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    • 44. 发明申请
    • Anti-staining antibacterial dentifrice
    • 抗菌抗菌牙膏
    • US20050271601A1
    • 2005-12-08
    • US10859264
    • 2004-06-02
    • Nebojsa MilanovichAbdul GaffarMichael PrencipeThomas Boyd
    • Nebojsa MilanovichAbdul GaffarMichael PrencipeThomas Boyd
    • A61K8/33A61K8/81A61Q11/00A61K9/16A61K9/50
    • A61K8/33A61K8/81A61K8/8164A61K2800/52A61Q11/00
    • An anti-staining, antibacterial dentifrice comprises an anti-staining effective amount of an orally acceptable polymer or copolymer that comprises a plurality of monomeric groups of formula (I) wherein (a) one of A and A′ is hydrogen and the other is a moiety (X)n(R)m, (b) n in individual such moieties is independently 0 or 1, (c) linking groups X if present independently comprise an oxygen, sulfur, nitrogen, phosphorus or silicon atom, (d) where n is 0, m is 1, and where n is 1, m is independently an integer from 1 to 3 as determined by X, (e) terminal groups R are independently hydrogen or C1-18 organic radicals, and (f) M and M′ are independently selected from hydrogen, alkali metal and ammonium; said polymer or copolymer having an average molecular weight of at least about 1,000. The dentifrice further comprises an antibacterial effective amount of an orally acceptable halogenated diphenylether antibacterial agent, and an antibacterial enhancing effective amount of an orally acceptable polyvinylmethylether/maleic anhydride copolymer.
    • 抗污染的抗菌洁齿剂包括抗染色有效量的口服可接受的聚合物或共聚物,其包含多个式(I)的单体基团,其中(a)A和A'之一是氢,另一个是 部分(X)单独的这些部分中的(b)n独立地为0或1,(c)连接基团X(如果存在)独立地包含氧 ,硫,氮,磷或硅原子,(d)其中n为0,m为1,n为1,m为独立地为1至3的整数,(e)端基R独立地为 氢或C 1-18个有机基团,和(f)M和M'独立地选自氢,碱金属和铵; 所述聚合物或共聚物的平均分子量至少约为1,000。 洁齿剂还包含抗菌有效量的口服可接受的卤化二苯醚抗菌剂,以及抗菌增强有效量的口服可接受的聚乙烯基甲基醚/马来酸酐共聚物。