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41. 发明申请

US20050245876A1 Apparatus and methods for facilitating access through a puncture including sealing compound therein 审中-公开
标题翻译：用于促进通过刺穿进入的装置和方法，包括其中的密封化合物
公开(公告)号：US20050245876A1
公开(公告)日：2005-11-03
申请号：US11112970
申请日：2005-04-22
申请人： Farhad Khosravi , Suresh Pai
发明人： Farhad Khosravi , Suresh Pai
IPC分类号： A61B17/00 , A61B17/08 , A61M5/178
CPC分类号： A61M25/0662 , A61B17/00491 , A61B17/0057 , A61B17/3431 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065 , A61B2017/3435
摘要： Apparatus for delivering a sleeve into a puncture through tissue includes a tubular sheath including a lumen extending between its proximal end and an opening in its distal end. The sleeve includes a hub on a first end thereof disposed adjacent the distal end of the sheath, and a second end extending into the opening and lumen of the sheath. The hub is slidable along an exterior of the sheath for drawing the sleeve out of the opening and along an exterior of the sheath. During use, a guide wire is placed through the puncture into a blood vessel, and sealing compound is introduced into the puncture around the guide wire. The sheath is advanced into the puncture over the guidewire while maintaining the hub adjacent the patient's skin, causing the sleeve to be deployed from the sheath and line the puncture as the sheath is advanced into the puncture.
摘要翻译：用于将套管输送穿过组织穿刺的装置包括管状护套，其包括在其近端和其远端中的开口之间延伸的内腔。所述套筒包括在其邻近护套的远端设置的第一端上的毂，以及延伸到护套的开口和内腔中的第二端。轮毂可以沿着护套的外部滑动，用于将套筒从开口外侧延伸出来并且沿着护套的外部。在使用过程中，将引导线穿过穿刺置于血管中，并将密封剂引入导丝周围的穿刺中。护套通过导丝进入穿刺，同时将轮毂保持在邻近患者皮肤的位置，导致套管从护套展开并且当护套进入穿刺时将其穿过穿刺线。

42. 发明授权

US06793672B2 Coiled sheet graft for single and bifurcated lumens and methods of making and use 失效
标题翻译：单片和分叉腔的卷片移植物及其制作和使用方法
公开(公告)号：US06793672B2
公开(公告)日：2004-09-21
申请号：US10224094
申请日：2002-08-19
申请人： Farhad Khosravi , Michael Hogendijk , John Spiridigliozzi , Michael R. Ross , Himanshu Patel
发明人： Farhad Khosravi , Michael Hogendijk , John Spiridigliozzi , Michael R. Ross , Himanshu Patel
IPC分类号： A61F206
CPC分类号： A61F2/92 , A61F2/07 , A61F2/93 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61F2220/0008 , A61F2220/0016 , A61F2220/0041 , A61F2220/005 , A61F2220/0075
摘要： A prosthesis is provided for treating aneurysms, occlusive disease of vessels and body organs, and arterio-venous fistulas, occurring in single and bifurcated lumens. The prosthesis comprises an expandable coiled sheet portion having a biocompatible graft, either a sheet or tube, affixed thereto along part or all of the circumference of the coiled sheet portion. The prosthesis has a small delivery profile, making it suitable for use in a variety of body vessels. Methods of making and deploying the prosthesis in single and bifurcated lumens are also provided.
摘要翻译：提供了一种假体，用于治疗动脉瘤，血管和身体器官的闭塞性疾病以及发生在单个和分叉腔内的动静脉瘘。假体包括具有生物相容性移植物（片或管）的可膨胀卷曲片部分，其沿着盘绕片部分的圆周的部分或全部固定到其上。假体具有小的输送轮廓，使其适用于各种身体血管。还提供了在单个和分叉腔内制造和部署假体的方法。

43. 发明授权

US06620182B1 Vascular filter having articulation region and methods of use in the ascending aorta 有权
公开(公告)号：US06620182B1
公开(公告)日：2003-09-16
申请号：US09635734
申请日：2000-08-09
申请人： Farhad Khosravi , L. N. Hopkins , Amr Salahieh , Jackson F. Demond , Jeff A. Krolik
发明人： Farhad Khosravi , L. N. Hopkins , Amr Salahieh , Jackson F. Demond , Jeff A. Krolik
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61B2017/2212 , A61F2/01 , A61F2002/011 , A61F2002/018 , A61F2230/0008 , A61F2230/008 , A61M2025/09183 , A61M2025/1052 , A61M2025/109
摘要： Apparatus and methods are provided for use in filtering emboli from a vessel such as the ascending aorta, wherein a vascular device comprises a support hoop having an articulation region connected near a distal end of an elongated member, a blood permeable sac affixed to the support hoop so that the support hoop forms a mouth of the blood permeable sac, a guide wire, and a delivery sheath. The articulation region comprises a reduced thickness region of the support hoop that prevents kinks from forming in the support hoop when the apparatus is contracted to its delivery state, and curved regions that close the mouth of the sac to prevent material escaping from the sac when the apparatus is collapsed for removal.

44. 发明授权

US06530939B1 Vascular device having articulation region and methods of use 有权
标题翻译：具有关节区域的血管装置和使用方法
公开(公告)号：US06530939B1
公开(公告)日：2003-03-11
申请号：US09364064
申请日：1999-07-30
申请人： Leo N. Hopkins , Farhad Khosravi , Amr Salahieh , Jeff A. Krolik , Jackson F. Demond
发明人： Leo N. Hopkins , Farhad Khosravi , Amr Salahieh , Jeff A. Krolik , Jackson F. Demond
IPC分类号： A61M2900
CPC分类号： A61F2/01 , A61B2017/2212 , A61F2/013 , A61F2002/011 , A61F2002/018 , A61F2230/0008 , A61F2230/008 , A61M2025/09183 , A61M2025/1052 , A61M2025/109
摘要： Apparatus and methods are provided for use in filtering emboli from a vessel and performing thrombectomy and embolectomy, wherein a vascular device comprises a support hoop having an articulation region connected near a distal end of a guide wire, and a blood permeable sac affixed to the support hoop so that the support hoop forms a mouth of the blood permeable sac. The articulation region comprises a reduced thickness region of the support hoop that prevents kinks from forming in the support hoop when the apparatus is contracted to its delivery state, and curved regions that close the mouth of the sac to prevent material escaping from the sac when the apparatus is collapsed for removal.
摘要翻译：提供了用于从血管过滤栓塞并执行血栓切除术和止血切除术的装置和方法，其中血管装置包括支撑环，所述支撑环具有连接在导丝的远端附近的关节区域，以及固定在支撑体上的血液渗透囊使得支撑环形成透血囊的口。铰接区域包括支撑环的减小的厚度区域，当装置收缩到其输送状态时，防止在支撑环中形成扭结;以及弯曲区域，其闭合囊的口以防止材料从囊中逸出，装置被塌缩以便移除。

45. 发明授权

US06378218B2 Methods and apparatus for making a drug infusion device 失效
标题翻译：制备药物输注装置的方法和装置
公开(公告)号：US06378218B2
公开(公告)日：2002-04-30
申请号：US09068635
申请日：1998-10-19
申请人： Ulrich Sigwart , Amir Abolfathi , Farhad Khosravi , Isidro Gandionco
发明人： Ulrich Sigwart , Amir Abolfathi , Farhad Khosravi , Isidro Gandionco
IPC分类号： B26F132
CPC分类号： B26F1/36 , B26F1/0015 , B26F1/24 , Y10T83/04 , Y10T83/0481
摘要： Methods and apparatus are provided for converting standard catheters or balloon catheters into drug infusion devices on an as-needed basis in a sterile environment, and which permit re-use of catheter devices previously used in a preceding non-invasive procedure. Apparatus is provided having a cavity for receiving a catheter device and a plurality of perforation pins or teeth for creating apertures in the catheter. Apparatus capable of converting a wide range of catheter devices into drug infusion devices is provided, which apparatus may be single-use disposable or re-sterilizable and re-usable.
摘要翻译：提供了用于在无菌环境中根据需要将标准导管或气囊导管转换成药物输注装置的方法和装置，并且其允许重新使用先前在先前非侵入性手术中使用的导管装置。提供具有用于接收导管装置的空腔和用于在导管中产生孔的多个穿孔针或齿的装置。提供了能够将各种导管装置转换成药物输注装置的装置，该装置可以是一次性使用的或可再消毒的并可重新使用。

46. 发明授权

US5824053A Helical mesh endoprosthesis and methods of use 失效
标题翻译：螺旋网内置假体及使用方法
公开(公告)号：US5824053A
公开(公告)日：1998-10-20
申请号：US820212
申请日：1997-03-18
申请人： Farhad Khosravi , Michael Hogendijk , Michael R. Ross
发明人： Farhad Khosravi , Michael Hogendijk , Michael R. Ross
IPC分类号： A61F2/88 , A61F2/92 , A61F2/06
CPC分类号： A61F2/88 , A61F2/92 , A61F2/91 , A61F2220/0016
摘要： A stent comprising a helical mesh coil is provided having a substantially rectangular cross-section and a band width equal to at least one-quarter to one-third of the maximum expanded circumference of the stent. The helical mesh has a multiplicity of openings forming a lattice which preferably provides about 60% open space or more. Alternative embodiments of the helical mesh may include specially designed free ends that preferentially overlap neighboring turns of the coil, to ensure that the free ends of the stent do not project into the body lumen, and integrally formed barbs that induce a ratcheting effect that ensures that the stent resists localized compressive forces. Methods of deploying the helical mesh coil stent also provided.
摘要翻译：提供了一种包括螺旋网状线圈的支架，其具有基本上矩形的横截面和等于支架的最大扩张圆周的至少四分之一至三分之一的带宽。螺旋网具有形成格子的多个开口，其优选地提供约60％的开放空间或更多。螺旋网的替代实施例可以包括优先重叠线圈的相邻匝的特别设计的自由端，以确保支架的自由端不会伸入体腔，以及整体形成的倒钩，其引起棘轮效应，从而确保支架抵抗局部压缩力。还提供了展开螺旋网状线圈支架的方法。

47. 发明授权

US5824052A Coiled sheet stent having helical articulation and methods of use 失效
标题翻译：具有螺旋关节的卷片支架和使用方法
公开(公告)号：US5824052A
公开(公告)日：1998-10-20
申请号：US819967
申请日：1997-03-18
申请人： Farhad Khosravi , Michael Hogendijk , John Spiridigliozzi
发明人： Farhad Khosravi , Michael Hogendijk , John Spiridigliozzi
IPC分类号： A61F2/00 , A61F2/06 , A61F2/88 , A61F2/92
CPC分类号： A61F2/88 , A61F2/92 , A61F2/91 , A61F2002/065 , A61F2250/0007 , A61F2250/0039
摘要： An endoprosthesis is provided having at least first and second resilient coiled sheet portions, and an intermediate region comprising a helical articulation. The coiled sheet portions may be of the same or different diameters so as to accommodate a taper in the body lumen, while the helical articulation comprises a mesh portion that provides both flexibility and high radial strength, and which contracts to its delivery profile with relatively few turns. The coiled sheet portions also may be of the same or different lengths, and for very long devices, may be interspersed between a plurality of helical articulation portions. The pitch of the helical articulation may be varied to create a partial telescoping of the helical articulation within one of the first and second coiled sheet portions when in a contracted state. The prosthesis may also be used for treating bifurcated vessels.
摘要翻译：提供具有至少第一和第二弹性盘绕片部分的内置假体以及包括螺旋关节的中间区域。螺旋片部分可以具有相同或不同的直径，以便容纳体腔中的锥形，而螺旋关节包括提供柔性和高径向强度的网状部分，并且其相对较少地收缩到其输送轮廓轮到螺旋片部分也可以具有相同或不同的长度，并且对于非常长的装置，可以散布在多个螺旋形关节部分之间。当处于收缩状态时，螺旋关节的间距可以变化以产生在第一和第二螺旋片部分之一内的螺旋关节的部分伸缩。假体也可用于治疗分叉血管。

48. 发明授权

US5782855A Stent delivery system 失效
公开(公告)号：US5782855A
公开(公告)日：1998-07-21
申请号：US630528
申请日：1996-04-10
申请人： Lilip Lau , William M. Hartigan , Farhad Khosravi , Kurt R. Klemm , Ulrich Sigwart
发明人： Lilip Lau , William M. Hartigan , Farhad Khosravi , Kurt R. Klemm , Ulrich Sigwart
IPC分类号： A61F2/82 , A61F2/06 , A61F2/84 , A61M25/00 , A61M25/01 , A61M29/00
CPC分类号： A61F2/97 , A61F2/958 , A61F2002/9517 , A61M2025/0183 , A61M2025/1081
摘要： The invention is directed to a stent delivery method and system which generally includes an elongated delivery sheath and a catheter disposed within an outer lumen of the sheath having an expandable member on its distal extremity. An expandable stent is mounted on the expandable member of the catheter. The distal portion of the sheath tapers down and is tucked within an elastic cone during transport of the stent to a stenotic region. A manipulating device is provided on the proximal end of the delivery system to effect relative axial movement between the sheath and the catheter so as to expose the stent mounted on the expandable member on the catheter within a body lumen such as a coronary artery and allow the expansion of the stent by the expansion of the expandable member. The elastic cone thereby disengages from the sheath and collapses about the distal end of the catheter. The delivery sheath has a first port in its distal end and a second port in the sheath wall proximally disposed from the distal end of the sheath. The catheter likewise has a first port in its distal end and a second port proximally disposed from the distal end of the catheter. An inner lumen extends within the distal portion of the catheter between the first and second ports and slidably receives a guiding member such as a guidewire. This system allows the stent to be delivered over a guidewire previously advanced to the desired location within a body lumen.

49. 发明授权

US5725572A Radiopaque stent 失效
标题翻译：不透射线支架
公开(公告)号：US5725572A
公开(公告)日：1998-03-10
申请号：US908906
申请日：1997-08-08
申请人： Sharon S. Lam , John J. Frantzen , Farhad Khosravi
发明人： Sharon S. Lam , John J. Frantzen , Farhad Khosravi
IPC分类号： A61F2/84 , A61B19/00 , A61F2/00 , A61F2/06 , A61F2/90
CPC分类号： A61F2/915 , A61B90/39 , A61F2/91 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2230/0013 , A61F2250/0098
摘要： A radiopaque marker associated with a stent which is adapted to be implanted into a patient's body lumen to maintain the patency thereof and a convenient and accurate method for affixing the radiopaque marker to the stent. The radiopaque marker defining an acceptable profile and capable of facilitating, under fluoroscopy, the identification of the position, diameter and length of a stent without obscuring the lesion being repaired and without impeding the deformation of an expandable stent.
摘要翻译：与支架相关联的不透射线标记，其适于植入患者体腔以保持其通畅性，以及用于将不透射线标记物固定到支架的方便且准确的方法。不透射线标记物限定可接受的轮廓，并且能够在透视下促进支架的位置，直径和长度的识别，而不会使正在修复的损伤变得模糊，而且不会阻碍可扩张支架的变形。

50. 发明授权

US5618299A Ratcheting stent 失效
标题翻译：棘轮支架
公开(公告)号：US5618299A
公开(公告)日：1997-04-08
申请号：US512300
申请日：1995-08-08
申请人： Farhad Khosravi , Michael S. Williams
发明人： Farhad Khosravi , Michael S. Williams
IPC分类号： A61F2/00 , A61F2/02 , A61F2/92 , A61M29/00
CPC分类号： A61F2/93 , A61F2/07 , A61F2/958 , A61F2210/0004 , A61F2250/0067
摘要： An intravascular stent including a cylindrical sheet having overlapping edges that interlock. The edges have a series of protrusions and apertures that interlock and ratchet as the stent expands to an open position to support a section of arterial wall. The stent may be expanded by a balloon catheter or it may be self-expanding. The stent is biocompatible, may be bio-erodible, and capable of localized drug delivery. A plurality of retaining members to keep the stent open are disclosed. In one embodiment a buckle fastening member is used, while in another embodiment a helical seam containing projections is employed. The stent may be wound in such a manner that during expansion of the stent one side of the sheet desires to return to its original shape, creating a bias. In addition, a variety of reticulated structure stents are disclosed, with novel geometric patterns that aid in increased flexibility while preserving radial strength and also allow blood-tissue interaction and side branch access. The intravascular stent may be made of a sheet of material strengthened and stiffened by pyrolytic carbon or by structural reinforcement as in composite laminates.
摘要翻译：包括具有互锁的重叠边缘的圆柱形片的血管内支架。边缘具有一系列突起和孔，当支架膨胀到打开位置以支撑动脉壁的一部分时，其互锁并棘轮。支架可以通过气囊导管扩张，或者可以是自扩张的。支架是生物相容的，可以是生物可蚀刻的，并且能够局部药物递送。公开了保持支架打开的多个保持构件。在一个实施例中，使用带扣紧固构件，而在另一实施例中采用了包含凸起的螺旋缝。支架可以以这样的方式被卷绕，即在支架的膨胀期间，片材的一侧期望返回到其原始形状，产生偏压。此外，公开了各种网状结构支架，其具有新颖的几何图案，其有助于增加柔性，同时保持径向强度并且还允许血液 - 组织相互作用和侧分支进入。血管内支架可以由通过热解碳强化和加固的材料制成，或者通过结构加强制成，如在复合层压板中。

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