专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明专利

AU2010303737B2 Genetically modified mice and engraftment 未知
公开(公告)号：AU2010303737B2
公开(公告)日：2014-05-29
申请号：AU2010303737
申请日：2010-10-04
申请人： INSTITUTE FOR RES IN BIOMEDICINE IRB , REGENERON PHARMA , UNIV YALE
发明人： STEVENS SEAN , MURPHY ANDREW J , FLAVELL RICHARD , EYNON ELIZABETH , GALAN JORGE , WILLINGER TIM , MANZ MARKUS , RONGVAUX ANTHONY
IPC分类号： A01K67/027 , A61K49/00
摘要： A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mIl2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/Il2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a myeloproliferative neoplasia.

42. 发明专利

CA2887706A1 GENETICALLY MODIFIED NON-HUMAN ANIMALS AND METHODS OF USE THEREOF 未知
公开(公告)号：CA2887706A1
公开(公告)日：2014-05-08
申请号：CA2887706
申请日：2013-11-05
申请人： REGENERON PHARMA , UNIV YALE , INST RES BIOMEDICINE IRB
发明人： FLAVELL RICHARD , STROWIG TILL , MANZ MARKUS G , BORSOTTI CHIARA , DHODAPKAR MADHAV , MURPHY ANDREW J , STEVENS SEAN , YANCOPOULOS GEORGE D
IPC分类号： A01K67/027 , C07K14/535 , C07K14/54
摘要： Genetically modified non-human animals are provided that may be used to model human hematopoietic cell development, function, or disease. The genetically modified non-human animals comprise a nucleic acid encoding human IL-6 operably linked to an IL-6 promoter. In some instances, the genetically modified non-human animal expressing human IL-6 also expresses at least one of human M-CSF, human IL-3, human GM-CSF, human SIRPa or human TPO. In some instances, the genetically modified non-human animal is immunodeficient. In some such instances, the genetically modified non-human animal is engrafted with healthy or diseased human hematopoietic cells. Also provided are methods for using the subject genetically modified non-human animals in modeling human hematopoietic cell development, function, and/or disease, as well as reagents and kits thereof that find use in making the subject genetically modified non-human animals and/or practicing the subject methods.

43. 发明专利

SG192606A1 HUMANIZED M-CSF MICE 未知
公开(公告)号：SG192606A1
公开(公告)日：2013-09-30
申请号：SG2013059076
申请日：2012-02-14
申请人： REGENERON PHARMA , UNIV YALE , INST RES BIOMEDICINE IRB
发明人： MURPHY ANDREW J , STEVENS SEAN , RATHINAM CHOZHAVENDAN , EYNON ELIZABETH , MANZ MARKUS , FLAVELL RICHARD , YANCOPOULOS GEORGE D
IPC分类号： C12Q1/68 , C12Q1/6897
摘要： Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein that have been engrafted with human cells such as human hematopoietic cells, and methods for making such engrafted mice. These mice find use in a number of applications, such as in modeling human immune disease and pathogen infection; in in vivo screens for agents that modulate hematopoietic cell development and/or activity, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to hematopoietic cells; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on hematopoietic cells; in in vivo screens of human hematopoietic cells from an individual to predict the responsiveness of an individual to a disease therapy, etc.

44. 发明专利

AU2016247892B2 Humanized SIRPA-IL15 knockin mice and methods of use thereof 未知
公开(公告)号：AU2016247892B2
公开(公告)日：2022-05-26
申请号：AU2016247892
申请日：2016-04-12
申请人： INSTITUTE FOR RES IN BIOMEDICINE IRB , REGENERON PHARMA , UNIV YALE
发明人： HERNDLER-BRANDSTETTER DIETMAR , FLAVELL RICHARD A , FRLETA DAVOR , GURER CAGAN , MANZ MARKUS GABRIEL , MURPHY ANDREW J , PALM NOAH W , SHAN LIANG , STEVENS SEAN , STROWIG TILL , YANCOPOULOS GEORGE D , DE ZOETE MARCEL
IPC分类号： A01K67/027 , A01K39/00
摘要： Genetically modified non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various

45. 发明专利

DK3417701T3 GENMODIFICEREDE MUS OG INDPODNING 未知
公开(公告)号：DK3417701T3
公开(公告)日：2022-03-14
申请号：DK18183928
申请日：2010-10-04
申请人： REGENERON PHARMA , UNIV YALE , INSTITUTE FOR RES IN BIOMEDICINE IRB
发明人： STEVENS SEAN , MURPHY ANDREW J , FLAVELL RICHARD , EYNON ELIZABETH , GALAN JORGE , WILLINGER TIM , MANZ MARKUS G , RONGVAUX ANTHONY , YANCOPOULOS GEORGE D
IPC分类号： A01K67/027 , A61K49/00 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/715 , C12N9/00

46. 发明专利

DK3556206T3 GENMODIFICEREDE IKKE-HUMANE DYR OG FREMGANGSMÅDER TIL ANVENDELSE DERAF 未知
公开(公告)号：DK3556206T3
公开(公告)日：2021-08-09
申请号：DK19176252
申请日：2013-11-05
申请人： REGENERON PHARMA , UNIV YALE , INSTITUTE FOR RES IN BIOMEDICINE IRB
发明人： FLAVELL RICHARD , STROWIG TILL , BORSOTTI CHIARA , DHODAPKAR MADHAV , MURPHY ANDREW J , STEVENS SEAN , YANCOPOULOS GEORGE D , MANZ MARKUS G
IPC分类号： A01K67/027 , C07K14/535 , C07K14/54

47. 发明专利

MY179927A GENETICALLY MODIFIED NON-HUMAN ANIMALS EXPRESSING HUMAN EPO 未知
公开(公告)号：MY179927A
公开(公告)日：2020-11-19
申请号：MYPI2016703949
申请日：2015-05-18
申请人： REGENERON PHARMA , UNIV YALE , INSTITUTE FOR RES IN BIOMEDICINE IRB
发明人： FLAVELL RICHARD , STEVENS SEAN , MANZ MARKUS , SHAN LIANG , MURPHY ANDREW J
摘要： Genetically modified non-human animals expressing human EPO from the animal genome are provided. Also provided are methods for making non-human animals expressing human EPO from the non-human animal genome, and methods for using non-human animals expressing human EPO from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human erythropoiesis and erythrocyte function; in modeling human pathogen infection of erythrocytes; in in vivo screens for agents that modulate erythropoiesis and/or erythrocyte function, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to erythrocytes or erythrocyte progenitors; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on erythrocytes or erythrocyte progenitors; in in vivo screens of erythrocytes or erythrocyte progenitors from an individual to predict the responsiveness of an individual to a disease therapy. Figure 2

48. 发明专利

AU2018213980B2 Humanized M-CSF mice 未知
公开(公告)号：AU2018213980B2
公开(公告)日：2020-04-30
申请号：AU2018213980
申请日：2018-08-06
申请人： INST RES BIOMEDICINE , REGENERON PHARMA , UNIV YALE
发明人： MURPHY ANDREW J , STEVENS SEAN , YANCOPOULOS GEORGE D , EYNON ELIZABETH , FLAVELL RICHARD , RATHINAM CHOZHAVENDAN , MANZ MARKUS
IPC分类号： A01K67/027
摘要： Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein that have been engrafted with human cells such as human hematopoietic cells, and methods for making such engrafted mice. These mice find use in a number of applications, such as in modeling human immune disease and pathogen infection; inin vivoscreens for agents that modulate hematopoietic cell development and/or activity, e.g. in a healthy or a diseased state; in in vivoscreens for agents that are toxic to hematopoietic cells; in in vivoscreens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on hematopoietic cells; in in vivo screens of human hematopoietic cells from an individual to predict the responsiveness of an individual to a disease therapy, etc.

49. 发明专利

AU2019216625A1 Genetically modified non-human animals and methods of use thereof 未知
公开(公告)号：AU2019216625A1
公开(公告)日：2019-09-05
申请号：AU2019216625
申请日：2019-08-13
申请人： INSTITUTE FOR RES IN BIOMEDICINE IRB , REGENERON PHARMA , UNIV YALE
发明人： FLAVELL RICHARD A , MANZ MARKUS , RONGVAUX ANTHONY , STROWIG TILL , WILLINGER TIM , MURPHY ANDREW J , STEVENS SEAN , YANCOPOULOS GEORGE
IPC分类号： A01K67/027 , A01K67/033 , A61K39/00
摘要： 1:\Interwovn\NRPortbl\DCC\FMT\19179005_I.DOCX-13/08/2019 The invention relates generally to genetically modified non-human animals expressing human polypeptides and their methods of use.

50. 发明专利

NZ724014A Humanized m-csf mice 未知
公开(公告)号：NZ724014A
公开(公告)日：2018-12-21
申请号：NZ72401412
申请日：2012-02-14
申请人： UNIV YALE , REGENERON PHARMA , INSTITUTE FOR RES IN BIOMEDICINE IRB
发明人： MURPHY ANDREW J , STEVENS SEAN , RATHINAM CHOZHAVENDAN , EYNON ELIZABETH , MANZ MARKUS , FLAVELL RICHARD , YANCOPOULOS GEORGE D
IPC分类号： A01K67/027 , C12Q1/6897 , C12Q1/68
摘要： Disclosed is a humanized M-CSF mouse, comprising a nucleic acid sequence incorporated into the genome of the humanized M-CSF mouse, which sequence encodes a human M-CSF protein and is operably linked to a regulatory sequence 5’ of the mouse M-CSF structural gene locus; wherein the mouse is immunocompromised for a mouse immune system as a result of one or more of the following: sub-lethal irradiation, the mouse is a NOD-SCID mouse, the mouse is a NOD-scid γc−/− (NSG) mouse, and the mouse is a NOD/Shi-scid γc−/− (NOG) mouse; and wherein the mouse expresses M-CSF RNA encoded by the nucleic acid sequence in bone marrow, spleen, blood, liver, brain, lung, testis and kidney Further disclosed is a method for making an activated human monocyte and/or activated human macrophage, comprising exposing a humanized M-CSF mouse to an immune stimulant under conditions sufficient for human monocytes and/or macrophages in the mouse to become activated, and isolating human monocytes and/or human macrophages from the mouse, wherein the mouse comprises a nucleic acid sequence incorporated into the genome of the mouse, which sequence encodes a human M-CSF protein and is operably linked to the endogenous promoter of the mouse M-CSF gene at the mouse M-CSF locus, wherein the mouse is immunocompromised for a mouse immune system, wherein the mouse comprises human hematopoietic cells, and wherein the mouse expresses M-CSF RNA encoded by the nucleic acid sequence in bone marrow, spleen, blood, liver, brain, lung, testis and kidney. Further disclosed is a method of isolating biologically active human M-CSF, the method comprising isolating biologically active human MCSF from a humanized M-CSF mouse, wherein the mouse comprises a nucleic acid sequence incorporated into the genome of the mouse, which sequence encodes a human M-CSF protein and is operably linked to the endogenous promoter of the mouse M-CSF gene at the mouse M-CSF locus, wherein the mouse is immunocompromised for a mouse immune system, and wherein the mouse expresses M-CSF RNA encoded by the nucleic acid sequence in bone marrow, spleen, blood, liver, brain, lung, testis and kidney.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式