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41. 发明公开

EP2970481A2 HUMAN ANTIBODIES TO NAV1.7 无效
标题翻译： MENSCHLICHEANTIKÖRPERGEGEN NAV1.7
公开(公告)号：EP2970481A2
公开(公告)日：2016-01-20
申请号：EP14722419.0
申请日：2014-03-12
申请人： Regeneron Pharmaceuticals, Inc.
发明人： MACDONALD, Lynn , MURPHY, Andrew, J. , PAPADOPOULOS, Nicholas, J. , STAHL, Neil , ALESSANDRI-HABER, Nicole
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/28 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/31 , C07K2317/33 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies that bind to the human voltage gated sodium channel designated Nav 1.7 and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human Nav 1.7 (hNav 1.7). The antibodies of the invention are useful for the treatment of diseases and disorders associated with one or more Nav 1.7 biological activities, including the treatment of acute or chronic pain conditions, or inflammatory conditions.
摘要翻译：本发明提供了与命名为Nav 1.7的人电压门控钠通道结合的抗体及其使用方法。根据本发明的某些实施方案，抗体是结合人Nav 1.7（hNav 1.7）的完全人抗体。本发明的抗体可用于治疗与一种或多种Nav 1.7生物学活性相关的疾病和病症，包括治疗急性或慢性疼痛病症或炎性病症。

42. 发明公开

EP2882778A1 ANTI-PCSK9 ANTIBODIES WITH PH-DEPENDENT BINDING CHARACTERISTICS 有权
标题翻译：抗-STATK9-ANTIKÖRPERMIT PH-ABHÄNGIGENBINDUNGSEIGENSCHAFTEN
公开(公告)号：EP2882778A1
公开(公告)日：2015-06-17
申请号：EP13751027.7
申请日：2013-08-12
申请人： Regeneron Pharmaceuticals, Inc.
发明人： YANCOPOULOS, George, D. , PAPADOPOULOS, Nicholas, J. , MURPHY,Andrew, J. , STAHL, Neil
IPC分类号： C07K16/40 , A61K39/395 , A61P3/06
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides antibodies and antigen-binding fragments thereof that specifically bind proprotein convertase subtilisin/kexin-9 (PCSK9) with greater affinity at neutral pH than at acidic pH. The antibodies of the invention may possess one or more amino acid changes as compared to antibodies that do not exhibit pH-dependent binding properties. For example, the present invention includes anti-PCSK9 antibodies which possess one or more histidine substitutions in one or more complementarity determining regions. The antibodies of the invention, with pH-dependent binding properties, remain in circulation and exhibit cholesterol lowering activity for prolonged periods of time in animal subjects as compared to anti-PCSK9 antibodies that do not exhibit pH-dependent binding properties. The antibodies of the invention are therefore useful for treating diseases and disorders related to elevated HDL cholesterol, wherein the antibodies of the invention can be administered to a patient at a lower dose and/or with less frequent dosing as compared to antibodies that do not exhibit pH-dependent binding properties.
摘要翻译：本发明提供抗体及其抗原结合片段，其在中性pH下比在酸性pH下具有更高的亲和力特异性结合前蛋白转化酶枯草杆菌蛋白酶/ kexin-9（PCSK9）。与不显示pH依赖性结合特性的抗体相比，本发明的抗体可具有一个或多个氨基酸变化。例如，本发明包括在一个或多个互补决定区具有一个或多个组氨酸取代的抗PCSK9抗体。与不具有pH依赖性结合特性的抗PCSK9抗体相比，具有pH依赖性结合特性的本发明抗体在动物受试者中保持循环并延长长时间的胆固醇降低活性。因此，本发明的抗体可用于治疗与升高的HDL胆固醇相关的疾病和病症，其中与不显示的抗体相比，本发明的抗体可以较低剂量和/或以较不频繁的给药方式施用于患者 pH依赖性结合性质。

43. 发明授权

EP2356151B1 HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN IL-4 RECEPTOR 有权
标题翻译：高亲和力人抗体对人IL-4受体
公开(公告)号：EP2356151B1
公开(公告)日：2013-04-10
申请号：EP09744292.5
申请日：2009-10-27
申请人： Regeneron Pharmaceuticals, Inc.
发明人： MARTIN, Joel, H. , HUANG, Tammy, T. , FAIRHURST, Jeanette, L. , PAPADOPOULOS, Nicholas, J.
IPC分类号： C07K16/28 , A61P37/08
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/76 , C07K2317/92
摘要： An isolated human antibody or antibody fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4R±) with high affinity (K0), capable of blocking hIL-4 and hIL-13 activity

44. 发明授权

EP2054082B1 Use of Dll4 antagonists in ischemic injury or vascular insufficiency 有权
标题翻译：使用Dll4的拮抗剂缺血性损伤或血管收缩的治疗
公开(公告)号：EP2054082B1
公开(公告)日：2012-12-26
申请号：EP07811137.4
申请日：2007-08-07
申请人： REGENERON PHARMACEUTICALS, INC.
发明人： WIEGAND, Stanley, J. , PAPADOPOULOS, Nicholas, J. , LOBOV, Ivan, B.
IPC分类号： A61K38/17 , A61K38/18 , C07K14/515 , C07K16/28
CPC分类号： C07K16/2863 , A61K38/1709 , A61K2039/505 , C07K2317/76 , C07K2319/30

45. 发明公开

EP2356151A1 HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN IL-4 RECEPTOR 有权
标题翻译：高亲和力人抗体对人IL-4受体
公开(公告)号：EP2356151A1
公开(公告)日：2011-08-17
申请号：EP09744292.5
申请日：2009-10-27
申请人： Regeneron Pharmaceuticals, Inc.
发明人： MARTIN, Joel, H. , HUANG, Tammy, T. , FAIRHURST, Jeanette, L. , PAPADOPOULOS, Nicholas, J.
IPC分类号： C07K16/28 , A61P37/08
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/76 , C07K2317/92
摘要： An isolated human antibody or antibody fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4R±) with high affinity (K0), capable of blocking hIL-4 and hIL-13 activity

46. 发明授权

EP1639007B1 VEGF TRAPS AND THERAPEUTIC USES THEREOF 有权
标题翻译： VEGF陷阱和它们的治疗应用
公开(公告)号：EP1639007B1
公开(公告)日：2009-04-08
申请号：EP04777335.3
申请日：2004-06-29
申请人： REGENERON PHARMACEUTICALS, INC.
发明人： DALY, Thomas, J. , FANDL, James, P. , PAPADOPOULOS, Nicholas, J.
IPC分类号： C07K14/71
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00
摘要： Nucleic acid molecules and multimeric proteins capable of binding vascular endothelial growth factor (VEGF). VEGF traps are disclosed which are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.

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