发现形成仍然包含图像中的乳房的缩小视野的轮廓，并且用于在所述减少的视野内进一步处理，传输或存档数据。

48. 发明申请

US20110083128A1 METHOD FOR SELECTING SOFTWARE AND INSTALLING SAME VIA A TELEMATIC MODULE IN A MOTOR VEHICLE 审中-公开
标题翻译：选择软件并通过电动车辆中的电话模块安装的方法
公开(公告)号：US20110083128A1
公开(公告)日：2011-04-07
申请号：US12572472
申请日：2009-10-02
申请人： Nathan Hoch , Andrew Smith
发明人： Nathan Hoch , Andrew Smith
IPC分类号： G06F9/445
CPC分类号： G06F8/61
摘要： Methods for configuring a telematic module and/or a non-telematic module in a motor vehicle.
摘要翻译：在机动车辆中配置远程信息处理模块和/或非远程信息模块的方法。

49. 发明申请

US20110069809A1 INTEGRATED MULTI-MODE MAMMOGRAPHY/TOMOSYNTHESIS X-RAY SYSTEM AND METHOD 有权
标题翻译：综合多模式人机界面/ TOMOSYNTHESIS X射线系统及方法
公开(公告)号：US20110069809A1
公开(公告)日：2011-03-24
申请号：US12954971
申请日：2010-11-29
申请人： Kenneth DEFREITAS , Tom Farbizio , Baori Ren , Chris Ruth , Ian Shaw , Andrew Smith , Jay Stein
发明人： Kenneth DEFREITAS , Tom Farbizio , Baori Ren , Chris Ruth , Ian Shaw , Andrew Smith , Jay Stein
IPC分类号： A61B6/04 , A61B6/00
CPC分类号： A61B6/4417 , A61B6/025 , A61B6/107 , A61B6/4291 , A61B6/4452 , A61B6/482 , A61B6/502 , G06T2207/30068
摘要： A system for multi-mode breast x-ray imaging which comprises a compression arm assembly for compressing and immobilizing a breast for x-ray imaging, an x-ray tube assembly, and an x-ray image receptor is provided. The system is configured for a plurality of imaging protocols and modes.
摘要翻译：提供了一种用于多模式乳房x射线成像的系统，其包括用于压缩和固定用于X射线成像的乳房的压缩臂组件，X射线管组件和x射线图像接收器。该系统被配置用于多个成像协议和模式。

50. 发明申请

US20100303202A1 Method and System for Controlling X-Ray Focal Spot Characteristics for Tomoysythesis and Mammography Imaging 有权
标题翻译：控制X光焦点特征的方法和系统，用于诊断和乳房造影成像
公开(公告)号：US20100303202A1
公开(公告)日：2010-12-02
申请号：US12623472
申请日：2009-11-23
申请人： Baorui Ren , Jay Stein , Zhenxue Jing , Andrew Smith
发明人： Baorui Ren , Jay Stein , Zhenxue Jing , Andrew Smith
IPC分类号： G01N23/04 , H05G1/52
CPC分类号： A61B6/4021 , A61B6/025 , A61B6/032 , A61B6/502 , H01J35/14 , H05G1/52
摘要： An x-ray tube is described that includes components for increasing x-ray image clarity in the presence of a moving x-ray source by modifying focal spot characteristics, including focal spot size and focal spot position. In a first arrangement a static focal spot is moved in a direction contrary to the movement of the x-ray source so that an effective focal spot position is essentially fixed in space relative to one of the imaged object and/or detector during a tomosynthesis exposure. In a second arrangement, the size of the static focal spot is increased, and the resulting increase in tube current reduces the exposure time and concomitant blur effect. The methods may be used alone or in combination; for example an x-ray tube with a larger, moveable static focal spot will result in a system that fully utilizes the x-ray tube generator, provides a high quality image with reduced blur and, due to the decrease in exposure time, may scan the patient more quickly.
摘要翻译：描述了一种X射线管，其包括用于通过改变焦点特性（包括焦点尺寸和焦斑位置）来增加在存在移动的X射线源的情况下增加x射线图像清晰度的部件。在第一布置中，静止焦斑在与x射线源的运动相反的方向上移动，使得在断层合成曝光期间，有效焦点位置相对于成像对象和/或检测器之一基本上固定在空间中。在第二种布置中，静态焦点的尺寸增加，并且由此导致的管电流的增加降低了曝光时间并伴随着模糊效果。这些方法可以单独使用或组合使用; 例如具有较大可移动静电焦点的X射线管将导致完全利用x射线管发生器的系统，提供具有减少的模糊的高质量图像，并且由于曝光时间的减少可能扫描病人更快

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