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41. 发明授权

EP2350279B1 METHODS FOR TREATING EYE DISORDERS 有权转让
标题翻译：方法眼病治疗
公开(公告)号：EP2350279B1
公开(公告)日：2016-01-27
申请号：EP09748890.2
申请日：2009-10-22
申请人： Quark Pharmaceuticals, Inc.
发明人： FEINSTEIN, Elena , ALPERT, Evgenia , METT, Igor , BAR-ILAN, Amir , SPIVAK, Igor , KALINSKI, Hagar , SLAGER, Netanja
IPC分类号： C12N15/113 , A61K31/711
CPC分类号： C12N15/113 , A61K9/0048 , C12N2310/11 , C12N2310/14 , C12N2320/30
摘要： The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at 5 least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.

42. 发明公开

EP2895607A2 DOUBLE-STRANDED OLIGONUCLEOTIDE MOLECULES TO DDIT4 AND METHODS OF USE THEREOF 有权转让
标题翻译：双链寡核苷酸分子DDIT4及其使用方法
公开(公告)号：EP2895607A2
公开(公告)日：2015-07-22
申请号：EP13773450.5
申请日：2013-09-12
申请人： Quark Pharmaceuticals, Inc.
发明人： FEINSTEIN, Elena , AVKIN-NACHUM, Sharon , KALINSKI, Hagar , METT, Igor
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/113 , C12N15/1135 , C12N15/1136 , C12N2310/14 , C12N2310/317 , C12N2310/319 , C12N2310/321 , C12N2310/3521 , C12N2320/30
摘要： The present application relates to nucleic acid compounds, compositions comprising same and methods of use thereof for treatment of various diseases, disorders and conditions. The compounds are preferably chemically synthesized and modified double-stranded nucleic acid molecules which down regulate expression of a p53 gene.

43. 发明公开

EP2681314A2 COMPOSITIONS AND METHODS FOR TREATING LUNG DISEASE AND INJURY 有权
标题翻译：组合物和方法用于治疗肺疾病和损伤
公开(公告)号：EP2681314A2
公开(公告)日：2014-01-08
申请号：EP12708474.7
申请日：2012-03-01
申请人： Quark Pharmaceuticals, Inc. , Washington University
发明人： GELMAN, Andrew E. , FEINSTEIN, Elena , ADAMSKY, Svetlana , METT, Igor , KALINSKI, Hagar , AVKIN-NACHUM, Sharon
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/713 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/344 , C12N2310/3521
摘要： Disclosed herein are therapeutic methods for treating lung diseases, disorders and injury in a mammal, including treatment of acute respiratory distress syndrome (ARDS), acute lung injury, pulmonary fibrosis (idiopathic), bleomycin induced pulmonary fibrosis, mechanical ventilator induced lung injury, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiolitis obliterans after lung transplantation and lung transplantation-induced acute graft dysfunction, including treatment, prevention or prevention of progression of primary graft failure, ischemia-reperfusion injury, reperfusion injury, reperfusion edema, allograft dysfunction, pulmonary reimplantation response, bronchiolitis obliterans after lung transplantation and/or primary graft dysfunction (PGD) after organ transplantation, in particular in lung transplantation, comprising downregulating the TLR2 gene or both the TLR2 gene and TLR4 gene. Provided herein are compositions, methods and kits for treating lung diseases, disorders and injury.
摘要翻译：公开的是用于治疗哺乳动物中的肺部疾病，病症和损伤，包括治疗急性呼吸窘迫综合征（ARDS），急性肺损伤，肺纤维症（特发性），博来霉素诱导的肺纤维化，呼吸机诱导的肺损伤，慢性的治疗方法阻塞性肺病（COPD），慢性支气管炎，肺气肿，肺移植，肺移植引起的急性移植物功能障碍，包括治疗，预防或预防原发性移植失败，缺血 - 再灌注损伤，再灌注损伤，再灌注水肿的进展后闭塞性细支气管炎，同种异体移植物功能障碍，肺再植响应，肺移植和/或器官移植后的主要移植物功能障碍（PGD）后闭塞性细支气管炎，在肺移植particulare，包括下调的基因TLR2或两个基因TLR2和TLR4基因。在本发明提供的组合物，方法和试剂盒用于治疗肺部疾病，病症和损伤。

44. 发明公开

EP2285385A2 siRNA COMPOUNDS FOR INHIBITING NRF2 审中-公开
标题翻译： siRNA化合物抑制NRF2
公开(公告)号：EP2285385A2
公开(公告)日：2011-02-23
申请号：EP09754323.5
申请日：2009-04-06
申请人： Quark Pharmaceuticals, Inc.
发明人： FEINSTEIN, Elena , METT, Igor , KALINSKI, Hagar
IPC分类号： A61K31/70
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/317 , C12N2310/319 , C12N2310/321 , C12N2310/3231 , C12N2310/332 , C12N2310/343 , C12N2310/344 , C12N2310/3521
摘要： The present invention provides chemically modified siRNA compounds that target the Nrf2 gene and pharmaceutical compositions comprising same useful for treating or preventing the incidence or severity of a cancerous disease, particularly various lung cancers.

45. 发明公开

EP2268316A2 NOVEL siRNA COMPOUNDS FOR INHIBITING RTP801 审中-公开
标题翻译：用于抑制RTP801的新型siRNA化合物
公开(公告)号：EP2268316A2
公开(公告)日：2011-01-05
申请号：EP09722841.5
申请日：2009-03-17
申请人： Quark Pharmaceuticals, Inc.
发明人： FEINSTEIN, Elena , SKALITER, Rami , KALINSKI, Hagar , METT, Igor
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , C12N2310/14 , C12N2320/31
摘要： The present invention provides chemically modified siRNA compounds that target RTP801 and pharmaceutical compositions comprising same useful for treating microvascular disorders, eye diseases, hearing impairment, neurodegenerative diseases and disorders, spinal cord injury and respiratory conditions.
摘要翻译：本发明提供了靶向RTP801的化学修饰的siRNA化合物和包含其的药物组合物，其用于治疗微血管病症，眼病，听力障碍，神经退行性疾病和病症，脊髓损伤和呼吸病症。

46. 发明公开

EP2026843A2 THERAPEUTIC USES OF INHIBITORS OF RTP801L 审中-公开
标题翻译： RTP801L的治疗用途
公开(公告)号：EP2026843A2
公开(公告)日：2009-02-25
申请号：EP07736435.4
申请日：2007-06-07
申请人： Quark Pharmaceuticals, Inc.
发明人： FEINSTEIN, Elena , METT, Igor
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/321 , C12N2320/31 , C12N2310/3521
摘要： The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases respiratory conditions and hearing disorders based upon inhibition of the RTP801L gene and/or protein.

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